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Issue Archive

Volume 4, Issue 23
December 8 2020
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORTS

Long-term remission in multiply relapsed enteropathy-associated T-cell lymphoma following CD30 CAR T-cell therapy
Clinical Trials & Observations
Timothy J. Voorhees,Nilanjan Ghosh,Natalie Grover,Jared Block,Catherine Cheng,Kaitlin Morrison,Anastasia Ivanova,Gianpietro Dotti,Jonathan Serody,Barbara Savoldo,Anne W. Beaven
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Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients
Clinical Trials & Observations
Susanne Ghandili,Susanne Pfefferle,Kevin Roedl,Piet Sonnemann,Panagiotis Karagiannis,Olaf Boenisch,Stefan Kluge,Stefan Schmiedel,Harald Ittrich,Holger Rohde,Marc Lütgehetmann,Katja Weisel,Carsten Bokemeyer,Dominic Wichmann,Walter Fiedler,Dominik Jarczak,Franziska Modemann
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Safety and efficacy of CAR T cells in a patient with lymphoma and a coexisting autoimmune neuropathy
Clinical Trials & Observations
Khushali S. Jhaveri,Ilana Schlam,Noa G. Holtzman,Monica Peravali,Perry K. Richardson,Saurabh Dahiya,Vera Malkovska,Aaron P. Rapoport
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A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN
Clinical Trials & Observations
Wenbin Xiao,Linde A. Miles,Robert L. Bowman,Vidushi Durani,Helen S. Tian,Nicole L. DelGaudio,Tanmay Mishra,Menglei Zhu,Yanming Zhang,Sarah E. Stump,Martin S. Tallman,Ross L. Levine,Sheng F. Cai
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REVIEW ARTICLE

Application of machine learning in the management of acute myeloid leukemia: current practice and future prospects
Clinical Trials & Observations
Jan-Niklas Eckardt,Martin Bornhäuser,Karsten Wendt,Jan Moritz Middeke
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CLINICAL TRIALS AND OBSERVATIONS

Glucose-6-phosphate dehydrogenase deficiency and susceptibility to childhood diseases in Kilifi, Kenya
Clinical Trials & Observations
Sophie Uyoga,Alex W. Macharia,Carolyne M. Ndila,Gideon Nyutu,Mohammed Shebe,Kennedy O. Awuondo,Neema Mturi,Norbert Peshu,Benjamin Tsofa,J. Anthony G. Scott,Kathryn Maitland,Thomas N. Williams
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Prolonged rituximab maintenance in follicular lymphoma patients: long-term results of the SAKK 35/03 randomized trial
Clinical Trials & Observations
Alden A. Moccia,Christian Taverna,Sämi Schär,Anna Vanazzi,Stéphanie Rondeau,Felicitas Hitz,Walter Mingrone,Thomas Pabst,Lidija Cevreska,Auro del Giglio,Johann Raats,Daniel Rauch,Daniel A. Vorobiof,Andreas Lohri,Céline Ruegsegger,Christine Biaggi Rudolf,Corinne Rusterholz,Stefanie Hayoz,Michele Ghielmini,Emanuele Zucca
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A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma
Clinical Trials & Observations
Nikhil C. Munshi,Herve Avet-Loiseau,Kenneth C. Anderson,Paola Neri,Bruno Paiva,Mehmet Samur,Meletios Dimopoulos,Margarita Kulakova,Annette Lam,Mahmoud Hashim,Jianming He,Bart Heeg,Jon Ukropec,Jessica Vermeulen,Sarah Cote,Nizar Bahlis
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Supplemental data
Zanubrutinib for the treatment of MYD88 wild-type Waldenström macroglobulinemia: a substudy of the phase 3 ASPEN trial
Clinical Trials & Observations
Meletios Dimopoulos,Ramon Garcia Sanz,Hui-Peng Lee,Marek Trneny,Marzia Varettoni,Stephen Opat,Shirley D'Sa,Roger G. Owen,Gavin Cull,Stephen Mulligan,Jaroslaw Czyz,Jorge J. Castillo,Marina Motta,Tanya Siddiqi,Mercedes Gironella Mesa,Miquel Granell Gorrochategui,Dipti Talaulikar,Pier Luigi Zinzani,Elham Askari,Sebastian Grosicki,Albert Oriol,Simon Rule,Janusz Kloczko,Alessandra Tedeschi,Christian Buske,Veronique Leblond,Judith Trotman,Wai Y. Chan,Jan Michel,Jingjing Schneider,Ziwen Tan,Aileen Cohen,Jane Huang,Constantine S. Tam,for the ASPEN investigators
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Supplemental data

HEALTH SERVICES AND OUTCOMES

Outcomes of patients with hematologic malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub
Clinical Trials & Observations
William A. Wood,Donna S. Neuberg,J. Colton Thompson,Martin S. Tallman,Mikkael A. Sekeres,Laurie H. Sehn,Kenneth C. Anderson,Aaron D. Goldberg,Nathan A. Pennell,Charlotte M. Niemeyer,Emily Tucker,Kathleen Hewitt,Robert M. Plovnick,Lisa K. Hicks
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Supplemental data

HEMATOPOIESIS AND STEM CELLS

Zebrafish Kit ligands cooperate with erythropoietin to promote erythroid cell expansion
Jana Oltova,Ondrej Svoboda,Olga Machonova,Petra Svatonova,David Traver,Michal Kolar,Petr Bartunek
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Supplemental data

LYMPHOID NEOPLASIA

Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes
Alessia Buratin,Maddalena Paganin,Enrico Gaffo,Anna Dal Molin,Juliette Roels,Giuseppe Germano,Maria Teresa Siddi,Valentina Serafin,Matthias De Decker,Stéphanie Gachet,Kaat Durinck,Frank Speleman,Tom Taghon,Geertruij te Kronnie,Pieter Van Vlierberghe,Stefania Bortoluzzi
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Supplemental data
Quantitative expression of Ikaros, IRF4, and PSMD10 proteins predicts survival in VRD-treated patients with multiple myeloma
Clinical Trials & Observations
Irena Misiewicz-Krzeminska,Cristina de Ramón,Luis A. Corchete,Patryk Krzeminski,Elizabeta A. Rojas,Isabel Isidro,Ramón García-Sanz,Joaquín Martínez-López,Albert Oriol,Joan Bladé,Juan-José Lahuerta,Jesús San Miguel,Laura Rosiñol,María-Victoria Mateos,Norma C. Gutiérrez,on behalf of the Grupo Español de Mieloma/Programa para el Estudio de la Terapeutica en Hemopatías Malignas Cooperative Study Groups
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Supplemental data
International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease
Clinical Trials & Observations
Frits van Rhee,Eric Oksenhendler,Gordan Srkalovic,Peter Voorhees,Megan Lim,Angela Dispenzieri,Makoto Ide,Sophia Parente,Stephen Schey,Matthew Streetly,Raymond Wong,David Wu,Ivan Maillard,Joshua Brandstadter,Nikhil Munshi,Wilbur Bowne,Kojo S. Elenitoba-Johnson,Alexander Fössa,Mary Jo Lechowicz,Shanmuganathan Chandrakasan,Sheila K. Pierson,Amy Greenway,Sunita Nasta,Kazuyuki Yoshizaki,Razelle Kurzrock,Thomas S. Uldrick,Corey Casper,Amy Chadburn,David C. Fajgenbaum,on behalf of the Castleman Disease Collaborative Network Scientific Advisory Board
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Supplemental data

MYELOID NEOPLASIA

Pacritinib demonstrates spleen volume reduction in patients with myelofibrosis independent of JAK2V617F allele burden
Clinical Trials & Observations
Douglas Tremblay,Ruben Mesa,Bart Scott,Sarah Buckley,Karisse Roman-Torres,Srdan Verstovsek,John Mascarenhas
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Supplemental data
Acute erythroid leukemia is enriched in NUP98 fusions: a report from the Children’s Oncology Group
Clinical Trials & Observations
Karen M. Chisholm,Amy E. Heerema-McKenney,John K. Choi,Jenny Smith,Rhonda E. Ries,Betsy A. Hirsch,Susana C. Raimondi,Todd A. Alonzo,Yi-Cheng Wang,Richard Aplenc,Lillian Sung,Alan S. Gamis,Soheil Meshinchi,Samir B. Kahwash
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Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Metabolic abnormalities in G6PC3-deficient human neutrophils result in severe functional defects
Christopher McKinney,Michael Ellison,Natalie J. Briones,Angelina Baroffio,John Murphy,Alexander D. Tran,Julie A. Reisz,Angelo D’Alessandro,Daniel R. Ambruso
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Supplemental data
NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease
Suk See De Ravin,Julie Brault,Ronald J. Meis,Linhong Li,Narda Theobald,Aylin C. Bonifacino,Hong Lei,Taylor Q. Liu,Sherry Koontz,Cristina Corsino,Marissa A. Zarakas,Jigar V. Desai,Aaron B. Clark,Uimook Choi,Mark E. Metzger,Kamille West,Steven L. Highfill,Elizabeth Kang,Douglas B. Kuhns,Michail S. Lionakis,David F. Stroncek,Cynthia E. Dunbar,John F. Tisdale,Robert E. Donahue,Gary A. Dahl,Harry L. Malech
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THROMBOSIS AND HEMOSTASIS

Association between congenital thrombophilia and outcomes in pulmonary embolism patients
Clinical Trials & Observations
Tian-Yu Lian,Dan Lu,Xin-Xin Yan,Jiang-Shan Tan,Fu-Hua Peng,Yong-Jian Zhu,Yun-Peng Wei,Tao Wu,Kai Sun,Xin Jiang,Lu Hua,Zhi-Cheng Jing
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Supplemental data

TRANSPLANTATION

High progression-free survival after intermediate intensity double unit cord blood transplantation in adults
Clinical Trials & Observations
Juliet N. Barker,Sean M. Devlin,Kristine A. Naputo,Kelcey Skinner,Molly A. Maloy,Lisa Flynn,Theodora Anagnostou,Scott T. Avecilla,Andromachi Scaradavou,Christina Cho,Parastoo B. Dahi,Sergio A. Giralt,Boglarka Gyurkocza,Alan M. Hanash,Katharine Hsu,Ann A. Jakubowski,Esperanza B. Papadopoulos,Jonathan U. Peled,Miguel-Angel Perales,Craig S. Sauter,Gunjan L. Shah,Brian C. Shaffer,Roni Tamari,James W. Young,Mikhail Roshal,Richard J. O’Reilly,Doris M. Ponce,Ioannis Politikos
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VASCULAR BIOLOGY

Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations
Clinical Trials & Observations
Caroline Diorio,Kevin O. McNerney,Michele Lambert,Michele Paessler,Elizabeth M. Anderson,Sarah E. Henrickson,Julie Chase,Emily J. Liebling,Chakkapong Burudpakdee,Jessica H. Lee,Frances B. Balamuth,Allison M. Blatz,Kathleen Chiotos,Julie C. Fitzgerald,Therese M. Giglia,Kandace Gollomp,Audrey R. Odom John,Cristina Jasen,Tomas Leng,Whitney Petrosa,Laura A. Vella,Char Witmer,Kathleen E. Sullivan,Benjamin L. Laskin,Scott E. Hensley,Hamid Bassiri,Edward M. Behrens,David T. Teachey
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Supplemental data
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Palma-Barqueros V, Bury L, Kunishima S, et al. Expanding the genetic spectrum of TUBB1-related thrombocytopenia. Blood Adv. 2021;5(24):5453–5467.
Visco C, Marcheselli L, Mina R, et al. A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study. Blood Adv. (2022);6(1):327-338.
Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs
Generation of a humanized afucosylated BAFF-R antibody with broad activity against human B-cell malignancies
Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept

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