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Multiple donor-derived leukemias in a recipient of allogeneic hematopoietic cell transplantation for myeloid malignancy
Successful transfer of anti–SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19
Risk-assessment models for VTE and bleeding in hospitalized medical patients: an overview of systematic reviews
Outcomes in patients with DLBCL treated with commercial CAR T cells compared with alternate therapies
Inhibitors and mortality in persons with nonsevere hemophilia A in the United States
Zanubrutinib (BGB-3111) plus obinutuzumab in patients with chronic lymphocytic leukemia and follicular lymphoma
Blastic plasmacytoid dendritic cell neoplasms: results of an international survey on 398 adult patients
Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy
Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma
Safety of venetoclax rapid dose escalation in CLL patients previously treated with B-cell receptor signaling antagonists
Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations
Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial
Safety and efficacy of anticoagulant therapy in pediatric catheter-related venous thrombosis (EINSTEIN-Jr CVC-VTE)
Prebiotics protect against acute graft-versus-host disease and preserve the gut microbiota in stem cell transplantation
Clinical activity of axicabtagene ciloleucel in adult patients with Richter syndrome
Busulfan and melphalan conditioning is superior to melphalan alone in autologous stem cell transplantation for high-risk MM
Issue Archive
October 13 2020
In this Issue
Table of Contents
BLOOD ADVANCES TALK
CLINICAL GUIDELINES
American Society of Hematology 2020 Guidelines for Management of Venous Thromboembolism: Treatment of Deep Vein Thrombosis and Pulmonary Embolism
Thomas L. Ortel,Ignacio Neumann,Walter Ageno,Rebecca Beyth,Nathan P. Clark,Adam Cuker,Barbara A. Hutten,Michael R. Jaff,Veena Manja,Sam Schulman,Caitlin Thurston,Suresh Vedantham,Peter Verhamme,Daniel M. Witt,Ivan D. Florez,Ariel Izcovich,Robby Nieuwlaat,Stephanie Ross,Holger J. Schünemann,Wojtek Wiercioch,Yuan Zhang,Yuqing Zhang
EXCEPTIONAL CASE REPORTS
Multiple donor-derived leukemias in a recipient of allogeneic hematopoietic cell transplantation for myeloid malignancy
Clinical Trials & Observations
Successful transfer of anti–SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19
Clinical Trials & Observations
Tim Luetkens,Ryan Metcalf,Vicente Planelles,Yue Zheng,Erin T. Larragoite,Emily S. Spivak,Adam M. Spivak,Mary Steinbach,Robert C. Blaylock,Stephanie V. Avila,Kim G. Hankey,Thomas B. Martins,Patricia R. Slev,Heather D. Mannuel,Mohammad Sajadi,Aaron P. Rapoport,Djordje Atanackovic
STIMULUS REPORTS
Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma
Dachuan Huang,Jing Quan Lim,Daryl Ming Zhe Cheah,Khalilatul Hanisah Binte Mohd Kahliab,Yurike Laurensia,Jane Wan Lu Pang,Esther Kam Yin Wong,Burton Kuan Hui Chia,Jasmine Goh,Xiyun Zhang,Jason Yongsheng Chan,Edward Kai-Hua Chow,Soo Yong Tan,Soon Thye Lim,Choon Kiat Ong
BRAFV600E or mutant MAP2K1 human CD34+ cells establish Langerhans cell–like histiocytosis in immune-deficient mice
Anahita Rafiei,C. Matthias Wilk,Patrick M. Helbling,Renier Myburgh,Yasuyuki Saito,Eugenia Haralambieva,Davide Soldini,Rikhia Chakraborty,Miriam Merad,Carl E. Allen,Cesar Nombela-Arrieta,Markus G. Manz
SYSTEMATIC REVIEW
Risk-assessment models for VTE and bleeding in hospitalized medical patients: an overview of systematic reviews
Clinical Trials & Observations
Andrea J. Darzi,Allen B. Repp,Frederick A. Spencer,Rami Z. Morsi,Rana Charide,Itziar Etxeandia-Ikobaltzeta,Kenneth A. Bauer,Allison E. Burnett,Mary Cushman,Francesco Dentali,Susan R. Kahn,Suely M. Rezende,Neil A. Zakai,Arnav Agarwal,Samer G. Karam,Tamara Lotfi,Wojtek Wiercioch,Reem Waziry,Alfonso Iorio,Elie A. Akl,Holger J. Schünemann
CLINICAL TRIALS AND OBSERVATIONS
Outcomes in patients with DLBCL treated with commercial CAR T cells compared with alternate therapies
Clinical Trials & Observations
David Sermer,Connie Batlevi,M. Lia Palomba,Gunjan Shah,Richard J. Lin,Miguel-Angel Perales,Michael Scordo,Parastoo Dahi,Martina Pennisi,Aishat Afuye,Mari Lynne Silverberg,Caleb Ho,Jessica Flynn,Sean Devlin,Philip Caron,Audrey Hamilton,Paul Hamlin,Steven Horwitz,Erel Joffe,Anita Kumar,Matthew Matasar,Ariela Noy,Colette Owens,Alison Moskowitz,David Straus,Gottfried von Keudell,Ildefonso Rodriguez-Rivera,Lorenzo Falchi,Andrew Zelenetz,Joachim Yahalom,Anas Younes,Craig Sauter
Inhibitors and mortality in persons with nonsevere hemophilia A in the United States
Clinical Trials & Observations
Zanubrutinib (BGB-3111) plus obinutuzumab in patients with chronic lymphocytic leukemia and follicular lymphoma
Clinical Trials & Observations
Constantine S. Tam,Hang Quach,Andrew Nicol,Xavier Badoux,Hannah Rose,H. Miles Prince,Michael F. Leahy,Richard Eek,Nicholas Wickham,Sushrut S. Patil,Jane Huang,Radha Prathikanti,Aileen Cohen,Rebecca Elstrom,William Reed,Jingjing Schneider,Ian W. Flinn
Blastic plasmacytoid dendritic cell neoplasms: results of an international survey on 398 adult patients
Clinical Trials & Observations
Kamel Laribi,Alix Baugier de Materre,Mohamad Sobh,Lorenzo Cerroni,Caterina Giovanna Valentini,Tomohiro Aoki,Ritsuro Suzuki,Kengo Takeuchi,Arthur E. Frankel,Carlo Cota,David Ghez,Ronan Le Calloch,Livio Pagano,Tony Petrella
HEMATOPOIESIS AND STEM CELLS
An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation
William Marion,Steffen Boettcher,Sonya Ruiz-Torres,Edroaldo Lummertz da Rocha,Vanessa Lundin,Vivian Morris,Stephanie Chou,Anna M. Zhao,Caroline Kubaczka,Olivia Aumais,Yosra Zhang,Akiko Shimamura,Thorsten M. Schlaeger,Trista E. North,Benjamin L. Ebert,Susanne I. Wells,George Q. Daley,R. Grant Rowe
IMMUNOBIOLOGY AND IMMUNOTHERAPY
Inverse relationship between oligoclonal expanded CD69− TTE and CD69+ TTE cells in bone marrow of multiple myeloma patients
Slavica Vuckovic,Christian E. Bryant,Ka Hei Aleks Lau,Shihong Yang,James Favaloro,Helen M. McGuire,Georgina Clark,Barbara Fazekas de St. Groth,Felix Marsh-Wakefield,Najah Nassif,Edward Abadir,Vinay Vanguru,Derek McCulloch,Christina Brown,Stephen Larsen,Scott Dunkley,Liane Khoo,John Gibson,Richard Boyle,Douglas Joshua,P. Joy Ho
Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy
Clinical Trials & Observations
Joanne E. Davis,Sasanka M. Handunnetti,Mandy Ludford-Menting,Chia Sharpe,Piers Blombery,Mary Ann Anderson,Andrew W. Roberts,John F. Seymour,Constantine S. Tam,David S. Ritchie,Rachel M. Koldej
Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma
Clinical Trials & Observations
Frederick L. Locke,John M. Rossi,Sattva S. Neelapu,Caron A. Jacobson,David B. Miklos,Armin Ghobadi,Olalekan O. Oluwole,Patrick M. Reagan,Lazaros J. Lekakis,Yi Lin,Marika Sherman,Marc Better,William Y. Go,Jeffrey S. Wiezorek,Allen Xue,Adrian Bot
LYMPHOID NEOPLASIA
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma
Clinical Trials & Observations
Paola Ghione,Promie Faruque,Neha Mehta-Shah,Venkatraman Seshan,Neval Ozkaya,Shakthi Bhaskar,James Yeung,Michael A. Spinner,Matthew Lunning,Giorgio Inghirami,Alison Moskowitz,Natasha Galasso,Nivetha Ganesan,Carrie van der Weyden,Jia Ruan,H. Miles Prince,Judith Trotman,Ranjana Advani,Ahmet Dogan,Steven Horwitz
BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus–associated T/NK-cell lymphoma
Nenad Sejic,Lindsay C. George,Rosemary J. Tierney,Catherine Chang,Olga Kondrashova,Ruth N. MacKinnon,Ping Lan,Andrew I. Bell,Guillaume Lessene,Heather M. Long,Andreas Strasser,Claire Shannon-Lowe,Gemma L. Kelly
TNFR2 is required for RIP1-dependent cell death in human leukemia
Júlia Aguadé-Gorgorió,Scott McComb,Cornelia Eckert,Anna Guinot,Blerim Marovca,Caterina Mezzatesta,Silvia Jenni,Liridon Abduli,Martin Schrappe,Maria Pamela Dobay,Martin Stanulla,Arend von Stackelberg,Gunnar Cario,Jean-Pierre Bourquin,Beat C. Bornhauser
Safety of venetoclax rapid dose escalation in CLL patients previously treated with B-cell receptor signaling antagonists
Clinical Trials & Observations
Kristin L. Koenig,Ying Huang,Emily K. Dotson,Shane Sheredy,Seema A. Bhat,John C. Byrd,Emily Desmond,Jill Ford,Shauna Iarocci,Jeffrey A. Jones,Margaret S. Lucas,Mollie E. Moran,Tracy E. Wiczer,Jennifer A. Woyach,Farrukh T. Awan,Kerry A. Rogers
MYELOID NEOPLASIA
Fusion partner–specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML
Hidemasa Matsuo,Kenichi Yoshida,Kana Nakatani,Yutarou Harata,Moe Higashitani,Yuri Ito,Yasuhiko Kamikubo,Yusuke Shiozawa,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Ai Okada,Yasuhito Nannya,June Takeda,Hiroo Ueno,Nobutaka Kiyokawa,Daisuke Tomizawa,Takashi Taga,Akio Tawa,Satoru Miyano,Manja Meggendorfer,Claudia Haferlach,Seishi Ogawa,Souichi Adachi
Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations
Clinical Trials & Observations
Simone Feurstein,Ayodeji Adegunsoye,Danijela Mojsilovic,Rekha Vij,Allison H. West DePersia,Padma Sheila Rajagopal,Afaf Osman,Robert H. Collins,Raymond H. Kim,Steven D. Gore,Peter Greenberg,Lucy A. Godley,Zejuan Li,Daniela del Gaudio,Hari Prasanna Subramanian,Soma Das,Tom Walsh,Suleyman Gulsuner,Jeremy P. Segal,Aliya N. Husain,Sandeep Gurbuxani,Mary-Claire King,Mary E. Strek,Jane E. Churpek
Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation
Damien Luque Paz,Rébecca Jouanneau-Courville,Jérémie Riou,Jean-Christophe Ianotto,Françoise Boyer,Aurélie Chauveau,Maxime Renard,Jean-Claude Chomel,Emilie Cayssials,Maria-Pilar Gallego-Hernanz,Cédric Pastoret,Anne Murati,Frédéric Courtier,Marie-Christine Rousselet,Isabelle Quintin-Roué,Laurane Cottin,Corentin Orvain,Sylvain Thépot,Jean-Marie Chrétien,Yves Delneste,Norbert Ifrah,Odile Blanchet,Mathilde Hunault-Berger,Eric Lippert,Valérie Ugo
Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial
Clinical Trials & Observations
Maria Teresa Voso,Richard A. Larson,Dan Jones,Guido Marcucci,Thomas Prior,Jürgen Krauter,Michael Heuser,Serena Lavorgna,Josep Nomdedeu,Susan M. Geyer,Alison Walker,Andrew H. Wei,Jorge Sierra,Miguel A. Sanz,Joseph M. Brandwein,Theo M. de Witte,Joop H. Jansen,Dietger Niederwieser,Frederick R. Appelbaum,Bruno C. Medeiros,Martin S. Tallman,Richard F. Schlenk,Arnold Ganser,Sergio Amadori,Yuan Cheng,YinMiao Chen,Celine Pallaud,Ling Du,Alfonso Piciocchi,Gerhard Ehninger,John Byrd,Christian Thiede,Konstanze Döhner,Richard M. Stone,Hartmut Döhner,Clara D. Bloomfield,Francesco Lo-Coco
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
Safety and efficacy of anticoagulant therapy in pediatric catheter-related venous thrombosis (EINSTEIN-Jr CVC-VTE)
Clinical Trials & Observations
Katharina Thom,Anthonie W. A. Lensing,Ildar Nurmeev,Fanny Bajolle,Damien Bonnet,Gili Kenet,M. Patricia Massicotte,Zeynep Karakas,Joseph S. Palumbo,Paola Saracco,Pascal Amedro,Juan Chain,Anthony K. Chan,Takanari Ikeyama,Joyce C. M. Lam,Cynthia Gauger,Ákos Ferenc Pap,Madhurima Majumder,Dagmar Kubitza,William T. Smith,Scott D. Berkowitz,Martin H. Prins,Paul Monagle,Guy Young,Christoph Male,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators,for the EINSTEIN-Jr CVC-VTE investigators
TRANSPLANTATION
Prebiotics protect against acute graft-versus-host disease and preserve the gut microbiota in stem cell transplantation
Clinical Trials & Observations
Kota Yoshifuji,Kyoko Inamoto,Yuko Kiridoshi,Kozue Takeshita,Satoshi Sasajima,Yukiko Shiraishi,Yuko Yamashita,Yuko Nisaka,Yukari Ogura,Rie Takeuchi,Takashi Toya,Aiko Igarashi,Yuho Najima,Noriko Doki,Takeshi Kobayashi,Kazuteru Ohashi,Wataru Suda,Koji Atarashi,Atsushi Shiota,Masahira Hattori,Kenya Honda,Kazuhiko Kakihana
Comparison of outcomes of HCT in blast phase of BCR-ABL1− MPN with de novo AML and with AML following MDS
Vikas Gupta,Soyoung Kim,Zhen-Huan Hu,Ying Liu,Mahmoud Aljurf,Ulrike Bacher,Amer Beitinjaneh,Jean-Yves Cahn,Jan Cerny,Edward Copelan,Shahinaz M. Gadalla,Robert Peter Gale,Siddhartha Ganguly,Biju George,Aaron T. Gerds,Usama Gergis,Betty K. Hamilton,Shahrukh Hashmi,Gerhard C. Hildebrandt,Rammurti T. Kamble,Tamila Kindwall-Keller,Hillard M. Lazarus,Jane L. Liesveld,Mark Litzow,Richard T. Maziarz,Taiga Nishihori,Richard F. Olsson,David Rizzieri,Bipin N. Savani,Sachiko Seo,Melhem Solh,Jeff Szer,Leo F. Verdonck,Baldeep Wirk,Ann Woolfrey,Jean A. Yared,Edwin P. Alyea,Uday R. Popat,Ronald M. Sobecks,Bart L. Scott,Ryotaro Nakamura,Wael Saber
COMMENTARIES
Clinical activity of axicabtagene ciloleucel in adult patients with Richter syndrome
Clinical Trials & Observations
Adam S. Kittai,David A. Bond,Basem William,Ayman Saad,Sam Penza,Yvonne Efebera,Karilyn Larkin,Sarah A. Wall,Hannah K. Choe,Bhavana Bhatnagar,Sumithira Vasu,Jonathan Brammer,Polina Shindiapina,Meixiao Long,Alice Mims,Lynn O’Donnell,Seema A. Bhat,Kerry A. Rogers,Jennifer A. Woyach,John C. Byrd,Samantha M. Jaglowski
CD1a is rarely expressed in pediatric or adult relapsed/refractory T-ALL: implications for immunotherapy
Sarah Leong,Sarah Inglott,Foteini Papaleonidopoulou,Karen Orfinada,Philip Ancliff,Jack Bartram,Ben Carpenter,Adele K. Fielding,Sara Ghorashian,Victoria Grandage,Rajeev Gupta,Rachael Hough,Asim Khwaja,Vesna Pavasovic,Anupama Rao,Sujith Samarasinghe,Ajay Vora,Marc R. Mansour,David O’Connor
Busulfan and melphalan conditioning is superior to melphalan alone in autologous stem cell transplantation for high-risk MM
Clinical Trials & Observations
Neeraj Saini,Qaiser Bashir,Denái R. Milton,Guilin Tang,Ruby Delgado,Gabriela Rondon,Uday R. Popat,Chitra M. Hosing,Yago Nieto,Partow Kebriaei,Amin M. Alousi,Rohtesh Mehta,Samer Srour,Issa F. Khouri,Donna M. Weber,Sheeba K. Thomas,Hans C. Lee,Krina K. Patel,Robert Z. Orlowski,Richard E. Champlin,Muzaffar H. Qazilbash
ERRATA
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Cover Image
Cover Image
COVER FIGURE
Zika virus in blood with red blood cells. Credit: ID 75228952 © Igor Zakharevich| Dreamstime.com. - PDF Icon PDF LinkFront Matter
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