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DRUG ADVANCES

STIMULUS REPORT

CLINICAL TRIALS AND OBSERVATIONS

Francine Garnache-Ottou,Chrystelle Vidal,Sabeha Biichlé,Florian Renosi,Eve Poret,Maïder Pagadoy,Maxime Desmarets,Anne Roggy,Estelle Seilles,Lou Soret,Françoise Schillinger,Sandrine Puyraimond,Tony Petrella,Claude Preudhomme,Christophe Roumier,Elisabeth A. MacIntyre,Véronique Harrivel,Yohan Desbrosses,Bérengère Gruson,Franck Geneviève,Sylvain Thepot,Yuriy Drebit,Thibaut Leguay,François-Xavier Gros,Nicolas Lechevalier,Pascale Saussoy,Véronique Salaun,Edouard Cornet,Zehaira Benseddik,Richard Veyrat-Masson,Orianne Wagner-Ballon,Célia Salanoubat,Marc Maynadié,Julien Guy,Denis Caillot,Marie-Christine Jacob,Jean-Yves Cahn,Rémy Gressin,Johann Rose,Bruno Quesnel,Estelle Guerin,Franck Trimoreau,Jean Feuillard,Marie-Pierre Gourin,Adriana Plesa,Lucile Baseggio,Isabelle Arnoux,Norbert Vey,Didier Blaise,Romaric Lacroix,Christine Arnoulet,Blandine Benet,Véronique Dorvaux,Caroline Bret,Bernard Drenou,Agathe Debliquis,Véronique Latger-Cannard,Caroline Bonmati,Marie-Christine Bene,Pierre Peterlin,Michel Ticchioni,Pierre-Simon Rohrlich,Anne Arnaud,Stefan Wickenhauser,Valérie Bardet,Sabine Brechignac,Benjamin Papoular,Victoria Raggueneau,Jacques Vargaftig,Rémi Letestu,Daniel Lusina,Thorsten Braun,Vincent Foissaud,Jérôme Tamburini,Hind Bennani,Nicolas Freynet,Catherine Cordonnier,Magali Le Garff-Tavernier,Nathalie Jacques,Karim Maloum,Damien Roos-Weil,Didier Bouscary,Vahid Asnafi,Ludovic Lhermitte,Felipe Suarez,Etienne Lengline,Frédéric Féger,Giorgia Battipaglia,Mohamad Mohty,Sabrina Bouyer,Ouda Ghoual,Elodie Dindinaud,Caroline Basle,Mathieu Puyade,Carinne Lafon,Thierry Fest,Mikael Roussel,Xavier Cahu,Elsa Bera,Sylvie Daliphard,Fabrice Jardin,Lydia Campos,Françoise Solly,Denis Guyotat,Anne-Cécile Galoisy,Alice Eischen,Caroline Mayeur-Rousse,Blandine Guffroy,Christian Recher,Marie Loosveld,Alice Garnier,Vincent Barlogis,Maria Alessandra Rosenthal,Sophie Brun,Nathalie Contentin,Sébastien Maury,Mary Callanan,Christine Lefebvre,Natacha Maillard,Patricia Okamba,Christophe Ferrand,Olivier Adotevi,Philippe Saas,Fanny Angelot-Delettre,Delphine Binda,Eric Deconinck

GENE THERAPY

HEMATOPOIESIS AND STEM CELLS

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Bioengineered hemophilia A–specific factor VIII (FVIII)–secreting vascular networks in hemophilic mice. Grafts were prepared with human hemophilia A–specific induced pluripotent stem cell–derived endothelial cells that were genetically engineered to overexpress full-length F8. Next, grafts were transplanted subcutaneously into immunodeficient hemophilic mice. After 7 days in vivo, immunofluorescence staining of the explanted grafts revealed the presence of human vessels expressing FVIII (green). Human lumens were stained by h-CD31 (red) and nuclei were stained by DAPI (blue). See the article by Neumeyer et al.

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