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Issue Archive

Volume 3, Issue 9
May 14 2019
Issue Cover

Table of Contents

CLINICAL TRIALS AND OBSERVATIONS

Favorable outcomes with de-escalated radiation therapy for limited-stage nodular lymphocyte-predominant Hodgkin lymphoma
Clinical Trials & Observations
Chelsea C. Pinnix,Sarah A. Milgrom,Chan Yoon Cheah,Jillian R. Gunther,Ethan B. Ludmir,Christine F. Wogan,Loretta J. Nastoupil,Sattva S. Neelapu,Jason Westin,Hun J. Lee,Swaminathan P. Iyer,Raphael E. Steiner,Luis E. Fayad,Nathan H. Fowler,Michael L. Wang,Felipe Samaniego,Maria A. Rodriguez,Amy E. Rich,L. Jeffrey Medeiros,Bouthaina S. Dabaja
View Article
Brentuximab vedotin followed by bendamustine supercharge for refractory or relapsed Hodgkin lymphoma
Clinical Trials & Observations
M. Picardi,R. Della Pepa,C. Giordano,N. Pugliese,C. Mortaruolo,F. Trastulli,M. G. Rascato,I. Cappuccio,M. Raimondo,M. Memoli,M. Monteverde,M. Mascolo,F. Pane
View Article
Acalabrutinib monotherapy in patients with chronic lymphocytic leukemia who are intolerant to ibrutinib
Clinical Trials & Observations
Farrukh T. Awan,Anna Schuh,Jennifer R. Brown,Richard R. Furman,John M. Pagel,Peter Hillmen,Deborah M. Stephens,Jennifer Woyach,Elena Bibikova,Prista Charuworn,Melanie M. Frigault,Ahmed Hamdy,Raquel Izumi,Bolan Linghu,Priti Patel,Min Hui Wang,John C. Byrd

The introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib revolutionized the treatment of chronic lymphocytic leukemia. However, because inefficacy or intolerable side effects, some patients do not benefit. Acalabrutinib is a covalent BTK inhibitor with greater selectivity than ibrutinib. Byrd and colleagues explored acalabrutinib in patients refractory to or intolerant of ibrutinib, finding exciting evidence for efficacy and tolerability.

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LYMPHOID NEOPLASIA

Childhood use of antimicrobials and risk of Hodgkin lymphoma: a Danish register–based cohort study
Clinical Trials & Observations
Henrik Hjalgrim,Signe Holst Søegaard,Lisa Lyngsie Hjalgrim,Klaus Rostgaard
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Efficacy and predictors of response of lenalidomide and rituximab in patients with treatment-naive and relapsed CLL
Clinical Trials & Observations
Paolo Strati,Koichi Takahashi,Christine B. Peterson,Michael J. Keating,Philip A. Thompson,Naval G. Daver,Nitin Jain,Jan A. Burger,Zeev Estrov,Susan M. O'Brien,Hagop M. Kantarjian,William G. Wierda,P. Andrew Futreal,Alessandra Ferrajoli
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MYELOID NEOPLASIA

Myeloid translocation gene CBFA2T3 directs a relapse gene program and determines patient-specific outcomes in AML
Nickolas Steinauer,Chun Guo,Chunfa Huang,Madeline Wong,Yifan Tu,Carl E. Freter,Jinsong Zhang
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Supplemental data
Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia
Jesus Izaguirre-Carbonell,Luke Christiansen,Robert Burns,Jesse Schmitz,Chenxuan Li,Rebekah L. Mokry,Theresa Bluemn,Yongwei Zheng,Jian Shen,Karen-Sue Carlson,Sridhar Rao,Demin Wang,Nan Zhu
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Supplemental data
Clinicopathologic and genetic characterization of nonacute NPM1-mutated myeloid neoplasms
Clinical Trials & Observations
Sanjay S. Patel,Caleb Ho,Ryan N. Ptashkin,Sam Sadigh,Adam Bagg,Julia T. Geyer,Mina L. Xu,Thomas Prebet,Emily F. Mason,Adam C. Seegmiller,Elizabeth A. Morgan,David P. Steensma,Eric S. Winer,Waihay J. Wong,Robert P. Hasserjian,Olga K. Weinberg
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PLATELETS AND THROMBOPOIESIS

Generation of transgenic zebrafish with 2 populations of RFP- and GFP-labeled thrombocytes: analysis of their lipids
Weam Fallatah,Imesha W. De Silva,Guido F. Verbeck,Pudur Jagadeeswaran
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Supplemental data
Dysregulated megakaryocyte distribution associated with nestin+ mesenchymal stem cells in immune thrombocytopenia
Min Wang,Ru Feng,Jia-min Zhang,Lin-lin Xu,Fei-er Feng,Chen-cong Wang,Qian-ming Wang,Xiao-lu Zhu,Yun He,Jing Xue,Hai-xia Fu,Meng Lv,Yuan Kong,Ying-jun Chang,Lan-ping Xu,Kai-yan Liu,Xiao-jun Huang,Xiao-hui Zhang
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Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Hyperfiltration predicts long-term renal outcomes in humanized sickle cell mice
Malgorzata Kasztan,Brandon M. Fox,Jeffrey D. Lebensburger,Kelly A. Hyndman,Joshua S. Speed,Jennifer S. Pollock,David M. Pollock
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Height-corrected low bone density associates with severe outcomes in sickle cell disease: SCCRIP cohort study results
Clinical Trials & Observations
Oyebimpe O. Adesina,James G. Gurney,Guolian Kang,Martha Villavicencio,Jason R. Hodges,Wassim Chemaitilly,Sue C. Kaste,Babette S. Zemel,Jane S. Hankins
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Supplemental data
Phthalides serve as potent modulators to boost fetal hemoglobin induction therapy for β-hemoglobinopathies
Wei-Ren Chen,Chia-Cheng Chou,Chia C. Wang
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Supplemental data

THROMBOSIS AND HEMOSTASIS

Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A
Randolph B. Lyde,Hyun Sook Ahn,Karen K. Vo,Danuta J. Jarocha,John Tkaczynski,Elsa Treffeisen,Spencer K. Sullivan,Rodney M. Camire,Denise E. Sabatino,Deborah L. French,Mortimer Poncz
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Supplemental data
Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products
Wojciech Jankowski,Yara Park,Joseph McGill,Eugene Maraskovsky,Marco Hofmann,Vincent P. Diego,Bernadette W. Luu,Tom E. Howard,Roberta Kellerman,Nigel S. Key,Zuben E. Sauna
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Supplemental data
Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib
Juliet Morgan,Muhammad Saleem,Ruiqi Ng,Caroline Armstrong,Szu S. Wong,Simon G. Caulton,Alice Fickling,Huw E. L. Williams,Adam D. Munday,José A. López,Mark S. Searle,Jonas Emsley
View Article
Supplemental data
Predictors of relapse and efficacy of rituximab in immune thrombotic thrombocytopenic purpura
Clinical Trials & Observations
Lova Sun,Johnathan Mack,Ang Li,Justine Ryu,Vivek A. Upadhyay,Lynne Uhl,Richard M. Kaufman,Christopher P. Stowell,Walter S. Dzik,Robert S. Makar,Pavan K. Bendapudi
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Supplemental data
Elimination of the fibrinogen integrin αMβ2-binding motif improves renal pathology in mice with sickle cell anemia
Md Nasimuzzaman,Paritha I. Arumugam,Eric S. Mullins,Jeanne M. James,Katherine VandenHeuvel,Marilou G. Narciso,Maureen A. Shaw,Sarah McGraw,Bruce J. Aronow,Punam Malik
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Supplemental data

TRANSPLANTATION

Antirelapse effect of pretransplant exposure to rabbit antithymocyte globulin
Clinical Trials & Observations
Rosy Dabas,Kareem Jamani,Shahbal B. Kangarloo,Poonam Dharmani-Khan,Tyler S. Williamson,Samar Ousia,Caylib Durand,Don Morris,Douglas Mahoney,Lynn Savoie,Ahsan Chaudhry,Victor H. Jimenez-Zepeda,Faisal M. Khan,Andrew Daly,Jan Storek
View Article
Supplemental data
GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia
Clinical Trials & Observations
Rohtesh S. Mehta,Shernan G. Holtan,Tao Wang,Michael T. Hemmer,Stephen R. Spellman,Mukta Arora,Daniel R. Couriel,Amin M. Alousi,Joseph Pidala,Hisham Abdel-Azim,Ibrahim Ahmed,Mahmoud Aljurf,Medhat Askar,Jeffery J. Auletta,Vijaya Bhatt,Christopher Bredeson,Saurabh Chhabra,Shahinaz Gadalla,James Gajewski,Robert Peter Gale,Usama Gergis,Peiman Hematti,Gerhard C. Hildebrandt,Yoshihiro Inamoto,Carrie Kitko,Pooja Khandelwal,Margaret L. MacMillan,Navneet Majhail,David I. Marks,Parinda Mehta,Taiga Nishihori,Richard F. Olsson,Attaphol Pawarode,Miguel Angel Diaz,Tim Prestidge,Muna Qayed,Hemalatha Rangarajan,Olle Ringden,Ayman Saad,Bipin N. Savani,Sachiko Seo,Ami Shah,Niketa Shah,Kirk R. Schultz,Melhem Solh,Thomas Spitzer,Jeffrey Szer,Takanori Teshima,Leo F. Verdonck,Kirsten M. Williams,Baldeep Wirk,John Wagner,Jean A. Yared,Daniel J. Weisdorf
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Supplemental data
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Definitive involved-site radiation therapy administered for stage IA nodular lymphocyte-predominant Hodgkin lymphoma of the right side of the neck. Lt, left; Rt, right. See the article by Pinnix et al.

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Palma-Barqueros V, Bury L, Kunishima S, et al. Expanding the genetic spectrum of TUBB1-related thrombocytopenia. Blood Adv. 2021;5(24):5453–5467.
Visco C, Marcheselli L, Mina R, et al. A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study. Blood Adv. (2022);6(1):327-338.
Randomized, Double Blinded, Placebo Controlled Trial of Allogeneic Cord Blood T-Regulatory Cell for Treatment of COVID-19 ARDS
Improved Access to HCT with Reduced Racial Disparities Through Integration with Leukemia Care and Haploidentical Donors
Characterization of the human platelet N- and O-glycome upon storage using tandem mass spectrometry

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