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Issue Archive

Volume 2005, Issue 1
January 1 2005
Issue Cover

Table of Contents

Ham-Wasserman Lecture

Venous Thrombosis: The Role of Genes, Environment, and Behavior
Frits R. Rosendaal
View Articletitled, Venous Thrombosis: The Role of Genes, Environment, and Behavior

Red Cells

Red Cell Membrane Disorders
Patrick G. Gallagher
View Articletitled, Red Cell Membrane Disorders
Red Cell Enzymes
Josef T. Prchal,Xylina T. Gregg
View Articletitled, Red Cell Enzymes
Neurovisceral Porphyrias: What a Hematologist Needs to Know
Herbert L. Bonkovsky
View Articletitled, Neurovisceral Porphyrias: What a Hematologist Needs to Know

Hemoglobinopathy

Pathophysiology of β Thalassemia—A Guide to Molecular Therapies
Swee Lay Thein
View Articletitled, Pathophysiology of β Thalassemia—A Guide to Molecular Therapies
Fetal Globin Induction—Can It Cure β Thalassemia?
Susan P. Perrine
View Articletitled, Fetal Globin Induction—Can It Cure β Thalassemia?
Gene Therapy for β-Thalassemia
Punam Malik,Paritha I. Arumugam
View Articletitled, Gene Therapy for β-Thalassemia

Sickle Cell Disease: Advances in Pathogenesis and Management

Cardiopulmonary Complications of Sickle Cell Disease: Role of Nitric Oxide and Hemolytic Anemia
Mark T. Gladwin,Gregory J. Kato
View Articletitled, Cardiopulmonary Complications of Sickle Cell Disease: Role of Nitric Oxide and Hemolytic Anemia
An Evidence-Based Approach to the Treatment of Adults with Sickle Cell Disease
Richard Lottenberg,Kathryn L. Hassell
View Articletitled, An Evidence-Based Approach to the Treatment of Adults with Sickle Cell Disease
Stem Cell Therapy for Sickle Cell Disease: Transplantation and Gene Therapy
Mark C. Walters
View Articletitled, Stem Cell Therapy for Sickle Cell Disease: Transplantation and Gene Therapy

Childhood and Adolescent Hematology

Hereditary Periodic Fever Syndromes
Daniel L. Kastner
View Articletitled, Hereditary Periodic Fever Syndromes
Familial and Acquired Hemophagocytic Lymphohistiocytosis
Gritta Janka,Udo zur Stadt
View Articletitled, Familial and Acquired Hemophagocytic Lymphohistiocytosis
Chronic Granulomatous Disease and Other Disorders of Phagocyte Function
Mary C. Dinauer
View Articletitled, Chronic Granulomatous Disease and Other Disorders of Phagocyte Function

Marrow Failure

Bone Marrow Failure: A Child Is Not Just a Small Adult (But an Adult Can Have a Childhood Disease)
Blanche P. Alter
View Articletitled, Bone Marrow Failure: A Child Is Not Just a Small Adult (But an Adult Can Have a Childhood Disease)
Aplastic Anemia: Management of Pediatric Patients
Eva C. Guinan
View Articletitled, Aplastic Anemia: Management of Pediatric Patients
Aplastic Anemia: Management of Adult Patients
Jaroslaw P. Maciejewski,Antonio M. Risitano
View Articletitled, Aplastic Anemia: Management of Adult Patients

Acute Lymphoblastic Leukemia in Adults

Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
Oliver G. Ottmann,Barbara Wassmann
View Articletitled, Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
The Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia
Daniel J. DeAngelo
View Articletitled, The Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia: Older Patients and Newer Drugs
Richard A. Larson
View Articletitled, Acute Lymphoblastic Leukemia: Older Patients and Newer Drugs

Acute Myeloid Leukemia

The Molecular Pathology of Acute Myeloid Leukemia
Jonathan D. Licht,David W. Sternberg
View Articletitled, The Molecular Pathology of Acute Myeloid Leukemia
New Strategies for the Treatment of Acute Myeloid Leukemia Including Antibodies and Other Novel Agents
Martin S. Tallman
View Articletitled, New Strategies for the Treatment of Acute Myeloid Leukemia Including Antibodies and Other Novel Agents
Role of Allogeneic Stem Cell Transplantation in Current Treatment of Acute Myeloid Leukemia
Jan J. Cornelissen,Bob Löwenberg
View Articletitled, Role of Allogeneic Stem Cell Transplantation in Current Treatment of Acute Myeloid Leukemia

Myelodysplastic Syndromes

Molecular Pathogenesis of MDS
A. Thomas Look
View Articletitled, Molecular Pathogenesis of MDS
Update on Supportive Care and New Therapies: Immunomodulatory Drugs, Growth Factors and Epigenetic-Acting Agents
Eva Hellström-Lindberg
View Articletitled, Update on Supportive Care and New Therapies: Immunomodulatory Drugs, Growth Factors and Epigenetic-Acting Agents
Optimization of Transplant Regimens for Patients with Myelodysplastic Syndrome (MDS)
H. Joachim Deeg
View Articletitled, Optimization of Transplant Regimens for Patients with Myelodysplastic Syndrome (MDS)

Chronic Myeloid Leukemia

Management of Early Stage Disease
Michael W.N. Deininger
View Articletitled, Management of Early Stage Disease
Loss of Response to Imatinib: Mechanisms and Management
Neil P. Shah
View Articletitled, Loss of Response to Imatinib: Mechanisms and Management
Pathobiology of Lymphoid and Myeloid Blast Crisis and Management Issues
Robert L. Ilaria, Jr.
View Articletitled, Pathobiology of Lymphoid and Myeloid Blast Crisis and Management Issues

Myeloproliferative Diseases

A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases
William Vainchenker,Stefan N. Constantinescu
View Articletitled, A Unique Activating Mutation in JAK2 (V617F) Is at the Origin of Polycythemia Vera and Allows a New Classification of Myeloproliferative Diseases
Management of Polycythemia Vera and Essential Thrombocythemia
Peter J. Campbell,Anthony R. Green
View Articletitled, Management of Polycythemia Vera and Essential Thrombocythemia
Recent Advances in the Diagnosis and Treatment of Hypereosinophilic Syndromes
Amy D. Klion
View Articletitled, Recent Advances in the Diagnosis and Treatment of Hypereosinophilic Syndromes

Translational Research in Hematologic Malignancies

Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy
Aaron D. Schimmer,Shadi Dalili
View Articletitled, Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy
The Ubiquitin Proteasome Pathway from Bench to Bedside
Robert Z. Orlowski
View Articletitled, The Ubiquitin Proteasome Pathway from Bench to Bedside
Modulating the Bcl-2 Family of Apoptosis Suppressors for Potential Therapeutic Benefit in Cancer
Gordon C. Shore,Jean Viallet
View Articletitled, Modulating the Bcl-2 Family of Apoptosis Suppressors for Potential Therapeutic Benefit in Cancer

Hodgkin Lymphoma

Immunobiology and Pathophysiology of Hodgkin Lymphomas
Sibrand Poppema
View Articletitled, Immunobiology and Pathophysiology of Hodgkin Lymphomas
Evolving Approaches to Primary Treatment of Hodgkin Lymphoma
Joseph M. Connors
View Articletitled, Evolving Approaches to Primary Treatment of Hodgkin Lymphoma
Therapies for Relapsed Hodgkin Lymphoma: Transplant and Non-Transplant Approaches Including Immunotherapy
Nancy L. Bartlett
View Articletitled, Therapies for Relapsed Hodgkin Lymphoma: Transplant and Non-Transplant Approaches Including Immunotherapy

Aggressive Non-Hodgkin Lymphoma

Diffuse Large B-Cell Lymphoma: Risk Stratification and Management of Relapsed Disease
John W. Sweetenham
View Articletitled, Diffuse Large B-Cell Lymphoma: Risk Stratification and Management of Relapsed Disease
Biology and Treatment of Epstein-Barr Virus–Associated Non-Hodgkin Lymphomas
Helen E. Heslop
View Articletitled, Biology and Treatment of Epstein-Barr Virus–Associated Non-Hodgkin Lymphomas
Aggressive Peripheral T-Cell Lymphomas (Specified and Unspecified Types)
Kerry J. Savage
View Articletitled, Aggressive Peripheral T-Cell Lymphomas (Specified and Unspecified Types)

Chronic Lymphocytic Leukemia

CLL Biology and Prognosis
Guillaume Dighiero
View Articletitled, CLL Biology and Prognosis
Chronic Lymphocytic Leukemia (CLL): First-Line Treatment
Michael Hallek,On Behalf Of The German CLL Study Group
View Articletitled, Chronic Lymphocytic Leukemia (CLL): First-Line Treatment
Salvage Therapy for CLL and the Role of Stem Cell Transplantation
John G. Gribben
View Articletitled, Salvage Therapy for CLL and the Role of Stem Cell Transplantation

Indolent Non-Hodgkin Lymphoma

Hematopathology Approaches to Diagnosis and Prognosis of Indolent B-Cell Lymphomas
Randy D. Gascoyne
View Articletitled, Hematopathology Approaches to Diagnosis and Prognosis of Indolent B-Cell Lymphomas
Clinical Presentation and Management of Marginal Zone Lymphomas
Catherine Thieblemont
View Articletitled, Clinical Presentation and Management of Marginal Zone Lymphomas
Biology and Management of Histologic Transformation of Indolent Lymphoma
Arnold S. Freedman
View Articletitled, Biology and Management of Histologic Transformation of Indolent Lymphoma

Monoclonal Antibody Therapy for Lymphoma: Targeting CD20

Multimodality Therapies and Optimal Schedule of Antibodies: Rituximab in Lymphoma as an Example
Michele Ghielmini
View Articletitled, Multimodality Therapies and Optimal Schedule of Antibodies: Rituximab in Lymphoma as an Example
Unique Toxicities and Resistance Mechanisms Associated with Monoclonal Antibody Therapy
Jonathan W. Friedberg
View Articletitled, Unique Toxicities and Resistance Mechanisms Associated with Monoclonal Antibody Therapy
Targeting CD20 in Follicular NHL: Novel Anti-CD20 Therapies, Antibody Engineering, and the Use of Radioimmunoconjugates
John P. Leonard
View Articletitled, Targeting CD20 in Follicular NHL: Novel Anti-CD20 Therapies, Antibody Engineering, and the Use of Radioimmunoconjugates

Myeloma

MGUS and Smoldering Multiple Myeloma: Update on Pathogenesis, Natural History, and Management
S. Vincent Rajkumar
View Articletitled, MGUS and Smoldering Multiple Myeloma: Update on Pathogenesis, Natural History, and Management
Early Genetic Events Provide the Basis for a Clinical Classification of Multiple Myeloma
W. Michael Kuehl,P. Leif Bergsagel
View Articletitled, Early Genetic Events Provide the Basis for a Clinical Classification of Multiple Myeloma
An Update of the Management of Multiple Myeloma: The Changing Landscape
Donna E. Reece
View Articletitled, An Update of the Management of Multiple Myeloma: The Changing Landscape

Plasma Cell Disorders: Atypical Plasma Cell Syndromes

POEMS Syndrome
Angela Dispenzieri
View Articletitled, POEMS Syndrome
Cryoglobulinemia
Enrica Morra
View Articletitled, Cryoglobulinemia
Solitary Bone and Extramedullary Plasmacytoma
Donna M. Weber
View Articletitled, Solitary Bone and Extramedullary Plasmacytoma

Hematopoietic Stem Cell Transplantation

Umbilical Cord Blood Transplantation: A New Alternative Option
William Tse,Mary J. Laughlin
View Articletitled, Umbilical Cord Blood Transplantation: A New Alternative Option
Reduced-Intensity Conditioning Regimens for Hematologic Malignancies: What Have We Learned over the Last 10 Years?
Sergio Giralt
View Articletitled, Reduced-Intensity Conditioning Regimens for Hematologic Malignancies: What Have We Learned over the Last 10 Years?
Haploidentical Stem Cell Transplantation: The Always Present but Overlooked Donor
Thomas R. Spitzer
View Articletitled, Haploidentical Stem Cell Transplantation: The Always Present but Overlooked Donor

Platelets

Inherited Platelet Disorders
Robert I. Handin
View Articletitled, Inherited Platelet Disorders
Acquired Disorders of Platelet Function
Amy A. Hassan,Michael H. Kroll
View Articletitled, Acquired Disorders of Platelet Function
Platelets and Thrombosis in Myeloproliferative Diseases
Claire N. Harrison
View Articletitled, Platelets and Thrombosis in Myeloproliferative Diseases

Clinical Management of Bleeding Disorders

Management of Bleeding Disorders in Children
Catherine S. Manno
View Articletitled, Management of Bleeding Disorders in Children
Diagnosis and Management of Mild Bleeding Disorders
Catherine P. M. Hayward
View Articletitled, Diagnosis and Management of Mild Bleeding Disorders
New Perspectives in Hemophilia Treatment
Craig M. Kessler
View Articletitled, New Perspectives in Hemophilia Treatment

Thrombosis I

Pathogenesis of Atherosclerosis
Mark A. Crowther
View Articletitled, Pathogenesis of Atherosclerosis
Genetic Risk Factors for Arterial Thrombosis and Inflammation
David Ginsburg
View Articletitled, Genetic Risk Factors for Arterial Thrombosis and Inflammation
The Cardiovascular Pharmacology of COX-2 Inhibition
Susanne Fries,Tilo Grosser
View Articletitled, The Cardiovascular Pharmacology of COX-2 Inhibition

Thrombosis II

Inherited Risk Factors for Venous Thrombosis
Mary Cushman
View Articletitled, Inherited Risk Factors for Venous Thrombosis
Acquired Risk Factors for Venous Thromboembolism in Medical Patients
Paolo Prandoni
View Articletitled, Acquired Risk Factors for Venous Thromboembolism in Medical Patients
Thrombosis and the Antiphospholipid Syndrome
Thomas L. Ortel
View Articletitled, Thrombosis and the Antiphospholipid Syndrome

Transfusion Medicine (with AABB)

Evaluation of Hematopoietic Stem Cell Donors
Mary M. Horowitz,Dennis L. Confer
View Articletitled, Evaluation of Hematopoietic Stem Cell Donors
Technology for Enhanced Transfusion Safety
Walter H. Dzik
View Articletitled, Technology for Enhanced Transfusion Safety
The Transfusion Services Committee—Responsibilities and Response to Adverse Transfusion Events
Ira A. Shulman,Sunita Saxena
View Articletitled, The Transfusion Services Committee—Responsibilities and Response to Adverse Transfusion Events

Ethical and Clinical Controversies in Hematology

Integrative Medicine in Hematology/Oncology: Benefits, Ethical Considerations, and Controversies
David S. Rosenthal,Elizabeth Dean-Clower
View Articletitled, Integrative Medicine in Hematology/Oncology: Benefits, Ethical Considerations, and Controversies
Practical and Ethical Issues with Genetic Screening
John E. Wagner
View Articletitled, Practical and Ethical Issues with Genetic Screening
Medical Errors
Angela Roddey Holder
View Articletitled, Medical Errors

Cancer Survivorship

Cancer Survivorship—Pediatric Issues
Smita Bhatia
View Articletitled, Cancer Survivorship—Pediatric Issues
Considerations for Adult Cancer Survivors
André Tichelli,Gérard Socié
View Articletitled, Considerations for Adult Cancer Survivors
Sexuality and Fertility after Cancer
Leslie R. Schover
View Articletitled, Sexuality and Fertility after Cancer

ASH Special Symposium: Anemia in the Elderly

Anemia in the Elderly: A Public Health Crisis in Hematology
Jack M. Guralnik,William B. Ershler,Stanley L. Schrier,Vincent J. Picozzi
View Articletitled, Anemia in the Elderly: A Public Health Crisis in Hematology

Special Plenary Session

On the Molecular Origins of the Chronic Myeloproliferative Disorders: It All Makes Sense
Kenneth Kaushansky
View Articletitled, On the Molecular Origins of the Chronic Myeloproliferative Disorders: It All Makes Sense

Hematology Grants Workshop

Hematology Grants K08 and K23
David M. Bodine
View Articletitled, Hematology Grants K08 and K23

Errata

Erratum
View Articletitled, Erratum

Appendix: Color Figures

Appendix: Color Figures
View Articletitled, Appendix: Color Figures
All Issues
Clinical screening for Ph-like ALL and the developing role of TKIs
Perioperative hemostasis for patients with hemophilia
Evidence-based management of pregnant women with sickle cell disease in high-income countries
Acute pain episodes, acute chest syndrome, and pulmonary thromboembolism in pregnancy
Optimal approach to T-cell ALL
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