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sickle cell disease

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Journal Articles
Journal: Blood
Blood (1997) 89 (5): 1787–1792.
Published: 1997
...Elliott P. Vichinsky; Lori A. Styles; Linda H. Colangelo; Elizabeth C. Wright; Oswaldo Castro; Bruce Nickerson; the Cooperative Study of Sickle Cell Disease Acute chest syndrome (ACS) is an important cause of morbidity and mortality in sickle cell disease (SCD). Previous studies reported...
Journal Articles
Journal: Blood
Blood (2000) 95 (6): 1918–1924.
Published: 2000
...; Francoise Bernaudin; Wing-Yen Wong; J. Paul Scott; David Margolis; Elliott Vichinsky; Donna A. Wall; Allen S. Wayne; Charles Pegelow; Rupa Redding-Lallinger; Joseph Wiley; Martin Klemperer; William C. Mentzer; Franklin O. Smith; Keith M. Sullivan Fifty children who had symptomatic sickle cell disease...
Journal Articles
Journal: Blood
Blood (2019) 134 (Supplement_1): 3559.
Published: 2019
...Dipti Gupta; Sarah Sturtevant, BSc; Benjamin Vieira, BS; Yukio Nakamura, MD PhD; Sriram Krishnamoorthy, PhD; Melanie Demers, PhD Sickle cell disease (SCD) is a genetic disorder caused by a missense mutation in the beta-globin gene [Glu6Val] resulting in the formation of HbS (sickle hemoglobin). HbS...
Journal Articles
Journal: Blood
Blood (2019) 134 (Supplement_1): 5856.
Published: 2019
...Lanetta Bronté-Hall, MPH, MSPH, MD; Matthew Parkin; Courtney Green; Elsa Tchouambou, DO; Lynn Huynh, MPH, MBA, DrPH; Charu Puri-Sharma, MS; Rose Chang, MSPH, MS, ScD; Anjulika Chawla, MD; James Signorovitch, PhD; Gershwin Theophilus Blyden, MD Background Sickle cell disease (SCD) is a progressively...
Journal Articles
Journal: Blood
Blood (2018) 132 (Supplement 1): 5805.
Published: 2018
...Stacy Desine, BA; Brittany Hollister, PhD; Anitra Persaud, BA; Vence L. Bonham, J.D. Introduction: One of the first therapeutic targets of CRISPR genome editing will likely be sickle cell disease (SCD), the most commonly inherited blood disorder in the U.S.SCD affects 100,000 individuals in the U.S...
Journal Articles
Journal: Blood
Blood (2017) 130 (Supplement 1): 3537.
Published: 2017
...Baba Inusa, MD MRCP; Jo Howard, MBBCh; Subarna Chakravorty, MBBS, PhD FRCPath, MRCP; Maria Pelidis, MD; Swee Lay Thein, DSc,FRCP,FRCPath,MBBS,MRCPath,MRCP; Fenella J Kirkham, MD Abstract Background: In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties...
Journal Articles
Journal Articles
Journal: Blood
Blood (2017) 130 (Supplement 1): 616.
Published: 2017
...; Andra H. James, MDMPH; Mark Rodeghier, PhD; Michael R. DeBaun, MD MPH Background: Sickle cell disease (SCD) is a major public health problem in Sub-Saharan Africa, which is home to about 70% of the affected individuals worldwide. Pregnancy is an emerging life-threatening complication of SCD with high...
Journal Articles
Journal: Blood
Blood (2006) 108 (11): 1233.
Published: 2006
...Patrick B. Walter, PhD; David W. Killilea, PhD; Ellen B. Fung, PhD; Annie Lui, BS; Jacqueline Madden, PNP; John Porter, MD; Patricia Evans, PhD; Bruce N. Ames, PhD; Elliott Vichinsky, MD; Paul Harmatz, MD Sickle cell disease (SCD) is a hemoglobinopathy characterized by micro-vascular hypoxia...
Journal Articles
Journal Articles
Journal: Blood
Blood (2012) 120 (21): 4760.
Published: 2012
... with sickle cell disease (SCD) in the world. Approximately 150,000 children are born with SCD each year (incident cases) in Nigeria, compared to a total of approximately 100,000 children and adults living with SCD in the United States (prevalent cases). Pulmonary complications, including asthma and asthma...
Journal Articles
Journal: Blood
Blood (2011) 118 (21): 9.
Published: 2011
..., FMedSci; Lorna M Williamson, FRCPath Abstract 9 Introduction: The rate of complications after surgery is increased in patients with Sickle Cell Disease (SCD) and pre-operative blood transfusion has historically been used to decrease this risk. Observational studies and one limited Randomised Controlled...
Journal Articles
Journal: Blood
Blood (2011) 118 (21): 4848.
Published: 2011
...Dalal H. Mulla-Ali, MD; Kevin H.M. Kuo, MD; Mathew Sermer, MD; Anne Mcleod, MD Abstract 4848 Introduction: Patients with sickle cell disease (SCD) have worse maternal and fetal outcomes compared to the general population, and experience antepartum complications unique to SCD patients, including...
Journal Articles
Journal: Blood
Blood (2009) 114 (22): 4607.
Published: 2009
...Raymond U. Osarogiagbon, MBBS; Syed N Haider, MD; Jun Tang, MS, Phd Abstract 4607 Introduction The high mortality risk that sickle cell disease (SCD) patients experience from infancy is cumulative through adulthood, largely because of the effect of cumulative end organ damage, which is a more...
Journal Articles
Journal: Blood
Blood (2009) 114 (22): 4625.
Published: 2009
...Ariel Koren, MD; Daniel Fink; Osnat Admoni; Yardena Tennenbaum-Rakover; Carina Levin Abstract 4625 BACKGROUND Blood transfusions are the standard of care in β thalassemia and transfusions are also indicated in Sickle Cell Disease (SCD) patients with hypersplenism, recurrent vaso-occlusive crises...
Journal Articles
Journal Articles
Journal: Blood
Blood (2019) 134 (Supplement_1): 2164.
Published: 2019
...Emily Riehm Meier, MD MSHS; Allistair Abraham, MD; Alexander I. Ngwube, MD; Isaac Janson, PhD; Gregory M.T. Guilcher, MD; John T. Horan, MDMPH; Kimberly A. Kasow, DO Background Hematopoietic stem cell transplantation (HSCT) provides a curative therapy for children severely affected by sickle cell...
Journal Articles
Journal: Blood
Blood (2018) 132 (Supplement 1): 5713.
Published: 2018
...Amer Assal, MD; Diane George, MD; Monica Bhatia, MD; Christian Gordillo, BS; Nicole Howard, BS; Ran Reshef, MD MSc; Markus Y Mapara, MD PhD Introduction: Sickle cell disease (SCD) affects 300,000 annual births globally, and about 100,000 individuals in the United States. Allogeneic hematopoietic...
Journal Articles
Journal: Blood
Blood (2017) 130 (Supplement 1): 3535.
Published: 2017
...; Shalini Shenoy, MD; John T Horan, MD Background: Myeloablative HLA-matched sibling donor hematopoietic cell transplantation (HCT) is highly curative for children and young adults with sickle cell disease (SCD). The most common regimen used worldwide has been Busulfan, Cyclophosphamide and anti-thymocyte...
Journal Articles
Journal: Blood
Blood (2019) 134 (Supplement_1): 2170.
Published: 2019
...; Kevin H. M. Kuo, MDMSc,FRCPC Rate of Sickle Hemoglobin Recovery in Sickle Cell Disease Patients Undergoing Red Blood Cell (RBC) Exchange Transfusion is Associated with Age of Patients and Number of RBC Units Transfused Introduction : Automated and manual red blood cell exchange (RBCX) transfusions...