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American Society of Hematology Self-Assessment Program, Seventh Edition
Edited by
Adam Cuker, MD, MS,
Adam Cuker, MD, MS
Senior Executive Editor
Perelman School of Medicine, University of Pennsylvania
Philadelphia, Pennsylvania
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Jessica K. Altman, MD,
Jessica K. Altman, MD
Junior Executive Editor
Northwestern University Feinberg School of Medicine
Chicago, Illinois
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Aaron T. Gerds, MD,
Aaron T. Gerds, MD
Associate Editor—Medical Education and Multimedia
Cleveland Clinic
Cleveland, Ohio
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Ted Wun, MD, FACP
Ted Wun, MD, FACP
Associate Editor—Question Writing
University of California, Davis, School of Medicine
Sacramento, California
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American Society of Hematology
ISBN electronic:
978-0-9789212-4-8
Publication date:
2019
American Society of Hematology Self-Assessment Program, Seventh Edition
Edited by: Adam Cuker, MD, MS, Jessica K. Altman, MD, Aaron T. Gerds, MD, Ted Wun, MD, FACP
ISBN (print): 978-0-9789212-3-1
ISBN (electronic): 978-0-9789212-4-8
Publisher: American Society of Hematology
Published: 2019
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Table of Contents
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Chapter 1: Molecular basis of hematologyByTanja A. Gruber,Tanja A. GruberTanja A. Gruber, MD, PhD Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TennesseeSearch for other works by this author on:Omar Abdel-WahabOmar Abdel-WahabOmar Abdel-Wahab, MD Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New YorkSearch for other works by this author on:
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Chapter 2: Consultative hematology I: hospital-based and selected outpatient topicsByNathan T. Connell,Nathan T. ConnellNathan T. Connell, MD, MPH Hematology Division, Brigham and Women’s Hospital, Boston, MassachusettsSearch for other works by this author on:Shannon L. CarpenterShannon L. CarpenterShannon L. Carpenter, MD, MS Division of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Children’s Mercy Hospital, Kansas City, MissouriSearch for other works by this author on:
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Chapter 3: Consultative hematology II: women’s health issuesByPeter A. Kouides,Peter A. KouidesPeter A. Kouides, MD Department of Hematology/Oncology, University of Rochester School of Medicine, Rochester, New YorkSearch for other works by this author on:Michael PaidasMichael PaidasMichael Paidas, MD Section of Maternal Fetal Medicine, Yale University School of Medicine, New Haven, ConnecticutSearch for other works by this author on:
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Chapter 4: Hematopoietic growth factorsByAlan E. Lichtin,Alan E. LichtinAlan E. Lichtin, MD Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OhioSearch for other works by this author on:Vinay PrasadVinay PrasadVinay Prasad, MD, MPH School of Medicine, Oregon Health and Science University, Portland, OregonSearch for other works by this author on:
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Chapter 5: Iron physiology, iron overload, and the porphyriasByHeather A. Leitch,Heather A. LeitchHeather A. Leitch, MD, PhD Division of Hematology, University of British Columbia, Vancouver, British Columbia, CanadaSearch for other works by this author on:Elizabeta NemethElizabeta NemethElizabeta Nemeth, PhD Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CaliforniaSearch for other works by this author on:
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Chapter 6: Acquired underproduction anemiasByMohandas Narla,Mohandas NarlaMohandas Narla, DSc New York Blood Center, New York, New YorkSearch for other works by this author on:Jacquelyn M. PowersJacquelyn M. PowersJacquelyn M. Powers, MD, MS Department of Pediatrics, Baylor College of Medicine, Houston, TexaSearch for other works by this author on:
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Chapter 7: Thalassemia, sickle cell disease, and other hemoglobinopathiesByFarzana Sayani,Farzana SayaniFarzana A. Sayani, MD Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaSearch for other works by this author on:Payal Desai,Payal DesaiPayal Desai, MD Division of Hematology, The Ohio State University, Columbus, OhioSearch for other works by this author on:Sophie LanzkronSophie LanzkronSophie Lanzkron, MD, MHS Division of Hematology, Department of Medicine, Johns Hopkins University, Baltimore, MarylandSearch for other works by this author on:
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Chapter 8: Hemolytic anemias excluding hemoglobinopathiesByRonald S. Go,Ronald S. GoRonald S. Go, MD Division of Hematology, Mayo Clinic, Rochester, MinnesotaSearch for other works by this author on:Kevin H. M. KuoKevin H. M. KuoKevin H. M. Kuo, MD, MSc Division of Hematology, University of Toronto, Toronto, Ontario, CanadaSearch for other works by this author on:
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Chapter 9: Thrombosis and thrombophiliaBySaskia Middeldorp,Saskia MiddeldorpSaskia Middeldorp, MD, PhD Department of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsSearch for other works by this author on:Paul Monagle,Paul MonaglePaul Monagle, MD Department of Clinical Haematology, University of Melbourne, Melbourne, Victoria, AustraliaSearch for other works by this author on:Ted WunTed WunTed Wun, MD Department of Internal Medicine, University of California, Davis, School, of Medicine, Sacramento, CaliforniaSearch for other works by this author on:
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Chapter 10: Bleeding disordersByRiten Kumar,Riten KumarRiten Kumar, MD Division of Hematology and Oncology, Nationwide Children’s, Hospital, The Ohio State University, Columbus, OhioSearch for other works by this author on:Christine L. KemptonChristine L. KemptonChristine L. Kempton, MD, MSc Division of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GeorgiaSearch for other works by this author on:
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Chapter 11: Disorders of platelet number and functionByMichele Lambert,Michele LambertMichele P. Lambert, MD, MSTR Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for other works by this author on:Adam Cuker,Adam CukerAdam Cuker, MD, MS Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaSearch for other works by this author on:Andreas GreinacherAndreas GreinacherAndreas Greinacher, MD Institut für Immunologie und Transfusionmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, GermanySearch for other works by this author on:
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Chapter 12: Laboratory hematologyByTracy I. George,Tracy I. GeorgeTracy I. George, MD Department of Pathology, University of Utah, Salt Lake City, UtahSearch for other works by this author on:Anne M. WinklerAnne M. WinklerAnne M. Winkler, MD, MSc Medical Affairs, Instrumentation Laboratory, Bedford, MassachusettsSearch for other works by this author on:
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Chapter 13: Transfusion medicineByWilliam Savage,William SavageWilliam Savage, MD, PhD Takeda Pharmaceutical Co., Cambridge, MassachusettsSearch for other works by this author on:Stella T. ChouStella T. ChouStella T. Chou, MD Division of Hematology and Apheresis Program, Children’s Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for other works by this author on:
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Chapter 14: Cellular basis of hematopoiesis and stem cell transplantationByIrum Khan,Irum KhanIrum Khan, MD Division of Hematology/Oncology, University of Illinois, Chicago, IllinoisSearch for other works by this author on:Kim-Hien T. DaoKim-Hien T. DaoKim-Hien T. Dao, DO, PhD Division of Hematology and Oncology, Oregon Health and Science University, Portland, OregonSearch for other works by this author on:
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Chapter 15: Clinical hematopoietic cell transplantation and adoptive cell therapyByMatthew J. Wieduwilt,Matthew J. WieduwiltMatthew J. Wieduwilt, MD, PhD Division of Bone Marrow Transplantation, Moores Cancer Center, University of California, San Diego, La Jolla, CaliforniaSearch for other works by this author on:Roland B. WalterRoland B. WalterRoland B. Walter, MD, PhD, MS Division of Hematology, Fred Hutchinson Cancer Research Center, Seattle, WashingtonSearch for other works by this author on:
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Chapter 16: Inherited marrow failure syndromes and myeloid disordersByAlison A. Bertuch,Alison A. BertuchAlison A. Bertuch, MD, PhD Department of Pediatrics, Baylor College of Medicine, Houston, TexasSearch for other works by this author on:Cynthia E. DunbarCynthia E. DunbarCynthia E. Dunbar, MD National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MarylandSearch for other works by this author on:
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Chapter 17: Chronic myeloid leukemiaByVivian G. Oehler,Vivian G. OehlerVivian G. Oehler, MD Clinical Research Division, Fred Hutchinson Cancer Research Center Seattle, WashingtonSearch for other works by this author on:Jane F. ApperleyJane F. ApperleyJane F. Apperley, MD Department of Haematology, Imperial College School of Medicine, London, United KingdomSearch for other works by this author on:
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Chapter 18: Myeloproliferative neoplasmsByBrady L. Stein,Brady L. SteinBrady L. Stein, MD Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IllinoisSearch for other works by this author on:Aaron T. GerdsAaron T. GerdsAaron T. Gerds, MD Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OhioSearch for other works by this author on:
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Chapter 19: Acquired marrow failure syndromes: aplastic anemia, paroxysmal nocturnal hemoglobinuria, and myelodysplastic syndromesByAmy E. DeZern,Amy E. DeZernAmy E. DeZern, MD, MHS Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MarylandSearch for other works by this author on:Catherine SmithCatherine SmithCatherine Smith, MD Division of Hematologic Malignancies, University of California San Francisco, San Francisco, CaliforniaSearch for other works by this author on:
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Chapter 20: Acute myeloid leukemiaByEytan M. Stein,Eytan M. SteinEytan M. Stein, MD Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New YorkSearch for other works by this author on:Neerav Shukla,Neerav ShuklaNeerav Shukla, MD Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New YorkSearch for other works by this author on:Jessica K. AltmanJessica K. AltmanJessica K. Altman, MD Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IllinoisSearch for other works by this author on:
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Chapter 21: Acute lymphoblastic leukemia and lymphoblastic lymphomaByOliver G. Ottmann,Oliver G. OttmannOliver Ottmann, MD Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United KingdomSearch for other works by this author on:Mats HeymanMats HeymanMats Heyman, MD, PhD Childhood Cancer Research Unit, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:
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Chapter 22: Hodgkin lymphomaByPamela B. Allen,Pamela B. AllenPamela B. Allen, MD, MSc Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GeorgiaSearch for other works by this author on:Andrew M. EvensAndrew M. EvensAndrew M. Evens, DO, MSc Rutgers Cancer Institute of New Jersey, New Brunswick, New JerseySearch for other works by this author on:
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Chapter 23: Non-Hodgkin lymphomasByJeremy S. Abramson,Jeremy S. AbramsonJeremy S. Abramson, MD Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MassachusettsSearch for other works by this author on:David T. YangDavid T. YangDavid T. Yang, MD Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WisconsinSearch for other works by this author on:
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Chapter 24: Chronic lymphocytic leukemia/small lymphocytic lymphomaByTanya Siddiqi,Tanya SiddiqiTanya Siddiqi, MD Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CaliforniaSearch for other works by this author on:Steven CoutreSteven CoutreSteven Coutre, MD Division of Hematology, Stanford University Medical Center, Stanford, CaliforniaSearch for other works by this author on:
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Chapter 25: Plasma cell disordersByMichaela Liedtke,Michaela LiedtkeMichaela Liedtke, MD Division of Hematology, Department of Medicine, Stanford University, Stanford, CaliforniaSearch for other works by this author on:Rafael FonsecaRafael FonsecaRafael Fonseca, MD Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, ArizonaSearch for other works by this author on:
