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Journal Articles

MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis

Xinfang Yu, Wei Li, Qipan Deng, Haidan Liu, Xu Wang, Hui Hu, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Mingzhi Zhang, Zhongxin Lu, Ken H. Young, Yong Li

Blood (2021) 137 (12): 1615–1627.

https://doi.org/10.1182/blood.2020004918

Published: 2021

Includes: Supplemental data

Journal Articles

A master erythroid regulator gets its own GPS

Lily Jun-shen Huang, James J. Bieker

Blood (2020) 135 (25): 2209–2210.

https://doi.org/10.1182/blood.2020005882

Published: 2020

Journal Articles

Wdr26 regulates nuclear condensation in developing erythroblasts

Ru Zhen, Chingyee Moo, Zhenzhen Zhao, Mengying Chen, He Feng, Xiaojun Zheng, Liang Zhang, Jiahai Shi, Caiyong Chen

Blood (2020) 135 (3): 208–219.

https://doi.org/10.1182/blood.2019002165

Published: 2020

Includes: Supplemental data

Journal Articles

MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma

Boheng Li, Junli Yan, The Phyu, Shuangyi Fan, Tae-Hoon Chung, Nurulhuda Mustafa, Baohong Lin, Lingzhi Wang, Pieter Johan Adam Eichhorn, Boon-Cher Goh, Siok-Bian Ng, Dennis Kappei, Wee-Joo Chng

Blood (2019) 134 (23): 2046–2058.

https://doi.org/10.1182/blood.2019000381

Published: 2019

Includes: Supplemental data

Journal Articles

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Scott R Best, BS, Vi Lam, Nur Bruss, BS, Taylor Hashiguchi Rowland, BS, Adam S. Kittai, MD, Tingting Liu, Allison J Berger, PhD, Alexey Danilov, MD PhD

Blood (2019) 134 (Supplement_1): 4313.

https://doi.org/10.1182/blood-2019-123600

Published: 2019

Journal Articles

Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators

Aparajita Hoskote Chourasia, PhD, Leah Fung, PhD, Brooke McElwee, BSc, Normand Richard, MSc, Imelda Lam, BSc, Eduardo Torres, MSc, Paul Erdman, MSc, Robert Sullivan, PhD, David Hecht, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, David I Stirling, PhD

Blood (2019) 134 (Supplement_1): 3361.

https://doi.org/10.1182/blood-2019-131872

Published: 2019

Journal Articles

Personalized Ubiquitination Signatures for Predicting Response to Proteasome Inhibitor-Based Therapy of MM Patients

Haim Tsubery, PhD, Lerman Gali, PhD, Kronenfeld Gali, MSc, Itamar Sela, PhD, Yifat Merbl, PhD, Ayelet Itzhaki-Alfia, PhD, Svetlana Trestman, MD, Yael C Cohen, MD, Irit Avivi, MD

Blood (2019) 134 (Supplement_1): 3371.

https://doi.org/10.1182/blood-2019-125274

Published: 2019

Journal Articles

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Ursula S.A. Stalmann, MD, Fabio Ticconi, MSc, Ronghui Li, MSc, Aaron B. Wong, PhD, Glenn Cowley, PhD, David E. Root, PhD, Dirk Heckl, PhD, Inge Snoeren, MSc, Sergio Martinez, PhDMSc, Tim H Brümmendorf, MD, Andreas Schuppert, PhD, Ivan Costa, PhD, Benjamin L. Ebert, MD PhD, Rebekka K. Schneider, MD PhD

Blood (2019) 134 (Supplement_1): 559.

https://doi.org/10.1182/blood-2019-122588

Published: 2019

Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 2073.

https://doi.org/10.1182/blood-2019-130666

Published: 2019

Journal Articles

Innate Immune Signaling Suppresses Acute Leukemia By Modifying MYC Oncogenic Activity

Tomoya Muto, MD PhD, Maria Guillamot, PhD, Jing Fang, MD PhD, Luna Zea Redondo, MS, Kwangmin Choi, PhD, Yixiao Gong, MSc, Callum S Walker, MSc, Kathleen Hueneman, Lyndsey C Bolanos, BSc, Laura Barreyro, PhD, Lynn Lee, MD, Kenneth D Greis, PhD, Alireza Khodadadi-Jamayran, M.Sc., Amaia Lujambio, PhD, Scott W. Lowe, PhD, Iannis Aifantis, PhD, Daniel T. Starczynowski, PhD

Blood (2019) 134 (Supplement_1): 727.

https://doi.org/10.1182/blood-2019-121423

Published: 2019

Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 731.

https://doi.org/10.1182/blood-2019-125959

Published: 2019

Journal Articles

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

Ryan Donaghy, Xu Han, Krasimira Rozenova, Kaosheng Lv, Qinqin Jiang, Miriam Doepner, Roger A. Greenberg, Wei Tong

Blood (2019) 133 (14): 1560–1571.

https://doi.org/10.1182/blood-2018-10-877563

Published: 2019

Includes: Supplemental data

Journal Articles

FBXO11 Activates Erythroid Gene Transcription By Degrading Heterochromatin-Associated Protein BAHD1

Peng Xu, PhD, Daniel C. Scott, PhD, Xing Tang, PhD, Yu Yao, MD, Yong-Dong Wang, PhD, Wenjian Bi, PhD, Lance E. Palmer, PhD, Ruopeng Feng, PhD, Arno F. Alpi, PhD, Chunliang Li, PhD, Yong Cheng, PhD, Brenda A. Schulman, PhD, Mitchell J. Weiss, MD PhD

Blood (2018) 132 (Supplement 1): 529.

https://doi.org/10.1182/blood-2018-99-117362

Published: 2018

Journal Articles

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Sajid Khan, PhD, Xuan Zhang, BMBS, Dongwen Lv, PhD, Yonghan He, MD, Peiyi Zhang, MS, Xingui Liu, PhD, Dinesh Thummuri, PhD, Qi Zhang, PhD, Marina Y. Konopleva, MD PhD, Robert A. Hromas, MD, Guangrong Zheng, Daohong Zhou, MD

Blood (2018) 132 (Supplement 1): 2698.

https://doi.org/10.1182/blood-2018-99-114762

Published: 2018

Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia

Samir H Barghout, BSPharm, MSc, Neil MacLean, G. Wei Xu, Geethu Thomas, PhDMSc,BSc, Zachary Blatman, Rose Hurren, BSc, Aaron D Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): 1350.

https://doi.org/10.1182/blood-2018-99-110406

Published: 2018

Journal Articles

The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis

Katrin Hetzner, Maria-Paz Garcia-Cuellar, Christian Büttner, Robert K. Slany

Blood (2018) 131 (6): 662–673.

https://doi.org/10.1182/blood-2017-11-815035

Published: 2018

Includes: Supplemental data

Journal Articles

De Novo UBE2A Mutations Are Recurrently Acquired during CML Progression and Interfere with Myeloid Differentiation Pathways

Blood (2017) 130 (Supplement 1): 44.

https://doi.org/10.1182/blood.V130.Suppl_1.44.44

Published: 2017

Journal Articles

Overexpression of BRD4 Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

Hima Bansal, Steven Kornblau, MD, Qiu Yihua, Kevin R Coombes, Subbarayalu Panneerdoss, Anand Karnad, MD, Steven Weitman, MD PhD, Gail Tomlinson, MD PhD, Sanjay Bansal, Swami P. Iyer, MD

Blood (2017) 130 (Supplement 1): 3794.

https://doi.org/10.1182/blood.V130.Suppl_1.3794.3794

Published: 2017

Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 814.

https://doi.org/10.1182/blood.V130.Suppl_1.814.814

Published: 2017

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MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis

A master erythroid regulator gets its own GPS

Wdr26 regulates nuclear condensation in developing erythroblasts

MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators

Personalized Ubiquitination Signatures for Predicting Response to Proteasome Inhibitor-Based Therapy of MM Patients

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Innate Immune Signaling Suppresses Acute Leukemia By Modifying MYC Oncogenic Activity

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

FBXO11 Activates Erythroid Gene Transcription By Degrading Heterochromatin-Associated Protein BAHD1

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia

The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis

De Novo UBE2A Mutations Are Recurrently Acquired during CML Progression and Interfere with Myeloid Differentiation Pathways

Overexpression of BRD4 Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

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