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Issue Archive

Volume 2007, Issue 1
January 1 2007
Issue Cover

Table of Contents

Ham-Wasserman Lecture

The Genetic Basis of Myeloproliferative Disorders
Radek Skoda
View Articletitled, The Genetic Basis of Myeloproliferative Disorders

Stem Cells

Hematopoietic Development from Human Embryonic Stem Cells
Mickie Bhatia
View Articletitled, Hematopoietic Development from Human Embryonic Stem Cells
Towards the Generation of Patient-Specific Pluripotent Stem Cells for Combined Gene and Cell Therapy of Hematologic Disorders
George Q. Daley
View Articletitled, Towards the Generation of Patient-Specific Pluripotent Stem Cells for Combined Gene and Cell Therapy of Hematologic Disorders

Bone Marrow Failure Syndromes

Aplastic Anemia: Pathogenesis and Treatment
Andrea Bacigalupo
View Articletitled, Aplastic Anemia: Pathogenesis and Treatment
Diagnosis, Genetics, and Management of Inherited Bone Marrow Failure Syndromes
Blanche P. Alter
View Articletitled, Diagnosis, Genetics, and Management of Inherited Bone Marrow Failure Syndromes
Bone Marrow Failure as a Risk Factor for Clonal Evolution: Prospects for Leukemia Prevention
Grover C. Bagby,Gabrielle Meyers
View Articletitled, Bone Marrow Failure as a Risk Factor for Clonal Evolution: Prospects for Leukemia Prevention

Hematopoietic Stem Cell Transplantation

Reduced-Intensity Stem Cell Transplantation: “...whereof a little More than a little is by much too much.” King Henry IV, part 1, I, 2
Joseph H. Antin
View Articletitled, Reduced-Intensity Stem Cell Transplantation<span class="subtitle-colon">: </span><span class="subtitle">“...whereof a little More than a little is by much too much.” King Henry IV, part 1, I, 2</span>
Umbilical Cord Blood (UCB) Transplantation: An Alternative to the Use of Unrelated Volunteer Donors?
Juliet N. Barker
View Articletitled, Umbilical Cord Blood (UCB) Transplantation: An Alternative to the Use of Unrelated Volunteer Donors?
GVHD—The Nuts and Bolts
Daniel Weisdorf
View Articletitled, GVHD—The Nuts and Bolts

RBCs and Hemoglobinopathies

Membrane Lipid Alterations in Hemoglobinopathies
Frans A. Kuypers
View Articletitled, Membrane Lipid Alterations in Hemoglobinopathies
Coagulation in the Pathophysiology of Hemolytic Anemias
Maria Domenica Cappellini
View Articletitled, Coagulation in the Pathophysiology of Hemolytic Anemias
Hemoglobin E Syndromes
Elliott Vichinsky
View Articletitled, Hemoglobin E Syndromes

Sickle Cell Anemia

Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell Disease
Marilyn J. Telen
View Articletitled, Role of Adhesion Molecules and Vascular Endothelium in the Pathogenesis of Sickle Cell Disease
Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem
Kenneth I. Ataga,Nigel S. Key
View Articletitled, Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem
Current Issues in Sickle Cell Pain and Its Management
Samir K. Ballas
View Articletitled, Current Issues in Sickle Cell Pain and Its Management

Platelet Disorders

Novel Thrombopoietic Agents
Biree Andemariam,Bethan Psaila,James B. Bussel
View Articletitled, Novel Thrombopoietic Agents
Aspirin and Clopidogrel Resistance
Desmond J. Fitzgerald,Andrew Maree
View Articletitled, Aspirin and Clopidogrel Resistance
TTP and ADAMTS13: When Is Testing Appropriate?
Pier Mannuccio Mannucci,Flora Peyvandi
View Articletitled, TTP and ADAMTS13: When Is Testing Appropriate?

Thrombophilia

Thrombophilia: Common Questions on Laboratory Assessment and Management
John A. Heit
View Articletitled, Thrombophilia: Common Questions on Laboratory Assessment and Management
The Antiphospholipid Syndrome
Jacob H. Rand
View Articletitled, The Antiphospholipid Syndrome
Management of Pregnant Women with Thrombophilia or a History of Venous Thromboembolism
Shannon M. Bates
View Articletitled, Management of Pregnant Women with Thrombophilia or a History of Venous Thromboembolism

Thrombosis and Bleeding Complications in Malignant Hematologic Disorders

Double Hazard of Thrombophilia and Bleeding in Leukemia
Hau C. Kwaan
View Articletitled, Double Hazard of Thrombophilia and Bleeding in Leukemia
Bleeding and Thrombosis Risks in Plasma Cell Dyscrasias
Charles S. Eby
View Articletitled, Bleeding and Thrombosis Risks in Plasma Cell Dyscrasias
Management of Thrombohemorrhagic Syndromes (THS) in Hematologic Malignancies
Anna Falanga,Frederick R. Rickles
View Articletitled, Management of Thrombohemorrhagic Syndromes (THS) in Hematologic Malignancies

Transfusion Medicine

Evidence-Based Platelet Transfusion Guidelines
Sherrill J. Slichter
View Articletitled, Evidence-Based Platelet Transfusion Guidelines
The Evidence-Based Use of FFP and Cryoprecipitate for Abnormalities of Coagulation Tests and Clinical Coagulopathy
Simon J. Stanworth
View Articletitled, The Evidence-Based Use of FFP and Cryoprecipitate for Abnormalities of Coagulation Tests and Clinical Coagulopathy
Blood and Coagulation Support in Trauma Care
John R. Hess
View Articletitled, Blood and Coagulation Support in Trauma Care

Hodgkin Lymphoma

Evaluation of the Risk of Therapy-Associated Complications in Survivors of Hodgkin Lymphoma
Lois B. Travis
View Articletitled, Evaluation of the Risk of Therapy-Associated Complications in Survivors of Hodgkin Lymphoma
Risk, Cure and Complications in Advanced Hodgkin Disease
Sandra J. Horning
View Articletitled, Risk, Cure and Complications in Advanced Hodgkin Disease
Epstein-Barr Virus and Hodgkin Lymphoma
Richard F. Ambinder
View Articletitled, Epstein-Barr Virus and Hodgkin Lymphoma

Follicular Lymphoma

The Biology of the Germinal Center
Yasodha Natkunam
View Articletitled, The Biology of the Germinal Center
Clinical Features, Prognosis and Treatment of Follicular Lymphoma
Gilles A. Salles
View Articletitled, Clinical Features, Prognosis and Treatment of Follicular Lymphoma
Follicular NHL: From Antibodies and Vaccines to Graft-versus-Lymphoma Effects
David G. Maloney
View Articletitled, Follicular NHL: From Antibodies and Vaccines to Graft-versus-Lymphoma Effects

Novel Immunotherapeutic Approaches for Lymphomas

Monoclonal Antibodies for B-Cell Lymphomas: Rituximab and Beyond
Celeste Bello,Eduardo M. Sotomayor
View Articletitled, Monoclonal Antibodies for B-Cell Lymphomas: Rituximab and Beyond
Vaccine Therapy for B-Cell Lymphomas: Next-Generation Strategies
Sattva S. Neelapu,Larry W. Kwak
View Articletitled, Vaccine Therapy for B-Cell Lymphomas: Next-Generation Strategies
Engineering Antitumor Immunity by T-Cell Adoptive Immunotherapy
Stanley R. Riddell
View Articletitled, Engineering Antitumor Immunity by T-Cell Adoptive Immunotherapy

Rational Therapeutic Targets in Large B-Cell and Mantle Cell Lymphomas

Antibody Therapy in Aggressive Lymphomas
Thomas M. Habermann
View Articletitled, Antibody Therapy in Aggressive Lymphomas
Molecular Signatures Define New Rational Treatment Targets in Large B-Cell Lymphomas
Margaret A. Shipp
View Articletitled, Molecular Signatures Define New Rational Treatment Targets in Large B-Cell Lymphomas
Mantle Cell Lymphoma: Identifying Novel Molecular Targets in Growth and Survival Pathways
Owen A. O’Connor
View Articletitled, Mantle Cell Lymphoma: Identifying Novel Molecular Targets in Growth and Survival Pathways

Pediatric Hematologic Malignancies: Non-Hodgkin Lymphoma

Burkitt Lymphoma: Revisiting the Pathogenesis of a Virus-Associated Malignancy
Gemma L. Kelly,Alan B. Rickinson
View Articletitled, Burkitt Lymphoma: Revisiting the Pathogenesis of a Virus-Associated Malignancy
Diagnosis and Treatment of Childhood Non-Hodgkin Lymphoma
Alfred Reiter
View Articletitled, Diagnosis and Treatment of Childhood Non-Hodgkin Lymphoma
Should Adolescents with NHL Be Treated as Old Children or Young Adults?
John T. Sandlund
View Articletitled, Should Adolescents with NHL Be Treated as Old Children or Young Adults?

Multiple Myeloma

Strategies for Risk-Adapted Therapy in Myeloma
Rafael Fonseca
View Articletitled, Strategies for Risk-Adapted Therapy in Myeloma
Stem Cell Transplantation in Multiple Myeloma
Michel Attal,Philippe Moreau,Herve Avet-Loiseau,Jean-Luc Harousseau
View Articletitled, Stem Cell Transplantation in Multiple Myeloma
The Treatment of Relapsed and Refractory Multiple Myeloma
Paul Richardson,Constantine Mitsiades,Robert Schlossman,Irene Ghobrial,Teru Hideshima,Dharminder Chauhan,Nikhil Munshi,Kenneth Anderson
View Articletitled, The Treatment of Relapsed and Refractory Multiple Myeloma

Chronic Lymphocytic Leukemia

Comprehensive Management of the CLL Patient: A Holistic Approach
Tait D. Shanafelt,Neil E. Kay
View Articletitled, Comprehensive Management of the CLL Patient: A Holistic Approach
Management of Infectious Complications in Patients with Chronic Lymphocytic Leukemia
Vicki A. Morrison
View Articletitled, Management of Infectious Complications in Patients with Chronic Lymphocytic Leukemia
Familial CLL: Genes and Environment
Lynn R. Goldin,Susan L. Slager
View Articletitled, Familial CLL: Genes and Environment

Myeloproliferative Disorders

Biology and Treatment of Primary Myelofibrosis
Ronald Hoffman,Damiano Rondelli
View Articletitled, Biology and Treatment of Primary Myelofibrosis
Navigating the Evolving Paradigms in the Diagnosis and Treatment of Myeloproliferative Disorders
Ruben A. Mesa
View Articletitled, Navigating the Evolving Paradigms in the Diagnosis and Treatment of Myeloproliferative Disorders
Thrombocytosis and Thrombosis
Alessandro M. Vannucchi,Tiziano Barbui
View Articletitled, Thrombocytosis and Thrombosis

Chronic Myeloid Leukemia

Medical Management of CML
Neil P. Shah
View Articletitled, Medical Management of CML
Chronic Myeloid Leukemia: Molecular Monitoring in Clinical Practice
Susan Branford
View Articletitled, Chronic Myeloid Leukemia: Molecular Monitoring in Clinical Practice
The Biology of CML Blast Crisis
Jerald P. Radich
View Articletitled, The Biology of CML Blast Crisis

Myelodysplastic Syndromes

Genetic Pathways in the Pathogenesis of Therapy-Related Myelodysplasia and Acute Myeloid Leukemia
Jens Pedersen-Bjergaard,Morten T. Andersen,Mette K. Andersen
View Articletitled, Genetic Pathways in the Pathogenesis of Therapy-Related Myelodysplasia and Acute Myeloid Leukemia
Management of RBC-Transfusion Dependence
Magda Melchert,Alan F. List
View Articletitled, Management of RBC-Transfusion Dependence
Modifying the Epigenome as a Therapeutic Strategy in Myelodysplasia
Guillermo Garcia-Manero
View Articletitled, Modifying the Epigenome as a Therapeutic Strategy in Myelodysplasia

Acute Myeloid Leukemia

Implication of the Molecular Characterization of Acute Myeloid Leukemia
Hartmut Döhner
View Articletitled, Implication of the Molecular Characterization of Acute Myeloid Leukemia
Prognostic Factors in Elderly Patients with AML and the Implications for Treatment
Harry P. Erba
View Articletitled, Prognostic Factors in Elderly Patients with AML and the Implications for Treatment
Targeting Treatment in AML
Alan K. Burnett,Steve Knapper
View Articletitled, Targeting Treatment in AML

Challenging Cases in Acute Leukemia

Philadelphia Chromosome–Positive Acute Lymphocytic Leukemia: A New Era of Challenges
Deborah A. Thomas
View Articletitled, Philadelphia Chromosome–Positive Acute Lymphocytic Leukemia: A New Era of Challenges
Which Patients with Adult Acute Lymphoblastic Leukemia Should Undergo a Hematopoietic Stem Cell Transplantation? Case-Based Discussion
Hillard M. Lazarus,Selina Luger
View Articletitled, Which Patients with Adult Acute Lymphoblastic Leukemia Should Undergo a Hematopoietic Stem Cell Transplantation? Case-Based Discussion
Etiology and Management of Therapy-Related Myeloid Leukemia
Richard A. Larson
View Articletitled, Etiology and Management of Therapy-Related Myeloid Leukemia

Gene Therapy: Progress and Challenges

The Yin and Yang of Stem Cell Gene Therapy: Insights into Hematopoiesis, Leukemogenesis, and Gene Therapy Safety
Cynthia E. Dunbar
View Articletitled, The Yin and Yang of Stem Cell Gene Therapy: Insights into Hematopoiesis, Leukemogenesis, and Gene Therapy Safety
Update on Progress and Hurdles in Novel Genetic Therapies for Hemophilia
Katherine A. High
View Articletitled, Update on Progress and Hurdles in Novel Genetic Therapies for Hemophilia
RNAi and Gene Therapy: A Mutual Attraction
Dirk Grimm,Mark A. Kay
View Articletitled, RNAi and Gene Therapy: A Mutual Attraction

Pitfalls of Clinical Trials and Their Interpretation

Limitations of Clinical Trials in Sickle Cell Disease: A Case Study of the Multi-center Study of Hydroxyurea (MSH) Trial and the Stroke Prevention (STOP) Trial
Michael R. DeBaun,Joshua J. Field
View Articletitled, Limitations of Clinical Trials in Sickle Cell Disease: A Case Study of the Multi-center Study of Hydroxyurea (MSH) Trial and the Stroke Prevention (STOP) Trial
Are There Circumstances in Which Phase 2 Study Results Should Be Practice-Changing?
Marcie R. Tomblyn,J. Douglas Rizzo
View Articletitled, Are There Circumstances in Which Phase 2 Study Results Should Be Practice-Changing?
Trials and Tribulations of Systematic Reviews and Meta-Analyses
Mark A. Crowther,Deborah J. Cook
View Articletitled, Trials and Tribulations of Systematic Reviews and Meta-Analyses

Research Development Forum

An Introduction to Foundation and Industry-Sponsored Research: Practical and Ethical Considerations
Kim A. Margolin,Koen van Besien,David J. Peace
View Articletitled, An Introduction to Foundation and Industry-Sponsored Research: Practical and Ethical Considerations

Hematology Grants I

Mechanisms for Mentored Career Development: The NIH Research Career Awards and Other National Awards
David Motto,Mark Roltsch,Mortimer Poncz
View Articletitled, Mechanisms for Mentored Career Development: The NIH Research Career Awards and Other National Awards

Appendix: Color Figures

Appendix: Color Figures
View Articletitled, Appendix: Color Figures
All Issues
Clinical screening for Ph-like ALL and the developing role of TKIs
Perioperative hemostasis for patients with hemophilia
Evidence-based management of pregnant women with sickle cell disease in high-income countries
Acute pain episodes, acute chest syndrome, and pulmonary thromboembolism in pregnancy
Optimal approach to T-cell ALL
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