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Impact of diagnosis to treatment interval in patients with newly diagnosed mantle cell lymphoma
Targeted therapy with the mutant IDH2 inhibitor enasidenib for high-risk IDH2-mutant myelodysplastic syndrome
CD19 CAR T cells are an effective therapy for posttransplant relapse in patients with B-lineage ALL: real-world data from Germany
Polatuzumab vedotin with infusional chemotherapy for untreated aggressive B-cell non-Hodgkin lymphomas
Pegcetacoplan controls hemolysis in complement inhibitor–naive patients with paroxysmal nocturnal hemoglobinuria
Comparison of the effectiveness and safety of direct oral anticoagulants: a nationwide propensity score–weighted study
Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post–CD19-directed CAR T-cell therapy: an EPICOVIDEHA survey
Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates
Lower incidence of chronic GVHD observed after transplantation with cryopreserved unrelated allogeneic stem cells
Low neutralizing activity of AZD7442 against current SARS-CoV-2 Omicron variants in patients with B-cell malignancies
Severe autoimmune intravascular hemolytic anemia in patients receiving alemtuzumab for multiple sclerosis
Issue Archive
June 13 2023
In this Issue
Table of Contents
INSIDE BLOOD ADVANCES
STIMULUS REPORT
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
Impact of diagnosis to treatment interval in patients with newly diagnosed mantle cell lymphoma
Clinical Trials & Observations
Narendranath Epperla,Jeffrey Switchenko,Veronika Bachanova,James N. Gerson,Stefan K. Barta,Max J. Gordon,Alexey V. Danilov,Natalie S. Grover,Stephanie Mathews,Madelyn Burkart,Reem Karmali,Yazeed Sawalha,Brian T. Hill,Nilanjan Ghosh,Steven I. Park,David A. Bond,Mehdi Hamadani,Timothy S. Fenske,Peter Martin,Mary-Kate Malecek,Brad S. Kahl,Christopher R. Flowers,Brian K. Link,Lawrence D. Kaplan,David J. Inwards,Andrew L. Feldman,Eric D. Hsi,Kami Maddocks,Kristie A. Blum,Nancy L. Bartlett,James R. Cerhan,John P. Leonard,Thomas M. Habermann,Matthew J. Maurer,Jonathon B. Cohen
Targeted therapy with the mutant IDH2 inhibitor enasidenib for high-risk IDH2-mutant myelodysplastic syndrome
Clinical Trials & Observations
Courtney D. DiNardo,Sangeetha Venugopal,Curtis Lachowiez,Koichi Takahashi,Sanam Loghavi,Guillermo Montalban-Bravo,Xuemei Wang,Hetty Carraway,Mikkael Sekeres,Ameenah Sukkur,Danielle Hammond,Kelly Chien,Abhishek Maiti,Lucia Masarova,Koji Sasaki,Yesid Alvarado,Tapan Kadia,Nicholas J. Short,Naval Daver,Gautam Borthakur,Farhad Ravandi,Hagop M. Kantarjian,Bhumika Patel,Amy Dezern,Gail Roboz,Guillermo Garcia-Manero
CD19 CAR T cells are an effective therapy for posttransplant relapse in patients with B-lineage ALL: real-world data from Germany
Clinical Trials & Observations
Peter Bader,Claudia Rossig,Martin Hutter,Francis Ayuketang Ayuk,Claudia D. Baldus,Veit L. Bücklein,Halvard Bonig,Gunnar Cario,Hermann Einsele,Udo Holtick,Christian Koenecke,Shahrzad Bakhtiar,Annette Künkele,Roland Meisel,Fabian Müller,Ingo Müller,Olaf Penack,Eva Rettinger,Martin G. Sauer,Paul-Gerhardt Schlegel,Jan Soerensen,Arend von Stackelberg,Brigitte Strahm,Julia Hauer,Tobias Feuchtinger,Andrea Jarisch
Polatuzumab vedotin with infusional chemotherapy for untreated aggressive B-cell non-Hodgkin lymphomas
Clinical Trials & Observations
Ryan C. Lynch,Christina Poh,Chaitra S. Ujjani,Edus H. Warren, III,Stephen D. Smith,Mazyar Shadman,Karolyn Morris,Sydney Lee,Heather Rasmussen,Susan Ottemiller,Megan Shelby,Sarith Keo,Kaitlin Verni,David M. Kurtz,Ash A. Alizadeh,Jacob J. Chabon,Gregory J. Hogan,Andre Schulz,Ted Gooley,Jenna M. Voutsinas,Ajay K. Gopal
Pegcetacoplan controls hemolysis in complement inhibitor–naive patients with paroxysmal nocturnal hemoglobinuria
Clinical Trials & Observations
Raymond Siu Ming Wong,Juan Ramon Navarro-Cabrera,Narcisa Sonia Comia,Yeow Tee Goh,Henry Idrobo,Daolada Kongkabpan,David Gómez-Almaguer,Mohammed Al-Adhami,Temitayo Ajayi,Paulo Alvarenga,Jessica Savage,Pascal Deschatelets,Cedric Francois,Federico Grossi,Teresita Dumagay
Comparison of the effectiveness and safety of direct oral anticoagulants: a nationwide propensity score–weighted study
Clinical Trials & Observations
Arnar B. Ingason,Johann P. Hreinsson,Arnar S. Agustsson,Sigrun H. Lund,Edward Rumba,Daniel A. Palsson,Indridi E. Reynisson,Brynja R. Gudmundsdottir,Pall T. Onundarson,Einar S. Bjornsson
Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post–CD19-directed CAR T-cell therapy: an EPICOVIDEHA survey
Clinical Trials & Observations
Jaap A. van Doesum,Jon Salmanton-García,Francesco Marchesi,Roberta Di Blasi,Iker Falces-Romero,Alba Cabirta,Francesca Farina,Caroline Besson,Barbora Weinbergerová,Jens Van Praet,Martin Schönlein,Alberto López-García,Sylvain Lamure,Anna Guidetti,Cristina De Ramón-Sánchez,Josip Batinić,Eleni Gavriilaki,Athanasios Tragiannidis,Maria Chiara Tisi,Gaëtan Plantefeve,Verena Petzer,Irati Ormazabal-Vélez,Joyce Marques de Almeida,Monia Marchetti,Johan Maertens,Marina Machado,Austin Kulasekararaj,José-Ángel Hernández-Rivas,Maria Gomes da Silva,Noemí Fernández,Ildefonso Espigado,Ľuboš Drgoňa,Giulia Dragonetti,Elisabetta Metafuni,Maria Calbacho,Ola Blennow,Dominik Wolf,Bjorn van Anrooij,Raquel Nunes Rodrigues,Anna Nordlander,Juan-Alberto Martín-González,Raphaël Liévin,Moraima Jiménez,Stefanie K. Gräfe,Ramón García-Sanz,Raúl Córdoba,Laman Rahimli,Tom van Meerten,Oliver A. Cornely,Livio Pagano
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
Dasatinib-induced spleen contraction leads to transient lymphocytosis
Ana Marcos-Jiménez,Daniela Claudino Carvoeiro,Nora Ruef,Carlos Cuesta-Mateos,Emilia Roy-Vallejo,Valle Gómez-García de Soria,Claudio Laganá,Lourdes del Campo,Pablo Zubiaur,Gonzalo Villapalos-García,Francisco Abad-Santos,Jens V. Stein,Cecilia Muñoz-Calleja
A novel polymer-conjugated human IL-15 improves efficacy of CD19-targeted CAR T-cell immunotherapy
Alexandre V. Hirayama,Cassie K. Chou,Takahiro Miyazaki,Rachel N. Steinmetz,Henna A. Di,Simon P. Fraessle,Jordan Gauthier,Salvatore Fiorenza,Reed M. Hawkins,Willem W. Overwijk,Stanley R. Riddell,Mario Q. Marcondes,Cameron J. Turtle
MYELOID NEOPLASIA
SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia
Richard J. Marrero,Xueyuan Cao,Huiyun Wu,Abdelrahman H. Elsayed,Jeffery M. Klco,Raul C. Ribeiro,Jeffrey E. Rubnitz,Xiaotu Ma,Soheil Meshinchi,Richard Aplenc,E. Anders Kolb,Rhonda E. Ries,Todd A. Alonzo,Stanley B. Pounds,Jatinder K. Lamba
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia
Jonathan D. Clayden,Hanne Stotesbury,Jamie M. Kawadler,April Slee,Melanie Kӧlbel,Dawn E. Saunders,Anna M. Hood,Olu Wilkey,Mark Layton,Baba Inusa,Maria Pelidis,Subarna Chakravorty,David C. Rees,Jo Howard,Moji Awogbade,Christina Liossi,Fenella J. Kirkham,Chris A. Clark
THROMBOSIS AND HEMOSTASIS
Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as a therapeutic target in COVID-19
Lukas J. Weiss,Maria Drayss,Georgi Manukjan,Maximilian Zeitlhöfler,Judith Kleiss,Mathis Weigel,Johannes Herrmann,Kristina Mott,Sarah Beck,Philipp Burkard,Thiên-Trí Lâm,Karina Althaus,Tamam Bakchoul,Stefan Frantz,Patrick Meybohm,Bernhard Nieswandt,Dirk Weismann,Harald Schulze
Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer
Chantal Kroone,Chris Tieken,Begüm Kocatürk,Madelon Paauwe,Erik J. Blok,Betül Ünlü,Yascha W. van den Berg,Eliana Stanganello,Maaike Y. Kapteijn,Nathalie Swier,Xi Zhang,Danique E. M. Duits,Yazhi Lin,Lisa V. E. Oostenbrink,Rob F. P. van den Akker,Laurent O. Mosnier,Lukas J. Hawinkels,Bart J. M. van Vlijmen,Wolfram Ruf,Peter J. Kuppen,Suzanne C. Cannegieter,Jeroen T. Buijs,Henri H. Versteeg
TRANSFUSION MEDICINE
TRANSPLANTATION
RESEARCH LETTERS
Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates
Clinical Trials & Observations
Antoine N. Saliba,Scott H. Kaufmann,Eytan M. Stein,Prapti A. Patel,Maria R. Baer,Wendy Stock,Michael Deininger,William Blum,Gary J. Schiller,Rebecca L. Olin,Mark R. Litzow,Tara L. Lin,Brian J. Ball,Michael M. Boyiadzis,Elie Traer,Olatoyosi Odenike,Martha L. Arellano,Alison Walker,Vu H. Duong,Tibor Kovacsovics,Robert H. Collins,Abigail B. Shoben,Nyla A. Heerema,Matthew C. Foster,Kevin L. Peterson,Paula A. Schneider,Molly Martycz,Theophilus J. Gana,Leonard Rosenberg,Sonja Marcus,Ashley O. Yocum,Timothy Chen,Mona Stefanos,Alice S. Mims,Uma Borate,Amy Burd,Brian J. Druker,Ross L. Levine,John C. Byrd,James M. Foran
Lower incidence of chronic GVHD observed after transplantation with cryopreserved unrelated allogeneic stem cells
Clinical Trials & Observations
Katie Maurer,Haesook T. Kim,Heather M. Garrity,Deborah Liney,Corey Cutler,Joseph H. Antin,John Koreth,Jerome Ritz,Roman M. Shapiro,Rizwan Romee,Vincent T. Ho,Mahasweta Gooptu,Robert J. Soiffer,Catherine J. Wu,Sarah Nikiforow
Low neutralizing activity of AZD7442 against current SARS-CoV-2 Omicron variants in patients with B-cell malignancies
Clinical Trials & Observations
Andres Chang,Jean L. Koff,Lilin Lai,Victor M. Orellana-Noia,Minal Surati,Alyssa M. K. Leal,Madison L. Ellis,Bushra Wali,Alberto Moreno,Susanne L. Linderman,Colin B. O’Leary,Pamela B. Allen,Michael C. Churnetski,Madhav V. Dhodapkar,Mehul S. Suthar,Jonathon B. Cohen,Rafi Ahmed
Severe autoimmune intravascular hemolytic anemia in patients receiving alemtuzumab for multiple sclerosis
Clinical Trials & Observations
Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation
Harry J. Iland,Nigel Russell,Richard Dillon,Andre C. Schuh,Aditya Tedjaseputra,Andrew Wei,Asim Khwaja,Steven Knapper,Steven W. Lane,John Reynolds,Mary Frances McMullin,Annalise Martin,Peter Tan,David C. Taussig,Anny Wong,John Taper,Christina Fraga,Richard Kelly,Kiran Tawana,Priyanka Mehta,Alain Mina,Jessica K. Altman,Ingolf Mølle,Sudhir Tauro,Eleni Tholouli
COMMENTARIES
RESPONSE
ERRATUM
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Cover Image
Cover Image
Top-down view of the brain, highlighting regions showing significant structural connectivity differences between a group of patients with sickle cell anemia and a control group. See the article by Clayden et al.
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On a collision course: SARS-CoV-2 variants and CAR T cells
Clinical Trials & Observations