A 56-year-old man presented for hematology consultation after splenomegaly (16 cm) was incidentally discovered on CT urogram. Laboratory evaluation was significant for mild thrombocytopenia (161 k/μL), with an otherwise normal complete blood count.
A bone marrow biopsy was performed and was normocellular for age (50%) with mildly increased megakaryocytes without overt atypia, unremarkable myeloid and erythroid maturation and morphology, and an increased population of large-sized cells on the aspirate smears (Figure). Flow cytometric analysis showed no evidence of hematolymphoid neoplasia, and karyotype was normal, 46,XY.
What is the finding depicted in the Figure?
Sea blue histiocytes
Gaucher cells/pseudo-Gaucher cells
Dr. Perez Botero and Dr. Hintzke indicated no relevant conflicts of interest.
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