Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?
GATA2 has been recognized to be of importance in bone marrow failure states and myeloid leukemias. In a Review Article, Bresnick and colleagues critically evaluate the role of human GATA2 mutations in hematologic disease, describing the multiple pathways that may be involved.
Systems-based hematology: highlighting successes and next steps
Systems-based hematology is an effort led by the American Society of Hematology to address improvements in the care of patients with blood disorders. May and colleagues detail progress by this group in the stewardship in the diagnosis and treatment of complex hematological disorders and future directions to expand into other critical areas of our field.
Effectiveness and safety of rivaroxaban compared with low-molecular-weight heparin in cancer-associated thromboembolism
In patients with cancer-associated deep venous thrombosis, there are differing recommendations on the use of direct-acting oral anticoagulants vs low-molecular-weight heparin (LMWH). Costa and colleagues evaluated outcomes in patients treated with rivaroxaban as compared to LMWH, with important clinical findings.
Variable CD34+ recovery of cryopreserved allogeneic HPC products: transplant implications during the COVID-19 pandemic
COVID-19 has disrupted and altered many clinical pathways. In the setting of allogeneic hematopoietic cell transplantation, a major alteration has been the routine cryopreservation of unrelated products to ensure their delivery prior to initiation of the transplant conditioning. Purtill and colleagues explored the impact of cryopreservation on hematopoietic stem and progenitor cell yields and advise caution.
HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation
Increasing fetal hemoglobin (HbF) production has been demonstrated to be an effective strategy to reduce complications of sickle cell disease (SCD). Abdulmalik and colleagues explored the role of heme-regulated inhibitor (HRI). Pharmacologic reduction of HRI in combination of other inducers of HbF was shown to be an effective approach to preserve erythroid function in SCD.
Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation
Much has been written about potential reservoirs of HIV infection that may escape treatment. Simpson and colleagues explored the role of HIV infection of platelets at early times postinfection and after antiretroviral therapy in a study with interesting and clinically impactful findings.
