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Issue Archive

Volume 2008, Issue 1
December 5 2008
Issue Cover

Table of Contents

Ham-Wasserman Lecture

Acute Myeloid Leukemia: The Challenge of Capturing Disease Variety
Bob Löwenberg
View Articletitled, Acute Myeloid Leukemia: The Challenge of Capturing Disease Variety

Research Development Forum

Identifying Grant Funding: Mentored Career Development and Transition Awards
Kevin T. McDonagh
View Articletitled, Identifying Grant Funding: Mentored Career Development and Transition Awards
Transitioning from Fellowship to a Physician-Scientist Career Track
Ari Melnick
View Articletitled, Transitioning from Fellowship to a Physician-Scientist Career Track
What Do You Do with the “Pink Sheets?”
Nelson Chao
View Articletitled, What Do You Do with the “Pink Sheets?”

Evidence-Based Guidelines

Evidence-Based Guidelines—An Introduction
Wendy Lim,Donald M. Arnold,Veronika Bachanova,Richard L. Haspel,Rachel P. Rosovsky,Andrei R. Shustov,Mark A. Crowther
View Articletitled, Evidence-Based Guidelines—An Introduction
Does Helicobacter pylori Eradication Therapy Result in a Platelet Count Improvement in Adults with Immune Thrombocytopenic Purpura Regardless of H pylori Infection?
Donald M. Arnold,Roberto Stasi
View Articletitled, Does <em>Helicobacter pylori</em> Eradication Therapy Result in a Platelet Count Improvement in Adults with Immune Thrombocytopenic Purpura Regardless of <em>H pylori</em> Infection?
How Is Hodgkin Lymphoma in Pregnancy Best Treated?
Veronika Bachanova,Joseph M. Connors
View Articletitled, How Is Hodgkin Lymphoma in Pregnancy Best Treated?
Which Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Should Be Treated with Eculizumab?
Richard L. Haspel,Peter Hillmen
View Articletitled, Which Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Should Be Treated with Eculizumab?
What Is the Evidence for the Off-label Use of Recombinant Factor VIIa (rFVIIa) in the Acute Reversal of Warfarin?
Rachel P. Rosovsky,Mark A. Crowther
View Articletitled, What Is the Evidence for the Off-label Use of Recombinant Factor VIIa (rFVIIa) in the Acute Reversal of Warfarin?
Does High-Dose Therapy and Autologous Hematopoietic Stem Cell Transplantation Have a Role in the Primary Treatment of Peripheral T-Cell Lymphomas?
Andrei R. Shustov,Kerry J. Savage
View Articletitled, Does High-Dose Therapy and Autologous Hematopoietic Stem Cell Transplantation Have a Role in the Primary Treatment of Peripheral T-Cell Lymphomas?

Myelodysplastic Syndromes

Myelodysplastic Syndromes: An Historical Perspective
Eva Hellström-Lindberg
View Articletitled, Myelodysplastic Syndromes: An Historical Perspective
MDS: A Stem Cell Disorder—But What Exactly Is Wrong with the Primitive Hematopoietic Cells in This Disease?
Stephen D. Nimer
View Articletitled, MDS: A Stem Cell Disorder—But What Exactly Is Wrong with the Primitive Hematopoietic Cells in This Disease?
The Role of JAK2 Mutations in RARS and Other MDS
Eva Hellström-Lindberg,Mario Cazzola
View Articletitled, The Role of JAK2 Mutations in RARS and Other MDS
Epigenetic Modulation and Other Options to Improve Outcome of Stem Cell Transplantation in MDS
Nicolaus Kröger
View Articletitled, Epigenetic Modulation and Other Options to Improve Outcome of Stem Cell Transplantation in MDS

Myeloproliferative Disorders

Philadelphia Chromosome–Negative Myeloproliferative Disorders: An Historical Perspective
Josef T. Prchal
View Articletitled, Philadelphia Chromosome–Negative Myeloproliferative Disorders: An Historical Perspective
The JAK2V617F Mutation in Polycythemia Vera and Other Myeloproliferative Disorders: One Mutation for Three Diseases?
Chloé James
View Articletitled, The JAK2V617F Mutation in Polycythemia Vera and Other Myeloproliferative Disorders: One Mutation for Three Diseases?
New Advances in the Pathogenesis and Therapy of Essential Thrombocythemia
Ross L. Levine,Mark Heaney
View Articletitled, New Advances in the Pathogenesis and Therapy of Essential Thrombocythemia
From Palliation to Epigenetic Therapy in Myelofibrosis
Alessandro Rambaldi,Tiziano Barbui,Giovanni Barosi
View Articletitled, From Palliation to Epigenetic Therapy in Myelofibrosis

Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria (PNH): An Historical Perspective
Edward J. Benz, Jr.
View Articletitled, Paroxysmal Nocturnal Hemoglobinuria (PNH): An Historical Perspective
Paroxysmal Nocturnal Hemoglobinuria: An Historical Overview
Charles J. Parker
View Articletitled, Paroxysmal Nocturnal Hemoglobinuria: An Historical Overview
The Pathophysiology of Disease in Patients with Paroxysmal Nocturnal Hemoglobinuria
Monica Bessler,Jeffrey Hiken
View Articletitled, The Pathophysiology of Disease in Patients with Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria: Stem Cells and Clonality
Robert A. Brodsky
View Articletitled, Paroxysmal Nocturnal Hemoglobinuria: Stem Cells and Clonality
The Role of Complement Inhibition in PNH
Peter Hillmen
View Articletitled, The Role of Complement Inhibition in PNH

Hematopoietic Stem Cell Transplantation: Late Critical Problems

Late Critical Problems in Transplantation: An Historical Perspective
Stephanie J. Lee
View Articletitled, Late Critical Problems in Transplantation: An Historical Perspective
Late Pulmonary, Cardiovascular, and Renal Complications after Hematopoietic Stem Cell Transplantation and Recommended Screening Practices
André Tichelli,Alicia Rovó,Alois Gratwohl
View Articletitled, Late Pulmonary, Cardiovascular, and Renal Complications after Hematopoietic Stem Cell Transplantation and Recommended Screening Practices
Recognizing and Managing Chronic Graft-Versus-Host Disease
Stephanie J. Lee,Mary E. D. Flowers
View Articletitled, Recognizing and Managing Chronic Graft-Versus-Host Disease
Old and New Cancers after Hematopoietic-Cell Transplantation
Navneet S. Majhail
View Articletitled, Old and New Cancers after Hematopoietic-Cell Transplantation

Iron in Hematology

Iron in Hematology: An Historical Perspective
Mario Cazzola
View Articletitled, Iron in Hematology: An Historical Perspective
The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron Metabolism
Mark D. Fleming
View Articletitled, The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron Metabolism
The Anemia of Inflammation/Malignancy: Mechanisms and Management
John W. Adamson
View Articletitled, The Anemia of Inflammation/Malignancy: Mechanisms and Management
Clinical Relevance of Anemia and Transfusion Iron Overload in Myelodysplastic Syndromes
Mario Cazzola,Matteo G. Della Porta,Luca Malcovati
View Articletitled, Clinical Relevance of Anemia and Transfusion Iron Overload in Myelodysplastic Syndromes

Current and Future Therapies of Sickle Cell Anemia

Current and Future Therapies of Sickle Cell Anemia: An Historical Perspective
Mark T. Gladwin
View Articletitled, Current and Future Therapies of Sickle Cell Anemia: An Historical Perspective
Mechanisms of Vasculopathy in Sickle Cell Disease and Thalassemia
Claudia R. Morris
View Articletitled, Mechanisms of Vasculopathy in Sickle Cell Disease and Thalassemia
Novel Small Molecule Therapeutics for Sickle Cell Disease: Nitric Oxide, Carbon Monoxide, Nitrite, and Apolipoprotein A-I
Gregory J. Kato
View Articletitled, Novel Small Molecule Therapeutics for Sickle Cell Disease: Nitric Oxide, Carbon Monoxide, Nitrite, and Apolipoprotein A-I
Gene Replacement Therapy for Sickle Cell Disease and Other Blood Disorders
Tim M. Townes
View Articletitled, Gene Replacement Therapy for Sickle Cell Disease and Other Blood Disorders

TRANSFUSION MEDICINE

Platelet Transfusions: An Historical Perspective
Morris A. Blajchman
View Articletitled, Platelet Transfusions: An Historical Perspective
New Strategies for the Optimal Use of Platelet Transfusions
Morris A. Blajchman,Sherrill J. Slichter,Nancy M. Heddle,Michael F. Murphy
View Articletitled, New Strategies for the Optimal Use of Platelet Transfusions

Chronic Immune Thrombocytopenia

Immune Thrombocytopenia (ITP): An Historical Perspective
Howard A. Liebman
View Articletitled, Immune Thrombocytopenia (ITP): An Historical Perspective
Helicobacter pylori and Chronic ITP
Roberto Stasi,Drew Provan
View Articletitled, <em>Helicobacter pylori</em> and Chronic ITP
Viral-Associated Immune Thrombocytopenic Purpura
Howard A. Liebman
View Articletitled, Viral-Associated Immune Thrombocytopenic Purpura
The Pathophysiology of ITP Revisited: Ineffective Thrombopoiesis and the Emerging Role of Thrombopoietin Receptor Agonists in the Management of Chronic Immune Thrombocytopenic Purpura
Terry B. Gernsheimer
View Articletitled, The Pathophysiology of ITP Revisited: Ineffective Thrombopoiesis and the Emerging Role of Thrombopoietin Receptor Agonists in the Management of Chronic Immune Thrombocytopenic Purpura

Thrombophilia and Thrombosis in Children

Pediatric Thrombophilia and Thrombosis: An Historical Perspective
Marilyn J. Manco-Johnson
View Articletitled, Pediatric Thrombophilia and Thrombosis: An Historical Perspective
Thrombophilia in Children: Who to Test, How, When, and Why?
Leslie Raffini
View Articletitled, Thrombophilia in Children: Who to Test, How, When, and Why?
Thrombophilia States and Markers of Coagulation Activation in the Prediction of Pediatric Venous Thromboembolic Outcomes: A Comparative Analysis with Respect to Adult Evidence
Neil A. Goldenberg
View Articletitled, Thrombophilia States and Markers of Coagulation Activation in the Prediction of Pediatric Venous Thromboembolic Outcomes: A Comparative Analysis with Respect to Adult Evidence
New Anticoagulants in Children
Guy Young
View Articletitled, New Anticoagulants in Children

Thrombosis

Warfarin: An Historical Perspective
Charles W. Francis
View Articletitled, Warfarin: An Historical Perspective
Duration of Anticoagulation Therapy for Venous Thromboembolism
Henri Bounameaux,Arnaud Perrier
View Articletitled, Duration of Anticoagulation Therapy for Venous Thromboembolism
New Issues in Oral Anticoagulants
Charles W. Francis
View Articletitled, New Issues in Oral Anticoagulants
Management of Excessive Anticoagulant Effect Due to Vitamin K Antagonists
Francesco Dentali,Mark A. Crowther
View Articletitled, Management of Excessive Anticoagulant Effect Due to Vitamin K Antagonists

Peripheral T-Cell Lymphomas

Peripheral T-Cell Lymphomas: An Historical Perspective
Kerry J. Savage
View Articletitled, Peripheral T-Cell Lymphomas: An Historical Perspective
Pathobiology and Molecular Profiling of Peripheral T-Cell Lymphomas
Laurence de Leval,Philippe Gaulard
View Articletitled, Pathobiology and Molecular Profiling of Peripheral T-Cell Lymphomas
Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas
Kerry J. Savage
View Articletitled, Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas
Novel Therapies and Role of Transplant in the Treatment of Peripheral T-Cell Lymphomas
Steven M. Horwitz
View Articletitled, Novel Therapies and Role of Transplant in the Treatment of Peripheral T-Cell Lymphomas

Plasma Cell Disorders

Plasma Cell Disorders: An Historical Perspective
Nikhil C. Munshi
View Articletitled, Plasma Cell Disorders: An Historical Perspective
Investigative Tools for Diagnosis and Management
Nikhil C. Munshi
View Articletitled, Investigative Tools for Diagnosis and Management
Induction Therapy in Multiple Myeloma
Jean-Luc Harousseau
View Articletitled, Induction Therapy in Multiple Myeloma
Skeletal Imaging and Management of Bone Disease
G. David Roodman
View Articletitled, Skeletal Imaging and Management of Bone Disease

Hodgkin Lymphoma: Clinical Challenges

Clinical Challenges in Hodgkin Lymphoma: An Historical Perspective
Joseph M. Connors
View Articletitled, Clinical Challenges in Hodgkin Lymphoma: An Historical Perspective
Limited-Stage Disease: Optimal Use of Chemotherapy and Radiation Treatment
John Radford
View Articletitled, Limited-Stage Disease: Optimal Use of Chemotherapy and Radiation Treatment
Management of Hodgkin Lymphoma in Relapse after Autologous Stem Cell Transplant
Michael Crump
View Articletitled, Management of Hodgkin Lymphoma in Relapse after Autologous Stem Cell Transplant
Challenging Problems: Coincident Pregnancy, HIV Infection, and Older Age
Joseph M. Connors
View Articletitled, Challenging Problems: Coincident Pregnancy, HIV Infection, and Older Age

Special Problems in B-Cell Lymphoma

Special Problems in B-Cell Lymphoma: An Historical Perspective
Brad S. Kahl
View Articletitled, Special Problems in B-Cell Lymphoma: An Historical Perspective
Burkitt Lymphoma in Adults
Archibald S. Perkins,Jonathan W. Friedberg
View Articletitled, Burkitt Lymphoma in Adults
Primary Mediastinal B-Cell Lymphoma
Peter W.M. Johnson,Andrew J. Davies
View Articletitled, Primary Mediastinal B-Cell Lymphoma
Marginal Zone Lymphomas: Management of Nodal, Splenic, and MALT NHL
Brad Kahl,David Yang
View Articletitled, Marginal Zone Lymphomas: Management of Nodal, Splenic, and MALT NHL

Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia: An Historical Perspective
Nita L. Seibel
View Articletitled, Acute Lymphoblastic Leukemia: An Historical Perspective
Molecular Determinants of Treatment Response in Acute Lymphoblastic Leukemia
Dario Campana
View Articletitled, Molecular Determinants of Treatment Response in Acute Lymphoblastic Leukemia
Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents: Peaks and Pitfalls
Nita L. Seibel
View Articletitled, Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents: Peaks and Pitfalls
The Treatment of Adults with Acute Lymphoblastic Leukemia
Adele Fielding
View Articletitled, The Treatment of Adults with Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

Acute Myeloid Leukemia; Decided Victories, Disappointments, and Detente: An Historical Perspective
Martin S. Tallman
View Articletitled, Acute Myeloid Leukemia; Decided Victories, Disappointments, and Detente: An Historical Perspective
Curative Strategies in Acute Promyelocytic Leukemia
Martin S. Tallman,Jessica K. Altman
View Articletitled, Curative Strategies in Acute Promyelocytic Leukemia
Molecular Genetic Pathways as Therapeutic Targets in Acute Myeloid Leukemia
Torsten Haferlach
View Articletitled, Molecular Genetic Pathways as Therapeutic Targets in Acute Myeloid Leukemia
Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia When a Matched Related Donor Is Not Available
Frederick R. Appelbaum
View Articletitled, Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia When a Matched Related Donor Is Not Available

Chronic Myeloid Leukemia

Chronic Myeloid Leukemia: An Historical Perspective
Michael W. Deininger
View Articletitled, Chronic Myeloid Leukemia: An Historical Perspective
Milestones and Monitoring in Patients with CML Treated with Imatinib
Michael W. Deininger
View Articletitled, Milestones and Monitoring in Patients with CML Treated with Imatinib
Novel Agents in CML Therapy: Tyrosine Kinase Inhibitors and Beyond
Junia V. Melo,Charles Chuah
View Articletitled, Novel Agents in CML Therapy: Tyrosine Kinase Inhibitors and Beyond
Chronic Myeloid Leukemia Stem Cells
Catriona H. Jamieson
View Articletitled, Chronic Myeloid Leukemia Stem Cells

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia: An Historical Perspective
John G. Gribben
View Articletitled, Chronic Lymphocytic Leukemia: An Historical Perspective
Molecular Profiling in CLL
John G. Gribben
View Articletitled, Molecular Profiling in CLL
Disease-Specific Complications of Chronic Lymphocytic Leukemia
Claire Dearden
View Articletitled, Disease-Specific Complications of Chronic Lymphocytic Leukemia
New Agents in the Treatment of CLL
Susan O’Brien
View Articletitled, New Agents in the Treatment of CLL

Pain Management and Supportive Care for Patients with Hematologic Disorders

Palliative Care: An Historical Perspective
Matthew J. Loscalzo
View Articletitled, Palliative Care: An Historical Perspective
Pain Management in Sickle Cell Disease: Palliative Care Begins at Birth?
Lennette Benjamin
View Articletitled, Pain Management in Sickle Cell Disease: Palliative Care Begins at Birth?
Patient and Family Requests for Hastened Death
Janet L. Abrahm
View Articletitled, Patient and Family Requests for Hastened Death
Palliative Care and Psychosocial Contributions in the ICU
Matthew J. Loscalzo
View Articletitled, Palliative Care and Psychosocial Contributions in the ICU

Appendix: Color Figures

Appendix: Color Figures
View Articletitled, Appendix: Color Figures
  • Cover Image

    Cover Image

    issue cover

    Monochromatic image of myelodysplastic erythroblasts stained for iron. Adapted from Hellström-Lindberg and Cazzola, Figure 1, middle panel (Perls staining of bone marrow smear showing numerous ringed sideroblasts). Courtesy of Rosangela Invernizzi. See the original, full color figure in the appendix on page 491.

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All Issues
Medical consult: aHUS, TTP? How to distinguish and what to do
Management of limited-stage Hodgkin lymphoma
Consumptive coagulopathy in the ICU
Pyruvate kinase activators for treatment of pyruvate kinase deficiency
Preventing relapse after CD19 CAR T-cell therapy for pediatric ALL: the role of transplant and enhanced CAR T cells
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