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Journal Articles

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan
Journal: Blood
Blood (2020) 136 (7): 845–856.
https://doi.org/10.1182/blood.2020004801
Published: 2020
Includes: Supplemental data
Journal Articles

A Comprehensive Analysis of Single-Cell Chromatin Accessibility and Gene Expression Identifies Intra-Tumor Heterogeneity and Molecular Treatment Responses in Relapsed/Refractory Multiple Myeloma

Alexandra M Poos, PhD, Jan-Philipp Mallm, PhD, Stephan M Tirier, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Katharina Bauer, Anja Baumann, Lukas John, MD, Isabelle Lander, BSc, Jing Xu, PhD, Moritz Przybilla, BSc, Anja Kunze, PhD, Carsten Mueller-Tidow, MD, Benedikt Brors, PhD, Oliver Stegle, PhD, Hartmut Goldschmidt, MD, Karsten Rippe, PhD, Marc S Raab, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 575.
https://doi.org/10.1182/blood-2019-130051
Published: 2019
Journal Articles

Epigenomic Determinants of Transcriptional Activity in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Alexandre Gaspar Maia, PhD, Ryan M. Carr, MD PhD, Christopher Pin, PhD, Kurt Berger, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2987.
https://doi.org/10.1182/blood-2019-123191
Published: 2019
Journal Articles

Distal Enhancer Elements in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Alexandre Gaspar Maia, PhD, Ryan M. Carr, MD PhD, Terra Lasho, PhD, Thomas E. Witzig, MD, Christopher Pin, PhD, Kurt Berger, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2981.
https://doi.org/10.1182/blood-2019-124917
Published: 2019
Journal Articles

Adult Hematopoietic Stem and Progenitor Cell Maintenance Requires Histone Variant H3.3 Regulation By Hira

Rebecca Murdaugh, BS, Kevin Hoegenauer, Xiangguo Shi, PhD, Ayumi Kitano, Richard Chapple, PhD, Tianyuan Hu, PhD, Jonathan Tiessen, BS, Daisuke Nakada, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2473.
https://doi.org/10.1182/blood-2019-131358
Published: 2019
Journal Articles

Preclinical Assessment of Non-Virally Engineered CD33.CAR Cytokine-Induced Killer (CIK) Cells in Chemoresistant AML Patient-Derived Xenografts

Maria Caterina Rotiroti, PhD, Chiara Buracchi, PhD, Silvia Arcangeli, PhD, Chiara F Magnani, PhD, Claudia Cappuzzello, PhD, Zsuzsanna Izsvak, PhD, Stefania Galimberti, PhD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Marta Serafini, PhD, Ettore Biagi, MD, Andrea Biondi, MD, Sarah Tettamanti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2665.
https://doi.org/10.1182/blood-2019-130399
Published: 2019
Journal Articles

Manufacture of an Allogeneic CAR-T Stem Cell Memory Product Candidate for Multiple Myeloma, P-Bcma-ALLO1, Is Robust, Reproducible and Highly Scalable

Stacey A Cranert, PhD, Maximilian Richter, PhD, Min Tong, MS, Leslie Weiss, MS, Yening Tan, MS, Eric M. Ostertag, MD PhD, Julia Coronella, PhD, Devon J Shedlock, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4445.
https://doi.org/10.1182/blood-2019-131839
Published: 2019
Journal Articles

Single-Cell RNA Sequencing of Healthy Human Marrow Hematopoietic Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Sachiko Kajigaya, PhD, Qingguo Liu, MD PhD, Zhijie Wu, MD, Xingmin Feng, PhD, Fengkui Zhang, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4997.
https://doi.org/10.1182/blood-2019-123249
Published: 2019
Journal Articles

PRDM1 Binds an Extensive Network of Genes to Regulate Human Natural Killer Cell Homeostasis

Xuxiang Liu, PhD, Yunfei Shi, MD PhD, Yuping Li, PhD, Ru Chen, PhD, Sheng Pan, PhD, Gehong Dong, MD PhD, Qiang Gong, PhD, Javeed Iqbal, PhD, Haiqing Li, PhD, Jinhui Wang, PhD, Shuhua Yi, MD, Timothy McKeithan, MD PhD, Wing C. Chan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2536.
https://doi.org/10.1182/blood-2019-129270
Published: 2019
Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1240.
https://doi.org/10.1182/blood-2019-125207
Published: 2019
Journal Articles

Priority lane to cDC1 open for IRF8 + progenitors

Martin Guilliams, Charlotte L. Scott
Journal: Blood
Blood (2019) 133 (17): 1795–1797.
https://doi.org/10.1182/blood-2019-03-900936
Published: 2019
Journal Articles

Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice

Daisuke Kurotaki, Wataru Kawase, Haruka Sasaki, Jun Nakabayashi, Akira Nishiyama, Herbert C. Morse, III, Keiko Ozato, Yutaka Suzuki, Tomohiko Tamura
Journal: Blood
Blood (2019) 133 (17): 1803–1813.
https://doi.org/10.1182/blood-2018-06-857789
Published: 2019
Includes: Supplemental data
Journal Articles

ARID1A Is Critical for Maintaining Normal Hematopoiesis in Mice

Lin Han, MSc, Vikas Madan, PhD, Anand Mayakonda, Pushkar Dakle, Weoi Woon Teoh, Pavithra Shyamsunder, PhD, Hazimah Binte Mohd Nordin, Zeya Cao, Janani Sundaresan, Ienglam Lei, Zhong Wang, H. Phillip Koeffler, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3833.
https://doi.org/10.1182/blood-2018-99-117993
Published: 2018
Journal Articles

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

Sun-Mi Park, PhD, Hyunwoo Cho, PhD, Angela Thornton, PhD, Trevor Stephen Barlowe, BA, Timothy Chou, BS, Sagar Chhangawala, PhD, Lauren Fairchild, PhD, Arthur Chow, BA, James Taggart, BA, Alexander Schurer, BA, Antoine Gruet, Matthew Witkin, Jun Hyun Kim, Ethan Shevach, Andrei Krivstov, Scott A. Armstrong, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3881.
https://doi.org/10.1182/blood-2018-99-115034
Published: 2018
Journal Articles

Dissecting the Epigenetic Landscape of Smoldering, Newly Diagnosed and Relapsed Multiple Myeloma Revealed IRAK3 As a Marker of Disease Progression

Mahshid Rahmat, PhD, Nicholas Haradhvala, BA, Romanos Sklavenitis-Pistofidis, MD, Jihye Park, PhD, Daisy Huynh, MS, Mark Bustoros, MD, Brianna Berrios, BS, Mairead Reidy, PhD, Adriana Perilla-Glen, Bradley Rivotto, BS, Kalvis Hornburg, BA, David M. Dorfman, MD, PhD, Jonathan D. Licht, MD, Gad Getz, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3896.
https://doi.org/10.1182/blood-2018-99-115046
Published: 2018
Journal Articles

Multiomic Insights into Novel Treg Subset

Oktay Kirak, MD PhD, Eugene Ke, Mohsen Sabouri-Ghomi, Justin R. Abadejos, Brent Freeman, Amy Nham, Nathaniel Phillips, Manching Ku, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 863.
https://doi.org/10.1182/blood-2018-99-118101
Published: 2018
Journal Articles

Inhibitor of DNA Binding 2 (ID2) Plays a Key Tumor Suppressor Role in Promoting Oncogenic Transformation in Multiple Myeloma

Tommaso Perini, MD, Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, Matthew Lawlor, Christopher J. Ott, PhD, Na Li, MD, Yan Xu, MD, Kenneth Wen, BS, Nicola Amodio, PhD, Eugenio Morelli, MD, Kenneth Anderson, MD, Fabio Ciceri, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 60.
https://doi.org/10.1182/blood-2018-99-118401
Published: 2018
Journal Articles

Relapse-Initiating Clones Preexisting at Diagnosis in B- Cell Acute Lymphoblastic Leukemia Help Predict Molecular Pathways of Relapse

Laura Garcia Prat, Stephanie M. Dobson, PhD, Michelle Chan-Seng-Yue, Robert Vanner, MD PhD, Alex Murison, Jeffery Wintersinger, Esme Waanders, PhD, Olga I. Gan, PhD, Jessica McLeod, BSc, Debbie Payne-Turner, Michael Edmonson, Zhaohui Gu, PhD, Xiaotu Ma, Yiping Fan, Pankaj Gupta, Michael Rusch, BS, Ying Shao, John Easton, PhD, Jinghui Zhang, Mark D. Minden, MD PhD, Quaid Morris, Mathieu Lupien, Charles G. Mullighan, MBBS, MD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 915.
https://doi.org/10.1182/blood-2018-99-118998
Published: 2018
Journal Articles

Targeted Disruption of the Cohesin Subunit STAG2 Leads to Loss of Insulation and Inappropriate Gene Activation in Response to Differentiation Signals

Jisha Antony, PhD, Gregory Giminez, PhD, Umaima Khatoon, BSc (Hons), Robert Day, PhD, Ian Morison, PhD, FRCPA, MBBS, Julia Horsfield, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 878.
https://doi.org/10.1182/blood-2018-99-117965
Published: 2018
Journal Articles

An Allosteric Mechanism for Epigenetic Activation of the V(D)J Recombinase

Meiling May, BA, Stephen Desiderio, MD PhD, John Thomas Bettridge, BA
Journal: Blood
Blood (2018) 132 (Supplement 1): 512.
https://doi.org/10.1182/blood-2018-99-116675
Published: 2018