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Journal Articles

Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells

Elina Parri, Heikki Kuusanmäki, Daria Bulanova, Satu Mustjoki, Krister Wennerberg
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1862–1875.
https://doi.org/10.1182/bloodadvances.2020003300
Published: 2021
Includes: Supplemental data
Journal Articles

Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study

Clinical Trials & Observations
Damien Luque Paz, Jérémie Riou, Emmanuelle Verger, Bruno Cassinat, Aurélie Chauveau, Jean-Christophe Ianotto, Brigitte Dupriez, Françoise Boyer, Maxime Renard, Olivier Mansier, Anne Murati, Jérôme Rey, Gabriel Etienne, Véronique Mansat-De Mas, Suzanne Tavitian, Olivier Nibourel, Stéphane Girault, Yannick Le Bris, François Girodon, Dana Ranta, Jean-Claude Chomel, Pascale Cony-Makhoul, Pierre Sujobert, Margot Robles, Raouf Ben Abdelali, Olivier Kosmider, Laurane Cottin, Lydia Roy, Ivan Sloma, Fabienne Vacheret, Mathieu Wemeau, Pascal Mossuz, Borhane Slama, Vincent Cussac, Guillaume Denis, Anouk Walter-Petrich, Barbara Burroni, Nathalie Jézéquel, Stéphane Giraudier, Eric Lippert, Gérard Socié, Jean-Jacques Kiladjian, Valérie Ugo
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1442–1451.
https://doi.org/10.1182/bloodadvances.2020003444
Published: 2021
Includes: Supplemental data
Journal Articles

Baseline and serial molecular profiling predicts outcomes with hypomethylating agents in myelodysplastic syndromes

Clinical Trials & Observations
Anthony M. Hunter, Rami S. Komrokji, Seongseok Yun, Najla Al Ali, Onyee Chan, Jinming Song, Mohammad Hussaini, Chetasi Talati, Kendra L. Sweet, Jeffrey E. Lancet, Eric Padron, Alan F. List, David A. Sallman
Journal: Blood Advances
Blood Adv (2021) 5 (4): 1017–1028.
https://doi.org/10.1182/bloodadvances.2020003508
Published: 2021
Includes: Supplemental data
Journal Articles

Genetic factors rather than blast reduction determine outcomes of allogeneic HCT in BCR-ABL –negative MPN in blast phase

Clinical Trials & Observations
Vikas Gupta, James A. Kennedy, Jose-Mario Capo-Chichi, Soyoung Kim, Zhen-Huan Hu, Edwin P. Alyea, Uday R. Popat, Ronald M. Sobecks, Bart L. Scott, Aaron T. Gerds, Rachel B. Salit, H. Joachim Deeg, Ryotara Nakamura, Wael Saber
Journal: Blood Advances
Blood Adv (2020) 4 (21): 5562–5573.
https://doi.org/10.1182/bloodadvances.2020002727
Published: 2020
Includes: Supplemental data
Journal Articles

Prognostic impact of the ELN2017 risk classification in patients with AML receiving allogeneic transplantation

Juliane Grimm, Madlen Jentzsch, Marius Bill, Karoline Goldmann, Julia Schulz, Dietger Niederwieser, Uwe Platzbecker, Sebastian Schwind
Journal: Blood Advances
Blood Adv (2020) 4 (16): 3864–3874.
https://doi.org/10.1182/bloodadvances.2020001904
Published: 2020
Includes: Supplemental data
Journal Articles

Molecular profiling and risk classification of patients with myeloproliferative neoplasms and splanchnic vein thromboses

Clinical Trials & Observations
Pierre-Edouard Debureaux, Bruno Cassinat, Juliette Soret-Dulphy, Barbara Mora, Emmanuelle Verger, Nabih Maslah, Aurelie Plessier, Pierre-Emmanuel Rautou, Isabelle Ollivier-Hourman, Victor De Ledinghen, Odile Goria, Christophe Bureau, Claudia Siracusa, Dominique Valla, Stephane Giraudier, Francesco Passamonti, Jean-Jacques Kiladjian
Journal: Blood Advances
Blood Adv (2020) 4 (15): 3708–3715.
https://doi.org/10.1182/bloodadvances.2020002414
Published: 2020
Includes: Supplemental data
Journal Articles

Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma

Christopher K. Rushton, Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, Nicole Thomas, Laura K. Hilton, Neil Michaud, Scott Daigle, Jordan Davidson, Kevin Bushell, Stephen Yu, Ryan N. Rys, Michael Jain, Lois Shepherd, Marco A. Marra, John Kuruvilla, Michael Crump, Koren Mann, Sarit Assouline, Joseph M. Connors, Christian Steidl, Mark S. Cragg, David W. Scott, Nathalie A. Johnson, Ryan D. Morin
Journal: Blood Advances
Blood Adv (2020) 4 (13): 2886–2898.
https://doi.org/10.1182/bloodadvances.2020001696
Published: 2020
Includes: Supplemental data
Journal Articles

Efficacy and safety of anti-CD19 CAR T-cell therapy in 110 patients with B-cell acute lymphoblastic leukemia with high-risk features

Clinical Trials & Observations
Xian Zhang, Xin-an Lu, Junfang Yang, Gailing Zhang, Jingjing Li, Lisong Song, Yunchao Su, Yanze Shi, Min Zhang, Jiujiang He, Dan Song, Fanyong Lv, Wenqian Li, Yan Wu, Hui Wang, Hongxing Liu, Xiaosu Zhou, Ting He, Peihua Lu
Journal: Blood Advances
Blood Adv (2020) 4 (10): 2325–2338.
https://doi.org/10.1182/bloodadvances.2020001466
Published: 2020
Includes: Supplemental data
Journal Articles

Integrative analysis of the genomic and transcriptomic landscape of double-refractory multiple myeloma

Bachisio Ziccheddu, Giulia Biancon, Filippo Bagnoli, Chiara De Philippis, Francesco Maura, Even H. Rustad, Matteo Dugo, Andrea Devecchi, Loris De Cecco, Marialuisa Sensi, Carolina Terragna, Marina Martello, Tina Bagratuni, Efstathios Kastritis, Meletios A. Dimopoulos, Michele Cavo, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Niccolo Bolli
Journal: Blood Advances
Blood Adv (2020) 4 (5): 830–844.
https://doi.org/10.1182/bloodadvances.2019000779
Published: 2020
Includes: Supplemental data
Journal Articles

A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients

Clinical Trials & Observations
Yu-Hung Wang, Chien-Chin Lin, Chi-Yuan Yao, Chia-Lang Hsu, Hsin-An Hou, Cheng-Hong Tsai, Wen-Chien Chou, Hwei-Fang Tien
Journal: Blood Advances
Blood Adv (2020) 4 (4): 644–654.
https://doi.org/10.1182/bloodadvances.2019001185
Published: 2020
Includes: Supplemental data
Journal Articles

Genomic context and TP53 allele frequency define clinical outcomes in TP53 -mutated myelodysplastic syndromes

Clinical Trials & Observations
Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Christopher B. Benton, Caleb A. Class, Kelly S. Chien, Koji Sasaki, Kiran Naqvi, Yesid Alvarado, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Koichi Takahashi, Elias Jabbour, Gautham Borthakur, Naveen Pemmaraju, Marina Konopleva, Kelly A. Soltysiak, Sherry R. Pierce, Carlos E. Bueso-Ramos, Keyur P. Patel, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood Advances
Blood Adv (2020) 4 (3): 482–495.
https://doi.org/10.1182/bloodadvances.2019001101
Published: 2020
Includes: Supplemental data
Journal Articles

Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern

Gerbrig Berger, Mylene Gerritsen, Guoqiang Yi, Theresia N. Koorenhof-Scheele, Leonie I. Kroeze, Marian Stevens-Kroef, Kenichi Yoshida, Yuichi Shiraishi, Eva van den Berg, Hein Schepers, Geert Huls, André B. Mulder, Seishi Ogawa, Joost H. A. Martens, Joop H. Jansen, Edo Vellenga
Journal: Blood Advances
Blood Adv (2019) 3 (20): 3111–3122.
https://doi.org/10.1182/bloodadvances.2019000518
Published: 2019
Includes: Supplemental data
Journal Articles

Phase 1b study of the MDM2 inhibitor AMG 232 with or without trametinib in relapsed/refractory acute myeloid leukemia

Clinical Trials & Observations
Harry P. Erba, Pamela S. Becker, Paul J. Shami, Michael R. Grunwald, Donna L. Flesher, Min Zhu, Erik Rasmussen, Haby A. Henary, Abraham A. Anderson, Eunice S. Wang
Journal: Blood Advances
Blood Adv (2019) 3 (13): 1939–1949.
https://doi.org/10.1182/bloodadvances.2019030916
Published: 2019
Journal Articles

Clinicopathologic and genetic characterization of nonacute NPM1 -mutated myeloid neoplasms

Clinical Trials & Observations
Sanjay S. Patel, Caleb Ho, Ryan N. Ptashkin, Sam Sadigh, Adam Bagg, Julia T. Geyer, Mina L. Xu, Thomas Prebet, Emily F. Mason, Adam C. Seegmiller, Elizabeth A. Morgan, David P. Steensma, Eric S. Winer, Waihay J. Wong, Robert P. Hasserjian, Olga K. Weinberg
Journal: Blood Advances
Blood Adv (2019) 3 (9): 1540–1545.
https://doi.org/10.1182/bloodadvances.2019000090
Published: 2019
Journal Articles

Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma

Ilyas Sahin, Yawara Kawano, Romanos Sklavenitis-Pistofidis, Michele Moschetta, Yuji Mishima, Salomon Manier, Antonio Sacco, Ruben Carrasco, Rafael Fonseca, Aldo M. Roccaro, Thomas Witzig, Irene M. Ghobrial
Journal: Blood Advances
Blood Adv (2019) 3 (7): 995–1002.
https://doi.org/10.1182/bloodadvances.2018028456
Published: 2019
Includes: Supplemental data
Journal Articles

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition

Céline Moison, Vincent-Philippe Lavallée, Clarisse Thiollier, Bernhard Lehnertz, Isabel Boivin, Nadine Mayotte, Yves Gareau, Mélanie Fréchette, Valérie Blouin-Chagnon, Sophie Corneau, Sylvie Lavallée, Sébastien Lemieux, Anne Marinier, Josée Hébert, Guy Sauvageau
Journal: Blood Advances
Blood Adv (2019) 3 (4): 552–563.
https://doi.org/10.1182/bloodadvances.2018028480
Published: 2019
Includes: Supplemental data
Journal Articles

Advanced forms of MPNs are accompanied by chromosomal abnormalities that lead to dysregulation of TP53

Clinical Trials & Observations
Bridget K. Marcellino, Ronald Hoffman, Joseph Tripodi, Min Lu, Heidi Kosiorek, John Mascarenhas, Raajit K. Rampal, Amylou Dueck, Vesna Najfeld
Journal: Blood Advances
Blood Adv (2018) 2 (24): 3581–3589.
https://doi.org/10.1182/bloodadvances.2018024018
Published: 2018
Journal Articles

p53 regulates CD46 expression and measles virus infection in myeloma cells

Anne Lok, Geraldine Descamps, Benoit Tessoulin, David Chiron, Marion Eveillard, Catherine Godon, Yannick Le Bris, Astrid Vabret, Celine Bellanger, Laurent Maillet, Sophie Barillé-Nion, Marc Gregoire, Jean-François Fonteneau, Steven Le Gouill, Philippe Moreau, Frederic Tangy, Martine Amiot, Agnes Moreau-Aubry, Catherine Pellat-Deceunynck
Journal: Blood Advances
Blood Adv (2018) 2 (23): 3492–3505.
https://doi.org/10.1182/bloodadvances.2018025106
Published: 2018
Includes: Supplemental data
Journal Articles

When to obtain genomic data in acute myeloid leukemia (AML) and which mutations matter

Gregory W. Roloff, Elizabeth A. Griffiths
Journal: Blood Advances
Blood Adv (2018) 2 (21): 3070–3080.
https://doi.org/10.1182/bloodadvances.2018020206
Published: 2018
Journal Articles

Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia

Clinical Trials & Observations
Zachary R. Hunter, Lian Xu, Nickolas Tsakmaklis, Maria G. Demos, Amanda Kofides, Cristina Jimenez, Gloria G. Chan, Jiaji Chen, Xia Liu, Manit Munshi, Joshua Gustine, Kirsten Meid, Christopher J. Patterson, Guang Yang, Toni Dubeau, Mehmet K. Samur, Jorge J. Castillo, Kenneth C. Anderson, Nikhil C. Munshi, Steven P. Treon
Journal: Blood Advances
Blood Adv (2018) 2 (21): 2937–2946.
https://doi.org/10.1182/bloodadvances.2018022962
Published: 2018
Includes: Supplemental data