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Vector-based SARS-CoV-2 vaccination is associated with improved T-cell responses in hematological neoplasia
Health-related quality of life and vulnerability among people with myelodysplastic syndromes: a US national study
A validated composite comorbidity index predicts outcomes of CAR T-cell therapy in patients with diffuse large B-cell lymphoma
Momelotinib long-term safety and survival in myelofibrosis: integrated analysis of phase 3 randomized controlled trials
Molecular associations of response to the new-generation BTK inhibitor zanubrutinib in marginal zone lymphoma
Candidate germline biomarkers of lenalidomide efficacy in mantle cell lymphoma: the Fondazione Italiana Linfomi MCL0208 trial
Use of statins and risk of myeloproliferative neoplasms: a Danish nationwide case-control study
Impact of type of induction therapy on outcomes in older adults with AML after allogeneic stem cell transplantation
Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms
Assessment of acute myeloid leukemia molecular measurable residual disease testing in an interlaboratory study
Prospective geriatric assessment and geriatric consultation in CAR T-cell therapy for older patients with lymphoma
Real-world experience of combined treatment with azacitidine and romidepsin in patients with peripheral T-cell lymphoma
Issue Archive
July 25 2023
In this Issue
Table of Contents
INSIDE BLOOD ADVANCES
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
Vector-based SARS-CoV-2 vaccination is associated with improved T-cell responses in hematological neoplasia
Clinical Trials & Observations
Robby Engelmann,Nadja Jaekel,Sabrina Jotschke,Beatrice Ludwig-Kraus,Frank Bernhard Kraus,Neha Kumari,Susann Schulze,Michael Hecker,Christina Zahn,Haifa Kathrin Al-Ali,Christian Junghanss,Sebastian Böttcher
Health-related quality of life and vulnerability among people with myelodysplastic syndromes: a US national study
Clinical Trials & Observations
Gregory A. Abel,Donnie Hebert,Cecilia Lee,Dana Rollison,Nancy Gillis,Rami Komrokji,James M. Foran,Jane Jijun Liu,Tareq Al Baghdadi,Joachim Deeg,Steven Gore,Wael Saber,Steffanie Wilson,Michael Otterstatter,Jason Thompson,Christine Borchert,Eric Padron,Amy DeZern,David Cella,Mikkael A. Sekeres
A validated composite comorbidity index predicts outcomes of CAR T-cell therapy in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations
Geoffrey Shouse,Andy Kaempf,Max J. Gordon,Andy Artz,David Yashar,Audrey M. Sigmund,Gordon Smilnak,Steven M. Bair,Agrima Mian,Lindsey A. Fitzgerald,Amneet Bajwa,Samantha Jaglowski,Neil Bailey,Mazyar Shadman,Krish Patel,Deborah M. Stephens,Manali Kamdar,Brian T. Hill,Jordan Gauthier,Reem Karmali,Loretta J. Nastoupil,Adam S. Kittai,Alexey V. Danilov
Momelotinib long-term safety and survival in myelofibrosis: integrated analysis of phase 3 randomized controlled trials
Clinical Trials & Observations
Srdan Verstovsek,Ruben Mesa,Vikas Gupta,David Lavie,Viviane Dubruille,Nathalie Cambier,Uwe Platzbecker,Marek Hus,Blanca Xicoy,Stephen T. Oh,Jean-Jacques Kiladjian,Alessandro M. Vannucchi,Aaron Gerds,Miklos Egyed,Jiří Mayer,Tomasz Sacha,Jun Kawashima,Marc Morris,Mei Huang,Claire Harrison
GENE THERAPY
HEALTH SERVICES AND OUTCOMES
HEMATOPOIESIS AND STEM CELLS
Physioxia improves the selectivity of hematopoietic stem cell expansion cultures
Kyomi J. Igarashi,Iwo Kucinski,Yan Yi Chan,Tze-Kai Tan,Hwei Minn Khoo,David Kealy,Joydeep Bhadury,Ian Hsu,Pui Yan Ho,Kouta Niizuma,John W. Hickey,Garry P. Nolan,Katherine S. Bridge,Agnieszka Czechowicz,Berthold Gottgens,Hiromitsu Nakauchi,Adam C. Wilkinson
IMMUNOBIOLOGY AND IMMUNOTHERAPY
Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma
Keisuke Watanabe,Angela M. Gomez,Shunichiro Kuramitsu,Mikko Siurala,Tong Da,Sangya Agarwal,Decheng Song,John Scholler,Antonia Rotolo,Avery D. Posey, Jr.,Alain H. Rook,Paul L. Haun,Marco Ruella,Regina M. Young,Carl H. June
LYMPHOID NEOPLASIA
Molecular associations of response to the new-generation BTK inhibitor zanubrutinib in marginal zone lymphoma
Clinical Trials & Observations
Maciej Tatarczuch,Mark Waltham,Jake Shortt,Galina Polekhina,Eliza A. Hawkes,Shir-Jing Ho,Judith Trotman,Daniella Brasacchio,Melannie Co,Jessica Li,Vanitha Ramakrishnan,Karin Dunne,Stephen S. Opat,Gareth P. Gregory,on behalf of the Australasian Leukaemia and Lymphoma Group
Unraveling the genetics of transformed splenic marginal zone lymphoma
Marta Grau,Cristina López,Alba Navarro,Gerard Frigola,Ferran Nadeu,Guillem Clot,Gabriela Bastidas-Mora,Miguel Alcoceba,Maria Joao Baptista,Margarita Blanes,Dolors Colomer,Dolors Costa,Eva Domingo-Domènech,Anna Enjuanes,Lourdes Escoda,Pilar Forcada,Eva Giné,Mónica Lopez-Guerra,Olga Ramón,Alfredo Rivas-Delgado,Laura Vicente Folch,Andrew Wotherspoon,Fina Climent,Elias Campo,Armando López-Guillermo,Estella Matutes,Sílvia Beà
Candidate germline biomarkers of lenalidomide efficacy in mantle cell lymphoma: the Fondazione Italiana Linfomi MCL0208 trial
Clinical Trials & Observations
Simone Ferrero,Daniele Grimaldi,Elena Arrigoni,Mariapia Pironti,Gian Maria Zaccaria,Beatrice Alessandria,Elisa Genuardi,Gabriele De Luca,Marco Ghislieri,Rita Tavarozzi,Alice Di Rocco,Alessandro Re,Vittorio Stefoni,Federica Cavallo,Carola Boccomini,Monica Balzarotti,Vittorio Zilioli,Filipa Moita,Luca Arcaini,Elisa Lucchini,Filippo Ballerini,Andrés J. M. Ferreri,Benedetta Puccini,Giuseppe A. Palumbo,Sara Galimberti,Sergio Cortelazzo,Antonello Di Paolo,Marco Ladetto
MYELOID NEOPLASIA
Use of statins and risk of myeloproliferative neoplasms: a Danish nationwide case-control study
Clinical Trials & Observations
Daniel Tuyet Kristensen,Andreas Kisbye Øvlisen,Lasse Hjort Kyneb Jakobsen,Marianne Tang Severinsen,Louise Hur Hannig,Jørn Starklint,Morten Hagemann Hilsøe,Anders Pommer Vallentin,Mette Brabrand,Hans Carl Hasselbalch,Tarec Christoffer El-Galaly,Anne Stidsholt Roug
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma
Steven Findlay,Remya Nair,Ronald A. Merrill,Zafir Kaiser,Alexandre Cajelot,Zahra Aryanpour,John Heath,Catherine St-Louis,David Papadopoli,Ivan Topisirovic,Julie St-Pierre,Michael Sebag,Aparna H. Kesarwala,Laura Hulea,Eric B. Taylor,Mala Shanmugam,Alexandre Orthwein
Impact of type of induction therapy on outcomes in older adults with AML after allogeneic stem cell transplantation
Clinical Trials & Observations
Nicholas J. Short,Faustine Ong,Farhad Ravandi,Graciela Nogueras-Gonzalez,Tapan M. Kadia,Naval Daver,Courtney D. DiNardo,Marina Konopleva,Gautam Borthakur,Betul Oran,Gheath Al-Atrash,Rohtesh Mehta,Elias J. Jabbour,Musa Yilmaz,Ghayas C Issa,Abhishek Maiti,Richard E Champlin,Hagop Kantarjian,Elizabeth J Shpall,Uday Popat
Human acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function
Yoshikane Kikushige,Toshihiro Miyamoto,Yu Kochi,Yuichiro Semba,Maki Ohishi,Hidetoshi Irifune,Kiwamu Hatakeyama,Yuya Kunisaki,Takeshi Sugio,Teppei Sakoda,Kohta Miyawaki,Koji Kato,Tomoyoshi Soga,Koichi Akashi
Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms
Clinical Trials & Observations
Yasuhito Nannya,Magnus Tobiasson,Shinya Sato,Elsa Bernard,Shigeki Ohtake,June Takeda,Maria Creignou,Lanying Zhao,Manabu Kusakabe,Yuhei Shibata,Nobuhiko Nakamura,Mizuki Watanabe,Nobuhiro Hiramoto,Yusuke Shiozawa,Yuichi Shiraishi,Hiroko Tanaka,Kenichi Yoshida,Nobuyuki Kakiuchi,Hideki Makishima,Masahiro Nakagawa,Kensuke Usuki,Mitsumasa Watanabe,Kazunori Imada,Hiroshi Handa,Masataka Taguchi,Toru Kiguchi,Kazuma Ohyashiki,Takayuki Ishikawa,Akifumi Takaori-Kondo,Hisashi Tsurumi,Senji Kasahara,Shigeru Chiba,Tomoki Naoe,Satoru Miyano,Elli Papaemanuil,Yasushi Miyazaki,Eva Hellström-Lindberg,Seishi Ogawa
Posttransplant MRD and T-cell chimerism status predict outcomes in patients who received allografts for AML/MDS
Justin Loke,Nicholas McCarthy,Aimee Jackson,Shamyla Siddique,Andrea Hodgkinson,John Mason,Charles Crawley,Maria Gilleece,Andrew Peniket,Rachel Protheroe,Rahuman Salim,Eleni Tholouli,Keith Wilson,Georgia Andrew,Richard Dillon,Naeem Khan,Victoria Potter,Pramila Krishnamurthy,Charles Craddock,Sylvie Freeman
Assessment of acute myeloid leukemia molecular measurable residual disease testing in an interlaboratory study
Clinical Trials & Observations
Stuart Scott,Richard Dillon,Christian Thiede,Sadia Sadiq,Ashley Cartwright,Hazel J. Clouston,Debbie Travis,Katya Mokretar,Nicola Potter,Andrew Chantry,Liam Whitby
Utility of targeted gene sequencing to differentiate myeloid malignancies from other cytopenic conditions
Amy E. DeZern,Johannes B. Goll,R. Coleman Lindsley,Rafael Bejar,Steffanie H. Wilson,Donnie Hebert,Joachim Deeg,Ling Zhang,Steven Gore,Tareq Al Baghdadi,Jaroslaw Maciejewski,Jane Liu,Eric Padron,Rami Komrojki,Wael Saber,Gregory Abel,Steven H. Kroft,Alexandra Harrington,Tyler Grimes,Harrison Reed,Robert S. Fulton,Nancy L. DiFronzo,Nancy Gillis,Mikkael A. Sekeres,Matthew J. Walter
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts
Ji Wu,Kenta Moriwaki,Tatsuya Asuka,Ritsuko Nakai,Satoshi Kanda,Manabu Taniguchi,Tatsuki Sugiyama,Shin-ichiro Yoshimura,Masataka Kunii,Takashi Nagasawa,Naoki Hosen,Eiji Miyoshi,Akihiro Harada
TRANSPLANTATION
Selected memory T cells infused post–haploidentical hematopoietic stem cell transplantation persist and hyperexpand
Jasper J. P. van Beek,Simone Puccio,Clara Di Vito,Federica De Paoli,Elisa Zaghi,Michela Calvi,Alice Scarpa,Clelia Peano,Gianluca Basso,Javier Cibella,Chiara De Philippis,Barbara Sarina,Inna Timofeeva,Rossana Capizzuto,Daniele Mannina,Rossana Mineri,Jacopo Mariotti,Roberto Crocchiolo,Armando Santoro,Luca Castagna,Stefania Bramanti,Domenico Mavilio,Enrico Lugli
PTCy, abatacept, and a short course of tacrolimus for GVHD prevention after haploidentical transplantation
A. Samer Al-Homsi,Frank Cirrone,Stephanie Wo,Kelli Cole,J. Andres Suarez-Londono,Sharon L. Gardner,Jingmei Hsu,Kelsey Stocker,Benedetto Bruno,Judith D. Goldberg,Benjamin A. Levinson,Maher Abdul-Hay
A diagnostic classifier for pediatric chronic graft-versus-host disease: results of the ABLE/PBMTC 1202 study
Geoffrey D. E. Cuvelier,Bernard Ng,Sayeh Abdossamadi,Eneida R. Nemecek,Alexis Melton,Carrie L. Kitko,Victor A. Lewis,Tal Schechter,David A. Jacobsohn,Andrew C. Harris,Michael A. Pulsipher,Henrique Bittencourt,Sung Won Choi,Emi H. Caywood,Kimberly A. Kasow,Monica Bhatia,Benjamin R. Oshrine,Sonali Chaudhury,Donald Coulter,Joseph H. Chewning,Michael Joyce,Süreyya Savaşan,Anna B. Pawlowska,Gail C. Megason,David Mitchell,Alexandra C. Cheerva,Anita Lawitschka,Elena Ostroumov,Kirk R. Schultz
Alemtuzumab and CXCL9 levels predict likelihood of sustained engraftment after reduced-intensity conditioning HCT
Ashley V. Geerlinks,Brooks Scull,Christa Krupski,Ryan Fleischmann,Michael A. Pulsipher,Mary Eapen,James A. Connelly,Catherine M. Bollard,Sung-Yun Pai,Christine N. Duncan,Leslie S. Kean,K. Scott Baker,Lauri M. Burroughs,Jeffrey R. Andolina,Shalini Shenoy,Philip Roehrs,Rabi Hanna,Julie-An Talano,Kirk R. Schultz,Elizabeth O. Stenger,Howard Lin,Adi Zoref-Lorenz,Kenneth L. McClain,Michael B. Jordan,Tsz-Kwong Man,Carl E. Allen,Rebecca A. Marsh
RESEARCH LETTERS
Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma
Elisa Gelli,Debora Soncini,Pamela Becherini,Claudia Martinuzzi,Katia Todoerti,Antonia Cagnetta,Sara Aquino,Fabio Guolo,Maurizio Miglino,Santina Bruzzone,Alessio Nencioni,Antonino Neri,Roberto M. Lemoli,Michele Cea
Prospective geriatric assessment and geriatric consultation in CAR T-cell therapy for older patients with lymphoma
Clinical Trials & Observations
Richard J. Lin,Soo Jung Kim,Samantha Brown,Theresa A. Elko,Josel D. Ruiz,Danielle M. Hanley,M. Lia Palomba,Miguel-Angel Perales,Gunjan L. Shah,Parastoo B. Dahi,Michael Scordo,Craig S. Sauter,Connie L. Batlevi,Ana Alarcon Tomas,Roni Shouval,Nicole Lee,Emma A. Pavkovic,Danielle E. Engstler,Jae H. Park,Gilles A. Salles,Sean M. Devlin,Beatriz Korc-Grodzicki,Paul A. Hamlin,Sergio A. Giralt
Preclinical evaluation of anti-CD38 therapy in mature T-cell neoplasms
Colleen Isabelle,William T. Johnson,Kathleen McConnell,Ashley Vogel,Jonathan E. Brammer,Amy Boles,Robyn Keller,Paola Sindaco,Liam Nisenfeld,Guldeep Uppal,Neda Nikbakht,Bruno Calabretta,Patrizia Porazzi,Jerald Gong,Nitin Chakravarti,Pierluigi Porcu,Anjali Mishra
Prospective evaluation of lymphoma response to immunomodulatory therapy criteria in GATA trial from the LYSA group
Yassine Al Tabaa,Rene Oliver Casasnovas,Clio Baillet,Emmanuel Bachy,Emmanuelle Nicolas-Virelizier,Jean Marc Schiano De colella,Clement Bailly,Salim Kanoun,Stéphanie Guidez,Emmanuel Gyan,Remy Gressin,Nadine Morineau,Loic Ysebaert,Steven Le Gouill,Herve Tilly,Roch Houot,F. Morschhauser,Guillaume Cartron,Charles Herbaux
Real-world experience of combined treatment with azacitidine and romidepsin in patients with peripheral T-cell lymphoma
Clinical Trials & Observations
Matko Kalac,Salvia Jain,Constantine S. Tam,Zhengrui Xiao,Francesca Montanari,Jennifer Kanakry,Bryan D. Huber,Mendel Goldfinger,Owen A. O’Connor,Enrica Marchi
COMMENTARIES
ERRATA
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Cover Image
Cover Image
Immunofluorescence staining of the mitochondrial marker COXIV (green) and 4′,6-diamidino-2-phenylindole (blue) in hindlimb muscles from E18.5 embryos are shown. Deletion of EHBP1L1 causes centronuclear myopathy–like alterations in mouse skeletal muscles, manifested as increased abnormal central positioning of nuclei and mitochondria. See the article by Wu et al.
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