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Waldenstrom's

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Journal Articles
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 816.
Published: 2021
... factors altering both humoral and cellular immunity. Assessing response in patients with the indolent lymphomas, Waldenström's Macroglobulinaemia (WM) and Follicular Lymphoma (FL), including cohorts on differing treatment regimens, may help elucidate some of these factors. Australia has had low prevalence...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 2692.
Published: 2021
... MYD88 mutations ( MYD88 MUT ) are present in 95-97% of patients with Waldenström's Macroglobulinemia (WM). Transgenic mouse studies show that MYD88 MUT alone is insufficient to drive oncogenesis. We previously reported the occurrence of non-overlapping somatic mutations in either CXCR4 ( CXCR4 MUT...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 835.
Published: 2021
...Karima Amaador; Pythia Nieuwkerk; Monique C. Minnema; Marie José Kersten; Josephine M.I. Vos Introduction The management of Waldenström's Macroglobulinemia (WM), a rare and incurable B-cell non-Hodgkin lymphoma, has evolved in recent years. Treatment options are increasing including more modern...
Journal Articles
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 46.
Published: 2021
...Daobin Zhou; Jie Jin; Zheng-zheng Fu; Shuhua Yi; Wei Li Zhao; Zimin Sun; Wei Yang; Dengju Li; Guohui Cui; Jianda Hu; Ting Liu; Yongping Song; Bing Xu; Zunmin Zhu; Wei Xu; Mingzhi Zhang; Yamin Tian; Huaqiang Zhu; Bin Zhang; Renbin Zhao; Xiang-Yang Zhang Background Waldenstrom's Macroglobulinemia (WM...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 1977.
Published: 2021
... Crosbie; Suzanne O Arulogun; Shirley D'Sa Introduction: Waldenström's Macroglobulinaemia (WM) is a rare indolent B-cell lymphoma characterised by lymphoplasmacytic infiltrate with an IgM paraproteinaemia. Approximately 400 patients (pts) are diagnosed annually in the United Kingdom (UK). National...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 1343.
Published: 2021
...Ibrahim Tohidi-Esfahani; Andrew Warden; Elena Malunis; Peter Liburdi deNardis; Michelle Postek; Shirley D'Sa; Marie José Kersten; Sheeba K Thomas; M. Lia Palomba; Adam J. Olszewski; Newton Guerin; Clare Scott; Judith Trotman Introduction: WhiMSICAL (Waldenström's Macroglobulinemia Study Involving...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 1353.
Published: 2021
...Jowon Laura Kim; Alina S. Gerrie; Kerry J. Savage; Diego Villa; David W. Scott; Jeffrey W Craig; Pedro Farinha; Brian Skinnider; Graham W. Slack; Joseph M. Connors; Laurie H. Sehn; Ciara L. Freeman Background: Waldenström macroglobulinemia (WM) is a rare, indolent B-cell lymphoproliferative...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 1362.
Published: 2021
...Steven P. Treon; Christian Buske; Sheeba K Thomas; Jorge J. Castillo; Andrew R. Branagan; Meletios A. Dimopoulos; Maria Gavriatopoulou; Diego Cadavid; Felix T Garzon; Weihua Tang; Sean Seyffert; Varun Garg; Shariq Ali; Arthur G. Taveras; Kelly Chen; Jeffrey V. Matous Background: Waldenström's...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 2394.
Published: 2021
... Dogan; Alexander Lesokhin; Ola Landgren; M. Lia Palomba; Francesco Maura; Meletios-Athanasios Dimopoulos The genomic landscape of Waldenström Macroglobulinemia (WM) is characterized by recurrent somatic mutations in MYD88 , with a lower incidence of mutations affecting CXCR4 , ARID1A , CD79B...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 3048.
Published: 2021
...Asher Chanan-Khan; Keri Yang; Sizhu Liu; Zhun Cao; Dorothy Baumer; Shanthi Krishnaswami; Boxiong Tang; Sikander Ailawadhi Introduction: Mantle cell lymphoma (MCL), Waldenström macroglobulinemia (WM), marginal zone lymphoma (MZL) and chronic lymphocytic leukemia (CLL) are subtypes of non-Hodgkin's...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 462.
Published: 2021
... mutation is highly prevalent in IgM monoclonal gammopathy of undetermined significance (MGUS), smoldering Waldenström macroglobulinemia (SWM) and symptomatic WM. Allele-specific PCR (AS-PCR) has been used routinely to assess MYD88 mutation; however, with the advent of more precise high-throughput...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 3529.
Published: 2021
...Shayna Sarosiek; Joshua Gustine; Catherine A Flynn; Carly Leventoff; Timothy P White; Kirsten Meid; Steven P Treon; Jorge J. Castillo The BTK-inhibitor ibrutinib is the first FDA approved therapy for Waldenström macroglobulinemia (WM) and produces overall response rates >90% and long-term...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 3548.
Published: 2021
...Suzanne O Arulogun; Charalampia Kyriakou; Jackie Horder; Fiona Newrick; Aisha S Patel; Ali Rismani; Kwee Yong; Ashutosh D. Wechalekar; Shirley D'Sa BACKGROUND The role of autologous stem cell transplantation (ASCT) in Waldenström Macroglobulinaemia (WM) is not well established, largely due...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 2678.
Published: 2021
... in patients with Waldenström Macroglobulinemia (WM) and its association with clinical outcomes. Methods We retrospectively reviewed clinical data of 602 patients with IgM monoclonal gammopathy of undetermined significance (MGUS), smoldering WM (SWM), and WM who had clinical next-generation sequencing (NGS...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 1599.
Published: 2021
...; Efstathios Kastritis Waldenström macroglobulinemia (WM) is a low-grade B- cell lymphoproliferative disorder characterized by bone marrow (BM) infiltration by small lymphoplasmacytic lymphoma (LPL) cells that secrete monoclonal IgM immunoglobulin. Our understanding of the pathogenesis of WM has improved...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 2526.
Published: 2021
... lymphoma (DLBCL). High CNS-International Prognostic Index (IPI), activated B-cell (ABC) subtype and MYD88 L265P mutation, features often found in transformed Waldenström macroglobulinemia (WM), are associated with a higher risk for developing CNS relapse. This study was aimed to describe CNS involvement...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 3801.
Published: 2021
... Luisa Guerrera; Marilyn T. Gammon; Kathleen J. Lively; Lisette Packer; Matthew Waterman; Raquel Gallagher; Boris Juleg; Galit Alter; Shayna Sarosiek BACKGROUND: Multiple myeloma (MM) and Waldenström macroglobulinemia (WM) are associated with significant immunoparesis. Based on the ongoing COVID-19...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 4513.
Published: 2021
...Xinting Hu; Hua Wang; Hongzhi Xu; Xin Liu; Ying Li; Xianghua Wang; Na Wang; Dai Yuan; Huiting Qu; Ya Zhang; Xin Wang Introduction: Waldenström macroglobulinaemia/ Lymphoplasmacytoid lymphoma (WM/LPL) is a rare lymphoproliferative neoplasm characterized by small B lymphocytes proliferation...