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Issue Archive

Volume 6, Issue 2
January 25 2022
Issue Cover

Table of Contents

CLINICAL GUIDELINES

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis
Adam Cuker,Eric K. Tseng,Robby Nieuwlaat,Pantep Angchaisuksiri,Clifton Blair,Kathryn Dane,Jennifer Davila,Maria T. DeSancho,David Diuguid,Daniel O. Griffin,Susan R. Kahn,Frederikus A. Klok,Alfred Ian Lee,Ignacio Neumann,Ashok Pai,Marc Righini,Kristen M. Sanfilippo,Deborah Siegal,Mike Skara,Deirdra R. Terrell,Kamshad Touri,Elie A. Akl,Reyad Nayif Al Jabiri,Yazan Nayif Al Jabiri,Angela M. Barbara,Antonio Bognanni,Imad Bou Akl,Mary Boulos,Romina Brignardello-Petersen,Rana Charide,Matthew Chan,Luis E. Colunga-Lozano,Karin Dearness,Andrea J. Darzi,Heba Hussein,Samer G. Karam,Philipp Kolb,Razan Mansour,Gian Paolo Morgano,Rami Z. Morsi,Giovanna Muti-Schünemann,Menatalla K. Nadim,Atefeh Noori,Binu A. Philip,Thomas Piggott,Yuan Qiu,Yetiani Roldan Benitez,Finn Schünemann,Adrienne Stevens,Karla Solo,Wojtek Wiercioch,Reem A. Mustafa,Holger J. Schünemann
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Supplemental data
The ASH-ASPHO Choosing Wisely Campaign: 5 hematologic tests and treatments to question
Sarah H. O’Brien,Sherif M. Badawy,Seth J. Rotz,Mona D. Shah,Julie Makarski,Rachel S. Bercovitz,Mary-Jane S. Hogan,Lori Luchtman-Jones,Julie A. Panepinto,Ginna M. Priola,Char M. Witmer,Julie A. Wolfson,Marianne Yee,Lisa K. Hicks
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Supplemental data

EXCEPTIONAL CASE REPORT

A clinical, histopathological, and molecular study of two cases of VEXAS syndrome without a definitive myeloid neoplasm
Peng Li,Shobi Venkatachalam,Daniela Ospina Cordona,Lorena Wilson,Tibor Kovacsovics,Karen A. Moser,Rodney R. Miles,David B. Beck,Tracy George,Srinivas K. Tantravahi
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Supplemental data
A novel NUP98-JADE2 fusion in a patient with acute myeloid leukemia resembling acute promyelocytic leukemia
Chi-Keung Cheng,Hoi-Yun Chan,Yuk-Lin Yung,Thomas S. K. Wan,Alex W. K. Leung,Chi-Kong Li,Ke Tian,Natalie P. H. Chan,Joyce S. Cheung,Margaret H. L. Ng
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Supplemental data

STIMULUS REPORT

Anti–IL-6 cytokine treatment has no impact on elevated hematocrit or splenomegaly in a polycythemia vera mouse model
Conny K. Baldauf,Peter Müller,Tobias R. Haage,Stephanie Adam-Frey,Juliane Lokau,Christoph Garbers,Thomas Fischer
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Supplemental data
Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival
Tianzeng Chen,Matthew Ho,Jenna Briere,Maria Moscvin,Peter G. Czarnecki,Kenneth C. Anderson,T. Keith Blackwell,Giada Bianchi
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Supplemental data
Idiopathic purpura fulminans associated with anti-protein S antibodies in children: a multicenter case series and systematic review
Clinical Trials & Observations
Alexandre Theron,Olivier Dautremay,Elodie Boissier,Amel Zerroukhi,Julien Baleine,Lionel Moulis,Michel Rodière,Jean-François Schved,Martha Duraes,Tarik Kanouni,Isabelle Cau-Diaz,Eric Jeziorski,Christine Biron-Andreani
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Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors
Ella R. Thompson,Tamia Nguyen,Yamuna Kankanige,John F. Markham,Mary Ann Anderson,Sasanka M. Handunnetti,Rachel Thijssen,Paul Sung-Hao Yeh,Constantine S. Tam,John F. Seymour,Andrew W. Roberts,David A. Westerman,Piers Blombery
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Supplemental data
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
Jana Krosl,Marie-Eve Bordeleau,Céline Moison,Tara MacRae,Isabel Boivin,Nadine Mayotte,Deanne Gracias,Irène Baccelli,Vincent-Philippe Lavallée,Richard Bisaillon,Bernhard Lehnertz,Rodrigo Mendoza-Sanchez,Réjean Ruel,Thierry Bertomeu,Jasmin Coulombe-Huntington,Geneviève Boucher,Nandita Noronha,Caroline Pabst,Mike Tyers,Patrick Gendron,Sébastien Lemieux,Frédéric Barabé,Anne Marinier,Josée Hébert,Guy Sauvageau
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Supplemental data
MCT1 is a predictive marker for lenalidomide maintenance therapy in multiple myeloma
Clinical Trials & Observations
Jacob Stroh,Anja Seckinger,Michael Heider,Martina Rudelius,Ruth Eichner,Markus Schick,Jolanta Slawska,Martina Emde-Rajaratnam,Hans Salwender,Uta Bertsch,Hartmut Goldschmidt,Katja Weisel,Christof Scheid,Ulrich Keller,Dirk Hose,Florian Bassermann
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CPX-351 induces remission in newly diagnosed pediatric secondary myeloid malignancies
Clinical Trials & Observations
Yixin Hu,Kenneth J. Caldwell,Mihaela Onciu,Sara M. Federico,Marta Salek,Sara Lewis,Shaohua Lei,Jinghui Zhang,Kim E. Nichols,Clifford M. Takemoto,Brandon M. Triplett,Jason E. Farrar,Jeffrey E. Rubnitz,Raul C. Ribeiro,Marcin W. Wlodarski
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Genetic features and clinical outcomes of patients with isolated and comutated DDX41-mutated myeloid neoplasms
Hassan B. Alkhateeb,Ahmad Nanaa,David Viswanatha,James M. Foran,Talha Badar,Lisa Sproat,Rong He,Phuong Nguyen,Dragan Jevremovic,Mohamad E. Salama,Patricia Greipp,Naseema Gangat,Ayalew Tefferi,Mark R. Litzow,Abhishek A. Mangaonkar,Mithun Vinod Shah,Mrinal Patnaik,Aref Al-Kali
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Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis
Clinical Trials & Observations
Adi Eshel,Itai Sharon,Arnon Nagler,David Bomze,Ivetta Danylesko,Joshua A. Fein,Mika Geva,Israel Henig,Avichai Shimoni,Tsila Zuckerman,Ilan Youngster,Omry Koren,Roni Shouval
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VpreB surrogate light chain expression in B-lineage ALL: a report from the Children’s Oncology Group
Stuart S. Winter,Amanda McCaustland,Chunxu Qu,No’eau Simeona,Nyla A. Heerema,Andrew J. Carroll,Brent L. Wood,Gabriela Gheorghe,Charles G. Mullighan,Bridget S. Wilson
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Toll-like receptor 4 selective inhibition in medullar microenvironment alters multiple myeloma cell growth
Léa Lemaitre,Malik Hamaidia,Jean-Gérard Descamps,Laura Do Souto Ferreira,Marie-Véronique Joubert,Mélanie Gadelorge,Hervé Avet-Loiseau,Arthur Justo,Nicolas Reina,Frederic Deschaseaux,Ludovic Martinet,Philippe Bourin,Jill Corre,Nicolas Espagnolle
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SYSTEMATIC REVIEW

Cost-effectiveness of diagnostic strategies for venous thromboembolism: a systematic review
Yuan Zhang,Housne A. Begum,Himmat Grewal,Itziar Etxeandia-Ikobaltzeta,Gian Paolo Morgano,Rasha Khatib,Robby Nieuwlaat,Chengyi Ding,Wojtek Wiercioch,Reem A. Mustafa,Wendy Lim,Holger J. Schünemann
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CLINICAL TRIALS AND OBSERVATIONS

Epidemiology and treatment patterns of idiopathic multicentric Castleman disease in the era of IL-6–directed therapy
Clinical Trials & Observations
Sudipto Mukherjee,Rabecka Martin,Brenda Sande,Jeremy S. Paige,David C. Fajgenbaum
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Supplemental data
Feasibility of high-dose methotrexate administered on day 1 of (R)CHOP in aggressive non-Hodgkin lymphomas
Clinical Trials & Observations
Megan Fleming,Ying Huang,Emily Dotson,David A. Bond,John Reneau,Narendranath Epperla,Lapo Alinari,Jonathan Brammer,Beth A. Christian,Robert A. Baiocchi,Kami Maddocks,Yazeed Sawalha
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Tumor-associated antigen–specific T cells with nivolumab are safe and persist in vivo in relapsed/refractory Hodgkin lymphoma
Clinical Trials & Observations
Hema Dave,Madeline Terpilowski,Mimi Mai,Keri Toner,Melanie Grant,Maja Stanojevic,Christopher Lazarski,Abeer Shibli,Stephanie A. Bien,Philip Maglo,Fahmida Hoq,Reuven Schore,Martha Glenn,Boyu Hu,Patrick J. Hanley,Richard Ambinder,Catherine M. Bollard
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Supplemental data
Polatuzumab vedotin plus bendamustine and rituximab in relapsed/refractory DLBCL: survival update and new extension cohort data
Clinical Trials & Observations
Laurie H. Sehn,Mark Hertzberg,Stephen Opat,Alex F. Herrera,Sarit Assouline,Christopher R. Flowers,Tae Min Kim,Andrew McMillan,Muhit Ozcan,Violaine Safar,Gilles Salles,Grace Ku,Jamie Hirata,Yi Meng Chang,Lisa Musick,Matthew J. Matasar
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Quality-of-life analysis of pembrolizumab vs brentuximab vedotin for relapsed/refractory classical Hodgkin lymphoma
Clinical Trials & Observations
Pier Luigi Zinzani,Radhakrishnan Ramchandren,Armando Santoro,Ewa Paszkiewicz-Kozik,Robin Gasiorowski,Nathalie A. Johnson,Jose S. R. de Oliveira,Valeria Buccheri,Guilherme Fleury Perini,Michael Dickinson,Andrew McDonald,Muhit Özcan,Naohiro Sekiguchi,Ying Zhu,Monika Raut,Todd L. Saretsky,Akash Nahar,John Kuruvilla
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Supplemental data
Dasatinib-based 2-step induction for adults with Philadelphia chromosome–positive acute lymphoblastic leukemia
Clinical Trials & Observations
Isamu Sugiura,Noriko Doki,Tomoko Hata,Ryuko Cho,Toshiro Ito,Youko Suehiro,Masatsugu Tanaka,Shinichi Kako,Mitsuhiro Matsuda,Hisayuki Yokoyama,Yuichi Ishikawa,Yasuhiro Taniguchi,Maki Hagihara,Yukiyasu Ozawa,Yasunori Ueda,Daiki Hirano,Toru Sakura,Masaaki Tsuji,Tsuyoshi Kamae,Hiroyuki Fujita,Nobuhiro Hiramoto,Masahiro Onoda,Shin Fujisawa,Yoshihiro Hatta,Nobuaki Dobashi,Satoshi Nishiwaki,Yoshiko Atsuta,Yukio Kobayashi,Fumihiko Hayakawa,Shigeki Ohtake,Tomoki Naoe,Yasushi Miyazaki,on behalf of the Japan Adult Leukemia Study Group
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Tisagenlecleucel outcomes in relapsed/refractory extramedullary ALL: a Pediatric Real World CAR Consortium Report
Clinical Trials & Observations
Vanessa A. Fabrizio,Christine L. Phillips,Adam Lane,Christina Baggott,Snehit Prabhu,Emily Egeler,Sharon Mavroukakis,Holly Pacenta,Jenna Rossoff,Heather E. Stefanski,Julie-An Talano,Amy Moskop,Steven P. Margossian,Michael R. Verneris,Gary Douglas Myers,Nicole A. Karras,Patrick A. Brown,Muna Qayed,Michelle Hermiston,Prakash Satwani,Christa Krupski,Amy K. Keating,Rachel Wilcox,Cara A. Rabik,Vasant Chinnabhandar,Michael Kunicki,A. Yasemin Goksenin,Kevin J. Curran,Crystal L. Mackall,Theodore W. Laetsch,Liora M. Schultz
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FlowCT for the analysis of large immunophenotypic data sets and biomarker discovery in cancer immunology
Cirino Botta,Catarina Maia,Juan-José Garcés,Rosalinda Termini,Cristina Perez,Irene Manrique,Leire Burgos,Aintzane Zabaleta,Diego Alignani,Sarai Sarvide,Juana Merino,Noemi Puig,María-Teresa Cedena,Marco Rossi,Pierfrancesco Tassone,Massimo Gentile,Pierpaolo Correale,Ivan Borrello,Evangelos Terpos,Tomas Jelinek,Artur Paiva,Aldo Roccaro,Hartmut Goldschmidt,Hervé Avet-Loiseau,Laura Rosinol,Maria-Victoria Mateos,Joaquin Martinez-Lopez,Juan-José Lahuerta,Joan Bladé,Jesús F. San-Miguel,Bruno Paiva,,on behalf of the Programa Para el Estudio de la Terapéutica en Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) cooperative group and the iMMunocell study group
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Supplemental data
Impaired immune response to COVID-19 vaccination in patients with B-cell malignancies after CD19 CAR T-cell therapy
Saurabh Dahiya,Tim Luetkens,Forat Lutfi,Stephanie Avila,Thierry Iraguha,Philip Margiotta,Kim G. Hankey,Patricia Lesho,Jennie Y. Law,Seung T. Lee,John Baddley,Mehmet Kocoglu,Jean A. Yared,Nancy M. Hardy,Aaron P. Rapoport,Djordje Atanackovic
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LYMPHOID NEOPLASIA

Clonal phylogeny and evolution of critical cytogenetic aberrations in multiple myeloma at single-cell level by QM-FISH
Yuting Yan,Xiaoqi Qin,Jiahui Liu,Huishou Fan,Wenqiang Yan,Lanting Liu,Chenxing Du,Zhen Yu,Yan Xu,Mu Hao,Shuhui Deng,Weiwei Sui,Rui Lyu,Wei Liu,Qi Wang,Dehui Zou,Linping Hu,Jianxiang Wang,Yu-Tzu Tai,Kenneth C. Anderson,Lei Zhang,Tao Cheng,Anders Zetterberg,Nikhil C. Munshi,Lugui Qiu,Gang An
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Supplemental data
High risk of relapsed disease in patients with NK/T-cell chronic active Epstein-Barr virus disease outside of Asia
Clinical Trials & Observations
Blachy J. Dávila Saldaña,Tami John,Challice Bonifant,David Buchbinder,Sharat Chandra,Shanmuganathan Chandrakasan,Weni Chang,Leon Chen,Hannah L. Elfassy,Ashley V. Geerlinks,Roger H. Giller,Rakesh Goyal,David Hagin,Shahidul Islam,Kanwaldeep Mallhi,Holly K. Miller,William Owen,Martha Pacheco,Niraj C. Patel,Christiane Querfeld,Troy Quigg,Nameeta Richard,Deborah Schiff,Evan Shereck,Elizabeth Stenger,Michael B. Jordan,Helen E. Heslop,Catherine M. Bollard,Jeffrey I. Cohen
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Supplemental data
Allogeneic transplant and CAR-T therapy after autologous transplant failure in DLBCL: a noncomparative cohort analysis
Mehdi Hamadani,Ajay K. Gopal,Marcelo Pasquini,Soyoung Kim,Xianmiao Qiu,Sairah Ahmed,Aleksandr Lazaryan,Vijaya Raj Bhatt,Andrew Daly,Premal Lulla,Stefan Ciurea,Jordan Gauthier,Vaibhav Agrawal,Natalie S. Grover,Lazaros Lekakis,Dipenkumar Modi,Parastoo B. Dahi,Megan M. Herr,P. Connor Johnson,Hamza Hashmi,Peiman Hematti,Frederick L. Locke
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Supplemental data
Integrative genomic and transcriptomic analysis in plasmablastic lymphoma identifies disruption of key regulatory pathways
Hanno M. Witte,Axel Künstner,Nadine Hertel,Heinz-Wolfram Bernd,Veronica Bernard,Stephanie Stölting,Hartmut Merz,Nikolas von Bubnoff,Hauke Busch,Alfred C. Feller,Niklas Gebauer
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MYELOID NEOPLASIA

Practice patterns and real-life outcomes for patients with acute promyelocytic leukemia in the United States
Clinical Trials & Observations
Jan Philipp Bewersdorf,Stephanie Prozora,Nikolai A. Podoltsev,Rory M. Shallis,Scott F. Huntington,Natalia Neparidze,Rong Wang,Amer M. Zeidan,Amy J. Davidoff
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Supplemental data
The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11
Clinical Trials & Observations
Marina Lafage-Pochitaloff,Bastien Gerby,Véronique Baccini,Laetitia Largeaud,Vincent Fregona,Naïs Prade,Pierre-Yves Juvin,Laura Jamrog,Pierre Bories,Sylvie Hébrard,Stéphanie Lagarde,Véronique Mansat-De Mas,Oliver M. Dovey,Kosuke Yusa,George S. Vassiliou,Joop H. Jansen,Tobias Tekath,David Rombaut,Geneviève Ameye,Carole Barin,Audrey Bidet,John Boudjarane,Marie-Agnès Collonge-Rame,Carine Gervais,Antoine Ittel,Christine Lefebvre,Isabelle Luquet,Lucienne Michaux,Nathalie Nadal,Hélène A. Poirel,Isabelle Radford-Weiss,Bénédicte Ribourtout,Steven Richebourg,Stéphanie Struski,Christine Terré,Isabelle Tigaud,Dominique Penther,Virginie Eclache,Michaela Fontenay,Cyril Broccardo,Eric Delabesse,,on behalf of Groupe Francophone de Cytogénétique Hématologique, Groupe Français des Myélodysplasies, and Groupe Francophone d’Hématologie Cellulaire
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Pevonedistat targets malignant cells in myeloproliferative neoplasms in vitro and in vivo via NFκB pathway inhibition
Tim Kong,Angelo B.A. Laranjeira,Taylor B. Collins,Elisa S. De Togni,Abigail J. Wong,Mary C. Fulbright,Marianna Ruzinova,Hamza Celik,Grant A. Challen,Daniel A.C. Fisher,Stephen T. Oh
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Supplemental data
Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia
Nithya Balasundaram,Saravanan Ganesan,Ezhilarasi Chendamarai,Hamenth Kumar Palani,Arvind Venkatraman,Ansu Abu Alex,Sachin David,Swathy Palani Kumar,Nair Reeshma Radhakrishnan,Mohammed Yasar,Sanjeev Krishna,Anu Korula,Uday Kulkarni,Nancy Beryl Janet,Poonkuzhali Balasubramanian,Vikram Mathews
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THROMBOSIS AND HEMOSTASIS

Whole-exome analysis of adolescents with low VWF and heavy menstrual bleeding identifies novel genetic associations
Clinical Trials & Observations
Brooke Sadler,Charles G. Minard,Gabe Haller,Christina A. Gurnett,Sarah H. O’Brien,Allison Wheeler,Shilpa Jain,Mutka Sharma,Ayesha Zia,Roshni Kulkarni,Eric Mullins,Margaret V. Ragni,Robert Sidonio,Jennifer E. Dietrich,Peter A. Kouides,Jorge Di Paola,Lakshmi Srivaths
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Supplemental data
Laminin G1 residues of protein S mediate its TFPI cofactor function and are competitively regulated by C4BP
Adrienn Teraz-Orosz,Magdalena Gierula,Anastasis Petri,David Jones,Renos Keniyopoullos,Patricia Badia Folgado,Salvatore Santamaria,James T. B. Crawley,David A. Lane,Josefin Ahnström
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Supplemental data

TRANSPLANTATION

Cytomegalovirus gastroenteritis in patients with acute graft-versus-host disease
Clinical Trials & Observations
Yu Akahoshi,Shun-ichi Kimura,Yuma Tada,Toshihiro Matsukawa,Masaharu Tamaki,Noriko Doki,Naoyuki Uchida,Masatsugu Tanaka,Hirohisa Nakamae,Takuro Kuriyama,Ken-ichi Matsuoka,Takashi Ikeda,Takafumi Kimura,Takahiro Fukuda,Yoshinobu Kanda,Yoshiko Atsuta,Makoto Murata,Seitaro Terakura,Hideki Nakasone
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Supplemental data

RESEARCH LETTER

Impact of ruxolitinib on survival of patients with myelofibrosis in the real world: update of the ERNEST Study
Clinical Trials & Observations
Paola Guglielmelli,Arianna Ghirardi,Alessandra Carobbio,Arianna Masciulli,Chiara Maccari,Barbara Mora,Elisa Rumi,Ana Triguero,Maria Chiara Finazzi,Helna Pettersson,Chiara Paoli,Francesco Mannelli,Daniele Vanni,Alessandro Rambaldi,Francesco Passamonti,Alberto Alvarez-Larràn,Bjorn Andreasson,Alessandro M. Vannucchi,Tiziano Barbui
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COMMENTARY

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
Martina Zátopková,Tereza Ševčíková,Viola Fanfani,Zuzana Chyra,Lucie Říhová,Renata Bezděková,David Žihala,Kateřina Growková,Jana Filipová,Lucie Černá,Lucie Broskevičova,Fedor Kryukov,Jiří Minařík,Jana Smejkalová,Vladimír Maisnar,Ĺubica Harvanová,Luděk Pour,Alexandra Jungova,Tereza Popková,Juli Rodriguez Bago,Anjana Anilkumar Sithara,Matouš Hrdinka,Tomáš Jelínek,Michal Šimíček,Giovanni Stracquadanio,Roman Hájek
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Supplemental data
Commentary on the ASH ISTH NHF WFH 2021 guidelines on the diagnosis of VWD: reflections based on recent contemporary test data
Emmanuel J. Favaloro
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  • Cover Image

    Cover Image

    issue cover

    Small and nonlobated megakaryocyte seen in myelodysplastic syndrome case with dual deletions of 5q and 11q chromosomes (May-Grünwald Giemsa staining, original magnification x100, Véronique Baccini). See the article by Lafage-Pochitaloff et al.

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