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RCTs on ruxolitinib (Rux).  Annual incidence of thrombosis per study per ar...
Published: 2020
Figure 2. RCTs on ruxolitinib (Rux). Annual incidence of thrombosis per study per arm with binomial CIs and corresponding calculated RRs. More
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Characterization of select BL- and DLBCL-derived cell lines.  (A) Western b...
Published: 2020
Figure 1. Characterization of select BL- and DLBCL-derived cell lines. (A) Western blotting for prosurvival proteins, proapoptotic BIM, and TP53 in human B-cell lymphoma lines. Probing for HSP70 was used as a loading control. Note that high TP53 protein levels in unstressed cells are indicative ... More
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CRISPR/CAS9-mediated loss of BCL-W does not effect the survival of select B...
Published: 2020
Figure 2. CRISPR/CAS9-mediated loss of BCL-W does not effect the survival of select BL and DLBCL cell lines. (A) Cell viability following doxycycline induction of nontargeting (sgNT) or BCL-W –targeting (sg BCL-W ) sgRNAs over 96 hours. Cell viability was measured by the proportion of cells tha... More
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Loss of BCL-W does not sensitize BL or DLBCL cell lines to BH3-mimetic drug...
Published: 2020
Figure 3. Loss of BCL-W does not sensitize BL or DLBCL cell lines to BH3-mimetic drugs. Viability of BCL-W –disrupted (sg BCL-W ) and control (sgNT) cells following treatment with indicated dose of BH3-mimetic drugs for 24 hours: S63845 (MCL-1 inhibitor), ABT-199 (BCL-2 inhibitor), ABT-737 (BCL... More
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shRNA-mediated knockdown of BCL-W expression does not induce apoptosis of B...
Published: 2020
Figure 4. shRNA-mediated knockdown of BCL-W expression does not induce apoptosis of B-lymphoma cells and does not sensitize them to BH3-mimetic drugs targeting other prosurvival BCL-2 proteins. (A) shRNA knockdown of BCL-W was confirmed by western blotting in cell lines containing nontargeti... More
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CCNA1-specific T-cell expansion and characterization.  (A) Fold expansion o...
Published: 2020
Figure 1. CCNA1-specific T-cell expansion and characterization. (A) Fold expansion of CCNA1-specific T cells (mean ± standard error of the mean [SEM]), based on cell counting using trypan blue exclusion (n = 12). (B) Immunophenotype of the expanded cell lines as assessed by flow cytometric analy... More
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CCNA1-specific T cells are polyfunctional and cytotoxic.  (A) Representativ...
Published: 2020
Figure 2. CCNA1-specific T cells are polyfunctional and cytotoxic. (A) Representative IFN-γ ICS data from 1 donor (left), and summary data for all responding donors (right; mean ± standard error of the mean; n = 11). (B) ICS analysis of dual (IFN-γ and TNF-α) cytokine secreting cells (representa... More
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Identification of immunogenic CCNA1 epitopes and HLA-restriction profiling ...
Published: 2020
Figure 3. Identification of immunogenic CCNA1 epitopes and HLA-restriction profiling studies . (A) Donor 2’s cell line was tested against each of the 21 minipools by IFN-γ ELISpot (SFC/1 × 10 5 ). (B) Arrangement of peptides into minipools; donor 2’s reactive minipools (intersecting at peptides 4... More
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CCNA1-specific T cells show cytotoxicity against HLA-matched, CCNA1   +   t...
Published: 2020
Figure 4. CCNA1-specific T cells show cytotoxicity against HLA-matched, CCNA1 + tumor cell lines. (A) Donor 2’s cell line showed high specific lysis toward U266 (HLA-B7 + and CCNA1+) in a 4-hour Cr 51 -release assay, compared with targets that express either HLA-B7 or CCNA1 alone. (B) Simil... More
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CCNA1-specific T cells do not cross-reactively recognize CCNA2.  (A) IFN-γ ...
Published: 2020
Figure 5. CCNA1-specific T cells do not cross-reactively recognize CCNA2. (A) IFN-γ ELISpot results of 6 CCNA1-directed T cell lines following exposure to either CCNA1 or CCNA2 pepmix. (B) Two representative cell lines following exposure to either CCNA1 epitopes or analogous peptides from CCNA2.... More
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Endogenous CCNA1-specific T cells detected in AML patients who remain in cl...
Published: 2020
Figure 6. Endogenous CCNA1-specific T cells detected in AML patients who remain in clinical remission posttransplant. CCNA1-specific T-cell responses detected in PBMCs (by IFN-γ ELISpot) isolated from patients with AML who received allo-HSCT (n = 8). Results are presented as SFC/1 × 10 5 . More
Journal Articles
Journal Articles
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RNA-sequencing of whole BM aspirate cells from patients with AML compared w...
Published: 2020
Figure 1. RNA-sequencing of whole BM aspirate cells from patients with AML compared with healthy control subjects. (A) A volcano plot illustrating differentially regulated gene expression in patients with AML (n = 10) compared with healthy control subjects (n = 10). RNA-sequencing analysis revea... More
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High-throughput SOMAscan proteomics platform identifies differentially expr...
Published: 2020
Figure 2. High-throughput SOMAscan proteomics platform identifies differentially expressed proteins in the BM microenvironment of patients with AML. (A) A principal component analysis showing variance between the SomaLogic calibrators, SomaLogic QC samples, internal QC samples, and biological sa... More
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Differential protein expression in the BM of patients with AML compared wit...
Published: 2020
Figure 3. Differential protein expression in the BM of patients with AML compared with healthy control subjects. (A) A heatmap representation of a total of 168 differentially expressed analytes measured by SOMAscan assay using the BM plasma samples obtained from patients with AML (n = 10) and he... More