... aggregates or soluble al- tered Igs, a lower mean concentration of 136 yglmL has been reported.6 Upon reevaluation of the RID technique by C From The William B. Castle Hematology Research Laboratory, Boston City Hospital; the Departments of Pathology and Medicine, Boston University School of Medicine, Boston...

...) together with cytochrome C (1.5 mg/mL) and incubated for various Isolation of neutrophils. From the William E. Castle Hematology Research Laboratory and Departments of Pathology and Medicine, Boston City Hospital, and Boston University School of Medicine, Boston, MA. Submitted August 1. 1989; accepted May...

... with regard to neutrophil activation mechanisms in general and for further elucidation of the basis for subsequent deactivation. In the studies we From the William B. Castle Research Hematology Laboratory, Boston City Hospital, and the Departments of Medicine and Pathology, Boston University School...

... structural variation in this site. From the William B. Castle Hematology Research Laboratory and the Departments of Medicine and Pathology, Boston City Hospital and Boston University School of Medicine: and the Department of Chemistry, Massachusetts Institute of Technology, Cambridge. Submitted February 6...

... to greater than 95% purity as and used within 2 hours of preparation. Efforts were made to avoid LPS contamination (neutrophils were processed using endotoxin-free water in all buffers), however, the possibility of LPS contamination From the William B. Castle Research Hematology Laboratory, Boston City...

... to vWF, it is not yet clear whether benefit from desmopressin is mediated by an increase in vWF concentration, a change in From the William B. Castle Hematology Research Laboratory. Department of Medicine. Boston City Hospital and Boston Univer- sity School of Medicine; and the Departments of Surgery...

... In the March issue of the Journal, the last item on page 366 should have been preceded by a heading indicating the Tuesday, November 29, 2:30 p.m., symposium on the subject, The Metabolic Basis of Megaloblastic Anaemias . Dr. William B. Castle was the moderator. © 1961 by American Society...

...Samar Kulkarni; John Murray; James Clarke; Mike Dennis; Amit Patel; Anna Castleton; James Cavet; Angela Leather; Lyndsey Ashton; Diane Sweeney; Joanna Tomlins; Adrian Bloor; Rita Angelica; Mark Williams Use of Cryopreserved Allogeneic PBSC Results in Delayed Engraftment And Increased Incidence...

... of the short arm ofchromosome 9. N Engl J Med 313:286, 1985 8. Murphy SB, Raimondi 5, Williams DL, Carroll AJ, Castle- berry RP, Crist WM: Lymphomatous ALL with abnormalities of the short arm ofchromosome 9. N EngI J Med 313:161 1, 1985 9. Carroll AJ, Castleberry RP, Crist WM: Lack of association between...

...JAMES H. JANDL, M.D.; RICHARD L. SIMMONS, M.D.; WILLIAM B. CASTLE, M.D. Studies were made of the filterability of normal and abnormal red cells through an inert membrane-type (Millipore) filter having uniform non-branching capillary pores 5 µ in diameter. With this filter it was possible to remove...

...FRANK H. BETHELL; WILLIAM B. CASTLE; STEVEN O. SCHWARTZ; MAXWELL M. WINTROBE © 1955 by American Society of Hematology, Inc. 1955 PANELS IN THERAPY Foreword A NEW DEPARTMENT-Panels its Therapy-begins with this issue. It is devoted to the practical problems of treating people who have specific...

...ROBERT F. SCHILLING, M.D.; JOHN W. HARRIS, M.D.; WILLIAM B. CASTLE, M.D. 1. Vitamin B 12a , derived from vitamin B 12 by catalytic hydrogenation, is as potent a hematopoietic agent as vitamin B 12 when administered parenterally to patients with pernicious anemia in relapse. 2. The hematopoietic...

... . The authors are indebted to our own mentors (John Adamson, Earl Davie, Clement Finch, Richard Cooper, Neil Abramson, Frank Bunn, James Jandl, and William Castle) for their example, inspiration, support, and friendship. References 1 Ishii T, Bruno E, Hoffman R, Xu M. Involvement of various...

... journal is an efficient way to provide information to a readership that is dedicated to moving discoveries from the bench to the bedside. After all, as exemplified by the work of the late Dr William B. Castle on pernicious anemia, 1 hematologists have a long and illustrious track record in integrating...

... : Soma Weiss, Chester Keefer, William B. Castle, and Charles A. Doan, to mention but a few. At the Boston City Hospital, some years before the Thorndike Laboratory was or- ganized, Dr. Ralph C. Larrabee had inaugurated one of the first (perhaps the first) Blood Laboratory in the country. Here...

...WN Valentine Copyright © 1977 by The American Society of Hematology 1977 EDITORIAL The Molecular Lesion of Hereditary Spherocytosis (HS): A Continuing Enigma By William N. Valentine . The one fundamental variatk. n from normal in congenital hemolytic icterus is the microspherocyzosis...

.... 7. William B. Castle (b. 1897). In 192.9 this investigator faced a disease in which, although the practical aspect of treatment seemed well-nigh settled, causation was just as obscure as ever. By a series of logically contrived investigations he showed that pernicious anemia was conditioned...

..., and are unable to revert to a biconcave disk. This would explain the fact that these forms are so rarely found to be reticulated when stained with brilliant cresyl blue. ACKNOWLEDGMENT I wish to express my gratitude to Dr. William B. Castle, Dr. William Dock (Department of Medicine) for many stimulating...

... investigators recruited to the Thorndike was Dr William Castle, who played a vital role in the research leading to the discovery of intrinsic factor and vitamin B 12 by a series of classic experiments in which he ingested 300 g of rare hamburger, extracted his own stomach contents 1 hour later, and 1 hour...

... forming organs, edited by William B. Castle, constairss about 146 pages and ab- stracts of some 95 articles. These are well selected for t-lseir general interest. Castle s com- ments at the end of many of the abstracts enhance their value insmeasurably. Recent interest in the purpuras is exemplified 1)y...