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Preclinical Evaluation of PRGN-3007, a Non-Viral, Multigenic, Autologous ROR1 UltraCAR-T Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

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Journal Articles

Preclinical Evaluation of Prgn-3007, a Non-Viral, Multigenic, Autologous ROR1 Ultracar-T ® Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

Tim Chan, Sean P Scott, Mengyan Du, Cheryl Bolinger, Carol Poortman, Lindsey Shepard, Byron Koenitzer, Adeline Govekung, Carlos Sailor, Rahim Johnson, Jacques Plummer, Steven Zilko, Shourik Dutta, Kannan Kunchithapautham, Taranjit Athwal, Bernward Klocke, Christian Zinser, Maha Abdeladhim, Shamim Ahmad, Simon Metenou, Roshanak Semnani, Douglas E Brough, Rutul R Shah, Helen Sabzevari
Journal: Blood
Blood (2021) 138 (Supplement 1): 1694.
https://doi.org/10.1182/blood-2021-149203
Published: 2021
... expression, rapid expansion, long-term persistence, and a predominant central memory phenotype of PRGN-3007 in tumor bearing mice. In summary, these preclinical data highlight the overall safety and improved efficacy of incorporating intrinsic downregulation of PD-1 expression on UltraCAR-T cells using non...