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Volume 8, Issue 13

July 9 2024

In this Issue

INSIDE BLOOD ADVANCES
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEALTH SERVICES AND OUTCOMES
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLASMA CELL DISORDERS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
RESEARCH LETTERS
COMMENTARIES

INSIDE BLOOD ADVANCES

Understanding CAR-T therapy in myeloma: 1 cell at a time

Madhav V. Dhodapkar

View Articletitled, Understanding CAR-T therapy in myeloma: 1 cell at a time

Immune thrombocytopenia guidelines get an annual checkup

Paul M. Gallo,Michele P. Lambert

View Articletitled, Immune thrombocytopenia guidelines get an annual checkup

REVIEW ARTICLE

The 2022 review of the 2019 American Society of Hematology guidelines on immune thrombocytopenia

Cindy E. Neunert,Donald M. Arnold,Rachael F. Grace,Thomas Kuhne,Keith R. McCrae,Deirdra R. Terrell

View Articletitled, The 2022 review of the 2019 American Society of Hematology guidelines on immune thrombocytopenia

Venetoclax: a new player in the treatment of children with high-risk myeloid malignancies?

Riccardo Masetti,Francesco Baccelli,Davide Leardini,Franco Locatelli

View Articletitled, Venetoclax: a new player in the treatment of children with high-risk myeloid malignancies?

CLINICAL TRIALS AND OBSERVATIONS

Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials
Clinical Trials & Observations

Matthew S. Davids,Jeff P. Sharman,Paolo Ghia,Jennifer A. Woyach,Toby A. Eyre,Wojciech Jurczak,Tanya Siddiqi,Paulo Miranda,Mina Shahkarami,Anna Butturini,Ugochinyere Emeribe,John C. Byrd

View Articletitled, Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials

Supplemental data

DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia
Clinical Trials & Observations

Kimberly A. Davidow,Robin E. Miller,Shannon M. Phillips,Alyssa M. Schlenz,Martina Mueller,Monica L. Hulbert,Lewis L. Hsu,Neha Bhasin,Robert J. Adams,Julie Kanter

View Articletitled, DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia

GENE THERAPY

Blockage of BCL-XL overcomes venetoclax resistance across BCL2⁺ lymphoid malignancies irrespective of BIM status

Alexandra Dolnikova,Dmitry Kazantsev,Magdalena Klanova,Eva Pokorna,Dana Sovilj,Cristina Daniela Kelemen,Liliana Tuskova,Eva Hoferkova,Marek Mraz,Karel Helman,Nikola Curik,Katerina Machova Polakova,Ladislav Andera,Marek Trneny,Pavel Klener

View Articletitled, Blockage of BCL-XL overcomes venetoclax resistance across BCL2<sup>+</sup> lymphoid malignancies irrespective of BIM status

Supplemental data

HEALTH SERVICES AND OUTCOMES

Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities

Nandita Khera,Sikander Ailawadhi,Ruta Brazauskas,Jinalben Patel,Benjamin Jacobs,Celalettin Ustun,Karen Ballen,Muhammad Bilal Abid,Miguel Angel Diaz Perez,A. Samer Al-Homsi,Hasan Hashem,Sanghee Hong,Reinhold Munker,Raquel M. Schears,Hillard M. Lazarus,Stefan Ciurea,Sherif M. Badawy,Bipin N. Savani,Baldeep Wirk,C. Fred LeMaistre,Neel S. Bhatt,Amer Beitinjaneh,Mahmoud Aljurf,Akshay Sharma,Jan Cerny,Jennifer M. Knight,Amar H. Kelkar,Jean A. Yared,Tamila Kindwall-Keller,Lena E. Winestone,Amir Steinberg,Staci D. Arnold,Sachiko Seo,Jaime M. Preussler,Nasheed M. Hossain,Warren B. Fingrut,Vaibhav Agrawal,Shahrukh Hashmi,Leslie E. Lehmann,William A. Wood,Hemalatha G. Rangarajan,Wael Saber,Theresa Hahn

View Articletitled, Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities

Supplemental data

“Don't keep me waiting”: estimating the impact of reduced vein-to-vein time on lifetime US 3L+ LBCL patient outcomes

Sachin Vadgama,Marcelo C. Pasquini,Richard T. Maziarz,Zhen-Huan Hu,Markqayne Ray,Harry Smith,Ash Bullement,Mark Edmondson-Jones,Will Sullivan,Guillaume Cartron

View Articletitled, “Don't keep me waiting”: estimating the impact of reduced vein-to-vein time on lifetime US 3L+ LBCL patient outcomes

Supplemental data

Decision theoretical foundations of clinical practice guidelines: an extension of the ASH thrombophilia guidelines

Benjamin Djulbegovic,Iztok Hozo,Gordon Guyatt

View Articletitled, Decision theoretical foundations of clinical practice guidelines: an extension of the ASH thrombophilia guidelines

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Cotargeting EBV lytic as well as latent cycle antigens increases T-cell potency against lymphoma

Sandhya Sharma,Naren U. Mehta,Tim Sauer,Lisa A. Rollins,Dirk P. Dittmer,Cliona M. Rooney

View Articletitled, Cotargeting EBV lytic as well as latent cycle antigens increases T-cell potency against lymphoma

Supplemental data

Lysosomal degradation pathways regulate mutant CRT and cell surface MPL levels in mutant CRT-driven MPNs

Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms

Amanpreet Kaur,Arunkumar Venkatesan,Malathi Kandarpa,Moshe Talpaz,Malini Raghavan

View Articletitled, Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms

Supplemental data

HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products

Pascal M. Winterhalter,Linda Warmuth,Philipp Hilgendorf,Julius M. Schütz,Sarah Dötsch,Torsten Tonn,Luka Cicin-Sain,Dirk H. Busch,Kilian Schober

View Articletitled, HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products

Supplemental data

A research center’s experience of T-cell–redirecting therapies in triple-class refractory multiple myeloma

Borja Puertas,Adolfo Fernández-Sánchez,Elena Alejo,Beatriz Rey-Búa,Ana A. Martín-López,Estefanía Pérez-López,Miriam López-Parra,Lucía López-Corral,Norma C. Gutiérrez-Gutiérrez,Ramón García-Sanz,Noemi Puig,Verónica González-Calle,María-Victoria Mateos

View Articletitled, A research center’s experience of T-cell–redirecting therapies in triple-class refractory multiple myeloma

Supplemental data

CD4⁺ CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy

Guy Ledergor,Zenghua Fan,Kai Wu,Elizabeth McCarthy,Axel Hyrenius-Wittsten,Alec Starzinski,Hewitt Chang,Mark Bridge,Serena Kwek,Alexander Cheung,Sophia Bylsma,Erik Hansen,Jeffrey Wolf,Sandy Wong,Nina Shah,Kole T. Roybal,Thomas Martin,Chun J. Ye,Lawrence Fong

View Articletitled, CD4<sup>+</sup> CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy

Supplemental data

LYMPHOID NEOPLASIA

Defining primary refractory large B-cell lymphoma

Allison M. Bock,Raphael Mwangi,Yucai Wang,Arushi Khurana,Matthew J. Maurer,Amy Ayers,Brad S. Kahl,Peter Martin,Jonathon B. Cohen,Carla Casulo,Izidore S. Lossos,Umar Farooq,Sabarish Ayyappan,Tanner Reicks,Thomas M. Habermann,Thomas E. Witzig,Christopher R. Flowers,James R. Cerhan,Loretta J. Nastoupil,Grzegorz S. Nowakowski

View Articletitled, Defining primary refractory large B-cell lymphoma

Supplemental data

The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas
Clinical Trials & Observations

Rahul S. Bhansali,Fredrik Ellin,Thomas Relander,Miao Cao,Wenrui Li,Qi Long,Nivetha Ganesan,Robert Stuver,Steven M. Horwitz,Kitsada Wudhikarn,Steven R. Hwang,N. Nora Bennani,Julio Chavez,Lubomir Sokol,Hayder Saeed,Frank Duan,Pierluigi Porcu,Priyanka Pullarkat,Neha Mehta-Shah,Jasmine M. Zain,Miguel Ruiz,Jonathan E. Brammer,Rishab Prakash,Swaminathan P. Iyer,Adam J. Olszewski,Ajay Major,Peter A. Riedell,Sonali M. Smith,Caroline Goldin,Bradley Haverkos,Bei Hu,Tony Z. Zhuang,Pamela B. Allen,Wael Toama,Murali Janakiram,Taylor R. Brooks,Deepa Jagadeesh,Nisha Hariharan,Aaron M. Goodman,Gabrielle Hartman,Paola Ghione,Fatima Fayyaz,Joanna M. Rhodes,Elise A. Chong,James N. Gerson,Daniel J. Landsburg,Sunita D. Nasta,Stephen J. Schuster,Jakub Svoboda,Mats Jerkeman,Stefan K. Barta

View Articletitled, The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas

Supplemental data

MYELOID NEOPLASIA

Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository
Clinical Trials & Observations

Morgan L. Shannon,J. Brett Heimlich,Sydney Olson,Ariana Debevec,Zachary Copeland,Ashwin Kishtagari,Caitlyn Vlasschaert,Christina Snider,Alexander J. Silver,Donovan Brown,Travis Spaulding,Manasa Bhatta,Kelly Pugh,Shannon S. Stockton,Jessica Ulloa,Yaomin Xu,Muhamed Baljevic,Javid Moslehi,Eiman Jahangir,P. Brent Ferrell,David Slosky,Alexander G. Bick,Michael R. Savona

View Articletitled, Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository

Supplemental data

Treatment approach and outcomes of patients with accelerated/blast-phase myeloproliferative neoplasms in the current era

Anand A. Patel,James J. Yoon,Hannah Johnston,Marta B. Davidson,Rory M. Shallis,Evan C. Chen,Madelyn Burkart,Timothy S. Oh,Sunil G. Iyer,Ellen Madarang,Chandrasekar Muthiah,Iyana Gross,Raven Dean,Joshua Kassner,Auro Viswabandya,Rafael Madero-Marroquin,Raajit K. Rampal,Guru Subramanian Guru Murthy,Terrence Bradley,Yasmin Abaza,Jacqueline S. Garcia,Vikas Gupta,Kristen M. Pettit,John F. Cursio,Olatoyosi Odenike

View Articletitled, Treatment approach and outcomes of patients with accelerated/blast-phase myeloproliferative neoplasms in the current era

Supplemental data

PLASMA CELL DISORDERS

Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis

Paolo Lopedote,Benjamin Evans,Alfredo Marchetti,Tianzeng Chen,Maria Moscvin,Samuel Boullt,Niccolò Bolli,Giada Bianchi

View Articletitled, Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis

THROMBOSIS AND HEMOSTASIS

Essential role of glycoprotein Ibα in platelet activation

Rong Yan,Yue Xia,Kangxi Zhou,Jun Liu,Yueyue Sun,Chunyan He,Xinxin Ge,Mengnan Yang,Chenglin Sun,Liuxia Yuan,Shujun Li,Biao Yang,Fanbi Meng,Lijuan Cao,Changgeng Ruan,Kesheng Dai

View Articletitled, Essential role of glycoprotein Ibα in platelet activation

Supplemental data

TRANSPLANTATION

The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD

Zachariah DeFilipp,Haesook T. Kim,Nikolaos Spyrou,Nikolaos Katsivelos,Steven Kowalyk,Gilbert Eng,Stelios Kasikis,Rahnuma Beheshti,Janna Baez,Yu Akahoshi,Francis Ayuk,Hannah Choe,Aaron Etra,Stephan A. Grupp,Elizabeth O. Hexner,William J. Hogan,Carrie L. Kitko,Muna Qayed,Ran Reshef,Ingrid Vasova,Robert Zeiser,Rachel Young,Ernst Holler,James L. M. Ferrara,Ryotaro Nakamura,John E. Levine,Yi-Bin Chen

View Articletitled, The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD

Supplemental data

RESEARCH LETTERS

Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion

Parvathy Venugopal,Peer Arts,Lucy C. Fox,Annet Simons,Devendra K. Hiwase,Peter G. Bardy,Annette Swift,David M. Ross,Lize F. D. van Vulpen,Arjan Buijs,Kelly L. Bolton,Bartlomiej Getta,Eliska Furlong,Tina Carter,Ingrid Krapels,Marlijn Hoeks,Adila Al Kindy,Farah Al Kindy,Sonja de Munnik,Pamela Evans,Mahalia S. B. Frank,Adam M. Bournazos,Sandra T. Cooper,Thuong Thi Ha,Matilda R. Jackson,Luis Arriola-Martinez,Kerry Phillips,Yvonne Brennan,Madhura Bakshi,Karen Ambler,Song Gao,Karin S. Kassahn,Rosalie Kenyon,Kevin Hung,Milena Babic,Alan McGovern,Lesley Rawlings,Cassandra Vakulin,Lucas Dejong,Rema Fathi,Simon McRae,Nicholas Myles,Dariusz Ladon,Marjolijn Jongmans,Roland P. Kuiper,Nicola K. Poplawski,Pasquale Barbaro,Piers Blombery,Anna L. Brown,Christopher N. Hahn,Hamish S. Scott

View Articletitled, Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion

Supplemental data

CAR T-cell therapy in mantle cell lymphoma with secondary CNS involvement: a multicenter experience
Clinical Trials & Observations

Gulrayz Ahmed,Aseel Alsouqi,Aniko Szabo,Laura Samples,Mazyar Shadman,Farrukh T. Awan,Alexandra E. Rojek,Peter A. Riedell,Madiha Iqbal,Timothy S. Fenske,Mohamed A. Kharfan-Dabaja,Sawa Ito,Mehdi Hamadani

View Articletitled, CAR T-cell therapy in mantle cell lymphoma with secondary CNS involvement: a multicenter experience

Risk of T-cell malignancy after CAR T-cell therapy in children, adolescents, and young adults

Adam J. Lamble,Liora M. Schultz,Khanh Nguyen,Emily M. Hsieh,Kevin McNerney,Rayne H. Rouce,Rebecca A. Gardner,Sara Ghorashian,Nirali N. Shah,Shannon L. Maude

View Articletitled, Risk of T-cell malignancy after CAR T-cell therapy in children, adolescents, and young adults

Industry payments to American Society of Hematology Clinical Practice Guideline authors

Jeremy W. Jacobs,Garrett S. Booth,Laura D. Stephens,Brian D. Adkins,Amarilis A. Martin,George D. Lundberg,Raeshun T. Glover,Shazia S. Khan,Julie K. Silver,Jennifer S. Woo

View Articletitled, Industry payments to American Society of Hematology Clinical Practice Guideline authors

Supplemental data

Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis
Clinical Trials & Observations

Gemma K. Reynolds,Marsali Maclean,Edward R. Scheffer Cliff,Benjamin W. Teh,Karin A. Thursky,Monica A. Slavin,Mary Ann Anderson,Eliza A. Hawkes

View Articletitled, Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis

Supplemental data

COMMENTARIES

The clinical trials landscape in immunoglobulin light chain amyloidosis: a systematic review

Ramya Ramachandran,Darshi Shah,Catherine Luo,Veer Shah,Edward R. Scheffer Cliff,Vaishali Sanchorawala,Suzanne Lentzsch,Rajshekhar Chakraborty

View Articletitled, The clinical trials landscape in immunoglobulin light chain amyloidosis: a systematic review

Supplemental data

ASH Guideline Oversight Subcommittee Response to Jacobs et al regarding Industry Payments to ASH Guideline Panelists

Menaka Pai,Michael Byrne,Adam Cuker,Benjamin Djulbegovic,Jim George,Matthew Seftel,Deirdra R. Terrell,Robert Kunkle,Matthew C. Cheung

View Articletitled, ASH Guideline Oversight Subcommittee Response to Jacobs et al regarding Industry Payments to ASH Guideline Panelists

Supplemental data

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Issue Archive

Table of Contents

INSIDE BLOOD ADVANCES

REVIEW ARTICLE

CLINICAL TRIALS AND OBSERVATIONS

Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials Clinical Trials & Observations

DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia Clinical Trials & Observations

GENE THERAPY

HEALTH SERVICES AND OUTCOMES

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas Clinical Trials & Observations

MYELOID NEOPLASIA

Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository Clinical Trials & Observations

PLASMA CELL DISORDERS

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

RESEARCH LETTERS

CAR T-cell therapy in mantle cell lymphoma with secondary CNS involvement: a multicenter experience Clinical Trials & Observations

Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis Clinical Trials & Observations

COMMENTARIES

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials
Clinical Trials & Observations

DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia
Clinical Trials & Observations

The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas
Clinical Trials & Observations

Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository
Clinical Trials & Observations

CAR T-cell therapy in mantle cell lymphoma with secondary CNS involvement: a multicenter experience
Clinical Trials & Observations

Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis
Clinical Trials & Observations