Search Results for leukemia

...; Sebastian Giebel; Emmanuelle Polge; Jordi Esteve; Arnon Nagler; Mohamad Mohty To analyze the influence of distinct combinations of molecular aberrations on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for cytogenetically normal acute myeloid leukemia (CN-AML), a retrospective...

...; Katarzyna Domanska-Czyz; Rainer Fietkau; Heinz-August Horst; Harald Rieder; Stefan Schwartz; Thomas Burmeister; Nicola Gökbuget This largest prospective multicenter trial for adult patients with Burkitt lymphoma/leukemia aimed to prove the efficacy and feasibility of short-intensive chemotherapy combined...

...Emanuela M. Ghia; Laura Z. Rassenti; Donna S. Neuberg; Alejandro Blanco; Fouad Yousif; Erin N. Smith; John D. McPherson; Thomas J. Hudson; the HALT Pan-Leukemia Gene Panel Consortium; Olivier Harismendy; Kelly A. Frazer; Thomas J. Kipps Targeted sequencing of 103 leukemia-associated genes...

...; Wilhelm Schmitz; Peter Schlenke; Michael McClelland; Wolfgang E. Berdel; Martin Dugas; Hubert Serve; on behalf of the Study Alliance Leukemia Acute myeloid leukemia (AML) is commonly associated with alterations in transcription factors because of altered expression or gene mutations. These changes might...

... Lewandowski; Beata Stella-Holowiecka; Kazimierz Sulek; Krzysztof Gawronski; Aleksander B. Skotnicki; Wieslaw Nowak; Krystyna Zawilska; Lucyna Molendowicz-Portala; Janusz Kloczko; Jarosław Sokolowski; Krzysztof Warzocha; Ilona Seferyńska; Bernardeta Ceglarek; Lech Konopka; for the Polish Adult Leukemia Group...

...Cesare Guglielmi; Stefania Bergantini; Simona Iacobelli; Anja van Biezen; Eduardo Olavarria; Alois Gratwohl; Antonius V.M.B. Schattenberg; Leo F. Verdonck; Dietger W. Niederwieser; T.M. de Witte; for the Chronic Leukemia Working Party of the EBMT Donor lymphocyte infusions (DLI) have radically...

...Norbert C. Gorin; Myriam Labopin; Vanderson Rocha; William Arcese; Meral Beksac; Eliane Gluckman; Olle Ringden; Tapani Ruutu; Josy Reiffers; Giuseppe Bandini; Michele Falda; Panagiotis Zikos; Roelf Willemze; Francesco Frassoni; for the Acute Leukemia Working Party (ALWP) of the European Cooperative...

... complications, we analyzed, in a retrospective, multicenter study, 387 children who underwent autologous hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia (AML) in first complete remission (CR). Median follow-up time from transplantation was 60 months. Transplantation of bone marrow...

...Michel Duval; Stefan Suciu; Alina Ferster; Xavier Rialland; Brigitte Nelken; Patrick Lutz; Yves Benoit; Alain Robert; Anne-Marie Manel; Etienne Vilmer; Jacques Otten; Noël Philippe Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma...

...M.C. Bene; M. Bernier; R.O. Casasnovas; G. Castoldi; W. Knapp; F. Lanza; W.D. Ludwig; E. Matutes; A. Orfao; C. Sperling; M.B. van't Veer We document findings on c-kit (CD117) expression in 1,937 pediatric and adult de novo acute leukemia cases, diagnosed in five single European centers. All cases...

... : Haploidentical (Haplo) stem cell transplantation (SCT) provide a curative option for nearly all Acute Myeloid Leukemia (AML) patients lacking an HLA matched donor. However, outcomes following Haplo-SCT vary and are dependent on a number of individual features. Integrative prognostic models for decision support...

... (H3K9me2), as well as several non-histone lysine sites. Recently, pharmacological and genetic targeting of the G9a was shown to be efficient in slowing down acute myeloid leukemia (AML) cell proliferation in a mouse model and human AML cell lines thus making this HMTase potential target for epigenetic...

... Karakasis, MD PhD; Bipin N. Savani, MD; Eliane Gluckman, MD PhD; Arnon Nagler Background. The efficacy of umbilical cord blood transplantation (UCBT) as treatment for acute myeloid leukemia (AML) relies heavily on immune-mediated graft-versus-leukemia effects. Following bone marrow or peripheral blood stem...

...; Christopher L Nobles, PhD; Frederic D Bushman, PhD; Elena Orlando, PhD; Stephan A. Grupp, MD PhD; Carl H June, MD; Jan Joseph Melenhorst, PhD T cells bearing a second-generation anti-CD19 chimeric antigen receptor (CAR) induce complete remission in >90% of patients with acute lymphoblastic leukemia (ALL...

... significance of leukemia stem cells (LSCs) in acute myeloid leukemia (AML). However, the identification of LSCs in acute lymphocytic leukemia (ALL) has proved challenging, as transplantation studies in immunocompromised mice have yielded conflicting results. The distinction between Philadelphia chromosome...

... PhD; Vanderson Rocha, MD PhD; Amit Gal, MSc; Ron Unger, PhD; Frederic Baron, MD PhD; Peter Bader, MD; Eliane Gluckman, MD; Arnon Nagler, MD MSc Background: Umbilical cord blood transplantation (UCBT) is a potentially curative therapy acute leukemia (AL) patients. Transplantation benefit must...

...Jordan Jacobelli, PhD; Eric Wigton; Scott B Thompson Background: Leukemia affects approximately 45,000 people each year in the USA with more than 20,000 fatalities. Many leukemia patients experience initial remission but often relapse, with the relapsing leukemia affecting organs...

... E. Bueso-Ramos, MD PhD; Jorge E. Cortes, MD; Michael Andreeff, MD PhD Background : The bone marrow (BM) niche protects Acute Myeloid Leukemia (AML) cells from chemotherapy. BM homing of AML cells is dependent on CXCR4 and its ligand CXCL12, and high levels of CXCR4 expression correlate with poor...

...; Xiao-Jie Yan, MD PhD; Nicholas Chiorazzi, MD BACKGROUND: In patients with chronic lymphocytic leukemia (CLL), the Bruton tyrosine kinase(BTK) inhibitor ibrutinib induces a rapid reduction in lymphadenopathy, accompanied by a transient lymphocytosis. Continuation of therapy leads to a reduction...

...Sara González-García; Marta Mosquera; Patricia Fuentes; Tiziana Palumbo; Adela Escudero; Antonio Pérez-Martínez; Manuel Ramírez; Anne E. Corcoran; Maria L. Toribio T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy resulting from the dysregulation of signaling...