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Stuart Orkin

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Journal Articles
Journal Articles
Journal Articles
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
Published: 2017
...Falak Sher, PhD; Vivien Schoonenberg, BS; Mitchel A. Cole, BS; Claudio Macias-Trevino, BS; Paolo Cifani, PhD; Patrick G Schupp, BS; Matthew C. Canver, BS; Ryo Kurita, PhD; Yukio Nakamura, MD PhD; Stuart Orkin; Alex Kentsis, MD PhD; Luca Pinello, PhD; Takahiro Maeda, MDPhD; Daniel E. Bauer, MD PhD...
Journal Articles
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
Published: 2017
...Nan Liu, PhD; Victoria V Hargreaves, PhD; Jiyoung Hong, PhD; Woojin Kim, PhD; Jesse Kurland, PhD; Qian Zhu, PhD; Falak Sher, PhD; Claudio Macias-Trevino, BS; Jill Rogers, PhD; Guo-Cheng Yuan, PhD; Daniel E. Bauer, MD PhD; Jian Xu, PhD; Martha L Bulyk, PhD; Stuart Orkin Fetal hemoglobin (HbF) level...
Journal Articles
Journal: Blood
Blood (2017) 130 (Supplement 1): 782.
Published: 2017
...Takuji Yamauchi, MDPhD; Takeshi Masuda, PhD; Matthew C. Canver, BS; Michael Seiler, PhD; Mohammad Shboul; Manami Maeda, MDPhD; Vivien Schoonenberg, BS; Mitchel A. Cole, BS; Claudio Macias-Trevino, BS; Yuichiro Semba, MD; Yuichi Ishikawa, MD PhD; Michitaka Nakano, MD; Fumio Arai, PhD; Stuart Orkin...
Journal Articles
Journal Articles
Blood Adv (2023) 7 (18): 5281–5293.
Published: 2023
...Bin E. Li; Grace Y. Li; Wenqing Cai; Qian Zhu; Davide Seruggia; Yuko Fujiwara; Christopher R. Vakoc; Stuart H. Orkin CRISPR/Cas9 screening approaches are powerful tool for identifying in vivo cancer dependencies. Hematopoietic malignancies are genetically complex disorders in which the sequential...
Includes: Supplemental data
Journal Articles
Journal: Blood
Blood (2014) 123 (20): 3175–3184.
Published: 2014
...Huilan Yao; Devorah C. Goldman; Tamilla Nechiporuk; Sunita Kawane; Shannon K. McWeeney; Jeffrey W. Tyner; Guang Fan; Marc A. Kerenyi; Stuart H. Orkin; William H. Fleming; Gail Mandel The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We...
Includes: Supplemental data
Journal Articles
Journal Articles
Journal: Blood
Blood (2023) 142 (Supplement 1): 3638.
Published: 2023
...Taku Harada; Monika Perez; Jeremie Kalfon; Rashad Batley; Flora Dievenich Braes; Stuart H Orkin; Maxim Pimkin The transcription factor (TF) MYB is a critical transcriptional dependency of acute myeloid leukemia (AML) where it has been a long-term focus of drug development efforts. However...
Journal Articles
Journal: Blood
Blood (2023) 142 (Supplement 1): 2678.
Published: 2023
...Mayuri Tanaka-Yano; Dahai Wang; Diana Chen; Biju Isaac; Tianxin Scarlett Liu; Liang Sun; Edroaldo Lummertz da Rocha; Berkley Gryder; Stuart H Orkin; Robert Grant Rowe Many blood diseases are biased in their age of onset toward infancy, childhood, or mature adulthood. This occurs in concert...
Journal Articles
Journal: Blood
Blood (2023) 142 (Supplement 1): 554.
Published: 2023
...Ge Zheng; Stuti Mehta; Maolu Yin; Linus Marx; Altantsetseq Buyanbat; Karin Tenglin; Benjamin Sewell-Grossman; Jiyoung Hong; Stuart H Orkin The zinc-finger (ZnF) repressor protein BCL11A regulates the switch from fetal (HbF, α 2 γ 2 ) to adult hemoglobin (HbA, α 2 β 2 ) through direct binding...
Journal Articles
Journal: Blood
Blood (2023) 142 (Supplement 1): 1309.
Published: 2023
...Wade W Sugden; Zachary LeBlanc; Mayuri Tanaka-Yano; Ran Jing; Maria Gonzalez di Tillio; Mohamad Najia; Yang Tang; Elizabeth Molnar; Stephan George; Brittney Love; Caroline Kubaczka; Nan Liu; Nah-Young Shin; Thorsten M. Schlaeger; Edroaldo Lummertz da Rocha; Alan B. Cantor; Stuart H Orkin; Robert...
Journal Articles
Journal: Blood
Blood (2022) 140 (Supplement 1): 2944–2945.
Published: 2022
...; Christian Brendel; Scot A. Wolfe; Stuart H. Orkin; Timothy Yu; Akiko Shimamura; Daniel E. Bauer * Asterisk with author names denotes non-ASH members. © 2022 by The American Society of Hematology 2022 1. Zhang, S., Shi, M., Hui, C.C., Rommens, J.M. 2006. Loss of the mouse ortholog...
Journal Articles
Journal: Blood
Blood (2022) 139 (16): 2534–2546.
Published: 2022
...; Hiroko Inada; Shinichiro Nakagawa; Shuichi Ohzono; Vidya Subramanian; Roberto Chiarle; Bertil Glader; Steven A. Carr; Martin J. Aryee; Anshul Kundaje; Stuart H. Orkin; Aviv Regev; Timothy L. McCavit; Hitoshi Kanno; Vijay G. Sankaran Master regulators, such as the hematopoietic transcription factor (TF...
Includes: Supplemental data
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 21.
Published: 2021
...Mayuri Tanaka-Yano; Dahai Wang; Eleanor Meader; Melissa A. Kinney; Vivian Morris; Edroaldo Lummertz da Rocha; Nan Liu; Stuart H. Orkin; Trista E. North; George Q. Daley; Robert Grant Rowe Polycomb group (PcG) proteins are a well-studied group of chromatin modifiers belonging to one of two distinct...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 285.
Published: 2021
...Hye Ji Cha; Özgün Uyan; Job Dekker; Stuart H. Orkin The nucleus is spatially organized by chromosome and interchromatin functional components. Global reorganization of chromatin interactions and compartmentalization occurring during differentiation requires proper chromosome positioning...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 3305.
Published: 2021
...Jana M Ellegast; Gabriela Alexe; Amanda Hamze; Shan Lin; Maxim Pimkin; Linda Ross; Neekesh V Dharia; Amanda L Robinchaud; Amy Conway; Delan Khalid; Mark Wunderlich; Lina Benajiba; Behnam Nabet; Nathanael S Gray; Stuart H. Orkin; Kimberly Stegmaier Leukemic blasts are immune cells gone awry. We...
Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 647.
Published: 2021
...Kenneth Eagle; Taku Harada; Jeremie Kalfon; Monika Perez; Yaser Heshmati; Jazmin Ewers; Kimberly Stegmaier; Stuart H. Orkin; Maxim Pimkin Relapse of AML after allogeneic hematopoietic stem cell transplantation (alloSCT) has been linked to reduced expression of major histocompatibility complex type...
Journal Articles
Journal: Blood
Blood (2004) 103 (2): 368–369.
Published: 2004
... evolution,” an erudite expression that means: we do not have the faintest idea of what is going on. The molecular mechanism controlling the formation of primitive and definitive red cells has been extensively investigated by Stuart Orkin's and Masi Yamamoto's labs. Both investigators have reported...