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Long-term follow-up of rituximab plus bendamustine and cytarabine in older patients with newly diagnosed MCL
A fixed-duration immunochemotherapy approach in CLL: 5.5-year results from the phase 2 ICLL-07 FILO trial
External validation of the PEGeD diagnostic algorithm for suspected pulmonary embolism in an independent cohort
Central nervous system relapse in younger patients with diffuse large B-cell lymphoma: a LYSA and GLA/DSHNHL analysis
Hodgkin lymphoma and female fertility: a multicenter study in women treated with doxorubicin, bleomycin, vinblastine, and dacarbazine
Successful treatment of non-Langerhans cell histiocytosis with the MEK inhibitor trametinib: a multicenter analysis
A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma
Circulating SARS-CoV-2+ megakaryocytes are associated with severe viral infection in COVID-19
Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia
Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma
Cost-effectiveness of targeted treatment vs chemoimmunotherapy in treatment-naive unfit CLL without TP53 aberrations
LSC17 score complements genetics and measurable residual disease in acute myeloid leukemia: an ALFA study
Posttransplant cyclophosphamide vs tacrolimus–based GVHD prophylaxis: lower incidence of relapse and chronic GVHD
Teclistamab impairs detection of BCMA CAR-T cells
Association of social deprivation with survival in younger adult patients with AML: an Alliance study
Pseudomonas aeruginosa ExoU-associated virulence in HCT recipients and patients with hematologic malignancies
Do sophisticated models give the full picture of allogeneic hematopoietic stem cell transplantation effect?
Issue Archive
August 8 2023
In this Issue
Table of Contents
INSIDE BLOOD ADVANCES
CLINICAL TRIALS AND OBSERVATIONS
Long-term follow-up of rituximab plus bendamustine and cytarabine in older patients with newly diagnosed MCL
Clinical Trials & Observations
Maria Chiara Tisi,Riccardo Moia,Caterina Patti,Andrea Evangelista,Simone Ferrero,Michele Spina,Monica Tani,Barbara Botto,Melania Celli,Benedetta Puccini,Emanuele Cencini,Alice Di Rocco,Claudio Chini,Chiara Ghiggi,Renato Zambello,Manuela Zanni,Roberta Sciarra,Riccardo Bruna,Martina Ferrante,Stefano Alessandro Pileri,Francesca Maria Quaglia,Caterina Stelitano,Alessandro Re,Stefano Volpetti,Vittorio Ruggero Zilioli,Annalisa Arcari,Francesco Merli,Carlo Visco
A fixed-duration immunochemotherapy approach in CLL: 5.5-year results from the phase 2 ICLL-07 FILO trial
Clinical Trials & Observations
Anne-Sophie Michallet,Rémi Letestu,Magali Le Garff-Tavernier,Lydia Campos,Michel Ticchioni,Marie-Sarah Dilhuydy,Stephane Morisset,Valérie Rouille,Béatrice Mahé,Kamel Laribi,Bruno Villemagne,Emmanuelle Ferrant,Olivier Tournilhac,Alain Delmer,Lysiane Molina,Véronique Leblond,Cécile Tomowiak,Sophie de Guibert,Frederique Orsini-Piocelle,Anne Banos,Philippe Carassou,Guillaume Cartron,Luc Mathieu Fornecker,Loic Ysebaert,Caroline Dartigeas,Margot Truchan-Graczyk,Jean-Pierre Vilque,Thérèse Aurran Schleinitz,Florence Cymbalista,Stéphane Leprêtre,Vincent Lévy,Florence Nguyen-Khac,Pierre Feugier,the French Innovative Leukemia Organization (FILO) CLL group
External validation of the PEGeD diagnostic algorithm for suspected pulmonary embolism in an independent cohort
Clinical Trials & Observations
Central nervous system relapse in younger patients with diffuse large B-cell lymphoma: a LYSA and GLA/DSHNHL analysis
Clinical Trials & Observations
Catherine Thieblemont,Bettina Altmann,Fabian Frontzek,Loïc Renaud,Loic Chartier,Nicolas Ketterer,Christian Récher,Viola Poeschel,Olivier Fitoussi,Gerhard Held,Olivier Casasnovas,Corinne Haioun,Franck Morschhauser,Bertram Glass,Nicolas Mounier,Herve Tilly,Andreas Rosenwald,German Ott,Georg Lenz,Thierry Molina,Marita Ziepert,Norbert Schmitz
Hodgkin lymphoma and female fertility: a multicenter study in women treated with doxorubicin, bleomycin, vinblastine, and dacarbazine
Clinical Trials & Observations
Antoine Machet,Caroline Poudou,Cécile Tomowiak,Thomas Gastinne,Martine Gardembas,Thomas Systchenko,Niels Moya,Celine Debiais,Anthony Levy,Cécile Gruchet,Florence Sabirou,Stéphanie Noel,Sabrina Bouyer,Xavier Leleu,Vincent Delwail,Stéphanie Guidez
Successful treatment of non-Langerhans cell histiocytosis with the MEK inhibitor trametinib: a multicenter analysis
Clinical Trials & Observations
Ashley Aaroe,Razelle Kurzrock,Gaurav Goyal,Aaron M. Goodman,Harsh Patel,Gordon Ruan,Gary Ulaner,Jason Young,Ziyi Li,Derek Dustin,Ronald S. Go,Eli L. Diamond,Filip Janku
A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma
Clinical Trials & Observations
Annalisa Arcari,Lugi Rigacci,Alessandra Tucci,Benedetta Puccini,Sara Veronica Usai,Federica Cavallo,Alberto Fabbri,Monica Balzarotti,Sabrina Pelliccia,Stefano Luminari,Elsa Pennese,Vittorio Ruggero Zilioli,Abdurraouf Mokhtar Mahmoud,Gerardo Musuraca,Dario Marino,Roberto Sartori,Barbara Botto,Guido Gini,Manuela Zanni,Stefan Hohaus,Giuseppe Tarantini,Leonardo Flenghi,Monica Tani,Alice Di Rocco,Michele Merli,Daniele Vallisa,Chiara Pagani,Luca Nassi,Daniela Dessì,Simone Ferrero,Emanuele Cencini,Patrizia Bernuzzi,Caterina Mammi,Luigi Marcheselli,Valentina Tabanelli,Michele Spina,Francesco Merli
Circulating SARS-CoV-2+ megakaryocytes are associated with severe viral infection in COVID-19
Clinical Trials & Observations
Seth D. Fortmann,Michael J. Patton,Blake F. Frey,Jennifer L. Tipper,Sivani B. Reddy,Cristiano P. Vieira,Vidya Sagar Hanumanthu,Sarah Sterrett,Jason L. Floyd,Ram Prasad,Jeremy D. Zucker,Andrew B. Crouse,Forest Huls,Rati Chkheidze,Peng Li,Nathaniel B. Erdmann,Kevin S. Harrod,Amit Gaggar,Paul A. Goepfert,Maria B. Grant,Matthew Might
GENE THERAPY
CAR NK-92 cell–mediated depletion of residual TCR+ cells for ultrapure allogeneic TCR-deleted CAR T-cell products
Jonas Kath,Weijie Du,Stefania Martini,Magdi Elsallab,Clemens Franke,Laura Hartmann,Vanessa Drosdek,Viktor Glaser,Maik Stein,Michael Schmueck-Henneresse,Petra Reinke,Hans-Dieter Volk,Mohamed Abou-el-Enein,Dimitrios L. Wagner
HEALTH SERVICES AND OUTCOMES
Analysis of disparities in time to allogeneic transplantation in adults with acute myelogenous leukemia
Warren B. Fingrut,Boglarka Gyurkocza,Jessica Flynn,Eric Davis,Sean Devlin,Andromachi Scaradavou,Stephanie Chinapen,Sean Quach,Christina Cho,Sergio A. Giralt,Ann A. Jakubowski,Richard J. Lin,Esperanza B. Papadopoulos,Miguel-Angel Perales,Doris Ponce,Brian C. Shaffer,Roni Tamari,James W. Young,Ioannis Politikos,Juliet N. Barker
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia
Clinical Trials & Observations
Daniel Leongamornlert,Jesús Gutiérrez-Abril,SooWah Lee,Emilio Barretta,Thomas Creasey,Gunes Gundem,Max F. Levine,Juan E. Arango-Ossa,Konstantinos Liosis,Juan S. Medina-Martinez,Krisztina Zuborne Alapi,Amy A. Kirkwood,Laura Clifton-Hadley,Pip Patrick,David Jones,Laura O’Neill,Adam P. Butler,Christine J. Harrison,Peter Campbell,Bela Patel,Anthony V. Moorman,Adele K. Fielding,Elli Papaemmanuil
Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma
Clinical Trials & Observations
Rebecca J. Brownlie,Ruth Kennedy,Erica B. Wilson,Maja Milanovic,Claire F. Taylor,Dapeng Wang,John R. Davies,Heather Owston,Emma J. Adams,Sophie Stephenson,Rebecca Caeser,Benjamin E. Gewurz,Peter V. Giannoudis,Claudio Scuoppo,Dennis McGonagle,Daniel J. Hodson,Reuben M. Tooze,Gina M. Doody,Gordon Cook,David R. Westhead,Ulf Klein
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability
Zhenguo Zi,Shujuan Du,Liming Zhang,Yuebo Wang,Ling Ding,Chongqi Zhang,Huanyu Wang,Jan Pawlicki,Yuan Cai,Yazhou Yao,Feng Zhou,Yin Tong,James L. Riley,Qiliang Cai,Xiaojing Ma,Fang Wei
Cytotoxicity of the CD3×CD20 bispecific antibody epcoritamab in CLL is increased by concurrent BTK or BCL-2 targeting
Maissa Mhibik,Erika M. Gaglione,David Eik,John Herrick,Janet Le,Inhye E. Ahn,Christopher Chiu,Monica Wielgos-Bonvallet,Ida H. Hiemstra,Esther C. W. Breij,Jenny Chen,Edward B. Reilly,Pearlie K. Epling-Burnette,Edith Szafer-Glusman,Clare Sun,Adrian Wiestner
Cost-effectiveness of targeted treatment vs chemoimmunotherapy in treatment-naive unfit CLL without TP53 aberrations
Clinical Trials & Observations
A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia
Katherine E. Masih,Rebecca A. Gardner,Hsien-Chao Chou,Abdalla Abdelmaksoud,Young K. Song,Luca Mariani,Vineela Gangalapudi,Berkley E. Gryder,Ashley L. Wilson,Serifat O. Adebola,Benjamin Z. Stanton,Chaoyu Wang,David Milewski,Yong Yean Kim,Meijie Tian,Adam Tai-Chi Cheuk,Xinyu Wen,Yue Zhang,Grégoire Altan-Bonnet,Michael C. Kelly,Jun S. Wei,Martha L. Bulyk,Michael C. Jensen,Rimas J. Orentas,Javed Khan
MYELOID NEOPLASIA
LSC17 score complements genetics and measurable residual disease in acute myeloid leukemia: an ALFA study
Clinical Trials & Observations
Loïc Vasseur,Laurène Fenwarth,Jérôme Lambert,Stéphane de Botton,Martin Figeac,Céline Villenet,Maël Heiblig,Pierre-Yves Dumas,Christian Récher,Céline Berthon,Emilie Lemasle,Delphine Lebon,Juliette Lambert,Christine Terré,Karine Celli-Lebras,Hervé Dombret,Claude Preudhomme,Meyling Cheok,Raphael Itzykson,Nicolas Duployez
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
Monique J. T. Crobach,Rayna J. S. Anijs,Sigrid K. Brækkan,Marianne T. Severinsen,Jens Hammerstrøm,Hanne Skille,Søren R. Kristensen,Benedikte Paulsen,Anne Tjønneland,Henri H. Versteeg,Kim Overvad,John-Bjarne Hansen,Inger A. Næss,Suzanne C. Cannegieter
TRANSPLANTATION
Posttransplant cyclophosphamide vs tacrolimus–based GVHD prophylaxis: lower incidence of relapse and chronic GVHD
Clinical Trials & Observations
Katie Maurer,Vincent T. Ho,Eno Inyang,Corey Cutler,John Koreth,Roman M. Shapiro,Mahasweta Gooptu,Rizwan Romee,Sarah Nikiforow,Joseph H. Antin,Catherine J. Wu,Jerome Ritz,Robert J. Soiffer,Haesook T. Kim
A simple prognostic system in patients with myelofibrosis undergoing allogeneic stem cell transplantation: a CIBMTR/EBMT analysis
Roni Tamari,Donal P. McLornan,Kwang Woo Ahn,Noel Estrada-Merly,Juan Carlos Hernández-Boluda,Sergio Giralt,Jeanne Palmer,Robert Peter Gale,Zachariah DeFilipp,David I. Marks,Marjolein van der Poel,Leo F. Verdonck,Minoo Battiwalla,Miguel Angel Diaz,Vikas Gupta,Haris Ali,Mark Robert Litzow,Hillard M. Lazarus,Usama Gergis,Asad Bashey,Jane Liesveld,Shahrukh Hashmi,Jeffrey J. Pu,Amer Beitinjaneh,Christopher Bredeson,David Rizzieri,Bipin N. Savani,Muhammad Bilal Abid,Siddhartha Ganguly,Vaibhav Agrawal,Vera Ulrike Bacher,Baldeep Wirk,Tania Jain,Corey Cutler,Mahmoud Aljurf,Tamila Kindwall-Keller,Mohamed A. Kharfan-Dabaja,Gerhard C. Hildebrandt,Attaphol Pawarode,Melhem M. Solh,Jean A. Yared,Michael R. Grunwald,Sunita Nathan,Taiga Nishihori,Sachiko Seo,Bart L. Scott,Ryotaro Nakamura,Betul Oran,Tomasz Czerw,Ibrahim Yakoub-Agha,Wael Saber
Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse
Roman M. Shapiro,Haesook T. Kim,Michela Ansuinelli,Indira Guleria,Corey S. Cutler,John Koreth,Mahasweta Gooptu,Joseph H. Antin,Amar Kelkar,Jerome Ritz,Catherine J. Wu,Robert J. Soiffer,Vincent T. Ho,Sarah Nikiforow,Rizwan Romee
RESEARCH LETTERS
Teclistamab impairs detection of BCMA CAR-T cells
Clinical Trials & Observations
Bettina Glatte,Kerstin Wenk,Anja Grahnert,Maik Friedrich,Maximilian Merz,Vladan Vucinic,Luise Fischer,Kristin Reiche,Miriam Alb,Michael Hudecek,Paul Franz,Stephan Fricke,Uwe Platzbecker,Ulrike Koehl,Ulrich Sack,Andreas Boldt,Sunna Hauschildt,Ronald Weiss
Flow cytometric assessment of leukemia-associated monocytes in childhood B-cell acute lymphoblastic leukemia outcome
Gloria P. Contreras Yametti,Nikki A. Evensen,Jennifer M. Schloss,Clemence Aldebert,Emily Duan,Yan Zhang,Jiyuan Hu,Tiffany M. Chambers,Michael E. Scheurer,David T. Teachey,Karen R. Rabin,Elizabeth A. Raetz,Iannis Aifantis,William L. Carroll,Matthew T. Witkowski
Association of social deprivation with survival in younger adult patients with AML: an Alliance study
Clinical Trials & Observations
Melanie Rebechi,Jessica Kohlschmidt,Krzysztof Mrózek,Deedra Nicolet,Alice S. Mims,James S. Blachly,Shelley Orwick,Karilyn T. Larkin,Christopher C. Oakes,Andrew Hantel,Andrew J. Carroll,William G. Blum,Bayard L. Powell,Geoffrey L. Uy,Richard M. Stone,Richard A. Larson,John C. Byrd,Electra D. Paskett,Jesse J. Plascak,Ann-Kathrin Eisfeld
Pseudomonas aeruginosa ExoU-associated virulence in HCT recipients and patients with hematologic malignancies
Clinical Trials & Observations
System-level immune monitoring reveals new pathophysiological features in hepatitis-associated aplastic anemia
Cecile Braudeau,Laurence Delbos,Marie-Laure Couec,Gwenvael Danic,Justine Chevreuil,Camille Lecuroux,Audrey Grain,Marion Eveillard,Fanny Rialland,Flore Sicre de Fontbrune,Gaelle Beriou,Nicolas Degauque,David Michonneau,Regis Josien,Régis Peffault de Latour,Caroline Thomas,Jerome C. Martin
Clonal hematopoiesis in survivors of childhood cancer
Danielle Novetsky Friedman,Irenaeus C. C. Chan,Chaya S. Moskowitz,Shanita Li,Kimberly Turner,Jie Liu,Nancy Bouvier,Michael F. Walsh,Barbara Spitzer,Andrew L. Kung,Michael Berger,Megan A. Cooper,Iskra Pusic,Geoffrey Uy,Daniel Link,Todd E. Druley,Luis A. Diaz, Jr.,Ross L. Levine,Neerav Shukla,Kelly L. Bolton
Mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemia
Brennan P. Bergeron,Kelly R. Barnett,Kashi Raj Bhattarai,Robert J. Mobley,Baranda S. Hansen,Anthony Brown,Kiran Kodali,Anthony A. High,Sima Jeha,Ching-Hon Pui,Junmin Peng,Shondra M. Pruett-Miller,Daniel Savic
COMMENTARIES
Do sophisticated models give the full picture of allogeneic hematopoietic stem cell transplantation effect?
Clinical Trials & Observations
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Cover Image
Cover Image
Mouse megakaryocytes sense fibronectin matrix stiffness using podosome containing F-actin (red) and phosphorylated focal adhesion kinase (green). See the article by Guinard et al.
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Peripheral megakaryocytes sound the alarm in COVID-19
Clinical Trials & Observations