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Generation and characterization of SS- Selp    −/−   mice.  (A)  Selp  −/− ...
Published: 2020
Figure 1. Generation and characterization of SS- Selp −/− mice. (A) Selp −/− mice were bred to Townes SS mice to generate SS- Selp −/− mice. Refer to supplemental Figure 1 for the breeding strategy. (B) Genomic PCR gel image showing the presence or absence of different alleles in C57BL... More
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Genetic deletion of P-selectin attenuates pulmonary vaso-occlusion in SCD m...
Published: 2020
Figure 2. Genetic deletion of P-selectin attenuates pulmonary vaso-occlusion in SCD mice. (A) SS and SS- Selp −/− mice were challenged IV with 0.1 µg/kg LPS, and qFILM was used 2 to 2.5 hours later to visualize the pulmonary microcirculation. (B) IV LPS (0.1 µg/kg) triggered occlusion of pulmo... More
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Representative patterns of response following platelet immunization . Plate...
Published: 2020
Figure 1. Representative patterns of response following platelet immunization . Platelet counts (10 9 /L; ○) are shown on the left ordinate and alloantibody (AlloAb; □) and autoantibody (AutoAb; △) responses on the right. Alloantibody responses are expressed as the ratio of the median fluorescenc... More
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Alloantibody, autoantibody, and platelet responses observed in all immuniza...
Published: 2020
Figure 2. Alloantibody, autoantibody, and platelet responses observed in all immunizations. Identity of strains used as platelet donors and recipients and number of mice in each of the 8 groups are shown in Table 2 . (A) Alloantibody responses were strongest in immunizations involving at least ... More
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Autoantibodies cause platelet clearance.  Individual “end-of-study” plasma ...
Published: 2020
Figure 3. Autoantibodies cause platelet clearance. Individual “end-of-study” plasma samples from selected mice were injected IV into individual syngeneic mice. Platelet counts measured 24 hours after injection were compared to preinjection counts and are expressed as a percentage of the preinjec... More
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Alloantibodies recognize GPIIb/IIIa on platelets from the strain used for i...
Published: 2020
Figure 4. Alloantibodies recognize GPIIb/IIIa on platelets from the strain used for immunization. Biotin-labeled platelet membrane proteins from the mouse strain used for immunization were immunoprecipitated with alloantibodies from immunized mice, subjected to SDS–polyacrylamide gel electrophor... More
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Proposed mechanism for conversion of an alloantibody to an autoantibody dur...
Published: 2020
Figure 5. Proposed mechanism for conversion of an alloantibody to an autoantibody during somatic hypermutation in an evolving humoral immune response. Blocks depict the antibody-antigen interface. (A; ▲) The polymorphic amino acid that determines an alloantigen and initially induces an alloantib... More
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Immunocharacterization of the AML, B-ALL, CML, and control BM.  (A) Visuali...
Published: 2020
Figure 1. Immunocharacterization of the AML, B-ALL, CML, and control BM. (A) Visualization of the quantitative BM immunocharacterization pipeline. FFPE BM tissue blocks of AML patients (n = 69) and age- and sex-matched controls (n = 12) were retrieved from the Helsinki Biobank. TMAs were constru... More
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Comparison of the AML and control BM.  (A) Immune cells (as proportion to a...
Published: 2020
Figure 2. Comparison of the AML and control BM. (A) Immune cells (as proportion to all cells in a TMA spot) and their immunophenotypes (as proportion to their parent immune cell) derived from mIHC and computerized image analysis are plotted on a heatmap and organized by hierarchical clustering u... More
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Clinicoimmunologic analysis of major AML immune profiles.  (A) The proporti...
Published: 2020
Figure 3. Clinicoimmunologic analysis of major AML immune profiles. (A) The proportion of immune cells and their single-marker immunophenotypes in AML patients (n = 69) in clusters 1 and 2 were compared (Mann-Whitney U test), P values corrected (Benjamini-Hochberg procedure), and results plo... More
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Immunologic prognostic biomarkers in intensively treated AML patients (HD-c...
Published: 2020
Figure 4. Immunologic prognostic biomarkers in intensively treated AML patients (HD-cytarabine–based induction treatment; n = 59). (A) Volcano plot of the HRs for an EFS incident of immune cells and their immunophenotypes and PB and BM laboratory values. Variables increasing the risk for an EFS ... More
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Comparison of immunophenotypes in BM and PB samples.  (A) Boxplots and dotp...
Published: 2020
Figure 5. Comparison of immunophenotypes in BM and PB samples. (A) Boxplots and dotplots displaying only significant comparisons (Mann-Whitney U test, P < .05) of CD8 + T- and NK-cell immunophenotypes quantified from paired BM and PB samples of AML patients at diagnosis. The center line ... More
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Trajectory of GFR by sex in pediatric and murine SCA.  Trajectory of eGFR (...
Published: 2020
Figure 1. Trajectory of GFR by sex in pediatric and murine SCA. Trajectory of eGFR (human) (A) and GFR (murine) (B) changes over time in sickle cell anemia by sex. More
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Journal Articles
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