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Volume 6, Issue 11

June 14 2022

In this Issue

STIMULUS REPORTS
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
RESEARCH LETTERS

STIMULUS REPORTS

Validation and clinical application of transactivation assays for RUNX1 variant classification

Melanie Decker,Anupriya Agarwal,Andreas Benneche,Jane Churpek,Nicolas Duployez,Adam Duvall,Martijn P. T. Ernst,Alisa Förster,Hildegunn Høberg-Vetti,Inga Hofmann,Michelle Nash,Marc H. G. P. Raaijmakers,Tor H. A. Tvedt,Adrianna Vlachos,Brigitte Schlegelberger,Thomas Illig,Tim Ripperger

View Articletitled, Validation and clinical application of transactivation assays for RUNX1 variant classification

Supplemental data

Mass spectrometry vs immunofixation for treatment monitoring in multiple myeloma

Noemí Puig,María-Teresa Contreras,Cristina Agulló,Joaquín Martínez-López,Albert Oriol,María-Jesús Blanchard,Rafael Ríos,Jesús Martín,María-Belén Iñigo,Anna Sureda,Miguel-Teodoro Hernández,Javier de la Rubia,Verónica González-Calle,Isabel Krsnik,Valentín Cabañas,Luis Palomera,José-María Moraleda,Joan Bargay,María-Teresa Cedena,Bruno Paiva,Laura Rosiñol,Joan Bladé,Jesús San Miguel,Juan-José Lahuerta,María-Victoria Mateos

View Articletitled, Mass spectrometry vs immunofixation for treatment monitoring in multiple myeloma

Supplemental data

Identification of novel γ-globin inducers among all potential erythroid druggable targets

Lei Yu,Greggory Myers,Emily Schneider,Yu Wang,Raven Mathews,Kim Chew Lim,David Siemieniak,Vi Tang,David Ginsburg,Ginette Balbin-Cuesta,Sharon A. Singh,Pongpon Phuwakanjana,Natee Jearawiriyapaisarn,Rami Khoriaty,James Douglas Engel

View Articletitled, Identification of novel γ-globin inducers among all potential erythroid druggable targets

Supplemental data

Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination

Agnes Y. Y. Lee,Muntadhar Al Moosawi,Erica A. Peterson,Rita K. McCracken,Steven K. W. Wong,Hamish Nicolson,Vicky Chan,Tyler Smith,Michelle P. Wong,Lauren J. Lee,Cameron Griffiths,Bhavdeep Rahal,Stephen Parkin,Kevin Afra,Kimberley Ambler,Luke Y. C. Chen,Thalia S. Field,Heather C. Lindsay,Martin Lavoie,Charles Li,David Migneault,Monika Naus,Jolanta Piszczek,Poupak Rahmani,Gayatri Sreenivasan,Tony Wan,Adrian Yee,Leslie Zypchen,David Sweet

View Articletitled, Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination

A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas

Manit Munshi,Xia Liu,Amanda Kofides,Nickolas Tsakmaklis,Maria Luisa Guerrera,Zachary R. Hunter,M. Lia Palomba,Kimon V. Argyropoulos,Christopher J. Patterson,Alexa G. Canning,Kirsten Meid,Joshua Gustine,Andrew R. Branagan,Catherine A. Flynn,Shayna Sarosiek,Jorge J. Castillo,Jinhua Wang,Sara J. Buhrlage,Nathanael S. Gray,Nikhil C. Munshi,Kenneth C. Anderson,Steven P. Treon,Guang Yang

View Articletitled, A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas

Supplemental data

Lasting shift in the gut microbiota in patients with acute myeloid leukemia
Clinical Trials & Observations

Armin Rashidi,Maryam Ebadi,Tauseef Ur Rehman,Heba Elhusseini,Hossam Fathi Halaweish,Thomas Kaiser,Shernan G. Holtan,Alexander Khoruts,Daniel J. Weisdorf,Christopher Staley

View Articletitled, Lasting shift in the gut microbiota in patients with acute myeloid leukemia

Supplemental data

Dissecting platelet proteomics to understand the pathophysiology of immune thrombocytopenia: studies in mouse models

Patricia Martínez-Botía,Marjolein Meinders,Iris M. De Cuyper,Johannes A. Eble,John W. Semple,Laura Gutiérrez

View Articletitled, Dissecting platelet proteomics to understand the pathophysiology of immune thrombocytopenia: studies in mouse models

Supplemental data

Genetic variants of PKLR are associated with acute pain in sickle cell disease

Xunde Wang,Kate Gardner,Mickias B. Tegegn,Clifton L. Dalgard,Camille Alba,Stephan Menzel,Hamel Patel,Mehdi Pirooznia,Yi-Ping Fu,Fayaz T. Seifuddin,Swee Lay Thein

View Articletitled, Genetic variants of PKLR are associated with acute pain in sickle cell disease

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Clinical activity of single-dose systemic oncolytic VSV virotherapy in patients with relapsed refractory T-cell lymphoma
Clinical Trials & Observations

Joselle Cook,Kah-Whye Peng,Thomas E. Witzig,Stephen M. Broski,Jose C. Villasboas,Jonas Paludo,Mrinal Patnaik,Vincent Rajkumar,Angela Dispenzieri,Nelson Leung,Francis Buadi,Nora Bennani,Stephen M. Ansell,Lianwen Zhang,Nandakumar Packiriswamy,Baskar Balakrishnan,Bethany Brunton,Marissa Giers,Brenda Ginos,Amylou C. Dueck,Susan Geyer,Morie A. Gertz,Rahma Warsame,Ronald S. Go,Suzanne R. Hayman,David Dingli,Shaji Kumar,Leif Bergsagel,Javier L. Munoz,Wilson Gonsalves,Taxiarchis Kourelis,Eli Muchtar,Prashant Kapoor,Robert A. Kyle,Yi Lin,Mustaqeem Siddiqui,Amie Fonder,Miriam Hobbs,Lisa Hwa,Shruthi Naik,Stephen J. Russell,Martha Q. Lacy

View Articletitled, Clinical activity of single-dose systemic oncolytic VSV virotherapy in patients with relapsed refractory T-cell lymphoma

Supplemental data

Posttransplant cyclophosphamide for prevention of graft-versus-host disease: results of the prospective randomized HOVON-96 trial
Clinical Trials & Observations

Annoek E. C. Broers,Cornelis N. de Jong,Katerina Bakunina,Mette D. Hazenberg,Marinus van Marwijk Kooy,Marco R. de Groot,Michel van Gelder,Jürgen Kuball,Bronno van der Holt,Ellen Meijer,Jan J. Cornelissen,,on behalf of the HOVON Stem Cell Transplantation Working Group

View Articletitled, Posttransplant cyclophosphamide for prevention of graft-versus-host disease: results of the prospective randomized HOVON-96 trial

Supplemental data

Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors
Clinical Trials & Observations

Amy D. Shapiro,Pantep Angchaisuksiri,Jan Astermark,Gary Benson,Giancarlo Castaman,Hermann Eichler,Victor Jiménez-Yuste,Kaan Kavakli,Tadashi Matsushita,Lone Hvitfeldt Poulsen,Allison P. Wheeler,Guy Young,Silva Zupančić-Šalek,Johannes Oldenburg,Pratima Chowdary

View Articletitled, Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors

Supplemental data

Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia
Clinical Trials & Observations

Paul M. Barr,Carolyn Owen,Tadeusz Robak,Alessandra Tedeschi,Osnat Bairey,Jan A. Burger,Peter Hillmen,Steve E. Coutre,Claire Dearden,Sebastian Grosicki,Helen McCarthy,Jian-Yong Li,Fritz Offner,Carol Moreno,Cathy Zhou,Emily Hsu,Anita Szoke,Thomas J. Kipps,Paolo Ghia

View Articletitled, Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia

Supplemental data

Zanubrutinib monotherapy in relapsed/refractory indolent non-Hodgkin lymphoma
Clinical Trials & Observations

Tycel Phillips,Henry Chan,Constantine S. Tam,Alessandra Tedeschi,Patrick Johnston,Sung Yong Oh,Stephen Opat,Hyeon-Seok Eom,Heather Allewelt,Jennifer C. Stern,Ziwen Tan,William Novotny,Jane Huang,Judith Trotman

View Articletitled, Zanubrutinib monotherapy in relapsed/refractory indolent non-Hodgkin lymphoma

Supplemental data

HEMATOPOIESIS AND STEM CELLS

A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo

Uta Margareta Demel,Raphael Lutz,Stefanie Sujer,Yasmin Demerdash,Shubhankar Sood,Florian Grünschläger,Andrea Kuck,Paula Werner,Sandra Blaszkiewicz,Hannah Julia Uckelmann,Simon Haas,Marieke Alida Gertruda Essers

View Articletitled, A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell–mediated tumor responses

John Daly,Subhashis Sarkar,Alessandro Natoni,Jessica C. Stark,Nicholas M. Riley,Carolyn R. Bertozzi,Mattias Carlsten,Michael E. O'Dwyer

View Articletitled, Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell–mediated tumor responses

Supplemental data

LYMPHOID NEOPLASIA

SIRPα⁺ macrophages are increased in patients with FL who progress or relapse after frontline lenalidomide and rituximab

Mario L. Marques-Piubelli,Edwin R. Parra,Lei Feng,Luisa Solis Soto,Mariana Gallardo,Sushanth Gouni,Felipe Samaniego,Mansoor Noorani,Fredrick B. Hagemeister,Jason R. Westin,Hun Ju Lee,Maria A. Rodriguez,Sattva S. Neelapu,Jillian R. Gunther,Nathan H. Fowler,Christopher R. Flowers,Ignacio I. Wistuba,Loretta J. Nastoupil,Francisco Vega,Paolo Strati

View Articletitled, SIRPα+ macrophages are increased in patients with FL who progress or relapse after frontline lenalidomide and rituximab

Supplemental data

Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia

Daniel C. Ferguson,J. Robert McCorkle,Kelly R. Barnett,Erik J. Bonten,Brennan P. Bergeron,Kashi Raj Bhattarai,Wenjian Yang,Colton Smith,Baranda S. Hansen,Richa Bajpai,Qian Dong,Robert J. Autry,Yoshihiro Gocho,Jonathan D. Diedrich,Kristine R. Crews,Shondra M. Pruett-Miller,Kathryn G. Roberts,Wendy Stock,Charles G. Mullighan,Hiroto Inaba,Sima Jeha,Ching-Hon Pui,Jun J. Yang,Mary V. Relling,William E. Evans,Daniel Savic

View Articletitled, Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia

Supplemental data

Sézary syndrome patient–derived models allow drug selection for personalized therapy

Fernando Gallardo,Evelyn Andrades,Arnau Iglesias,Jessica González,Laura Solé,Yolanda Guillén,Gonzalo Blanco,Luis Colomo,Eva Gimeno,David Conde,Eva Rodriguez,Isabel Bielsa-Marso,Mar Iglesias,Beatriz Bellosillo,Ramon M. Pujol,José R. Regueiro,Anna Bigas,Lluís Espinosa

View Articletitled, Sézary syndrome patient–derived models allow drug selection for personalized therapy

Supplemental data

Extracellular vesicle proteomic analysis leads to the discovery of HDGF as a new factor in multiple myeloma biology

Dominique B. Hoelzinger,Sophia J. Quinton,Denise K. Walters,Trupti Vardam-Kaur,Renee C. Tschumper,Henrique Borges da Silva,Diane F. Jelinek

View Articletitled, Extracellular vesicle proteomic analysis leads to the discovery of HDGF as a new factor in multiple myeloma biology

Supplemental data

MYELOID NEOPLASIA

Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia

Genki Yamato,Tomoko Kawai,Norio Shiba,Junji Ikeda,Yusuke Hara,Kentaro Ohki,Shin-Ichi Tsujimoto,Taeko Kaburagi,Kenichi Yoshida,Yuichi Shiraishi,Satoru Miyano,Nobutaka Kiyokawa,Daisuke Tomizawa,Akira Shimada,Manabu Sotomatsu,Hirokazu Arakawa,Souichi Adachi,Takashi Taga,Keizo Horibe,Seishi Ogawa,Kenichiro Hata,Yasuhide Hayashi

View Articletitled, Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia

Supplemental data

Deep sequencing in CD34⁺ cells from peripheral blood enables sensitive detection of measurable residual disease in AML

Sebastian Stasik,Clara Burkhard-Meier,Michael Kramer,Jan M. Middeke,Uta Oelschlaegel,Katja Sockel,Gerhard Ehninger,Hubert Serve,Carsten Müller-Tidow,Claudia D. Baldus,Christoph Röllig,Martin Bornhäuser,Uwe Platzbecker,Christian Thiede

View Articletitled, Deep sequencing in CD34+ cells from peripheral blood enables sensitive detection of measurable residual disease in AML

Supplemental data

Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia

Zachary D. Epstein-Peterson,Andriy Derkach,Susan Geyer,Krzysztof Mrózek,Jessica Kohlschmidt,Jae H. Park,Sridevi Rajeeve,Eytan M. Stein,Yanming Zhang,Harry Iland,Lynda J. Campbell,Richard A. Larson,Xavier Poiré,Bayard L. Powell,Wendy Stock,Richard M. Stone,Martin S. Tallman

View Articletitled, Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia

Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells

Ge Tan,Witold E. Wolski,Sandra Kummer,Mara Hofstetter,Alexandre P. A. Theocharides,Markus G. Manz,Ruedi Aebersold,Fabienne Meier-Abt

View Articletitled, Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells

Supplemental data

A predictive model for bone marrow disease in cytopenia based on noninvasive procedures

Dicte Træden,Morten Tulstrup,Jack Bernard Cowland,Lene Dissing Sjö,Martin Bøgsted,Kirsten Grønbæk,Mette Klarskov Andersen,Jakob Werner Hansen

View Articletitled, A predictive model for bone marrow disease in cytopenia based on noninvasive procedures

Supplemental data

PLATELETS AND THROMBOPOIESIS

Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver

Sandra Gostynska,Thamizhiniyan Venkatesan,Kumar Subramani,Brienne Cortez,Amanda Robertson,Sandeep Subrahmanian,Pratibha Dube,Jasimuddin Ahamed

View Articletitled, Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver

Supplemental data

THROMBOSIS AND HEMOSTASIS

SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa

Kenneth C. Childers,Shaun C. Peters,Pete Lollar,Harold Trent Spencer,Christopher B. Doering,Paul C. Spiegel, Jr

View Articletitled, SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa

Supplemental data

Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C

Miao Jiang,Fei Yang,Yizhi Jiang,Lu Cheng,Jingjing Han,Jiawei Yi,Guige Zhang,Zhenni Ma,Lijuan Cao,Bin Zuo,Lixia Zhou,Lulu Huang,Siying Niu,Zhisong Xia,Xuefeng Zhou,Xia Bai,Naomi L. Esmon,Changgeng Ruan,Lijun Xia,Yue Han,Charles T. Esmon,Depei Wu,Jun Xu

View Articletitled, Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C

Supplemental data

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

Michael W. Henderson,Franciele Lima,Carla Roberta Peachazepi Moraes,Anton Ilich,Stephany Cares Huber,Mayck Silva Barbosa,Irene Santos,Andre C. Palma,Thyago Alves Nunes,Raisa Gusso Ulaf,Luciana Costa Ribeiro,Ana Flavia Bernardes,Bruna Bombassaro,Sergio San Juan Dertkigil,Maria Luiza Moretti,Sidney Strickland,Joyce M. Annichino-Bizzacchi,Fernanda Andrade Orsi,Eli Mansour,Licio A. Velloso,Nigel S. Key,Erich Vinicius De Paula

View Articletitled, Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

Supplemental data

A novel flow cytometry procoagulant assay for diagnosis of vaccine-induced immune thrombotic thrombocytopenia

Christine S.M. Lee,Hai Po Helena Liang,David E. Connor,Agnibesh Dey,Ibrahim Tohidi-Esfahani,Heather Campbell,Shane Whittaker,David Capraro,Emmanuel J. Favaloro,Dea Donikian,Mayuko Kondo,Sarah M. Hicks,Philip Y.-I. Choi,Elizabeth E. Gardiner,Lisa Joanne Clarke,Huyen Tran,Freda H. Passam,Timothy Andrew Brighton,Vivien M. Chen

View Articletitled, A novel flow cytometry procoagulant assay for diagnosis of vaccine-induced immune thrombotic thrombocytopenia

Supplemental data

TRANSFUSION MEDICINE

Donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

Abdulrahman Alshalani,Fabrice Uhel,Olaf L. Cremer,Marcus J. Schultz,Karen M. K. de Vooght,Robin van Bruggen,Jason P. Acker,Nicole P. Juffermans,on behalf of the MARS Consortium

View Articletitled, Donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

Supplemental data

TRANSPLANTATION

Prediction of outcomes after second-line treatment for acute graft-versus-host disease

Phuong Vo,Ted A. Gooley,Paul A. Carpenter,Mohamed L. Sorror,Margaret L. MacMillan,Todd E. DeFor,Paul J. Martin

View Articletitled, Prediction of outcomes after second-line treatment for acute graft-versus-host disease

RESEARCH LETTERS

TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms

Roman R. Schimmer,Larisa V. Kovtonyuk,Nancy Klemm,Jonas Fullin,Sebastian M. Stolz,Jan Mueller,Francisco Caiado,Kari J. Kurppa,Benjamin L. Ebert,Markus G. Manz,Steffen Boettcher

View Articletitled, TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms

Supplemental data

CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma

Akinao Okamoto,Hidetsugu Fujigaki,Chisako Iriyama,Naoe Goto,Hideyuki Yamamoto,Keichiro Mihara,Yoko Inaguma,Yasuo Miura,Katsuya Furukawa,Yukiya Yamamoto,Yoshiki Akatsuka,Senji Kasahara,Kotaro Miyao,Masutaka Tokuda,Seiko Sato,Yuki Mizutani,Michiko Osawa,Keiko Hattori,Sachiko Iba,Ryoko Kajiya,Masataka Okamoto,Kuniaki Saito,Akihiro Tomita

View Articletitled, CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma

Supplemental data

G3BP2-KIT drives leukemia amenable to kinase inhibition in Ph-like ALL

Ilaria Iacobucci,Reiji Fukano,Jake D. Friske,Chunxu Qu,Laura J. Janke,Yaqi Zhao,Pradyuamna Baviskar,Emily A. Backhaus,Peter Chockley,Aman Seth,A. Douglas Laird,Anjali S. Advani,Charles G. Mullighan

View Articletitled, G3BP2-KIT drives leukemia amenable to kinase inhibition in Ph-like ALL

Supplemental data

Hard-wired biases in trials: maintenance azacitidine in patients with acute myeloid leukemia and framework for future trials
Clinical Trials & Observations

Timothée Olivier,Vinay Prasad,Bernard L. Marini

View Articletitled, Hard-wired biases in trials: maintenance azacitidine in patients with acute myeloid leukemia and framework for future trials

Survival of mantle cell lymphoma in the era of Bruton tyrosine kinase inhibitors: a population-based analysis

Mengyang Di,Can Cui,Shalin K. Kothari,Amer M. Zeidan,Nikolai A. Podoltsev,Natalia Neparidze,Rory M. Shallis,Rong Wang,Xiaomei Ma,Scott F. Huntington

View Articletitled, Survival of mantle cell lymphoma in the era of Bruton tyrosine kinase inhibitors: a population-based analysis

Supplemental data

Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping

Jeffrey Jean,Alexandra E. Kovach,Andrew Doan,Matthew Oberley,Jianling Ji,Ryan J. Schmidt,Jaclyn A. Biegel,Deepa Bhojwani,Gordana Raca

View Articletitled, Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping

Supplemental data

Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia

Tessa Noordermeer,Ivar van Asten,Roger E. G. Schutgens,Anke J. Lakerveld,Cornelis A. Koekman,Kay Y. Hage,Silvie A. E. Sebastian,Albert Huisman,Dave J. van den Heuvel,Hans C. Gerritsen,Suzanne J. A. Korporaal,Marc Bierings,Jasper J. van der Smagt,Mariëlle E. van Gijn,Rolf T. Urbanus

View Articletitled, Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia

Deferasirox-induced robust and dose-dependent reversal of anemia in a patient with variants in the TRIB2 and ABCB6 genes

Julia Stomper,Paulina Richter-Pechanska,Dietmar Pfeifer,Immacolata Andolfo,Achille Iolascon,Martina U. Muckenthaler,Michael Lübbert

View Articletitled, Deferasirox-induced robust and dose-dependent reversal of anemia in a patient with variants in the TRIB2 and ABCB6 genes

Supplemental data

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High concentration of CD68⁺CD115⁺CD172⁺ macrophages in a follicular lymphoma sample post-lenalidomide and rituximab (R2) analyzed by multiplex immunofluorescence. See the article by Strati et al.
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Emapalumab for the treatment of refractory cytokine release syndrome in pediatric patients

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Issue Archive

Table of Contents

STIMULUS REPORTS

Lasting shift in the gut microbiota in patients with acute myeloid leukemia Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Clinical activity of single-dose systemic oncolytic VSV virotherapy in patients with relapsed refractory T-cell lymphoma Clinical Trials & Observations

Posttransplant cyclophosphamide for prevention of graft-versus-host disease: results of the prospective randomized HOVON-96 trial Clinical Trials & Observations

Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors Clinical Trials & Observations

Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia Clinical Trials & Observations

Zanubrutinib monotherapy in relapsed/refractory indolent non-Hodgkin lymphoma Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

THROMBOSIS AND HEMOSTASIS

TRANSFUSION MEDICINE

TRANSPLANTATION

RESEARCH LETTERS

Hard-wired biases in trials: maintenance azacitidine in patients with acute myeloid leukemia and framework for future trials Clinical Trials & Observations

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Lasting shift in the gut microbiota in patients with acute myeloid leukemia
Clinical Trials & Observations

Clinical activity of single-dose systemic oncolytic VSV virotherapy in patients with relapsed refractory T-cell lymphoma
Clinical Trials & Observations

Posttransplant cyclophosphamide for prevention of graft-versus-host disease: results of the prospective randomized HOVON-96 trial
Clinical Trials & Observations

Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors
Clinical Trials & Observations

Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia
Clinical Trials & Observations

Zanubrutinib monotherapy in relapsed/refractory indolent non-Hodgkin lymphoma
Clinical Trials & Observations

Hard-wired biases in trials: maintenance azacitidine in patients with acute myeloid leukemia and framework for future trials
Clinical Trials & Observations