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Blood Advances Talks

IMMUNOBIOLOGY

MYELOID NEOPLASIA

THROMBOSIS AND HEMOSTASIS

  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Genomic distribution of 51 clonal chromosomal mosaic events detected in blood DNA by whole-genome single-nucleotide polymorphism arrays in 130 patients with Fanconi anemia (FA). The circular plot shows the chromosomal location of each of the 51 mosaic events detected (red bars, losses; blue bars, gains; orange bars, multicopy gains; and green bars, copy-neutral events or uniparental disomies). The detected frequency of clonal events is over 100-fold higher in individuals with FA (n = 130) than in age-matched healthy controls (n = 15 743). These clonal events reflect the cytogenetic status of the bone marrow, and their presence is strongly associated with increased cancer risk and poor survival. See the article by Reina-Castillón et al.

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