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Volume 8, Issue 24

December 24 2024

In this Issue

EDITORIAL
INSIDE BLOOD ADVANCES
ADVANCES VIEWPOINT
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
RESEARCH LETTER
ERRATA

EDITORIAL

Celebrating a year of immunotherapy/cell and gene therapy in Blood Advances

Catherine M. Bollard,Andrew S. Weyrich

View Articletitled, Celebrating a year of immunotherapy/cell and gene therapy in Blood Advances

INSIDE BLOOD ADVANCES

Time to revisit reduced-dose radiotherapy for PCNSL?
Clinical Trials & Observations

Maciej Tatarczuch

View Articletitled, Time to revisit reduced-dose radiotherapy for PCNSL?

ADVANCES VIEWPOINT

American Society of Hematology: building a comprehensive minority recruitment and retention professional program

Margo R. Rollins,Rahma M. Warsame,Melody Smith,Arturo Molina,Rayne H. Rouce,Belinda R. Avalos,Cage S. Johnson,Jose A. Lopez,Alexis A. Thompson,Lisa Fanning,Patricia Frustace,Keelin Roche,Nathalie van Havre,Devon Mack,Christopher R. Flowers,Deirdra R. Terrell

View Articletitled, American Society of Hematology: building a comprehensive minority recruitment and retention professional program

REVIEW ARTICLE

Cardiovascular toxicities associated with novel cellular immune therapies

Malak Munir,Ahmed Sayed,Daniel Addison,Narendranath Epperla

View Articletitled, Cardiovascular toxicities associated with novel cellular immune therapies

CLINICAL TRIALS AND OBSERVATIONS

Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease
Clinical Trials & Observations

Charles R. Jonassaint,Christina M. Lalama,C. Patrick Carroll,Sherif M. Badawy,Megan E. Hamm,Jennifer N. Stinson,Chitra Lalloo,Santosh L. Saraf,Victor R. Gordeuk,Robert M. Cronin,Nirmish Shah,Sophie M. Lanzkron,Darla Liles,Julia A. O’Brien,Cassandra Trimnell,Lakiea Bailey,Raymona H. Lawrence,Leshana Saint Jean,Michael DeBaun,Laura M. De Castro,Tonya M. Palermo,Kaleab Z. Abebe

View Articletitled, Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltration

Nektarios Kostopoulos,Francesca Costabile,Elisavet Krimitza,Silvia Beghi,Denisa Goia,Renzo Perales-Linares,George Thyfronitis,Michael J. LaRiviere,Elise A. Chong,Stephen J. Schuster,Amit Maity,Constantinos Koumenis,John P. Plastaras,Andrea Facciabene

View Articletitled, Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltration

Supplemental data

LYMPHOID NEOPLASIA

Evolving consolidation patterns and outcomes for a large cohort of patients with primary CNS lymphoma
Clinical Trials & Observations

Kathryn R. Tringale,Michael Scordo,Joachim Yahalom,Charlie White,Zhigang Zhang,Javin Schefflein,Gustav Cederquist,Lauren R. Schaff,Lisa DeAngelis,Brandon S. Imber,Christian Grommes

View Articletitled, Evolving consolidation patterns and outcomes for a large cohort of patients with primary CNS lymphoma

Supplemental data

HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma

Amanda Chantziou,Cloe Brenna,Kalliopi Ioannidou,Oliver Y. Chen,Penelope Korkolopoulou,Anastasia Antoniadou,Mina Psichogiou,Maria Papaioannou,Panagiotis Tsirigotis,Periklis G. Foukas,Laurence de Leval,Constantinos Petrovas

View Articletitled, HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma

Supplemental data

PI3Kδ activation, IL-6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas

Alberto J. Arribas,Sara Napoli,Eugenio Gaudio,Charles Herbaux,Eleonora Cannas,Chiara Tarantelli,Roberta Bordone-Pittau,Luciano Cascione,Nicolas Munz,Luca Aresu,Jacopo Sgrignani,Andrea Rinaldi,Ivo Kwee,Davide Rossi,Andrea Cavalli,Emanuele Zucca,Georg Stussi,Anastasios Stathis,Callum Sloss,Matthew S. Davids,Francesco Bertoni

View Articletitled, PI3Kδ activation, IL-6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas

Supplemental data

Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify 2 clinicobiological subtypes

Stella Charalampopoulou,Elise Chapiro,Ferran Nadeu,Thorsten Zenz,Sílvia Beà,Ares Martínez-Farran,Marta Aymerich,Maria Rozman,Damien Roos-Weil,Olivier Bernard,Santos A. Susin,Helen Parker,Renata Walewska,Christopher C. Oakes,Jonathan C. Strefford,Elías Campo,Estela Matutes,Martí Duran-Ferrer,Florence Nguyen-Khac,José I. Martín-Subero

View Articletitled, Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify 2 clinicobiological subtypes

Supplemental data

Retreatment of multiple myeloma with previously refractory drugs

Utkarsh Goel,Charalampos Charalampous,Prashant Kapoor,Moritz Binder,Francis K. Buadi,David Dingli,Angela Dispenzieri,Amie Fonder,Morie A. Gertz,Wilson I. Gonsalves,Suzanne R. Hayman,Miriam A. Hobbs,Yi L. Hwa,Taxiarchis Kourelis,Martha Q. Lacy,Nelson Leung,Yi Lin,Rahma M. Warsame,Robert A. Kyle,S. Vincent Rajkumar,Shaji K. Kumar

View Articletitled, Retreatment of multiple myeloma with previously refractory drugs

Supplemental data

MYELOID NEOPLASIA

Identification of factors predicting low-risk febrile neutropenia admissions in adults with acute myeloid leukemia

Khushboo V. Pal,Megan Othus,Zahra Ali,Katherine Russell,Carole Shaw,Mary-Elizabeth M. Percival,Paul C. Hendrie,Jacob S. Appelbaum,Roland B. Walter,Anna B. Halpern

View Articletitled, Identification of factors predicting low-risk febrile neutropenia admissions in adults with acute myeloid leukemia

Supplemental data

Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy
Clinical Trials & Observations

Geoffrey L. Uy,Vinod Pullarkat,Praneeth Baratam,Robert K. Stuart,Roland B. Walter,Eric S. Winer,Qi Wang,Stefan Faderl,Divya Chakravarthy,Diane Menno,Ronald S. Cheung,Tara L. Lin

View Articletitled, Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy

Supplemental data

PLATELETS AND THROMBOPOIESIS

Efficacy and safety of TPO receptor agonists in treatment of ITP associated with predominantly antibody deficiencies

Margaux Soulard,Lionel Galicier,Nizar Mahlaoui,Claire Fieschi,Samuel Deshayes,Delphine Gobert,Clément Gourguechon,Hélène Henique,Sebastien Humbert,Carole Lacout,Ronan Le Calloch,Marc Michel,Marie-lea Piel-julian,Jean François Viallard,Alain Lescoat,Bertrand Godeau,Antoinette Perlat

View Articletitled, Efficacy and safety of TPO receptor agonists in treatment of ITP associated with predominantly antibody deficiencies

Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia
Clinical Trials & Observations

Alexandra Schifferli,Gautier Le Gavrian,Nathalie Aladjidi,Guillaume Moulis,Bertrand Godeau,Thierry Leblanc,Sébastien Héritier,Helder Fernandes,Thomas Kühne

View Articletitled, Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia

Supplemental data

THROMBOSIS AND HEMOSTASIS

Impact of thrombocytopenia on bleeding and thrombotic outcomes in adults with cancer-associated splanchnic vein thrombosis
Clinical Trials & Observations

Michael Andersen, Jr.,Maria J. Fernandez Turizo,Laura E. Dodge,Charles Hsu,Kevin Barnum,Jonathan Berry,Jeffrey I. Zwicker,Rushad Patell

View Articletitled, Impact of thrombocytopenia on bleeding and thrombotic outcomes in adults with cancer-associated splanchnic vein thrombosis

Supplemental data

Guideline concordance of aspirin use for primary prevention in adult outpatients
Clinical Trials & Observations

Naina Chipalkatti,Geoffrey D. Barnes,Linda Bashaw,Adam Davie,Jennifer J. Griggs,Molly Harrod,Jacob E. Kurlander,Christine Medaugh,Rebeca Packard,Corey Powell,Suman Sood,Elizabeth Spranger,Sarah E. Vordenberg,Jordan K. Schaefer

View Articletitled, Guideline concordance of aspirin use for primary prevention in adult outpatients

Supplemental data

RESEARCH LETTER

Incidence of preexisting B-cell aplasia in B-ALL: implications for post–CAR T-cell monitoring
Clinical Trials & Observations

Isha Sahai,Paul Borgman,Bonnie Yates,Sergio Rosenzweig,Shakuntala Rampertaap,Alexander W. Rankin,Nirali N. Shah

View Articletitled, Incidence of preexisting B-cell aplasia in B-ALL: implications for post–CAR T-cell monitoring

ERRATA

Lin A, Brown S, Chinapen S, et al. Patterns of CMV infection after letermovir withdrawal in recipients of posttransplant cyclophosphamide–based transplant. Blood Adv. 2023;7(23):7153-7160.

View Articletitled, Lin A, Brown S, Chinapen S, et al. Patterns of CMV infection after letermovir withdrawal in recipients of posttransplant cyclophosphamide–based transplant. Blood Adv. 2023;7(23):7153-7160.

Jalink M, Jacobs CF, Khwaja J, et al. Daratumumab monotherapy in refractory warm autoimmune hemolytic anemia and cold agglutinin disease. Blood Adv. 2024;8(11):2622-2634.

View Articletitled, Jalink M, Jacobs CF, Khwaja J, et al. Daratumumab monotherapy in refractory warm autoimmune hemolytic anemia and cold agglutinin disease. Blood Adv. 2024;8(11):2622-2634.

Cover Image

Cover Image

Multiplex immunofluorescence image of a biopsy from a patient with Hodgkin lymphoma, showing the presence of CD4 (magenta), PD-1 (orange), CD57 (yellow), and GATA-3 (cyan) cells. See the article by Chantziou et al.

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Cancer cachexia and weight loss before CAR T-cell therapy for lymphoma are independently associated with poor outcomes

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Table of Contents

EDITORIAL

Celebrating a year of immunotherapy/cell and gene therapy in Blood Advances

INSIDE BLOOD ADVANCES

Time to revisit reduced-dose radiotherapy for PCNSL?
Clinical Trials & Observations

ADVANCES VIEWPOINT

American Society of Hematology: building a comprehensive minority recruitment and retention professional program

REVIEW ARTICLE

Cardiovascular toxicities associated with novel cellular immune therapies

CLINICAL TRIALS AND OBSERVATIONS

Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease
Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltration

LYMPHOID NEOPLASIA

Evolving consolidation patterns and outcomes for a large cohort of patients with primary CNS lymphoma
Clinical Trials & Observations

HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma

PI3Kδ activation, IL-6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas

Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify 2 clinicobiological subtypes

Retreatment of multiple myeloma with previously refractory drugs

MYELOID NEOPLASIA

Identification of factors predicting low-risk febrile neutropenia admissions in adults with acute myeloid leukemia

Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy
Clinical Trials & Observations

PLATELETS AND THROMBOPOIESIS

Efficacy and safety of TPO receptor agonists in treatment of ITP associated with predominantly antibody deficiencies

Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia
Clinical Trials & Observations

THROMBOSIS AND HEMOSTASIS

Impact of thrombocytopenia on bleeding and thrombotic outcomes in adults with cancer-associated splanchnic vein thrombosis
Clinical Trials & Observations

Guideline concordance of aspirin use for primary prevention in adult outpatients
Clinical Trials & Observations

RESEARCH LETTER

Incidence of preexisting B-cell aplasia in B-ALL: implications for post–CAR T-cell monitoring
Clinical Trials & Observations

ERRATA

Lin A, Brown S, Chinapen S, et al. Patterns of CMV infection after letermovir withdrawal in recipients of posttransplant cyclophosphamide–based transplant. Blood Adv. 2023;7(23):7153-7160.

Jalink M, Jacobs CF, Khwaja J, et al. Daratumumab monotherapy in refractory warm autoimmune hemolytic anemia and cold agglutinin disease. Blood Adv. 2024;8(11):2622-2634.

Email alerts

ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

EDITORIAL

INSIDE BLOOD ADVANCES

Time to revisit reduced-dose radiotherapy for PCNSL? Clinical Trials & Observations

ADVANCES VIEWPOINT

REVIEW ARTICLE

CLINICAL TRIALS AND OBSERVATIONS

Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

Evolving consolidation patterns and outcomes for a large cohort of patients with primary CNS lymphoma Clinical Trials & Observations

MYELOID NEOPLASIA

Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy Clinical Trials & Observations

PLATELETS AND THROMBOPOIESIS

Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia Clinical Trials & Observations

THROMBOSIS AND HEMOSTASIS

Impact of thrombocytopenia on bleeding and thrombotic outcomes in adults with cancer-associated splanchnic vein thrombosis Clinical Trials & Observations

Guideline concordance of aspirin use for primary prevention in adult outpatients Clinical Trials & Observations

RESEARCH LETTER

Incidence of preexisting B-cell aplasia in B-ALL: implications for post–CAR T-cell monitoring Clinical Trials & Observations

ERRATA

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Time to revisit reduced-dose radiotherapy for PCNSL?
Clinical Trials & Observations

Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease
Clinical Trials & Observations

Evolving consolidation patterns and outcomes for a large cohort of patients with primary CNS lymphoma
Clinical Trials & Observations

Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy
Clinical Trials & Observations

Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia
Clinical Trials & Observations

Impact of thrombocytopenia on bleeding and thrombotic outcomes in adults with cancer-associated splanchnic vein thrombosis
Clinical Trials & Observations

Guideline concordance of aspirin use for primary prevention in adult outpatients
Clinical Trials & Observations

Incidence of preexisting B-cell aplasia in B-ALL: implications for post–CAR T-cell monitoring
Clinical Trials & Observations