Search Results for Stuart Orkin

...Falak Sher, PhD; Vivien Schoonenberg, BS; Mitchel A. Cole, BS; Claudio Macias-Trevino, BS; Paolo Cifani, PhD; Patrick G Schupp, BS; Matthew C. Canver, BS; Ryo Kurita, PhD; Yukio Nakamura, MD PhD; Stuart Orkin; Alex Kentsis, MD PhD; Luca Pinello, PhD; Takahiro Maeda, MDPhD; Daniel E. Bauer, MD PhD...

...Nan Liu, PhD; Victoria V Hargreaves, PhD; Jiyoung Hong, PhD; Woojin Kim, PhD; Jesse Kurland, PhD; Qian Zhu, PhD; Falak Sher, PhD; Claudio Macias-Trevino, BS; Jill Rogers, PhD; Guo-Cheng Yuan, PhD; Daniel E. Bauer, MD PhD; Jian Xu, PhD; Martha L Bulyk, PhD; Stuart Orkin Fetal hemoglobin (HbF) level...

...Takuji Yamauchi, MDPhD; Takeshi Masuda, PhD; Matthew C. Canver, BS; Michael Seiler, PhD; Mohammad Shboul; Manami Maeda, MDPhD; Vivien Schoonenberg, BS; Mitchel A. Cole, BS; Claudio Macias-Trevino, BS; Yuichiro Semba, MD; Yuichi Ishikawa, MD PhD; Michitaka Nakano, MD; Fumio Arai, PhD; Stuart Orkin...

...Elayne Chan-Penebre; Veronica Gibaja; John Campbell; Ogunbodede Olu; Elizabeth Admirand; Dorothy Brach; Cuyue Tang; Alejandra Raimondi; Tami Hood; Alexis Cocozaki; Sule Karaman; Kimberly Stickland; Christopher Plescia; Michael Munchhof; Kelli Armstrong; Thomas Riera; Stuart Orkin; Ann Boriack...

...Bin E. Li; Grace Y. Li; Wenqing Cai; Qian Zhu; Davide Seruggia; Yuko Fujiwara; Christopher R. Vakoc; Stuart H. Orkin CRISPR/Cas9 screening approaches are powerful tool for identifying in vivo cancer dependencies. Hematopoietic malignancies are genetically complex disorders in which the sequential...

...Huilan Yao; Devorah C. Goldman; Tamilla Nechiporuk; Sunita Kawane; Shannon K. McWeeney; Jeffrey W. Tyner; Guang Fan; Marc A. Kerenyi; Stuart H. Orkin; William H. Fleming; Gail Mandel The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We...

..., PhD; Mignon L. Loh, MD; Stephen P. Hunger, MD; David T Teachey, MD; Karen R. Rabin, MD PhD; Stuart S. Winter, MD; Kimberly P. Dunsmore, MD; Brent Wood, MD PhD; Lewis B. Silverman, MD; Stephen E. Sallan, MD; Pieter Van Vlierberghe, PhD; Stuart H. Orkin, MD; Birgit Knoechel, MDPhD; Anthony Letai, MD PhD...

...Jiazhuo Li; Panpan Zhu; Zhiling Shi; Longping Wen; Stuart H Orkin; Huafeng Xie Erythropoiesis is a complex yet tightly controlled process encompassing distinct stages, during which autophagy plays important roles. Autophagy is essential in the removal of organelles such as mitochondria...

... evolution,” an erudite expression that means: we do not have the faintest idea of what is going on. The molecular mechanism controlling the formation of primitive and definitive red cells has been extensively investigated by Stuart Orkin's and Masi Yamamoto's labs. Both investigators have reported...

...Taku Harada; Monika Perez; Jeremie Kalfon; Rashad Batley; Flora Dievenich Braes; Stuart H Orkin; Maxim Pimkin The transcription factor (TF) MYB is a critical transcriptional dependency of acute myeloid leukemia (AML) where it has been a long-term focus of drug development efforts. However...

...Mayuri Tanaka-Yano; Dahai Wang; Diana Chen; Biju Isaac; Tianxin Scarlett Liu; Liang Sun; Edroaldo Lummertz da Rocha; Berkley Gryder; Stuart H Orkin; Robert Grant Rowe Many blood diseases are biased in their age of onset toward infancy, childhood, or mature adulthood. This occurs in concert...

...Ge Zheng; Stuti Mehta; Maolu Yin; Linus Marx; Altantsetseq Buyanbat; Karin Tenglin; Benjamin Sewell-Grossman; Jiyoung Hong; Stuart H Orkin The zinc-finger (ZnF) repressor protein BCL11A regulates the switch from fetal (HbF, α 2 γ 2 ) to adult hemoglobin (HbA, α 2 β 2 ) through direct binding...

...Wade W Sugden; Zachary LeBlanc; Mayuri Tanaka-Yano; Ran Jing; Maria Gonzalez di Tillio; Mohamad Najia; Yang Tang; Elizabeth Molnar; Stephan George; Brittney Love; Caroline Kubaczka; Nan Liu; Nah-Young Shin; Thorsten M. Schlaeger; Edroaldo Lummertz da Rocha; Alan B. Cantor; Stuart H Orkin; Robert...

...; Christian Brendel; Scot A. Wolfe; Stuart H. Orkin; Timothy Yu; Akiko Shimamura; Daniel E. Bauer * Asterisk with author names denotes non-ASH members. © 2022 by The American Society of Hematology 2022 1. Zhang, S., Shi, M., Hui, C.C., Rommens, J.M. 2006. Loss of the mouse ortholog...

...; Hiroko Inada; Shinichiro Nakagawa; Shuichi Ohzono; Vidya Subramanian; Roberto Chiarle; Bertil Glader; Steven A. Carr; Martin J. Aryee; Anshul Kundaje; Stuart H. Orkin; Aviv Regev; Timothy L. McCavit; Hitoshi Kanno; Vijay G. Sankaran Master regulators, such as the hematopoietic transcription factor (TF...

...Mayuri Tanaka-Yano; Dahai Wang; Eleanor Meader; Melissa A. Kinney; Vivian Morris; Edroaldo Lummertz da Rocha; Nan Liu; Stuart H. Orkin; Trista E. North; George Q. Daley; Robert Grant Rowe Polycomb group (PcG) proteins are a well-studied group of chromatin modifiers belonging to one of two distinct...

...Jana M Ellegast; Gabriela Alexe; Amanda Hamze; Shan Lin; Maxim Pimkin; Linda Ross; Neekesh V Dharia; Amanda L Robinchaud; Amy Conway; Delan Khalid; Mark Wunderlich; Lina Benajiba; Behnam Nabet; Nathanael S Gray; Stuart H. Orkin; Kimberly Stegmaier Leukemic blasts are immune cells gone awry. We...

...Hye Ji Cha; Özgün Uyan; Job Dekker; Stuart H. Orkin The nucleus is spatially organized by chromosome and interchromatin functional components. Global reorganization of chromatin interactions and compartmentalization occurring during differentiation requires proper chromosome positioning...