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Volume 2015, Issue 1

December 5 2015

In this Issue

Ham-Wasserman Manuscript
Anemia: When Something's Wrong with Iron
Challenges in Hemophilia Care
Challenging Scenarios in Thrombosis
Contemporary Therapy of Lymphoma
Cytosis: Too Much of a Good Thing
Evolving Issues in Anticoagulation
Great Expectations: Hematology in Pregnancy
Guiding Hematologic Care with Genetic Testing
Hemophagocytic Lymphohistiocytosis in Adults
Imaging and Treating the Clot: What's New?
Immunological Ctrl-Alt-Del: Stem Cell Transplantation for Hematological Malignancies
Management of Challenging Bleeding Complications
Managing Typical and Atypical Chronic Myeloid Leukemia
Multiple Advances in Myeloma
Myelodysplastic Syndromes: Evolving Diagnosis and Therapy
- Evidence-Based Mini-Review
Myeloproliferative Neoplasms: A Clinical Update
New Approaches in Chronic Lymphocytic Leukemia and Prolymphocytic Leukemia
New Insights in Hemolytic Anemia
Novel Approaches to Acute Lymphoblastic Leukemia
Optimizing Therapy in Sickle Cell Disease
- Evidence-Based Mini-Review
Optimizing Transfusion Therapy (AABB Session)
- Evidence-Based Mini-Review
Palliative Care in Hematological Malignancies
- Evidence-Based Mini-Review
Patient-Reported Outcomes in Hematology
Pediatric Hematological Malignancies: Beyond Acute Lymphocytic Leukemia
Practical Management of T-Cell and Natural Killer Cell Lymphomas
Recent Advances in Histiocytic Neoplasms
Treatment of Acute Myeloid Leukemia: Moving Beyond 3 + 7
Update in Large Cell Lymphoma
Update on Diagnosis and Management of Thrombotic Thrombocytopenic Purpura
- Evidence-Based Mini-Review
Erratum

Ham-Wasserman Manuscript

Game of clones: the genomic evolution of severe congenital neutropenia

Ivo P. Touw

View Articletitled, Game of clones: the genomic evolution of severe congenital neutropenia

Anemia: When Something's Wrong with Iron

Iron deficiency: new insights into diagnosis and treatment

Clara Camaschella

View Articletitled, Iron deficiency: new insights into diagnosis and treatment

Understanding anemia of chronic disease

Paula G. Fraenkel

View Articletitled, Understanding anemia of chronic disease

Diagnosis and treatment of sideroblastic anemias: from defective heme synthesis to abnormal RNA splicing

Mario Cazzola,Luca Malcovati

View Articletitled, Diagnosis and treatment of sideroblastic anemias: from defective heme synthesis to abnormal RNA splicing

Challenges in Hemophilia Care

The long and short of it: using the new factor products

Amy Dunn

View Articletitled, The long and short of it: using the new factor products

Emerging genetic and pharmacologic therapies for controlling hemostasis: beyond recombinant clotting factors

Paul E. Monahan

View Articletitled, Emerging genetic and pharmacologic therapies for controlling hemostasis: beyond recombinant clotting factors

Managing older patients with hemophilia

Dana Angelini,Suman L. Sood

View Articletitled, Managing older patients with hemophilia

Challenging Scenarios in Thrombosis

Perinatal thrombosis: implications for mothers and neonates

Sarah H. O'Brien

View Articletitled, Perinatal thrombosis: implications for mothers and neonates

The antiphospholipid syndrome: still an enigma

Shruti Chaturvedi,Keith R. McCrae

View Articletitled, The antiphospholipid syndrome: still an enigma

Mechanical circulatory support: balancing bleeding and clotting in high-risk patients

Lisa Baumann Kreuziger,M. Patricia Massicotte

View Articletitled, Mechanical circulatory support: balancing bleeding and clotting in high-risk patients

Contemporary Therapy of Lymphoma

Checkpoint blockade in lymphoma

Philippe Armand

View Articletitled, Checkpoint blockade in lymphoma

What is the role of autologous transplant for lymphoma in the current era?

Patrick Stiff

View Articletitled, What is the role of autologous transplant for lymphoma in the current era?

B-cell receptor pathway modulators in NHL

Kristie A. Blum

View Articletitled, B-cell receptor pathway modulators in NHL

Cytosis: Too Much of a Good Thing

Eosinophilia: a pragmatic approach to diagnosis and treatment

Amy D. Klion

View Articletitled, Eosinophilia: a pragmatic approach to diagnosis and treatment

Diagnosis and management of mastocytosis: an emerging challenge in applied hematology

Peter Valent

View Articletitled, Diagnosis and management of mastocytosis: an emerging challenge in applied hematology

Lymphocytosis, lymphadenopathy: benign or malignant?

Jane N. Winter,LoAnn C. Peterson

View Articletitled, Lymphocytosis, lymphadenopathy: benign or malignant?

Evolving Issues in Anticoagulation

Anticoagulants in children and adolescents

Guy Young

View Articletitled, Anticoagulants in children and adolescents

Monitoring and reversal of direct oral anticoagulants

Adam Cuker,Deborah Siegal

View Articletitled, Monitoring and reversal of direct oral anticoagulants

Using direct oral anticoagulants (DOACs) in cancer and other high-risk populations

Nick van Es,Harry R. Büller

View Articletitled, Using direct oral anticoagulants (DOACs) in cancer and other high-risk populations

Great Expectations: Hematology in Pregnancy

Postpartum hemorrhage: a continuing challenge

Evelyn Lockhart

View Articletitled, Postpartum hemorrhage: a continuing challenge

Fertility issues in patients with hematologic malignancies

Alison W. Loren

View Articletitled, Fertility issues in patients with hematologic malignancies

Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn

Meghan Delaney,Dana C. Matthews

View Articletitled, Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn

Guiding Hematologic Care with Genetic Testing

Using genetic diagnostics in hemophilia and von Willebrand disease

Laura L. Swystun,Paula James

View Articletitled, Using genetic diagnostics in hemophilia and von Willebrand disease

Sickle cell trait diagnosis: clinical and social implications

Rakhi P. Naik,Carlton Haywood, Jr

View Articletitled, Sickle cell trait diagnosis: clinical and social implications

Using red blood cell genomics in transfusion medicine

Jill M. Johnsen

View Articletitled, Using red blood cell genomics in transfusion medicine

Hemophagocytic Lymphohistiocytosis in Adults

Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis

Carl E. Allen,Kenneth L. McClain

View Articletitled, Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis

The unique aspects of presentation and diagnosis of hemophagocytic lymphohistiocytosis in adults

Sarah Nikiforow,Nancy Berliner

View Articletitled, The unique aspects of presentation and diagnosis of hemophagocytic lymphohistiocytosis in adults

Treatment of hemophagocytic lymphohistiocytosis in adults

Paul La Rosée

View Articletitled, Treatment of hemophagocytic lymphohistiocytosis in adults

Imaging and Treating the Clot: What's New?

Incidentally found pulmonary embolism: what's the clinician to do?

Casey O'Connell

View Articletitled, Incidentally found pulmonary embolism: what's the clinician to do?

Current challenges in diagnostic imaging of venous thromboembolism

Menno V. Huisman,Frederikus A. Klok

View Articletitled, Current challenges in diagnostic imaging of venous thromboembolism

Venous clot lysis and stenting

Suresh Vedantham

View Articletitled, Venous clot lysis and stenting

Immunological Ctrl-Alt-Del: Stem Cell Transplantation for Hematological Malignancies

Immune reconstitution following stem cell transplantation

Marcel R. M. van den Brink,Enrico Velardi,Miguel-Angel Perales

View Articletitled, Immune reconstitution following stem cell transplantation

Use of alternative donors for allogeneic stem cell transplantation

Claudio Anasetti

View Articletitled, Use of alternative donors for allogeneic stem cell transplantation

Graft-versus-host disease versus graft-versus-leukemia

Robert S. Negrin

View Articletitled, Graft-versus-host disease versus graft-versus-leukemia

Management of Challenging Bleeding Complications

Acquired bleeding disorders in the elderly

Rebecca Kruse-Jarres

View Articletitled, Acquired bleeding disorders in the elderly

Bleeding complications in immune thrombocytopenia

Donald M. Arnold

View Articletitled, Bleeding complications in immune thrombocytopenia

Coagulopathy in liver disease: a balancing act

Jody L. Kujovich

View Articletitled, Coagulopathy in liver disease: a balancing act

Managing Typical and Atypical Chronic Myeloid Leukemia

Is there a best TKI for chronic phase CML?

Richard A. Larson

View Articletitled, Is there a best TKI for chronic phase CML?

Molecular monitoring in CML and the prospects for treatment-free remissions

Michael W. Deininger

View Articletitled, Molecular monitoring in CML and the prospects for treatment-free remissions

What's different about atypical CML and chronic neutrophilic leukemia?

Kim-Hien T. Dao,Jeffrey W. Tyner

View Articletitled, What's different about atypical CML and chronic neutrophilic leukemia?

Multiple Advances in Myeloma

Evolving diagnostic criteria for multiple myeloma

S. Vincent Rajkumar

View Articletitled, Evolving diagnostic criteria for multiple myeloma

Maintenance therapy for multiple myeloma in the era of novel agents

Thierry Facon

View Articletitled, Maintenance therapy for multiple myeloma in the era of novel agents

Novel combination approaches for myeloma

Sagar Lonial,Ajay K. Nooka

View Articletitled, Novel combination approaches for myeloma

Myelodysplastic Syndromes: Evolving Diagnosis and Therapy

Reclassifying myelodysplastic syndromes: what's where in the new WHO and why

Daniel A. Arber,Robert P. Hasserjian

View Articletitled, Reclassifying myelodysplastic syndromes: what's where in the new WHO and why

The shadowlands of MDS: idiopathic cytopenias of undetermined significance (ICUS) and clonal hematopoiesis of indeterminate potential (CHIP)

Luca Malcovati,Mario Cazzola

View Articletitled, The shadowlands of MDS: idiopathic cytopenias of undetermined significance (ICUS) and clonal hematopoiesis of indeterminate potential (CHIP)

Nine years without a new FDA-approved therapy for MDS: how can we break through the impasse?

Amy E. DeZern

View Articletitled, Nine years without a new FDA-approved therapy for MDS: how can we break through the impasse?

Evidence-Based Mini-Review

Do somatic mutations in de novo MDS predict for response to treatment?

Mark A. Schroeder,Amy E. DeZern

View Articletitled, Do somatic mutations in de novo MDS predict for response to treatment?

Myeloproliferative Neoplasms: A Clinical Update

Looking forward: novel therapeutic approaches in chronic and advanced phases of myelofibrosis

John Mascarenhas

View Articletitled, Looking forward: novel therapeutic approaches in chronic and advanced phases of myelofibrosis

Management of symptoms in polycythemia vera and essential thrombocythemia patients

Deepti Radia,Holly L. Geyer

View Articletitled, Management of symptoms in polycythemia vera and essential thrombocythemia patients

Surveying the landscape of MDS/MPN research: overlap among the overlap syndromes?

Eric Padron

View Articletitled, Surveying the landscape of MDS/MPN research: overlap among the overlap syndromes?

New Approaches in Chronic Lymphocytic Leukemia and Prolymphocytic Leukemia

Patterns of resistance to B cell–receptor pathway antagonists in chronic lymphocytic leukemia and strategies for management

Jennifer A. Woyach

View Articletitled, Patterns of resistance to B cell–receptor pathway antagonists in chronic lymphocytic leukemia and strategies for management

Management of prolymphocytic leukemia

Claire Dearden

View Articletitled, Management of prolymphocytic leukemia

Prognostic markers and standard management of chronic lymphocytic leukemia

Stephan Stilgenbauer

View Articletitled, Prognostic markers and standard management of chronic lymphocytic leukemia

New Insights in Hemolytic Anemia

Management of hemolytic anemia following allogeneic stem cell transplantation

Andreas Holbro,Jakob R. Passweg

View Articletitled, Management of hemolytic anemia following allogeneic stem cell transplantation

Complement in hemolytic anemia

Robert A. Brodsky

View Articletitled, Complement in hemolytic anemia

Diagnosis and management of rare congenital nonimmune hemolytic disease

Patrick G. Gallagher

View Articletitled, Diagnosis and management of rare congenital nonimmune hemolytic disease

Novel Approaches to Acute Lymphoblastic Leukemia

The use of novel monoclonal antibodies in the treatment of acute lymphoblastic leukemia

Daniel J. DeAngelo

View Articletitled, The use of novel monoclonal antibodies in the treatment of acute lymphoblastic leukemia

Management of adult Ph-positive acute lymphoblastic leukemia

Sabina Chiaretti,Robin Foà

View Articletitled, Management of adult Ph-positive acute lymphoblastic leukemia

How can we improve on the already impressive results in pediatric ALL?

Angela Thomas

View Articletitled, How can we improve on the already impressive results in pediatric ALL?

Optimizing Therapy in Sickle Cell Disease

The five key things you need to know to manage adult patients with sickle cell disease

Sophie Lanzkron,Carlton Haywood, Jr

View Articletitled, The five key things you need to know to manage adult patients with sickle cell disease

Can selectin and iNKT cell therapies meet the needs of people with sickle cell disease?

Joshua J. Field

View Articletitled, Can selectin and iNKT cell therapies meet the needs of people with sickle cell disease?

Optimizing hydroxyurea therapy for sickle cell anemia

Russell E. Ware

View Articletitled, Optimizing hydroxyurea therapy for sickle cell anemia

Evidence-Based Mini-Review

Sickle solubility test to screen for sickle cell trait: what's the harm?

Venée N. Tubman,Joshua J. Field

View Articletitled, Sickle solubility test to screen for sickle cell trait: what's the harm?

Optimizing Transfusion Therapy (AABB Session)

Implementing a blood utilization program to optimize transfusion practice

William Savage

View Articletitled, Implementing a blood utilization program to optimize transfusion practice

Red blood cell transfusion for hematologic disorders

Chang Liu,Brenda J. Grossman

View Articletitled, Red blood cell transfusion for hematologic disorders

Platelet transfusion goals in oncology patients

Ross M. Fasano,Cassandra D. Josephson

View Articletitled, Platelet transfusion goals in oncology patients

Evidence-Based Mini-Review

Plasma versus prothrombin complex concentrate for warfarin-associated major bleeding: a systematic review

Deborah M. Siegal,William J. Savage

View Articletitled, Plasma versus prothrombin complex concentrate for warfarin-associated major bleeding: a systematic review

Palliative Care in Hematological Malignancies

When and why should patients with hematologic malignancies see a palliative care specialist?

Thomas W. LeBlanc,Areej El-Jawahri

View Articletitled, When and why should patients with hematologic malignancies see a palliative care specialist?

Spanning the canyon between stem cell transplantation and palliative care

Eric Roeland,Grace Ku

View Articletitled, Spanning the canyon between stem cell transplantation and palliative care

Palliative care in pediatric patients with hematologic malignancies

Lisa Humphrey,Tammy I. Kang

View Articletitled, Palliative care in pediatric patients with hematologic malignancies

Evidence-Based Mini-Review

Early integration of palliative care into the care of patients with cancer

Rachel Thienprayoon,Thomas LeBlanc

View Articletitled, Early integration of palliative care into the care of patients with cancer

Patient-Reported Outcomes in Hematology

Patient-reported outcomes in drug development for hematology

Catherine Acquadro,Antoine Regnault

View Articletitled, Patient-reported outcomes in drug development for hematology

Patient-reported outcomes in clinical practice

Sarah Dobrozsi,Julie Panepinto

View Articletitled, Patient-reported outcomes in clinical practice

Pediatric Hematological Malignancies: Beyond Acute Lymphocytic Leukemia

Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies

E. Anders Kolb,Soheil Meshinchi

View Articletitled, Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies

Hodgkin lymphoma in children and adolescents: improving the therapeutic index

Kara M. Kelly

View Articletitled, Hodgkin lymphoma in children and adolescents: improving the therapeutic index

Advances in therapies for non-Hodgkin lymphoma in children

Rachel Kobos,William Terry

View Articletitled, Advances in therapies for non-Hodgkin lymphoma in children

Practical Management of T-Cell and Natural Killer Cell Lymphomas

Choosing a systemic treatment for advanced stage cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome

Madeleine Duvic

View Articletitled, Choosing a systemic treatment for advanced stage cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome

Zebras and hen's teeth: recognition and management of rare T and NK lymphomas

Neha Mehta–Shah,Steven Horwitz

View Articletitled, Zebras and hen's teeth: recognition and management of rare T and NK lymphomas

Peripheral T-cell lymphoma, NOS, and anaplastic large cell lymphoma

Anne W. Beaven,Louis F. Diehl

View Articletitled, Peripheral T-cell lymphoma, NOS, and anaplastic large cell lymphoma

Recent Advances in Histiocytic Neoplasms

Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders

Carl E. Allen,D. Williams Parsons

View Articletitled, Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders

Treatment of Langerhans cell histiocytosis: role of BRAF/MAPK inhibition

Oussama Abla,Sheila Weitzman

View Articletitled, Treatment of Langerhans cell histiocytosis: role of BRAF/MAPK inhibition

Uncommon histiocytic disorders: Rosai–Dorfman, juvenile xanthogranuloma, and Erdheim–Chester disease

Julien Haroche,Oussama Abla

View Articletitled, Uncommon histiocytic disorders: Rosai–Dorfman, juvenile xanthogranuloma, and Erdheim–Chester disease

Treatment of Acute Myeloid Leukemia: Moving Beyond 3 + 7

Molecularly targeted therapies for acute myeloid leukemia

Eytan M. Stein

View Articletitled, Molecularly targeted therapies for acute myeloid leukemia

Antigen-specific immunotherapies for acute myeloid leukemia

Sarah A. Buckley,Roland B. Walter

View Articletitled, Antigen-specific immunotherapies for acute myeloid leukemia

New approaches to transplantation in acute myelogenous leukemia

Marcos de Lima

View Articletitled, New approaches to transplantation in acute myelogenous leukemia

Update in Large Cell Lymphoma

Update in large cell lymphoma: understanding the pathology report

Eric D. Hsi

View Articletitled, Update in large cell lymphoma: understanding the pathology report

Using the pathology report in initial treatment decisions for diffuse large B-cell lymphoma: time for a precision medicine approach

Jonathan W. Friedberg

View Articletitled, Using the pathology report in initial treatment decisions for diffuse large B-cell lymphoma: time for a precision medicine approach

Treatment of patients with transformed lymphoma

Silvia Montoto

View Articletitled, Treatment of patients with transformed lymphoma

Update on Diagnosis and Management of Thrombotic Thrombocytopenic Purpura

What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura

J. Evan Sadler

View Articletitled, What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura

Treatment of thrombotic thrombocytopenic purpura beyond therapeutic plasma exchange

Paul Coppo,for the French Reference Center for Thrombotic Microangiopathies,Antoine Froissart,for the French Reference Center for Thrombotic Microangiopathies

View Articletitled, Treatment of thrombotic thrombocytopenic purpura beyond therapeutic plasma exchange

Syndromes of thrombotic microangiopathy associated with pregnancy

James N. George,Carla M. Nester,Jennifer J. McIntosh

View Articletitled, Syndromes of thrombotic microangiopathy associated with pregnancy

Evidence-Based Mini-Review

Evidence for Janus kinase (JAK) inhibitors for the prevention of major morbid events in patients with myeloproliferative neoplasms (MPNs)

Naveen Pemmaraju,Ruben Mesa

View Articletitled, Evidence for Janus kinase (JAK) inhibitors for the prevention of major morbid events in patients with myeloproliferative neoplasms (MPNs)

Erratum

Evens AM, Kostakoglu L. The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. Hematology Am Soc Hematol Educ Program. 2014;2014:135-143.

View Articletitled, Evens AM, Kostakoglu L. The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. <em>Hematology Am Soc Hematol Educ Program.</em> 2014;2014:<span class="related-article">135-143</span>.

Cover Image

Cover Image

Cover: Cancer cell death. Colored scanning electron micrograph showing killer T-lymphocytes (orange) inducing a cancer cell (mauve) to undergo programmed cell death (PCD). Mauve vesicles, or apoptotic bodies emerging from the cancer cell, indicate PCD (known as apoptosis). Killer T-lymphocytes are part of the body's immune response system. They are programmed to seek out, attach themselves and kill cancer cells, usually using chemicals. In this case the lymphocytes have released a chemical which specifically induces apoptosis in the cancer cell. Apoptosis is a natural method of cell death which is being used as a potential treatment for cancer. © Carmelle Liepins/Science Photo Library/Corbis
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Ph− ALL: immunotherapy in upfront treatment

Ph+ ALL: new approaches for upfront therapy

Issue Archive

Table of Contents

Ham-Wasserman Manuscript

Anemia: When Something's Wrong with Iron

Challenges in Hemophilia Care

Challenging Scenarios in Thrombosis

Contemporary Therapy of Lymphoma

Cytosis: Too Much of a Good Thing

Evolving Issues in Anticoagulation

Great Expectations: Hematology in Pregnancy

Guiding Hematologic Care with Genetic Testing

Hemophagocytic Lymphohistiocytosis in Adults

Imaging and Treating the Clot: What's New?

Immunological Ctrl-Alt-Del: Stem Cell Transplantation for Hematological Malignancies

Management of Challenging Bleeding Complications

Managing Typical and Atypical Chronic Myeloid Leukemia

Multiple Advances in Myeloma

Myelodysplastic Syndromes: Evolving Diagnosis and Therapy

Evidence-Based Mini-Review

Myeloproliferative Neoplasms: A Clinical Update

New Approaches in Chronic Lymphocytic Leukemia and Prolymphocytic Leukemia

New Insights in Hemolytic Anemia

Novel Approaches to Acute Lymphoblastic Leukemia

Optimizing Therapy in Sickle Cell Disease

Evidence-Based Mini-Review

Optimizing Transfusion Therapy (AABB Session)

Evidence-Based Mini-Review

Palliative Care in Hematological Malignancies

Evidence-Based Mini-Review

Patient-Reported Outcomes in Hematology

Pediatric Hematological Malignancies: Beyond Acute Lymphocytic Leukemia

Practical Management of T-Cell and Natural Killer Cell Lymphomas

Recent Advances in Histiocytic Neoplasms

Treatment of Acute Myeloid Leukemia: Moving Beyond 3 + 7

Update in Large Cell Lymphoma

Update on Diagnosis and Management of Thrombotic Thrombocytopenic Purpura

Evidence-Based Mini-Review

Erratum

Cover Image

ASH Publications

American Society of Hematology

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