Figure 3.
Presence of IgG subclasses of anti-ADAMTS13 IgG autoantibodies in the Japanese iTTP cohort. IgG subclasses were determined using ELISA by coating rADAMTS13 and detecting bound anti-ADAMTS13 autoantibodies with HRP-labeled anti-human IgG1, IgG2, IgG3, or IgG4 antibodies. (A) Percentage of patients with iTTP having the different IgG subclasses of anti-ADAMTS13 autoantibodies is depicted. (B) Number of patients with iTTP with different combinations of IgG subclasses is depicted. Plus signs denote the presence of a subclass, minus signs denote the absence of a subclass.
