...ASH Staff Pictured (L-R) Sarah Holstein, MD, PhD; Alan Rosmarin, MD; Sen. Elizabeth Warren (D-MA); Jonathan Hoggatt, PhD Pictured (L-R) Sarah Holstein, MD, PhD; Alan Rosmarin, MD; Sen. Elizabeth Warren (D-MA); Jonathan Hoggatt, PhD Every August, members of Congress return home...

... on Government Affairs Dr. Jennifer Holter Chakrabarty and new Vice Chair Dr. Jonathan Hoggatt, to learn how ASH members can help build relationships with newly elected officials. As Chair and Vice Chair of the Committee on Government Affairs, Drs. Holter Chakrabarty and Hoggatt work with committee members...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. September 14, 1990. Anaheim, California : The Seattle Mariners were playing the California Angels. In the first inning, Ken Griffey Sr. hits a home run to center. Next at bat, his son Ken Griffey Jr...

...Francois Mercier, MD; Catherine Rhee, PhD; Jonathan Hoggatt, PhD Dr. Mercier, Dr. Rhee, and Dr. Hoggatt indicated no relevant conflicts of interest. Sugimura R, Jha DK, Han A, et al. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017;545...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, et al. A tunable diffusion-consumption mechanism of cytokine propagation enables plasticity in cell-to-cell communication in the immune system. Immunity...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Buggenthin F, Buettner F, Hoppe PS, et al. Prospective identification of hematopoietic lineage choice by deep learning. Nat Methods. 2017;14:403-406. https://www.ncbi.nlm.nih.gov/pubmed/28218899...

...Jonathan Hoggatt, PhD Evidence of the ability of stem cells to count their divisions creates many additional questions for further discovery. 1) How do stem cells maintain a record of their divisions? There have been case reports of telomere shortening being associated with poor graft outcomes...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Diagram of the Biological Functions of Mitochondrial Dynamics. A) The mitochondrial life cycle starts with growth and division of pre-existing organelles (biogenesis) and ends with degradation...

...Jonathan Hoggatt, PhD Dr. Jonathan Hoggatt is an equity stake holder in Magenta Therapeutics. The first bone marrow stem cell transplantations were attempted almost 60 years ago. Since then, this procedure has continued to expand in not only the number of patients, but also an ever...

...Bin-Kuan Chou, MD; Jonathan Hoggatt, PhD Dr. Chou and Dr. Hoggatt indicated no relevant conflicts of interest. Rentas S, Holzapfel NT, Belew MS, et al. Musashi-2 attenuates AHR signaling to expand human hematopoietic stem cells. Nature. 2016;532:508-511. http...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Agudo J, Ruzo A, Park ES, et al. GFP-specific CD8T cells enable targeted cell depletion and visualization of T-cell interactions. Nat Biotechnol. 2015;33:1287-1292. http://www.ncbi.nlm.nih.gov...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Acar M, Kocherlakota KS, Murphy MM, et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature. 2015;526:126-130. http://www.ncbi.nlm.nih.gov/pubmed...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Hematopoietic stem cell transplantation is often the only curative treatment modality for a number of hematologic diseases. There are more than 50,000 bone marrow transplants performed each year worldwide...

...Jonathan Hoggatt, PhD Macrophages are key regulators of both innate and adaptive immunity. Classically, macrophages are thought of as scavengers, phagocytizing dead cells and debris, but they can also act as sentries, on the lookout for foreign invaders and ready to call in reinforcements from...

...Hannah K. Rasmussen; Jonathan Hoggatt, PhD Dr. Hoggatt and Hannah Rasmussen indicated no relevant conflicts of interest. Mantel CR, O'Leary HA, Chitteti BR, et al. Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock. Cell. 2015;161:1553-1565...

...Jonathan Hoggatt, PhD “Because the edited embryos are genetically mosaic, it would be impossible to predict gene editing outcomes through pre-implantation genetic diagnosis (PGD). Our study underscores the challenges facing clinical applications of CRISPR/Cas9.” Despite the media reports...

...Jonathan Hoggatt, PhD Several therapies to treat or prevent Ebola are under development, though none have passed phase I development. 2  Largely, our ability to develop and test novel therapies for subsequent clinical trials is based on small animal models of disease. Advances in Ebola...

...Jonathan Hoggatt, PhD Since prior work has relied on transplantation to evaluate HSCs, the authors used their mouse model in a transplantation assay to determine the clonal repertoire in a mouse 64 weeks after genetic tagging, presumably when transient progenitors are exhausted and blood should...

...John Byon, MD, PhD; Michael Linenberger, MD Goessling W, North TE, Loewer S et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009;136:1136-47. Hoggatt J, Singh P, Sampath J et al. Prostaglandin E2 enhances...

... is the basis of much of the current research into the so-called stem cell niche  (see Diffusion article in this issue by Dr. Jonathan Hoggatt), a field most people think was recently invented. Their model was also applied to other settings such as high-dose radiation exposures and leukemia. These experiments...