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Norman Iscove

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Journal: Blood
Blood (2001) 98 (7): 1999.
Published: 2001
...Norman Iscove Copyright © 2001 The American Society of Hematology 2001 A short while ago, tissue stem cells in adults were thought to be restricted to generating only the kinds of cells typical of the originating system. For example, neural stem cells would make only neuronal progeny...
Journal Articles
Journal: Blood
Blood (2007) 110 (7): 2631–2640.
Published: 2007
...Jiu-Wei Cui; You-Jun Li; Aloke Sarkar; Jeremy Brown; Ye-Hui Tan; Marina Premyslova; Crystal Michaud; Norman Iscove; Guan-Jun Wang; Yaacov Ben-David MicroRNAs (miRNAs) are a newly discovered class of posttranscriptional regulatory noncoding small RNAs. Recent evidence has shown that miRNA...
Journal Articles
Journal: Blood
Blood (2014) 124 (21): 650.
Published: 2014
...Iman Fares; Jalila Chagaroui; Yves Gareau; Stéphane Gingras; Nadine Mayotte; Elizabeth Csaszar; Hans-Peter Kiem; Norman N. Iscove; R. Keith Humphries; Connie J. Eaves; Sandra Cohen; Anne Marinier, PhD; Peter W. Zandstra; Guy Sauvageau, MD PhD The widespread use of cord blood (CB) unit...
Journal Articles
Journal: Blood
Blood (2012) 119 (11): 2510–2522.
Published: 2012
...Stephen B. Ting; Eric Deneault; Kristin Hope; Sonia Cellot; Jalila Chagraoui; Nadine Mayotte; Jonas F. Dorn; Jean-Philippe Laverdure; Michael Harvey; Edwin D. Hawkins; Sarah M. Russell; Paul S. Maddox; Norman N. Iscove; Guy Sauvageau The stem cell–intrinsic model of self-renewal via asymmetric cell...
Includes: Multimedia, Supplemental data
Journal Articles
Journal: Blood
Blood (2011) 117 (16): 4253–4261.
Published: 2011
...Gordon Chan; Laurene S. Cheung; Wentian Yang; Michael Milyavsky; Ashley D. Sanders; Shengqing Gu; Wan Xing Hong; Aurora X. Liu; Xiaonan Wang; Mary Barbara; Tarun Sharma; Joehleen Gavin; Jeffery L. Kutok; Norman N. Iscove; Kevin M. Shannon; John E. Dick; Benjamin G. Neel; Benjamin S. Braun Src...
Includes: Supplemental data
Journal Articles
Journal: Blood
Blood (2010) 116 (21): SCI-42.
Published: 2010
...Norman N. Iscove, MD, PhD Abstract SCI-42 For many years a distinction was drawn between prospectively separable murine HSC populations with long-term, essentially permanent reconstituting potential (LT-HSC), versus HSC populations yielding short-term engraftment lasting only 4 – 6 weeks after...
Journal Articles
Journal: Blood
Blood (2010) 116 (19): 3792–3801.
Published: 2010
...Alexandra Berger; Patricia Benveniste; Steven A. Corfe; Anne H. Tran; Mary Barbara; Andrew Wakeham; Tak W. Mak; Norman N. Iscove; Christopher J. Paige Hemokinin-1 (HK-1), encoded by the TAC4 gene, is a tachykinin peptide that is predominantly expressed in non-neuronal cells, such as immune cells...
Journal Articles
Journal: Blood
Blood (2010) 115 (4): 792–803.
Published: 2010
...Julie Lacombe; Sabine Herblot; Shanti Rojas-Sutterlin; André Haman; Stéphane Barakat; Norman N. Iscove; Guy Sauvageau; Trang Hoang The majority of long-term reconstituting hematopoietic stem cells (LT-HSCs) in the adult is in G 0 , whereas a large proportion of progenitors are more cycling. We show...
Includes: Supplemental data
Journal Articles
Journal: Blood
Blood (2009) 114 (22): 2520.
Published: 2009
...Julie Lacombe, PhD; Sabine Herblot, PhD; Shanti Rojas-Sutterlin, MSc; André Haman; Stephane Barakat, PhD; Norman N. Iscove, MD, PhD; Guy Sauvageau, MD, PhD; Trang Hoang, PhD Abstract 2520 Poster Board II-497 The life-long production of blood cells depends on the regenerative capacity of a rare...
Journal Articles
Journal: Blood
Blood (2008) 112 (11): 3655.
Published: 2008
...Christine V. Ichim, MSc; Marciano D. Reis, MD; Alden Chesney, II, MD; Gisele Knowles, MSc; Norman N. Iscove, MD, PhD; Richard A. Wells, MD, DPhil This abstract was removed at the request of the author. Corresponding author 2008, The American Society of Hematology 2008...
Journal Articles
Journal: Blood
Blood (2007) 110 (11): 400.
Published: 2007
...Christine V. Ichim, MSc; Alden Chesney, MD; Marciano D. Reis, MD; Norman N. Iscove, MD, PhD; Richard A. Wells, MD, DPhil A central conundrum in the biology of myelodysplastic syndrome (MDS) is the observation that haematopoietic cells derived from the MDS clone have an increased disposition...
Journal Articles
Journal: Blood
Blood (2006) 108 (11): 2539.
Published: 2006
...Christine V. Ichim, MSc; Harold L. Atkins, MD, PhD; Norman N. Iscove, MD, PhD; Richard A. Wells, MD, DPhil AML cells are heterogeneous in their capacity to proliferate and form colonies in vitro. Determination of the genes whose expression is necessary for clonogenicity has been hindered...
Journal Articles
Journal: Blood
Blood (2005) 105 (2): 552–561.
Published: 2005
...Adrienne Halupa; Monica L. Bailey; Kai Huang; Norman N. Iscove; David E. Levy; Dwayne L. Barber Erythropoietin (EPO) activates many distinct signal transduction cascades on engagement of its receptor. Deletion of the EPO, EPO receptor (EPO-R), or JAK2 genes in mice results in embryonic lethality...
Includes: Supplemental data
Journal Articles
Journal: Blood
Blood (2004) 104 (11): 3226.
Published: 2004
...Christine V. Ichim, MSc; Mahadeo A. Sukhai, MSc; J. Brandwein, MD; Mark D. Minden, MD, PhD; Aaron D. Schimmer, MD, PhD; Andre C. Schuh, MD; Suzanne Kamel-Reid, PhD; Norman N. Iscove, MD, PhD; Richard A. Wells, MD, DPhil Primary acute myelogenous leukaemia (AML) samples are heterogeneous...
Journal Articles
Journal: Blood
Blood (2001) 97 (8): 2257–2268.
Published: 2001
...Filio Billia; Mary Barbara; Jon McEwen; Maryanne Trevisan; Norman N. Iscove Although hematopoiesis is known to proceed from stem cells through a graded series of multipotent, oligopotent, and unipotent precursor cells, it has been difficult to resolve these cells physically one from another...
Journal Articles
Journal: Blood
Blood (1998) 92 (2): 607–615.
Published: 1998
...Jean Labrecque; Deborah Allan; Pierre Chambon; Norman N. Iscove; David Lohnes; Trang Hoang Transcripts for the retinoic acid receptors (RARs) α1, α2, γ1, and γ2 were found in the granulocytic lineage (Gr-1 + cells) through semiquantitative polymerase chain reaction (PCR) analysis. The screening...
Journal Articles
Journal: Blood
Blood (1997) 89 (9): 3155–3165.
Published: 1997
...Cathleen L. Cooper; Gerard Brady; Fillio Bilia; Norman N. Iscove; Peter J. Quesenberry To better understand the molecular mechanism(s) by which growth and differentiation of the primitive hematopoietic stem cell is initiated, as well as the means by which the maturing cell can commit to development...
Journal Articles
Journal: Blood
Blood (1992) 80 (5): 1218–1223.
Published: 1992
..., Irma Ziegler, and Beatrice Ward for their skillful technical assistance, and to Gordon Keller and Norman Iscove for helpful discussions. REFERENCES 1. Paul SR, Bennet F, Calvetti JA, Kelleher K, Wood CR, OHara RM, Leary AC, Sibley B, Clark SC, Williams DA, Yang Y C Molecular cloning of a cDNA encoding...
Journal Articles
Journal: Blood
Blood (1972) 39 (3): 451–452.
Published: 1972
... Crosby, William H. Ingram, Vernon Cudkowicz, Gustavo Iscove, Norman Blood, Vol. 39, No. 3 (March), 1972 451 452 ACKNOWLEDGMENT TO REVIEWERS Itano, Harvey A. Rapaport, Samuel I. Jamieson, Graham A. Rappazzo, Mary Jandi, James H. Rath, Charles E. Johnson, Alan J. Ratnoff, Oscar D. Kan, Yuet W. Rauscher, Jr...
Journal Articles
Journal: Blood
Blood (1989) 73 (3): 700–705.
Published: 1989
... conditioned by the murine myebomonocytic leukemic WEHI- 3 (a gift from Dr Norman Iscove), or from 48-hour supernatants of Con A-stimulated rat spleen cells. Alpha methyl mannoside was included in the cultures to preclude any effects that Con A remain- ing in the rat spleen cell supernatants might have...