...Elliott P. Vichinsky; Lori A. Styles; Linda H. Colangelo; Elizabeth C. Wright; Oswaldo Castro; Bruce Nickerson; the Cooperative Study of Sickle Cell Disease Acute chest syndrome (ACS) is an important cause of morbidity and mortality in sickle cell disease (SCD). Previous studies reported...

...; Francoise Bernaudin; Wing-Yen Wong; J. Paul Scott; David Margolis; Elliott Vichinsky; Donna A. Wall; Allen S. Wayne; Charles Pegelow; Rupa Redding-Lallinger; Joseph Wiley; Martin Klemperer; William C. Mentzer; Franklin O. Smith; Keith M. Sullivan Fifty children who had symptomatic sickle cell disease...

...Dipti Gupta; Sarah Sturtevant, BSc; Benjamin Vieira, BS; Yukio Nakamura, MD PhD; Sriram Krishnamoorthy, PhD; Melanie Demers, PhD Sickle cell disease (SCD) is a genetic disorder caused by a missense mutation in the beta-globin gene [Glu6Val] resulting in the formation of HbS (sickle hemoglobin). HbS...

...Lanetta Bronté-Hall, MPH, MSPH, MD; Matthew Parkin; Courtney Green; Elsa Tchouambou, DO; Lynn Huynh, MPH, MBA, DrPH; Charu Puri-Sharma, MS; Rose Chang, MSPH, MS, ScD; Anjulika Chawla, MD; James Signorovitch, PhD; Gershwin Theophilus Blyden, MD Background Sickle cell disease (SCD) is a progressively...

...Stacy Desine, BA; Brittany Hollister, PhD; Anitra Persaud, BA; Vence L. Bonham, J.D. Introduction: One of the first therapeutic targets of CRISPR genome editing will likely be sickle cell disease (SCD), the most commonly inherited blood disorder in the U.S.SCD affects 100,000 individuals in the U.S...

...Patrick B. Walter, PhD; David W. Killilea, PhD; Ellen B. Fung, PhD; Annie Lui, BS; Jacqueline Madden, PNP; John Porter, MD; Patricia Evans, PhD; Bruce N. Ames, PhD; Elliott Vichinsky, MD; Paul Harmatz, MD Sickle cell disease (SCD) is a hemoglobinopathy characterized by micro-vascular hypoxia...

...Baba Inusa, MD MRCP; Jo Howard, MBBCh; Subarna Chakravorty, MBBS, PhD FRCPath, MRCP; Maria Pelidis, MD; Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP; Fenella J Kirkham, MD Abstract Background: In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties...

..., PhD; Gupta Atul, MD; Simrat Sarkaria; Christina Liossi, PhD; Fenella J Kirkham, MD; Baba Inusa, MD MRCP Background: Complications in sickle cell anemia (SCA, HbSS) include neurocognitive difficulties in attention and processing speed associated with low daytime and night-time oxygen saturation...

...; Andra H. James, MDMPH; Mark Rodeghier, PhD; Michael R. DeBaun, MD MPH Background: Sickle cell disease (SCD) is a major public health problem in Sub-Saharan Africa, which is home to about 70% of the affected individuals worldwide. Pregnancy is an emerging life-threatening complication of SCD with high...

... Cell Disease Observatory (ISCDO) is an international group, established in 2011, including representatives from countries where sickle cell disease (SCD) is highly prevalent, in order to collect and share information of SCD patient's to improve patients care and quality of life, to define common...

... with sickle cell disease (SCD) in the world. Approximately 150,000 children are born with SCD each year (incident cases) in Nigeria, compared to a total of approximately 100,000 children and adults living with SCD in the United States (prevalent cases). Pulmonary complications, including asthma and asthma...

..., FMedSci; Lorna M Williamson, FRCPath Abstract 9 Introduction: The rate of complications after surgery is increased in patients with Sickle Cell Disease (SCD) and pre-operative blood transfusion has historically been used to decrease this risk. Observational studies and one limited Randomised Controlled...

...Dalal H. Mulla-Ali, MD; Kevin H.M. Kuo, MD; Mathew Sermer, MD; Anne Mcleod, MD Abstract 4848 Introduction: Patients with sickle cell disease (SCD) have worse maternal and fetal outcomes compared to the general population, and experience antepartum complications unique to SCD patients, including...

...Ariel Koren, MD; Daniel Fink; Osnat Admoni; Yardena Tennenbaum-Rakover; Carina Levin Abstract 4625 BACKGROUND Blood transfusions are the standard of care in β thalassemia and transfusions are also indicated in Sickle Cell Disease (SCD) patients with hypersplenism, recurrent vaso-occlusive crises...

...Raymond U. Osarogiagbon, MBBS; Syed N Haider, MD; Jun Tang, MS, Phd Abstract 4607 Introduction The high mortality risk that sickle cell disease (SCD) patients experience from infancy is cumulative through adulthood, largely because of the effect of cumulative end organ damage, which is a more...

...-related adverse events, and decrease in hospitalizations. Increase in ferritin is an expected outcome in transfused patients since chelation was not a part of this transfusion protocol. On completion of the study, the potential benefits of transfusion therapy on sickle cell disease morbidity including...

...Emily Riehm Meier, MD MSHS; Allistair Abraham, MD; Alexander I. Ngwube, MD; Isaac Janson, PhD; Gregory M.T. Guilcher, MD; John T. Horan, MDMPH; Kimberly A. Kasow, DO Background Hematopoietic stem cell transplantation (HSCT) provides a curative therapy for children severely affected by sickle cell...

...Amer Assal, MD; Diane George, MD; Monica Bhatia, MD; Christian Gordillo, BS; Nicole Howard, BS; Ran Reshef, MD MSc; Markus Y Mapara, MD PhD Introduction: Sickle cell disease (SCD) affects 300,000 annual births globally, and about 100,000 individuals in the United States. Allogeneic hematopoietic...

...; Shalini Shenoy, MD; John T Horan, MD Background: Myeloablative HLA-matched sibling donor hematopoietic cell transplantation (HCT) is highly curative for children and young adults with sickle cell disease (SCD). The most common regimen used worldwide has been Busulfan, Cyclophosphamide and anti-thymocyte...

...; Kevin H. M. Kuo, MDMSc,FRCPC Rate of Sickle Hemoglobin Recovery in Sickle Cell Disease Patients Undergoing Red Blood Cell (RBC) Exchange Transfusion is Associated with Age of Patients and Number of RBC Units Transfused Introduction : Automated and manual red blood cell exchange (RBCX) transfusions...