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Preclinical Evaluation of PRGN-3007, a Non-Viral, Multigenic, Autologous ROR1 UltraCAR-T Therapy with Novel Mechanism of Intrinsic PD-1 Blockade for Treatment of Hematological and Solid Cancers

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Journal Articles
Journal: Blood
Blood (2021) 138 (Supplement 1): 1694.
Published: 2021
... expression, rapid expansion, long-term persistence, and a predominant central memory phenotype of PRGN-3007 in tumor bearing mice. In summary, these preclinical data highlight the overall safety and improved efficacy of incorporating intrinsic downregulation of PD-1 expression on UltraCAR-T cells using non...