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©2018 by the American Society of Hematology

ISSN 1520-4391
eISSN 1520-4383

Hematology, the ASH Education Program, is published annually by the American Society of Hematology (ASH) in one volume per year.

All business correspondence and purchase and reprint requests should be addressed to the American Society of Hematology, 2021 L Street, NW, Suite 900, Washington, DC 20036, USA; phone: 202-776-0544; fax: 202-776-0545; e-mail:

©2018 by The American Society of Hematology. All rights reserved. Copyright is not claimed in any works of the United States Government. Except as expressly permitted in this statement, no part of this publication may be used (as hereinafter defined) in any form or by any means now or hereafter known, electronic or mechanical, without permission in writing from the Publisher, The American Society of Hematology. For purposes of this notice, the term “use” includes but is not limited to reproduction, photocopying, storage in a retrieval system, translation, and transmittal. The Publisher hereby consents to the use of this publication or any part hereof for any non-commercial educational purpose within the health field such as classroom instruction and clinical and residency training. This publication or any part thereof may be used for educational purposes at conferences, continuing education courses, and other educational activity, provided no fee or other compensation is charged therefore. All materials so used must acknowledge the Publisher’s copyright therein as “©2018 by The American Society of Hematology.” When requesting the Publisher’s permission to use this publication or any part thereof, please contact the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923, USA; phone: 978-750-8400; fax: 978-750-4470; or The American Society of Hematology Publishing at 2021 L Street, NW, Suite 900, Washington, DC 20036, USA; phone: 202-776-0544; fax: 202-776-0545.

Article Citations

Cite articles in this volume by listing Author(s), Title, Hematology Am Soc Hematol Educ Program. 2018;2018:beginning page number ending page number.

Hematology Rights and Permission 
To request permission to reprint or reuse Hematology articles, figures, or tables, please visit the Hematology page at the Copyright Clearance Center (

The publisher disclaims responsibility for opinions expressed by the authors.


Martin S. Tallman, MD
Executive Editor, Hematology 2018
Chief, Leukemia Service
Department of Medicine
Memorial Sloan-Kettering Cancer Center
Professor of Medicine
Weill Cornell Medical College
New York, NY

Keith R. McCrae, MD
Deputy Editor, Hematology 2018
Director, Benign Hematology
Taussig Cancer Institute
Professor, Cleveland Clinic Lerner College of Medicine
Cleveland Clinic
Cleveland, OH

Sonali Smith, MD
Deputy Editor, Hematology 2018
Elwood V. Jenson Professor of Medicine
Director, Lymphoma Program
University of Chicago
Chicago, IL

Committee on Educational Affairs
Michael L. Linenberger, MD (’19) (Chair)
Marc J. Kahn, MD, MBA (’19) (Vice Chair)
Anjali Advani, MD (’18)
Jennifer R. Brown, MD, PhD (’21)
Eldad Dann, MD (’21)
James Foran, MD (’18)
Heidi Klepin, MD (’18)
Casey L. O’Connell, MD (’19)
Heather A. O’Leary, PhD (’19)
Miguel-Angel Perales, MD (’20)
Adriana Seber, MD (’21)
B. Douglas Smith, MD (’19)
Julie Stakiw, MD, FRCPC (’19)
Andrew D. Zelenetz, MD, PhD (’21)

Alexis Thompson, MD, MPH (President)
Roy L. Silverstein, MD (President-Elect)
Stephanie J. Lee, MD, MPH (Vice President)

Adam Cuker, MD, MS (Co-Chair, 2018 Education Program; Junior Editor, ASH-SAP6)
Laurie Sehn, MD, MPH (Co-Chair, 2018 Education Program)
Kenneth Cohen, MD (Chair, Teaching Cases Subcommittee)
Molly Weidner Mandernach, MD, MPH (Chair, Committee on Practice)
David P. Steensma, MD (Senior Editor, ASH-SAP6)
Martin S. Tallman, MD (Executive Editor, Hematology)
Robert A. Brodsky, MD (Secretary)

Composite colored scanning electron micrograph of a bacterial blood infection caused by a rod-shaped bacterium. Short chains of a bacillus bacterium are shown among red blood cells and platelets from the circulatory system. Magnification: 31600 when the shortest axis is printed at 25 mm. Source: Dennis Kunkel Microscopy/Science Photo Library.

This activity is supported by educational grants from AstraZeneca and Novartis Oncology.

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