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Olutasidenib: from bench to bedside
Cardiac events after standard of care idecabtagene vicleucel for relapsed and refractory multiple myeloma
Orelabrutinib for the treatment of relapsed or refractory MCL: a phase 1/2, open-label, multicenter, single-arm study
Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study
Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial
Tacrolimus/methotrexate vs tacrolimus/reduced-dose methotrexate/mycophenolate for graft-versus-host disease prevention
Adding venetoclax to lenalidomide and rituximab is safe and effective in patients with untreated mantle cell lymphoma
A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial
Optimized vitamin D repletion with oral thin film cholecalciferol in patients undergoing stem cell transplant
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease
Return emergency department visits for recurrent pulmonary embolism symptoms in children and adolescents
Exposure-response analysis of alemtuzumab in pediatric allogeneic HSCT for nonmalignant diseases: the ARTIC study
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD
Efficacy, safety, and pharmacokinetics of a new, ready-to-use, liquid hydroxyurea in children with sickle cell anemia
In-person and virtual assessment of short physical performance battery test in older adults with myeloid malignancies
Issue Archive
August 22 2023
In this Issue
Table of Contents
INSIDE BLOOD ADVANCES
DRUG ADVANCES
Olutasidenib: from bench to bedside
Clinical Trials & Observations
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Cardiac events after standard of care idecabtagene vicleucel for relapsed and refractory multiple myeloma
Clinical Trials & Observations
Dae Hyun Lee,Abhishek Kumar,Turab Mohammed,Lauren C. Peres,Melissa Alsina,Christina Bachmeier,Brandon J. Blue,Jason Brayer,Sanjay Chandrasekhar,Ariel Grajales Cruz,Gabe De Avila,Hany Elmariah,Rawan Faramand,Ciara Freeman,Michael Jain,Sushmita Khadka,Farhad Khimani,Hien Liu,Taiga Nishihori,Laura B. Oswald,Omar A. Castaneda Puglianini,Kenneth H. Shain,Eric Smith,Rachid C. Baz,Frederick L. Locke,Guilherme H. Oliveira,Mohammed Alomar,Doris K. Hansen
Orelabrutinib for the treatment of relapsed or refractory MCL: a phase 1/2, open-label, multicenter, single-arm study
Clinical Trials & Observations
Li-Juan Deng,Ke-Shu Zhou,Li-Hong Liu,Ming-Zhi Zhang,Zhi-Ming Li,Chun-Yan Ji,Wei Xu,Ting Liu,Bing Xu,Xin Wang,Su-Jun Gao,Hui-Lai Zhang,Yu Hu,Yan Li,Ying Cheng,Hai-Yan Yang,Jun-Ning Cao,Zun-Min Zhu,Jian-Da Hu,Wei Zhang,Hong-Mei Jing,Kai-Yang Ding,Xiang-Yang Zhang,Ren-Bin Zhao,Bin Zhang,Ya-Min Tian,Yong-Ping Song,Yu-Qin Song,Jun Zhu
Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study
Clinical Trials & Observations
Emmanuel Bachy,Kerry J. Savage,Huiqiang Huang,Yok-Lam Kwong,Giuseppe Gritti,Qingyuan Zhang,Anna Marina Liberati,Junning Cao,Haiyan Yang,Siguo Hao,Jianda Hu,Keshu Zhou,Mario Petrini,Filomena Russo,Huilai Zhang,Wei Sang,Jie Ji,Andrés José María Ferreri,Gandhi Laurent Damaj,Hui Liu,Wei Zhang,Xiaoyan Ke,Chiara Ghiggi,Sha Huang,Xiaotong Li,Hui Yao,Jason Paik,William Novotny,Wenxiao Zhou,Hongjie Zhu,Pier Luigi Zinzani

An updated risk-oriented strategy resulting in 3-year OS and DFS rates >60% in adult patients 18-65 years with Ph-negative ALL
Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial
Clinical Trials & Observations
Renato Bassan,Sabina Chiaretti,Irene Della Starza,Orietta Spinelli,Alessandra Santoro,Francesca Paoloni,Monica Messina,Loredana Elia,Maria Stefania De Propris,Anna Maria Scattolin,Ernesta Audisio,Laura Marbello,Erika Borlenghi,Patrizia Zappasodi,Elisa Mauro,Giovanni Martinelli,Daniele Mattei,Nicola Fracchiolla,Monica Bocchia,Paolo De Fabritiis,Massimiliano Bonifacio,Anna Candoni,Vincenzo Cassibba,Paolo Di Bartolomeo,Giancarlo Latte,Silvia Trappolini,Anna Guarini,Antonella Vitale,Paola Fazi,Alfonso Piciocchi,Alessandro Rambaldi,Robin Foà
Tacrolimus/methotrexate vs tacrolimus/reduced-dose methotrexate/mycophenolate for graft-versus-host disease prevention
Clinical Trials & Observations
Betty K. Hamilton,Lisa A. Rybicki,Hong Li,Taylor Lucas,Donna Corrigan,Matt Kalaycio,Ronald Sobecks,Rabi Hanna,Seth J. Rotz,Robert M. Dean,Aaron T. Gerds,Deepa Jagadeesh,Claudio Brunstein,Craig S. Sauter,Edward A. Copelan,Navneet S. Majhail
Adding venetoclax to lenalidomide and rituximab is safe and effective in patients with untreated mantle cell lymphoma
Clinical Trials & Observations
Tycel J. Phillips,David Bond,Radihka Takiar,Karson Kump,Malalthi Kandarpa,Philip Boonstra,Tera Lynn Mayer,Victoria Nachar,Ryan A. Wilcox,Shannon A. Carty,Yasmin H. Karimi,Zaneta Nikolovska-Coleska,Mark S. Kaminski,Alex F. Herrera,Kami Maddocks,Leslie Popplewell,Alexey V. Danilov
A randomized comparison of CPX-351 and FLAG-Ida in adverse karyotype AML and high-risk MDS: the UK NCRI AML19 trial
Clinical Trials & Observations
Jad Othman,Charlotte Wilhelm-Benartzi,Richard Dillon,Steve Knapper,Sylvie D. Freeman,Leona M. Batten,Joanna Canham,Emily L. Hinson,Julie Wych,Sophie Betteridge,William Villiers,Michelle Kleeman,Amanda Gilkes,Nicola Potter,Ulrik Malthe Overgaard,Priyanka Mehta,Panagiotis Kottaridis,Jamie Cavenagh,Claire Hemmaway,Claire Arnold,Mike Dennis,Nigel H. Russell,on behalf of the UK National Cancer Research Institute Acute Myeloid Leukaemia Working Group
Optimized vitamin D repletion with oral thin film cholecalciferol in patients undergoing stem cell transplant
Clinical Trials & Observations
Allison L. Bartlett,Grace Zhang,Gregory Wallace,Stacie McLean,Kasiani C. Myers,Ashley Teusink-Cross,Cynthia Taggart,Bhaumik Patel,Robert Davidson,Stella M. Davies,Sonata Jodele
HEALTH SERVICES AND OUTCOMES
Current clinical practices and challenges in molecular testing: a GOAL Consortium Hematopathology Working Group report
Thomas D. Lee,Dara L. Aisner,Marjorie P. David,Celeste C. Eno,Jeffrey Gagan,Christopher D. Gocke,Natalya V. Guseva,Lisa Haley,Audrey N. Jajosky,Daniel Jones,Mahesh M. Mansukhani,Pawel Mroz,Sarah S. Murray,Kimberly J. Newsom,Vera Paulson,Somak Roy,Chase Rushton,Jeremy P. Segal,T. Niroshini Senaratne,Alexa J. Siddon,Petr Starostik,Jessica A. G. Van Ziffle,David Wu,Rena R. Xian,Sophia Yohe,Annette S. Kim
HEMATOPOIESIS AND STEM CELLS
Cell-free DNA measurable residual disease as a predictor of postallogeneic hematopoietic cell transplant outcomes
Sergiu Pasca,Matthew Z. Guo,Shiyu Wang,Kristin Stokvis,Audra Shedeck,Aparna Pallavajjala,Cynthia Shams,Roshni Pallavajjala,Amy E. DeZern,Ravi Varadhan,Christopher D. Gocke,Richard J. Jones,Lukasz P. Gondek
IMMUNOBIOLOGY AND IMMUNOTHERAPY
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
Camille Philippon,Sudan Tao,Dennis Clement,Alvaro Haroun-Izquierdo,Katherine M. Kichula,Herman Netskar,Ludwig Brandt,Vincent Sheng Oei,Minoru Kanaya,Pilar Maria Lanuza,Marie Schaffer,Jodie P. Goodridge,Amir Horowitz,Faming Zhu,Quirin Hammer,Ebba Sohlberg,Rakesh Kumar Majhi,Lise Kveberg,Björn Önfelt,Paul J. Norman,Karl-Johan Malmberg
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease
Clinical Trials & Observations
Holly Wobma,Malika Kapadia,Haesook T. Kim,Francesca Alvarez-Calderon,Susanne H. C. Baumeister,Christine Duncan,Suzanne Forrest,Lev Gorfinkel,Jennifer Huang,Leslie E. Lehmann,Hojun Li,Marc Schwartz,John Koreth,Jerome Ritz,Leslie S. Kean,Jennifer S. Whangbo
LYMPHOID NEOPLASIA
Outcomes of patients with primary refractory multiple myeloma in the era of triplet and quadruplet induction therapy
Charalampos Charalampous,Utkarsh Goel,Prashant Kapoor,Moritz Binder,Francis K. Buadi,Joselle Cook,David Dingli,Angela Dispenzieri,Amie L. Fonder,Morie A. Gertz,Wilson Gonsalves,Suzanne R. Hayman,Miriam A. Hobbs,Yi L. Hwa,Taxiarchis Kourelis,Martha Q. Lacy,Nelson Leung,Yi Lin,Rahma Warsame,Robert A. Kyle,S. Vincent Rajkumar,Shaji K. Kumar
Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions
Ajay Major,Jovian Yu,Navika Shukla,Yan Che,Theodore G. Karrison,Rachel Treitman,Manali K. Kamdar,Bradley M. Haverkos,James Godfrey,Melissa A. Babcook,Timothy J. Voorhees,Sophie Carlson,Daria Gaut,Caspian Oliai,Jason T. Romancik,Allison M. Winter,Brian T. Hill,Radhika Bansal,Jose C. Villasboas Bisneto,Imran A. Nizamuddin,Reem Karmali,Lindsey A. Fitzgerald,Deborah M. Stephens,Priyanka A. Pophali,Asaad Trabolsi,Jonathan H. Schatz,Marie Hu,Veronika Bachanova,Michael J. Slade,Nathan Singh,Nausheen Ahmed,Joseph P. McGuirk,Michael R. Bishop,Peter A. Riedell,Justin Kline
Time to progression of disease and outcomes with second-line BTK inhibitors in relapsed/refractory mantle cell lymphoma
Diego Villa,Aixiang Jiang,Carlo Visco,Nicola Crosbie,Rory McCulloch,Michael J. Buege,Anita Kumar,David A. Bond,Jonas Paludo,Matthew J. Maurer,Gita Thanarajasingam,Katharine L. Lewis,Chan Y. Cheah,Joachim Baech,Tarec C. El-Galaly,Laveniya Kugathasan,David W. Scott,Alina S. Gerrie,David Lewis
MYELOID NEOPLASIA
Genomic landscape of TP53-mutated myeloid malignancies
Haley J. Abel,Karolyn A. Oetjen,Christopher A. Miller,Sai M. Ramakrishnan,Ryan B. Day,Nichole M. Helton,Catrina C. Fronick,Robert S. Fulton,Sharon E. Heath,Stefan P. Tarnawsky,Sridhar Nonavinkere Srivatsan,Eric J. Duncavage,Molly C. Schroeder,Jacqueline E. Payton,David H. Spencer,Matthew J. Walter,Peter Westervelt,John F. DiPersio,Timothy J. Ley,Daniel C. Link
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
Computer vision quantitation of erythrocyte shape abnormalities provides diagnostic, prognostic, and mechanistic insight
Brody H. Foy,Jonathan A. Stefely,Pavan K. Bendapudi,Robert P. Hasserjian,Hanny Al-Samkari,Abner Louissaint, Jr.,Megan J. Fitzpatrick,Bailey Hutchison,Christopher Mow,Julia Collins,Hasmukh R. Patel,Chhaya H. Patel,Nikita Patel,Samantha N. Ho,Richard M. Kaufman,Walter H. Dzik,John M. Higgins,Robert S. Makar
THROMBOSIS AND HEMOSTASIS
Return emergency department visits for recurrent pulmonary embolism symptoms in children and adolescents
Clinical Trials & Observations
TRANSPLANTATION
Exposure-response analysis of alemtuzumab in pediatric allogeneic HSCT for nonmalignant diseases: the ARTIC study
Clinical Trials & Observations
Federica R. Achini-Gutzwiller,Marco W. Schilham,Erik G. J. von Asmuth,Anja M. Jansen-Hoogendijk,Cornelia M. Jol-van der Zijde,Maarten J. D. van Tol,Robbert G. M. Bredius,Tayfun Güngör,Arjan C. Lankester,Dirk Jan A. R. Moes
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD
Clinical Trials & Observations
Yu Akahoshi,Nikolaos Spyrou,William J. Hogan,Francis Ayuk,Zachariah DeFilipp,Daniela Weber,Hannah K. Choe,Elizabeth O. Hexner,Wolf Rösler,Aaron M. Etra,Karamjeet Sandhu,Gregory A. Yanik,Chantiya Chanswangphuwana,Carrie L. Kitko,Ran Reshef,Sabrina Kraus,Matthias Wölfl,Matthias Eder,Hannah Bertrand,Muna Qayed,Pietro Merli,Stephan A. Grupp,Paibel Aguayo-Hiraldo,Tal Schechter,Evelyn Ullrich,Janna Baez,Rahnuma Beheshti,Sigrun Gleich,Steven Kowalyk,George Morales,Rachel Young,Deukwoo Kwon,Ryotaro Nakamura,John E. Levine,James L. M. Ferrara,Yi-Bin Chen
RESEARCH LETTERS
Efficacy, safety, and pharmacokinetics of a new, ready-to-use, liquid hydroxyurea in children with sickle cell anemia
Clinical Trials & Observations
Angela Rankine-Mullings,Russell Keenan,Subarna Chakravorty,Baba Inusa,Paul Telfer,Mark Velangi,Russell E. Ware,Jon J. Moss,Adam L. Lloyd,Sarah Edwards,Hussain Mulla
Venetoclax-based therapies in pediatric advanced MDS and relapsed/refractory AML: a multicenter retrospective analysis
Riccardo Masetti,Francesco Baccelli,Davide Leardini,Francesca Gottardi,Francesca Vendemini,Alessandro Di Gangi,Marco Becilli,Mariachiara Lodi,Manuela Tumino,Luca Vinci,Miriam Erlacher,Brigitte Strahm,Charlotte M. Niemeyer,Franco Locatelli
Abatacept for the prevention of GVHD in patients receiving mismatched unrelated transplants: a real-world analysis
Sharmila Raghunandan,Lev Gorfinkel,Michael Graiser,Brandi Bratrude,Yvonne Suessmuth,Scott Gillespie,Adrianna Lynn Westbrook,Kirsten M. Williams,Michelle L. Schoettler,Leslie S. Kean,John Horan,Amelia A. Langston,Muna Qayed,Benjamin Watkins
In-person and virtual assessment of short physical performance battery test in older adults with myeloid malignancies
Clinical Trials & Observations
Chandrika Sanapala,Marielle Jensen-Battaglia,Erin E. Watson,Sravani Konatham,Marissa LoCastro,Ying Wang,Eva Culakova,Michael Sohn,Marie Flannery,Allison Magnuson,Tanya M. Wildes,Kah Poh Loh
Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models
Elisa ten Hacken,Shanye Yin,Robert Redd,María Hernández Sánchez,Kendell Clement,Gabriela Brunsting Hoffmann,Fara F. Regis,Elizabeth Witten,Shuqiang Li,Donna Neuberg,Luca Pinello,Kenneth J. Livak,Catherine J. Wu
Framework of clonal mutations concurrent with WT1 mutations in adults with acute myeloid leukemia: Alliance for Clinical Trials in Oncology study
Bhavana Bhatnagar,Jessica Kohlschmidt,Shelley J. Orwick,Daelynn R. Buelow,Sydney Fobare,Christopher C. Oakes,Jonathan E. Kolitz,Geoff Uy,Wendy Stock,Bayard L. Powell,Deedra Nicolet,Erin K. Hertlein,Krzysztof Mrózek,James S. Blachly,Ann-Kathrin Eisfeld,Sharyn D. Baker,John C. Byrd
COMMENTARIES
Use of letermovir in umbilical cord blood transplantation based on risk scores
Monica M. Rivera Franco,Hanadi Rafii,Fernanda Volt,Chantal Kenzey,Barbara Cappelli,Graziana Maria Scigliuolo,Vanderson Rocha,Nicole Raus,Jean-Hugues Dalle,Patrice Chevallier,Marie Robin,Marie Thérèse Rubio,Annalisa Ruggeri,Eliane Gluckman,on behalf of Eurocord and Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Identifying experts for clinical practice guidelines: perspectives from the ASH Guideline Oversight Subcommittee
Michael Byrne,Ryan Mattison,Rachel Bercovitz,Richard Lottenberg,Suely M. Rezende,Roy Silverstein,Deirdra Terrell,Rob Kunkle,Deion Smith,Catherine Bollard,Sandra Haberichter,Jennifer Holter-Chakrabarty,Menaka Pai,Matthew Cheung,Adam Cuker,Matthew Seftel,Benjamin Djulbegovic
How I read an article that uses machine learning methods
Aziz Nazha,Olivier Elemento,Shannon McWeeney,Moses Miles,Torsten Haferlach,on behalf of the American Society of Hematology Artificial Intelligence Taskforce
ERRATA
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Cover Image
Cover Image
Tetraspanin domain organization and function. Tetraspanins are characterized by 4 transmembrane domains (labeled 1-4) that, together with the palmitoylation sites (green triangles), are crucial for the formation of tetraspanin-enriched microdomains. The disulfide-stabilized variable region of the large extracellular loop adjoins the conserved region, which mediates homodimerization. The C terminus interacts with signaling and cytoskeletal proteins. See the article by Quagliano et al.
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More evidence for low-dose IL-2 for chronic GVHD in children
Clinical Trials & Observations