... congressional office takes time, but the impact that it can have on hematology is invaluable. “I said earlier that every constituent has a voice — that is perhaps the most remarkable thing about our democracy,” said Dr. Hoggatt. “Hematologists, like everyone, should make sure to use it.” “Finally, what I...

... the resources available because as she put it, “Congress works for us, and we should make sure we tell them what we want!” Dr. Hoggatt echoed using social media to establish a connection with your legislators and noted, “Every congressional member has multiple social media accounts. Follow your legislator...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. September 14, 1990. Anaheim, California : The Seattle Mariners were playing the California Angels. In the first inning, Ken Griffey Sr. hits a home run to center. Next at bat, his son Ken Griffey Jr...

...Francois Mercier, MD; Catherine Rhee, PhD; Jonathan Hoggatt, PhD Dr. Mercier, Dr. Rhee, and Dr. Hoggatt indicated no relevant conflicts of interest. Sugimura R, Jha DK, Han A, et al. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017;545...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, et al. A tunable diffusion-consumption mechanism of cytokine propagation enables plasticity in cell-to-cell communication in the immune system. Immunity...

...Jonathan Hoggatt, PhD Buggenthin F, Buettner F, Hoppe PS, et al. Prospective identification of hematopoietic lineage choice by deep learning. Nat Methods. 2017;14:403-406. https://www.ncbi.nlm.nih.gov/pubmed/28218899 “ Alexa, is this a stem cell? ” Dr. Hoggatt...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Bernitz JM, Kim HS, MacArthur B, et al. Hematopoietic stem cells count and remember self-renewal divisions. Cell. 2016;167:1296-1309. https://www.ncbi.nlm.nih.gov/pubmed/27839867...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Lifelong production of blood by hematopoietic stem and progenitor cells is regulated by a balance of self-renewal of stem cells, maintaining their limited supply throughout life; and differentiation...

...Jonathan Hoggatt, PhD Remarkably, the method of conditioning a patient for bone marrow transplantation has not changed much since the original studies; doses of irradiation and/or chemotherapeutic agents are used to clear the marrow space of resident hematopoietic and immune cells, allowing...

...Bin-Kuan Chou, MD; Jonathan Hoggatt, PhD Dr. Chou and Dr. Hoggatt indicated no relevant conflicts of interest. Rentas S, Holzapfel NT, Belew MS, et al. Musashi-2 attenuates AHR signaling to expand human hematopoietic stem cells. Nature. 2016;532:508-511. http...

...Jonathan Hoggatt, PhD Hematology research has become increasingly focused on the study of cellular heterogeneity and parsing out the biologic roles of specific cells. For example, such investigations may explore novel T cell subsets mediating immune responses, distinguish pre-leukemic cells...

...Jonathan Hoggatt, PhD Dr. Ray Schofield first hypothesized the concept of a hematopoietic stem cell (HSC) niche in 1978. 1  He proposed that: Dr. Hoggatt indicated no relevant conflicts of interest. Acar M, Kocherlakota KS, Murphy MM, et al. Deep imaging of bone marrow...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Hematopoietic stem cell transplantation is often the only curative treatment modality for a number of hematologic diseases. There are more than 50,000 bone marrow transplants performed each year worldwide...

...Jonathan Hoggatt, PhD This study elegantly demonstrates in immune-competent mouse models that the therapeutic effects of anti-CD47 therapy are a result of both innate and adaptive immune responses. Blocking CD47 does much more than ring the dinner bell for macrophages to devour tumor cells...

...Hannah K. Rasmussen; Jonathan Hoggatt, PhD Dr. Hoggatt and Hannah Rasmussen indicated no relevant conflicts of interest. Effects of EPHOSS on Hematopoietic Stem Cells. Hematopoietic stem cells (HSC) collected in air results in increased reactive oxygen species (ROS) production...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Liang P, Xu Y, Zhang X, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell. 2015;6:363-372. http://www.ncbi.nlm.nih.gov/pubmed/25894090 The idea...

...Jonathan Hoggatt, PhD Dr. Hoggatt indicated no relevant conflicts of interest. Lüdtke A, Oestereich L, Ruibal P, et al. Ebola virus disease in mice transplanted with human hematopoietic stem cells. J Virol. 2015 [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed...

...Jonathan Hoggatt, PhD Expanding the Sleeping Beauty model to settings of hematopoietic challenge such as major blood loss, sublethal myeloablation, aging, or infection is likely to provide further insights into the clonal contribution of HSC to hematopoiesis. In the future, we may have to change...

...:1136-47. Hoggatt J, Singh P, Sampath J et al. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood. 2009. [Epub ahead of print] These studies are significant for delineating the functional and molecular effects of PGE 2 on HSCs, the intersection...

... article in this issue by Dr. Jonathan Hoggatt), a field most people think was recently invented. Their model was also applied to other settings such as high-dose radiation exposures and leukemia. These experiments in rodents and dogs required a continuous 24- to 48-hour 3 H-thymidine infusion...