...Mark D McKenzie, PhD; Margherita Ghisi, PhD; Luisa Cimmino, PhD; Michael Erlichster; Ethan P Oxley; Cynthia Liu; Matthew T Witkowski, PhD; Grace Liu, PhD; Aleksandar Dakic, PhD; Emilia Simankowicz; Ladina DiRago; Donald Metcalf, MD; Stephen L Nutt, PhD; Meaghan Wall, MBBS, PhD FRACP, FRCPA; Matthew...

...Kylie D. Mason, MBBS; Marina R. Carpinelli, PhD; Janelle E. Collinge, PhD; Adrienne A. Hilton; Jamie I. Fletcher, PhD; Andrew W. Roberts, MBBS,PhD; Donald Metcalf, MBBS; David C.S. Huang, MBBS,PhD; Benjamin T. Kile, PhD Platelets are small, anuclear cytoplasmic fragments that play an essential role...

...William S. Stevenson, MD; Donald Metcalf, MD; Douglas J. Hilton, PhD; Andrew W. Roberts, MD, PhD; Warren S. Alexander, PhD The genes that regulate variation in steady-state platelet count are largely unknown. We have attempted to identify novel genes that regulate platelet production by creating...

...Seth L. Masters; Mordechay Gerlic; Donald Metcalf; Simon P. Preston; Marc Pellegrini; Joanne A. O'Donnell; Kate McArthur; Tracey M. Baldwin; Stephane Chevrier; Cameron J. Nowell; Louise H. Cengia; Katya J. Henley; Janelle E. Collinge; Daniel L. Kastner; Lionel Feigenbaum; Douglas J. Hilton; Warren...

...William S. Stevenson, MBBS; Donald Metcalf, MD; Warren S. Alexander, PhD; Douglas J. Hilton, PhD; Andrew W. Roberts, MBBS, PhD A substantial proportion of patients with Essential Thrombocythemia (ET) have evidence of an acquired Jak2V617F mutation that causes the myeloproliferative phenotype...

...Catherine L Carmichael, PhD; Donald Metcalf; Katya J. Henley; Elizabeth A Kruse, PhD; Ladina Di Rago; Sandra Mifsud; Jian Zhong Tang, PhD; Warren S. Alexander; Benjamin T. Kile Abstract 1283 ETS-related gene, ERG , is a key regulator of hematopoietic stem cell (HSC) function, and a potent oncogene...

...Emma C. Josefsson; Deborah L. Burnett; Marlyse A. Debrincat; Katya J. Henley; Rachael M. Lane; Marion Lebois; Lorraine A. O'Reilly; Marc Pellegrini; Simon P. Preston; Ben A. Croker; Donald Metcalf; Andreas Strasser; Benjamin T. Kile Abstract 389 The survival of megakaryocytes and platelets...

...Andrew W. Roberts, MD PhD; Ben A. Croker, PhD; Warren Alexander, PhD; Donald Metcalf, MD Studies using mice with germline or tissue-specific deletion of SOCS3 indicate that SOCS3 is a negative regulator of IL-6, LIF, Leptin and G-CSF-induced STAT3 phosphorylation. We have investigated...

...Ben A Croker; O'Donnell A Joanne; Donald Metcalf; Rickard James; Joseph Evans; Seth L. Masters; Andrew W. Roberts, MBBS, PhD; Motti Gerlic; John Silke Introduction Cell death can be triggered by many stimuli leading to apoptosis, pyroptosis (Caspase-1-dependent cell death) or necroptosis (Receptor...

...Mark D McKenzie; Luisa Cimmino; Yifang Hu; Ladina Di Rago; Sandra Mifsud; Donald Metcalf; Gordon K Smyth; Ross Dickins Abstract 2432 Introduction Acute myeloid leukemia (AML) is a genetically and morphologically heterogeneous disease characterized by the accumulation of immature myeloid lineage...

...Andrew W. Roberts, MBBS, PhD; Lisa Mielke, BSc; Sam Wormald, PhD; Hiu Kiu, BSc; Ben A. Croker, PhD; Douglas J. Hilton, PhD; Donald Metcalf, MD; Warren S. Alexander, PhD Studies using primary cells from mice with germline or tissue-specific deletion of SOCS3 indicate that SOCS3 is a negative...

...Donald Metcalf © 2008 by The American Society of Hematology 2008 In this issue of Blood , Lux and colleagues and Ghiaur and colleagues shed new light on the controversy of whether hematopoietic stem cells (HSCs) arise in the yolk sac (YS) or the aorta-gonad-mesonephros (AGM) region...

...Emma C Josefsson; Chloé James; Katya J Henley; Marlyse A Debrincat; Kelly L Rogers; Mark R Dowling; Michael J White; Elizabeth A Kruse; Sarah Ellis; Paquita Nurden; Cassandra J Vandenberg; Kylie D Mason; A O'Reilly Lorraine; Donald Metcalf; Andrew W Roberts; David CS Huang; Benjamin T Kile...

...Martin J. Cline, M.D.; Noel L. Warner, Ph.D.; Donald Metcalf, M.D. Bone marrow colony-derived mononuclear phagocytes are macrophages on the basis of morphology, glass adherence, the phagocytosis of a range of particles including erythrocytes, yeast, and bacteria, and the possession of receptors...

...Soh Ha Chan, M.B., B.S. N.H. and M.R.C.; Donald Metcalf, M.D. Local production of the granulocyte and macrophage regulator, colony-stimulating factor (CSF), within the mouse bone marrow cavity was assessed by determining the capacity of marrow cells or the bone shaft to release or produce active...

...Donald Metcalf A somewhat similar outcome was observed when blast colonies were stimulated to develop by the combination of stem cell factor (SCF) and interleukin-3 (IL-3). Compared with the content of eosinophil progenitors in SCF-stimulated blast colonies, the SCF/IL-3 combination resulted...

...Masakazu Hasegawa; Tracey M. Baldwin; Donald Metcalf; Simon J. Foote Granulocyte colony-stimulating factor (G-CSF) can effectively mobilize hematopoietic stem and progenitor cells from bone marrow into blood, thereby allowing peripheral blood stem cells (PBSCs) to be used for transplantation...

...Ashley P. Ng; Craig D. Hyland; Donald Metcalf; Catherine L. Carmichael; Stephen J. Loughran; Ladina Di Rago; Benjamin T. Kile; Warren S. Alexander Down syndrome is characterized by multiple phenotypic manifestations associated with trisomy of chromosome 21. The transient myeloproliferative disorder...

...DONALD METCALF, M.D.; SOH HA CHAN, MB., B.S.; FREDERICK W. GUNZ, M.D.; PAUL VINCENT, M.B., B.S., M.R.A.C.P.; ROBERT B. M. RAVICH, MB., Ch.B., M.R.A.C.P. Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic...

...Donald Metcalf; Nicos A. Nicola; Sandra Mifsud; Ladina Di Rago Marrow cells from mice lacking high-affinity receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF; βc −/− mice) were shown to bind and internalize much less GM-CSF than cells from normal (βc +/+ ) mice. βc −/− mice...