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Issue Archive

Volume 7, Issue 10
May 23 2023
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Small but mighty: T-replete cords for myeloid disease
Clinical Trials & Observations
James L. LaBelle
View Articletitled, Small but mighty: T-replete cords for myeloid disease

STIMULUS REPORT

Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis
Clinical Trials & Observations
Paul Milne,Simon Bomken,Olga Slater,Ashish Kumar,Adam Nelson,Somak Roy,Jessica Velazquez,Kshitij Mankad,James Nicholson,Dan Yeomanson,Richard Grundy,Ahmed Kamal,Anthony Penn,Jane Pears,Gerard Millen,Bruce Morland,James Hayden,Jason Lam,Maymoon Madkhali,Jamie MacDonald,Preeti Singh,Sarah Pagan,Carlos Rodriguez-Galindo,Milen Minkov,Jean Donadieu,Jennifer Picarsic,Carl Allen,Venetia Bigley,Matthew Collin
View Articletitled, Lineage switching of the cellular distribution of <em>BRAF</em><sup><em>V600E</em></sup> in multisystem Langerhans cell histiocytosis
Supplemental data

REVIEW ARTICLE

Applying CRISPR-Cas9 screens to dissect hematological malignancies
Deepak Narayanan Iyer,Aaron D. Schimmer,Hong Chang
View Articletitled, Applying CRISPR-Cas9 screens to dissect hematological malignancies
Supplemental data

SYSTEMATIC REVIEW

Adding caplacizumab to standard of care in thrombotic thrombocytopenic purpura: a systematic review and meta-analysis
Mia Djulbegovic,Jiayi Tong,Alice Xu,Joanna Yang,Yong Chen,Adam Cuker,Allyson M. Pishko
View Articletitled, Adding caplacizumab to standard of care in thrombotic thrombocytopenic purpura: a systematic review and meta-analysis
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL
Clinical Trials & Observations
Nitin Jain,Jayastu Senapati,Beenu Thakral,Alessandra Ferrajoli,Philip Thompson,Jan Burger,Sreyashi Basu,Tapan Kadia,Naval Daver,Gautam Borthakur,Marina Konopleva,Naveen Pemmaraju,Erin Parry,Catherine J. Wu,Joseph Khoury,Carlos Bueso-Ramos,Naveen Garg,Xuemei Wang,Wanda Lopez,Ana Ayala,Susan O’Brien,Hagop Kantarjian,Michael Keating,James Allison,Padmanee Sharma,William Wierda
View Articletitled, A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL
Supplemental data
Clinical impact of ibrutinib plus R-CHOP in untreated DLBCL coexpressing BCL2 and MYC in the phase 3 PHOENIX trial
Clinical Trials & Observations
Peter W. M. Johnson,Sriram Balasubramanian,Brendan Hodkinson,S. Martin Shreeve,Steven Sun,Srimathi Srinivasan,Andrew J. Steele,Jessica Vermeulen,Laurie H. Sehn,Wyndham H. Wilson
View Articletitled, Clinical impact of ibrutinib plus R-CHOP in untreated DLBCL coexpressing BCL2 and MYC in the phase 3 PHOENIX trial
Supplemental data

HEALTH SERVICES AND OUTCOMES

What do patients think about palliative care? A national survey of hematopoietic stem cell transplant recipients
Anna Barata,Hannah R. Abrams,Christa Meyer,Lih-Wen Mau,Deborah Mattila,Linda J. Burns,Christina Ullrich,Hemant Murthy,William A. Wood,Effie Petersdorf,Thomas W. LeBlanc,Areej El-Jawahri
View Articletitled, What do patients think about palliative care? A national survey of hematopoietic stem cell transplant recipients
Outcomes before and after providing interdisciplinary hematology and pulmonary care for children with sickle cell disease
Clinical Trials & Observations
Rachel N. Zeno,Joseph Stanek,Courtney Pugh,Michelle Gillespie,Benjamin T. Kopp,Susan Creary
View Articletitled, Outcomes before and after providing interdisciplinary hematology and pulmonary care for children with sickle cell disease
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition
Cansu Koyunlar,Emanuele Gioacchino,Disha Vadgama,Hans de Looper,Joke Zink,Mariette N. D. ter Borg,Remco Hoogenboezem,Marije Havermans,Mathijs A. Sanders,Eric Bindels,Elaine Dzierzak,Ivo P. Touw,Emma de Pater
View Articletitled, <em>Gata2</em>-regulated <em>Gfi1b</em> expression controls endothelial programming during endothelial-to-hematopoietic transition
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Outcomes following posttransplant virus-specific T-cell therapy in patients with sickle cell disease
Clinical Trials & Observations
Hannah Kinoshita,Mamatha Mandava,Mariah Jensen-Wachspress,Haili Lang,Elisabeth Joy,Jay Tanna,Chase D. McCann,Samuel O’Brien,Sianna Burnett,Abeer Shibli,Fahmida Hoq,Monica Bhatia,Patrick J. Hanley,Blachy Dávila Saldaña,Kris M. Mahadeo,Catherine M. Bollard,Michael D. Keller,Allistair Abraham
View Articletitled, Outcomes following posttransplant virus-specific T-cell therapy in patients with sickle cell disease
Supplemental data
Analysis of immune responses in patients with CLL after heterologous COVID-19 vaccination
Hye Kyung Lee,Manuela A. Hoechstetter,Maike Buchner,Trang Thu Pham,Jin Won Huh,Katharina Müller,Sabine Zange,Heiner von Buttlar,Philipp Girl,Roman Wölfel,Lisa Brandmeier,Lisa Pfeuffer,Priscilla A. Furth,Clemens-Martin Wendtner,Lothar Hennighausen
View Articletitled, Analysis of immune responses in patients with CLL after heterologous COVID-19 vaccination
Supplemental data

LYMPHOID NEOPLASIA

Therapy selection for Hodgkin lymphoma in sickle cell disease: balancing risks and benefits
Claire E. Fraley,Christopher McKinney,Rachelle Nuss,Anna R. K. Franklin
View Articletitled, Therapy selection for Hodgkin lymphoma in sickle cell disease: balancing risks and benefits

MYELOID NEOPLASIA

TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia
Teppei Sakoda,Yoshikane Kikushige,Toshihiro Miyamoto,Hidetoshi Irifune,Takuya Harada,Kiwamu Hatakeyama,Yuya Kunisaki,Koji Kato,Koichi Akashi
View Articletitled, TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Membrane bending and sphingomyelinase-associated, sulfatide-dependent hypoxic adhesion of sickle mature erythrocytes
Utku Goreke,Erdem Kucukal,Fang Wang,Ran An,Nicole Arnold,Erina Quinn,Charlotte Yuan,Allison Bode,Ailis Hill,Yuncheng Man,Bryan C. Hambley,Robert Schilz,Mahazarin Ginwalla,Jane A. Little,Umut A. Gurkan
View Articletitled, Membrane bending and sphingomyelinase-associated, sulfatide-dependent hypoxic adhesion of sickle mature erythrocytes
Supplemental data

THROMBOSIS AND HEMOSTASIS

Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice
Steven P. Grover,Vanthana Bharathi,Jens J. Posma,John H. Griffin,Joseph S. Palumbo,Nigel Mackman,Silvio Antoniak
View Articletitled, Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice
Obstetric and perioperative management of patients with factor XI deficiency: a retrospective observational study
Shivani Handa,Michelle Sterpi,Guilherme Sacchi De Camargo Correia,David S. Frankel,Yaakov Beilin,Lawrence Cytryn,Katherine Hawkins,Etta Frankel
View Articletitled, Obstetric and perioperative management of patients with factor XI deficiency: a retrospective observational study
Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study
Nils Skajaa,Jan P. Vandenbroucke,Claus Ziegler Simonsen,Henrik Toft Sørensen,Kasper Adelborg
View Articletitled, Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study
Supplemental data
Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
Diego Butera,Haoqing Jerry Wang,Heng-Giap Woon,Yunduo Charles Zhao,Lining Arnold Ju,Philip J. Hogg
View Articletitled, Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
Supplemental data
INR and vitamin K–dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma
Clinical Trials & Observations
Christopher Hood,Joshua N. Goldstein,Truman J. Milling,Majed A. Refaai,Paolo Bajcic,Brahm Goldstein,Ravi Sarode
View Articletitled, INR and vitamin K–dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma
Supplemental data
Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state
Shuang Li,Jie Sun,Shixuan Liu,Fengbo Zhou,Michael L. Gross,Weikai Li
View Articletitled, Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state
Supplemental data

TRANSPLANTATION

Outcomes of subsequent neoplasms after umbilical cord blood transplantation in Europe
Hanadi Rafii,Annalisa Ruggeri,Chantal Kenzey,Jaime Sanz,Régis Peffault De La Tour,Albert Esquirol,Gérard Michel,Patrice Chevallier,Marie-Thérèse Rubio,Jan J. Cornelissen,Mauricette Michallet,Fernanda Volt,Monica M. Rivera-Franco,Graziana Maria Scigliuolo,Barbara Cappelli,Vanderson Rocha,Eliane Gluckman
View Articletitled, Outcomes of subsequent neoplasms after umbilical cord blood transplantation in Europe
Incidence, risk factors, and impact of early cardiac toxicity after allogeneic hematopoietic cell transplant
Amanda Isabel Pérez-Valencia,Enric Cascos,Sara Carbonell-Ordeig,Paola Charry,Marta Gómez-Hernando,Luis Gerardo Rodríguez-Lobato,María Suárez-Lledó,Nuria Martínez-Cibrian,María Gabriela Antelo,María Teresa Solano,Jordi Arcarons,Meritxell Nomdedeu,Joan Cid,Miquel Lozano,Maribel Díaz-Ricart,Laura Rosiñol,Jordi Esteve,Álvaro Urbano-Ispizua,Enric Carreras,Carmen Martínez,Francesc Fernández-Avilés,Montserrat Rovira,María Queralt Salas
View Articletitled, Incidence, risk factors, and impact of early cardiac toxicity after allogeneic hematopoietic cell transplant
Supplemental data
Comorbidities in transplant recipients with acute myeloid leukemia receiving low-intensity conditioning regimens: an ALWP EBMT study
Joshua A. Fein,Roni Shouval,Jacques-Emmanuel Galimard,Myriam Labopin,Gérard Socié,Jürgen Finke,Jan J. Cornelissen,Ram Malladi,Maija Itälä-Remes,Patrice Chevallier,Kim H. Orchard,Donald Bunjes,Mahmoud Aljurf,Marie Thérèse Rubio,Jurjen Versluis,Mohamad Mohty,Arnon Nagler
View Articletitled, Comorbidities in transplant recipients with acute myeloid leukemia receiving low-intensity conditioning regimens: an ALWP EBMT study
Supplemental data
T-cell replete cord transplants give superior outcomes in high-risk and relapsed/refractory pediatric myeloid malignancy
Claire Horgan,Khushnuma Mullanfiroze,Archana Rauthan,Katharine Patrick,Naeem Akram Butt,Oana Mirci-Danicar,Olya O’Connor,Caroline Furness,Akshay Deshpande,Sarah Lawson,Valerie Broderick,Pamela Evans,Brenda Gibson,Wing Roberts,Salah Ali,Sevasti Galani,Amy A. Kirkwood,Jelena Jovanovic,Richard Dillon,Paul Virgo,Beki James,Kanchan Rao,Persis J. Amrolia,Robert F. Wynn
View Articletitled, T-cell replete cord transplants give superior outcomes in high-risk and relapsed/refractory pediatric myeloid malignancy
Small but mighty: T-replete cords for myeloid disease
Clinical Trials & Observations
James L. LaBelle
View Articletitled, Small but mighty: T-replete cords for myeloid disease
Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease
Pradeep Shrestha,Ali Turan,Lalit Batra,Ayse Ece Gulen,Zhengda Sun,Helen Tan,Nadir Askenasy,Haval Shirwan,Esma S. Yolcu
View Articletitled, Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease
Supplemental data
Abatacept GVHD prophylaxis in unrelated hematopoietic cell transplantation for pediatric bone marrow failure
Clinical Trials & Observations
Elizabeth O. Stenger,Benjamin Watkins,Kelsey Rogowski,Kuang-Yueh Chiang,Ann Haight,Kathryn Leung,Muna Qayed,Sharmila Raghunandan,Yvonne Suessmuth,Leslie Kean,John Horan
View Articletitled, Abatacept GVHD prophylaxis in unrelated hematopoietic cell transplantation for pediatric bone marrow failure
Supplemental data

RESEARCH LETTERS

Third-dose SARS-CoV-2 mRNA vaccine increases Omicron variant neutralization in patients with chronic myeloid disorders
Patrick Harrington,Ashwini Kurshan,Marc Delord,Thomas Lechmere,Amna Sheikh,Jamie Saunders,Chandan Saha,Richard Dillon,Claire Woodley,Susan Asirvatham,Natalia Curto-Garcia,Jennifer O’ Sullivan,Shahram Kordasti,Deepti Radia,Donal McLornan,Michael H. Malim,Claire Harrison,Katie J. Doores,Hugues de Lavallade
View Articletitled, Third-dose SARS-CoV-2 mRNA vaccine increases Omicron variant neutralization in patients with chronic myeloid disorders
Supplemental data
Sustained hematologic remission after discontinuation of sutimlimab treatment in patients with cold agglutinin disease
Clinical Trials & Observations
Georg Gelbenegger,Ulrich Jäger,Michael Fillitz,Christian Schörgenhofer,Christian Sillaber,Bernd Jilma
View Articletitled, Sustained hematologic remission after discontinuation of sutimlimab treatment in patients with cold agglutinin disease
Supplemental data
Gender equity analysis of nontrainee hemostasis and thrombosis recognition award recipients
Jeremy W. Jacobs,Brian D. Adkins,Allison P. Wheeler,Jennifer C. Yui,Garrett S. Booth
View Articletitled, Gender equity analysis of nontrainee hemostasis and thrombosis recognition award recipients
Inaccuracies in assignment of patient race and ethnicity: implications for unrelated donor searches and health care delivery
Warren B. Fingrut,Eric Davis,Stephanie Chinapen,Kristine Naputo,Ioannis Politikos,Andromachi Scaradavou,Juliet N. Barker
View Articletitled, Inaccuracies in assignment of patient race and ethnicity: implications for unrelated donor searches and health care delivery
TET2 truncating mutations predict a worse outcome in blastic plasmacytoid dendritic cell neoplasm
Hannah Beird,C. Cameron Yin,Joseph D. Khoury,Sherry Pierce,Hussein A. Abbas,Li Zhao,Anna Skwarska,Muzaffar Qazilbash,Marina Konopleva,P. Andrew Futreal,Naveen Pemmaraju
View Articletitled, <em>TET2</em> truncating mutations predict a worse outcome in blastic plasmacytoid dendritic cell neoplasm
Supplemental data
Systematic review of outcome reporting in studies of SCD and pregnancy: marked heterogeneity hinders meaningful data synthesis
Eran Ashwal,Nadine Shehata,Kevin H. M. Kuo,Michelle Jiyon Ryu,Richard Ward,Ann Kinga Malinowski
View Articletitled, Systematic review of outcome reporting in studies of SCD and pregnancy: marked heterogeneity hinders meaningful data synthesis
Supplemental data
The transcriptional landscape of human liver endothelial cells
Pablo Toledano-Sanz,Paula Reventun,Maria Viskadourou,William O. Osburn,Nunzio Alcharani,Charles J. Lowenstein,Marios Arvanitis
View Articletitled, The transcriptional landscape of human liver endothelial cells
Supplemental data
Cellular and humoral immune responses to SARS-CoV-2 vaccination in patients after CD19.CAR T-cell therapy
Hannah Reimann,Anita N. Kremer,Viktoria Blumenberg,Katja Schmidt,Michael Aigner,Benedikt Jacobs,Nina Eisenhauer,Alina Kämpf,Wolf Rösler,Soraya Kharboutli,Dimitrios Mougiakakos,Vanessa Lang,Christopher Lischer,Pascal Irrgang,Moritz Leppkes,Julio Vera Gonzalez,Gerhard Krönke,Andreas E. Kremer,Matthias Tenbusch,Heiko Bruns,Thomas Harrer,Fabian Müller,Georg Schett,Andreas Mackensen,Marion Subklewe,Simon Völkl
View Articletitled, Cellular and humoral immune responses to SARS-CoV-2 vaccination in patients after CD19.CAR T-cell therapy
Supplemental data
The chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential novel biomarkers of warm autoimmune hemolytic anemia
Donald R. Branch,Regina M. Leger,Darinka Sakac,Qilong Yi,Trang Duong,Rae S. M. Yeung,Beth Binnington,Evgenia M. Bloch
View Articletitled, The chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential novel biomarkers of warm autoimmune hemolytic anemia
Supplemental data
Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia
Carolin Escherich,Wenan Chen,Satoshi Miyamoto,Yui Namikawa,Wenjian Yang,David T. Teachey,Zhenhua Li,Elizabeth A. Raetz,Eric Larsen,Meenakshi Devidas,Paul L. Martin,W. Paul Bowman,Gang Wu,Ching-Hon Pui,Stephen P. Hunger,Mignon L. Loh,Masatoshi Takagi,Jun J. Yang
View Articletitled, Identification of <em>TCF3</em> germline variants in pediatric B-cell acute lymphoblastic leukemia
Supplemental data
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
Natividad Alquezar-Artieda,Daniela Kuzilkova,Jennie Roberts,Katerina Hlozkova,Alena Pecinova,Petr Pecina,Martina Zwyrtkova,Eliska Potuckova,Daniel Kavan,Ivana Hermanova,Marketa Zaliova,Petr Novak,Tomas Mracek,Lucie Sramkova,Daniel A. Tennant,Jan Trka,Julia Starkova
View Articletitled, Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
Supplemental data
Prospective changes of pancreatic iron in patients with thalassemia major and association with chelation therapy
Antonella Meloni,Laura Pistoia,Paolo Ricchi,Massimo Allò,Rosamaria Rosso,Liana Cuccia,Tommaso Casini,Valerio Cecinati,Marilena Serra,Vincenza Rossi,Riccardo Righi,Stefania Renne,Antonino Vallone,Vincenzo Positano,Filippo Cademartiri
View Articletitled, Prospective changes of pancreatic iron in patients with thalassemia major and association with chelation therapy
Treatment of primary mediastinal B-cell lymphoma with dose-adjusted REPOCH during pregnancy
Kaitlin Annunzio,Michael Cackovic,David Bond,Yazeed Sawalha,Timothy J. Voorhees,Walter Hanel,Lapo Alinari,Robert Baiocchi,John Reneau,Jonathan Brammer,Kami Maddocks,Beth Christian,Narendranath Epperla
View Articletitled, Treatment of primary mediastinal B-cell lymphoma with dose-adjusted REPOCH during pregnancy

COMMENTARY

Caplacizumab as frontline therapy in addition to standard treatment in iTTP
Joan Cid,Miquel Lozano
View Articletitled, Caplacizumab as frontline therapy in addition to standard treatment in iTTP
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