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Issue Archive

Volume 6, Issue 17
September 13 2022
Issue Cover

Table of Contents

CLINICAL GUIDELINES

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients
Adam Cuker,Eric K. Tseng,Robby Nieuwlaat,Pantep Angchaisuksiri,Clifton Blair,Kathryn Dane,Maria T. DeSancho,David Diuguid,Daniel O. Griffin,Susan R. Kahn,Frederikus A. Klok,Alfred Ian Lee,Ignacio Neumann,Ashok Pai,Marc Righini,Kristen M. Sanfilippo,Deborah M. Siegal,Mike Skara,Deirdra R. Terrell,Kamshad Touri,Elie A. Akl,Reyad Al Jabiri,Yazan Al Jabiri,Angela M. Barbara,Antonio Bognanni,Mary Boulos,Romina Brignardello-Petersen,Rana Charide,Luis E. Colunga-Lozano,Karin Dearness,Andrea J. Darzi,Heba Hussein,Samer G. Karam,Razan Mansour,Gian Paolo Morgano,Rami Z. Morsi,Giovanna Muti-Schünemann,Menatalla K. Nadim,Binu A. Philip,Yuan Qiu,Yetiani Roldan Benitez,Adrienne Stevens,Karla Solo,Wojtek Wiercioch,Reem A. Mustafa,Holger J. Schünemann
View Articletitled, American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients
Supplemental data
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients
Adam Cuker,Eric K. Tseng,Holger J. Schünemann,Pantep Angchaisuksiri,Clifton Blair,Kathryn Dane,Maria T. DeSancho,David Diuguid,Daniel O. Griffin,Susan R. Kahn,Frederikus A. Klok,Alfred Ian Lee,Ignacio Neumann,Ashok Pai,Marc Righini,Kristen M. Sanfilippo,Deborah M. Siegal,Mike Skara,Deirdra R. Terrell,Kamshad Touri,Elie A. Akl,Reyad Al Jabiri,Yazan Al Jabiri,Mary Boulos,Romina Brignardello-Petersen,Rana Charide,Luis E. Colunga-Lozano,Karin Dearness,Andrea J. Darzi,Samer G. Karam,Gian Paolo Morgano,Rami Z. Morsi,Binu A. Philip,Yetiani Roldan Benitez,Adrienne Stevens,Karla Solo,Wojtek Wiercioch,Reem A. Mustafa,Robby Nieuwlaat
View Articletitled, American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients
Supplemental data

STIMULUS REPORT

Invariant NKT cells dictate antitumor immunity elicited by a bispecific antibody cotargeting CD3 and BCMA
Mika Casey,Cui Tu,Simon J. Harrison,Kyohei Nakamura
View Articletitled, Invariant NKT cells dictate antitumor immunity elicited by a bispecific antibody cotargeting CD3 and BCMA
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Clinical characteristics and outcomes of IgD myeloma: experience across UK national trials
Clinical Trials & Observations
Charles Agbuduwe,Gulnaz Iqbal,David Cairns,Tom Menzies,Janet Dunn,Walter Gregory,Martin Kaiser,Roger Owen,Charlotte Pawlyn,J. Anthony Child,Faith Davies,Gareth J. Morgan,Graham H. Jackson,Mark T. Drayson,Supratik Basu
View Articletitled, Clinical characteristics and outcomes of IgD myeloma: experience across UK national trials
Supplemental data
Pevonedistat plus azacitidine vs azacitidine alone in higher-risk MDS/chronic myelomonocytic leukemia or low-blast-percentage AML
Clinical Trials & Observations
Lionel Adès,Larisa Girshova,Vadim A. Doronin,María Díez-Campelo,David Valcárcel,Suman Kambhampati,Nora-Athina Viniou,Dariusz Woszczyk,Raquel De Paz Arias,Argiris Symeonidis,Achilles Anagnostopoulos,Eduardo Ciliao Munhoz,Uwe Platzbecker,Valeria Santini,Robert J. Fram,Ying Yuan,Sharon Friedlander,Douglas V. Faller,Mikkael A. Sekeres
View Articletitled, Pevonedistat plus azacitidine vs azacitidine alone in higher-risk MDS/chronic myelomonocytic leukemia or low-blast-percentage AML
Supplemental data
Real-world study of children and young adults with myeloproliferative neoplasms: identifying risks and unmet needs
Clinical Trials & Observations
Marta Sobas,Jean-Jacques Kiladjian,Yan Beauverd,Natalia Curto-Garcia,Parvis Sadjadian,Lee Yung Shih,Timothy Devos,Dorota Krochmalczyk,Serena Galli,Maria Bieniaszewska,Ilona Seferynska,Mary Frances McMullin,Anna Armatys,Adrianna Spalek,Joanna Waclaw,Mihnea Zdrenghea,Laurence Legros,François Girodon,Krzysztof Lewandowski,Anna Angona Figueras,Jan Samuelsson,Aitor Abuin Blanco,Pascale Cony-Makhoul,Angela Collins,Chloé James,Rajko Kusec,Marie Lauermannova,Maria Sol Noya,Malgorzata Skowronek,Lukasz Szukalski,Anna Szmigielska-Kaplon,Marielle Wondergem,Iryna Dudchenko,Joanna Gora Tybor,Kamel Laribi,Anna Kulikowska de Nalecz,Jean-Loup Demory,Katell Le Du,Sonja Zweegman,Carlos Besses Raebel,Radek Skoda,Stéphane Giraudier,Martin Griesshammer,Claire N. Harrison,Jean-Christophe Ianotto
View Articletitled, Real-world study of children and young adults with myeloproliferative neoplasms: identifying risks and unmet needs
Supplemental data

HEALTH SERVICES AND OUTCOMES

Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
Elizabeth K. O’Donnell,Yael N. Shapiro,Andrew J. Yee,Omar Nadeem,Jacob P. Laubach,Andrew R. Branagan,Kenneth C. Anderson,Clifton C. Mo,Nikhil C. Munshi,Irene M. Ghobrial,Adam S. Sperling,Emerentia A. Agyemang,Jill N. Burke,Cynthia C. Harrington,Bonnie Y. Hu,Paul G. Richardson,Noopur S. Raje,Areej El-Jawahri
View Articletitled, Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Third-party CMV- and EBV-specific T-cells for first viral reactivation after allogeneic stem cell transplant
Wei Jiang,Leighton E. Clancy,Selmir Avdic,Gaurav Sutrave,Janine Street,Renee Simms,Helen M. McGuire,Ellis Patrick,Adam S. Chan,Georgia McCaughan,Nadav Myers,Kenneth P. Micklethwaite,Vicki Antonenas,Adrian G. Selim,David Ritchie,Caroline M. Bateman,Peter J. Shaw,Emily Blyth,David J. Gottlieb
View Articletitled, Third-party CMV- and EBV-specific T-cells for first viral reactivation after allogeneic stem cell transplant
Supplemental data
NK cells CD56bright and CD56dim subset cytokine loss and exhaustion is associated with impaired survival in myeloma
Frances Seymour,Jamie D. Cavenagh,Janet Mathews,John G. Gribben
View Articletitled, NK cells CD56<sup>bright</sup> and CD56<sup>dim</sup> subset cytokine loss and exhaustion is associated with impaired survival in myeloma
Supplemental data

LYMPHOID NEOPLASIA

Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma
Lucía Peña-Pérez,Nicolai Frengen,Julia Hauenstein,Charlotte Gran,Charlotte Gustafsson,Jesper Eisfeldt,Marcin Kierczak,Fanny Taborsak-Lines,Remi-André Olsen,Ann Wallblom,Aleksandra Krstic,Philip Ewels,Anna Lindstrand,Robert Månsson
View Articletitled, Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma
Supplemental data
D-dimer and risk for thrombosis in adults with newly diagnosed acute lymphoblastic leukemia
Daniela R. Anderson,Wendy Stock,Theodore G. Karrison,Avi Leader
View Articletitled, D-dimer and risk for thrombosis in adults with newly diagnosed acute lymphoblastic leukemia
Supplemental data
Causes of death in low-grade B-cell lymphomas in the rituximab era: a prospective cohort study
Aung M. Tun,Arushi Khurana,Raphael Mwangi,Brian K. Link,Yucai Wang,Andrew L. Feldman,Carrie A. Thompson,Anne J. Novak,Jose C. Villasboas,Gita Thanarajasingam,Umar Farooq,Sergei Syrbu,Grzegorz S. Nowakowski,Thomas E. Witzig,Stephen M. Ansell,Lisa M. Rimsza,James R. Cerhan,Thomas M. Habermann,Matthew J. Maurer
View Articletitled, Causes of death in low-grade B-cell lymphomas in the rituximab era: a prospective cohort study
Supplemental data

MYELOID NEOPLASIA

BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors
Daelynn R. Buelow,Bhavana Bhatnagar,Shelley J. Orwick,Jae Yoon Jeon,Eric D. Eisenmann,Jack C. Stromatt,Navjot Singh Pabla,James S. Blachly,Sharyn D. Baker,Bradley W. Blaser
View Articletitled, BMX kinase mediates gilteritinib resistance in <em>FLT3</em>-mutated AML through microenvironmental factors
Supplemental data
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies
Francois E. Mercier,Jiantao Shi,David B. Sykes,Toshihiko Oki,Maja Jankovic,Cheuk Him Man,Youmna S. Kfoury,Elizabeth Miller,Shutao He,Alexander Zhu,Radovan Vasic,John Doench,Alexandre Orthwein,Franziska Michor,David T. Scadden
View Articletitled, In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies
Supplemental data

PLATELETS AND THROMBOPOIESIS

CPT2 K79 acetylation regulates platelet life span
Xuemei Fan,Yang Wang,Xiaohong Cai,Yingzhi Shen,Tongran Xu,Yanyan Xu,Jinke Cheng,Xuefeng Wang,Lin Zhang,Jing Dai,Shuhai Lin,Junling Liu
View Articletitled, CPT2 K79 acetylation regulates platelet life span
Supplemental data
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
Eugenio D. Hottz,Remy Martins-Gonçalves,Lohanna Palhinha,Isaclaudia G. Azevedo-Quintanilha,Mariana M. de Campos,Carolina Q. Sacramento,Jairo R. Temerozo,Vinicius Cardoso Soares,Suelen S. Gomes Dias,Lívia Teixeira,Ícaro Castro,Cassia Righy,Thiago Moreno L. Souza,Pedro Kurtz,Bruno B. Andrade,Helder I. Nakaya,Robson Q. Monteiro,Fernando A. Bozza,Patrícia T. Bozza
View Articletitled, Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
Supplemental data
Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency
Gauthami Jalagadugula,Guangfen Mao,Lawrence E. Goldfinger,Jeremy Wurtzel,Fabiola Del Carpio-Cano,Michele P. Lambert,Brian Estevez,Deborah L. French,Mortimer Poncz,A. Koneti Rao
View Articletitled, Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in <em>RUNX1</em> deficiency
Supplemental data
Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice
Maximilian Englert,Katja Aurbach,Isabelle C. Becker,Annika Gerber,Tobias Heib,Lou M. Wackerbarth,Charly Kusch,Kristina Mott,Gabriel H. M. Araujo,Ayesha A. Baig,Sebastian Dütting,Ulla G. Knaus,Christian Stigloher,Harald Schulze,Bernhard Nieswandt,Irina Pleines,Zoltan Nagy
View Articletitled, Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice
Supplemental data
Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease
Verónica Palma-Barqueros,Nuria Revilla,Carlo Zaninetti,Ana María Galera,Ana Sánchez-Fuentes,Ana Zámora-Cánovas,Natalia Bohdan,José Padilla,Ana Marín-Quilez,Agustín Rodriguez-Alen,José Luis Fuster,Andreas Greinacher,Vicente Vicente,José María Bastida,José Rivera,María Luisa Lozano
View Articletitled, Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease
Supplemental data

THROMBOSIS AND HEMOSTASIS

Noncanonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity
Arundhati Tiwari,Deepa Gautam,Paresh P. Kulkarni,Mohammad Ekhlak,Vijay K. Sonkar,Vikas Agrawal,Debabrata Dash
View Articletitled, Noncanonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity
Supplemental data
A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization
Sophia Gruber,Achim Löf,Adina Hausch,Fabian Kutzki,Res Jöhr,Tobias Obser,Gesa König,Reinhard Schneppenheim,Camilo Aponte-Santamaría,Frauke Gräter,Maria A. Brehm,Martin Benoit,Jan Lipfert
View Articletitled, A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization
Supplemental data
Lower-leg injury and knee arthroscopy have distinct effects on coagulation
Clinical Trials & Observations
Carolina E. Touw,Banne Nemeth,Araci M. R. Rondon,Raymond A. van Adrichem,Ton Lisman,Henri H. Versteeg,Inger B. Schipper,Rob G. H. H. Nelissen,Mettine H. A. Bos,Suzanne C. Cannegieter
View Articletitled, Lower-leg injury and knee arthroscopy have distinct effects on coagulation
Supplemental data

TRANSPLANTATION

Outcomes of allogeneic hematopoietic cell transplantation in adults with fusions associated with Ph-like ALL
Ibrahim Aldoss,Dongyun Yang,Vanina Tomasian,Sally Mokhtari,Ryan Jackson,Zhaohui Gu,Milhan Telatar,Hooi Yew,Monzr M. Al Malki,Amandeep Salhotra,Samer Khaled,Haris Ali,Ahmed Aribi,Karamjeet S. Sandhu,Matthew Mei,Shukaib Arslan,Paul Koller,Andrew Artz,Patricia Aoun,Dongqing Gu,David Snyder,Forrest M. Stewart,Peter Curtin,Anthony S. Stein,Raju Pillai,Guido Marcucci,Stephen J. Forman,Vinod Pullarkat,Ryotaro Nakamura,Michelle Afkhami
View Articletitled, Outcomes of allogeneic hematopoietic cell transplantation in adults with fusions associated with Ph-like ALL
Supplemental data
Efflux capacity and aldehyde dehydrogenase both contribute to CD8+ T-cell resistance to posttransplant cyclophosphamide
Michael T. Patterson,Natalia S. Nunes,Lucas P. Wachsmuth,Amrit Panjabi,Rochelle E. Fletcher,Shanzay M. Khan,Dimana Dimitrova,Jennifer A. Kanakry,Leo Luznik,Christopher G. Kanakry
View Articletitled, Efflux capacity and aldehyde dehydrogenase both contribute to CD8<sup>+</sup> T-cell resistance to posttransplant cyclophosphamide
Supplemental data

RESEARCH LETTERS

Transplant outcomes after CPX-351 vs 7 + 3 in older adults with newly diagnosed high-risk and/or secondary AML
Clinical Trials & Observations
Geoffrey L. Uy,Laura F. Newell,Tara L. Lin,Stuart L. Goldberg,Matthew J. Wieduwilt,Robert J. Ryan,Stefan Faderl,Jeffrey E. Lancet
View Articletitled, Transplant outcomes after CPX-351 vs 7 + 3 in older adults with newly diagnosed high-risk and/or secondary AML
Supplemental data
Direct oral anticoagulants in sickle cell disease: a systematic review and meta-analysis
Waail Rozi,Alaa Rahhal,Elrazi A. Ali,Abdulrahman Al-Mashdali,Yousef Hilan,Ibrahim Khamees,Liam J. Fernyhough,Mohamed A. Yassin
View Articletitled, Direct oral anticoagulants in sickle cell disease: a systematic review and meta-analysis
Genetic characterization and drug sensitivity study of newly derived HGBL double/triple-hit lymphoma cell lines
Jibin Zhang,Tingting Wang,Kunal Shetty,Serhan Alkan,Senlin Xu,Qiang Gong,Xuxiang Liu,Yuping Li,Zunsong Hu,Wendong Huang,Hans-Guido Wendel,Alex F. Herrera,Raju K. Pillai,Joo Y. Song,Wing C. Chan
View Articletitled, Genetic characterization and drug sensitivity study of newly derived HGBL double/triple-hit lymphoma cell lines
Supplemental data
Combined BCL2 and BTK inhibition in CLL demonstrates efficacy after monotherapy with both classes
Clinical Trials & Observations
Jonathan M. Hyak,Ying Huang,Kerry A. Rogers,Seema A. Bhat,Michael R. Grever,John C. Byrd,Adam S. Kittai,Dan Jones,Cecelia R. Miller,Jennifer A. Woyach
View Articletitled, Combined BCL2 and BTK inhibition in CLL demonstrates efficacy after monotherapy with both classes
Supplemental data
Hematologist encounters among Medicaid patients who have sickle cell disease
Sophia S. Horiuchi,Mei Zhou,Angela Snyder,Susan T. Paulukonis
View Articletitled, Hematologist encounters among Medicaid patients who have sickle cell disease
Supplemental data
Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia
Véronique Lisi,Ève Blanchard,Michael Vladovsky,Éric Audemard,Albert Ferghaly,Sébastien Lemieux,Josée Hébert,Guy Sauvageau,Vincent-Philippe Lavallée
View Articletitled, Unified gene expression signature of novel <em>NPM1</em> exon 5 mutations in acute myeloid leukemia
Supplemental data
Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy
Emily M. Hsieh,Regina M. Myers,Bonnie Yates,Colleen Annesley,Samuel John,Agne Taraseviciute,Seth M. Steinberg,Jennifer Sheppard,Perry Chung,Lee Chen,Daniel W. Lee,Amanda DiNofia,Stephan A. Grupp,Michael R. Verneris,Theodore W. Laetsch,Deepa Bhojwani,Patrick A. Brown,Michael A. Pulsipher,Susan R. Rheingold,Rebecca A. Gardner,Lia Gore,Nirali N. Shah,Adam J. Lamble
View Articletitled, Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy
Cardiac events in patients with acute myeloid leukemia treated with venetoclax combined with hypomethylating agents
Isla M. Johnson,Evandro D. Bezerra,Faiqa Farrukh,Kristen McCullough,Aref Al-Kali,Hassan B. Alkhateeb,Kebede Begna,Mark R. Litzow,William J. Hogan,Mithun Vinod Shah,Mrinal M. Patnaik,Ayalew Tefferi,Naseema Gangat
View Articletitled, Cardiac events in patients with acute myeloid leukemia treated with venetoclax combined with hypomethylating agents
Supplemental data

COMMENTARIES

Graft-versus-host disease may cause pulmonary restriction, but not all restriction is graft-versus-host disease
Ajay Sheshadri,Howard J. Huang,Lara Bashoura,Amin M. Alousi,Mansour Alkhunaizi,Husham Sharifi,Joe L. Hsu
View Articletitled, Graft-versus-host disease may cause pulmonary restriction, but not all restriction is graft-versus-host disease
The dosing of ibrutinib and related Bruton’s tyrosine kinase inhibitors: eliminating the use of brute force
Clinical Trials & Observations
Mark J. Ratain,Ian F. Tannock,Allen S. Lichter
View Articletitled, The dosing of ibrutinib and related Bruton’s tyrosine kinase inhibitors: eliminating the use of brute force
Commentary on the 2021 ASH Guidelines on use of anticoagulation in patients with COVID-19 being discharged from the hospital
Clinical Trials & Observations
Alex C. Spyropoulos,Renato D. Lopes
View Articletitled, Commentary on the 2021 ASH Guidelines on use of anticoagulation in patients with COVID-19 being discharged from the hospital

RESPONSE

A starting point for the phenotypic classification of pulmonary chronic graft-versus-host disease
Yifan Pang,Ananth V. Charya,Michael B. Keller,Arlene Sirajuddin,Yi-Ping Fu,Noa G. Holtzman,Steven Z. Pavletic,Sean Agbor-Enoh
View Articletitled, A starting point for the phenotypic classification of pulmonary chronic graft-versus-host disease

ERRATUM

Tam CS, Dimopoulos M, Garcia-Sanz R, et al. Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies. Blood Adv. 2022;6(4):1296-1308.
View Articletitled, Tam CS, Dimopoulos M, Garcia-Sanz R, et al. Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies. <em>Blood Adv</em>. 2022;6(4):1296-1308.
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