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Journal Articles

The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis

Alanna C. Green, Gavin Tjin, Samuel C. Lee, Alistair M. Chalk, Lenny Straszkowski, Diannita Kwang, Emma K. Baker, Julie M. Quach, Takaharu Kimura, Joy Y. Wu, Louise E. Purton

Blood (2021) 138 (4): 304–317.

DOI: https://doi.org/10.1182/blood.2020005865

Published: 2021

Includes: Supplemental data

Journal Articles

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Mykel D Green, Mitchell Schaffler, PhD, Gilda A Barabino, PhD

Blood (2019) 134 (Supplement_1): 3561.

DOI: https://doi.org/10.1182/blood-2019-128950

Published: 2019

Journal Articles

Megakaryocyte-Driven Myelofibrosis Leads to Progressive Osteosclerosis in G6b-B Knockout Mice

Mariya Stavnichuk, BSc, Zoltan Nagy, Yotis A. Senis, Svetlana V. Komarova

Blood (2019) 134 (Supplement_1): 4199.

DOI: https://doi.org/10.1182/blood-2019-124186

Published: 2019

Journal Articles

Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-β Signaling Pathway

Ehsan Malek, MD, Sunjin Hwang, MD, Marcos de Lima, MD, Paolo Caimi, MD, Molly M Gallogly, MD PhD, Leland Metheny, III, MD, Folashade Otegbeye, MBBChir,MPH, Benjamin K. Tomlinson, MD, Kirsten M Boughan, DO, Brenda Cooper, MD, James Driscoll, MD PhD, John Letterio, MD

Blood (2019) 134 (Supplement_1): 3232.

DOI: https://doi.org/10.1182/blood-2019-126728

Published: 2019

Journal Articles

B Cell Specific Knockdown of the Erythropoietin (EPO) Receptor Attenuates EPO-Induced Bone Loss in Mice

Albert Kolomansky, MD, Naamit Deshet-Unger, PhD, Nathalie Ben-Califa, PhD, Zamzam Awida, Maria Ibrahim, B.Sc., Tamar Liron, PhD, Sahar Hiram-Bab, PhD, Howard S. Oster, MD PhD, Moshe Mittelman, MD, Martina Rauner, PhD, Ben Wielockx, PhD, Yankel Gabet, DMD, PhD, Drorit Neumann, PhD

Blood (2019) 134 (Supplement_1): 939.

DOI: https://doi.org/10.1182/blood-2019-127092

Published: 2019

Journal Articles

Mature Osteoblasts Provide a Protective Niche Against Multiple Myeloma Growth and Survival within the Tumor Microenvironment

Keertik Fulzele, PhD, Cristina Panaroni, PhD, Rosemary Soucy, Ka Tat Siu, PhD, Kenta Mukaihara, MD PhD, Noopur Raje, MD

Blood (2018) 132 (Supplement 1): 4476.

DOI: https://doi.org/10.1182/blood-2018-99-118377

Published: 2018

Journal Articles

Erythropoietin (EPO) Regulates Bone Mass Via EPO Receptors on Myeloid and Lymphocytic Cells

Sahar Hiram-Bab, PhD, Albert Kolomansky, MD, Naamit Deshet-Unger, PhD, Nathalie Ben-Califa, PhD, Tamar Liron, PhD, Martina Rauner, PhD, Ben Wielockx, PhD, Moshe Mittelman, MD, Howard S. Oster, MD PhD, Yankel Gabet, DMD, PhD, Drorit Neumann, PhD

Blood (2018) 132 (Supplement 1): 846.

DOI: https://doi.org/10.1182/blood-2018-99-111643

Published: 2018

Journal Articles

Acute Myeloid Leukemia Expands Osteoprogenitor Rich Niche in the Bone Marrow but Resorbs Mature Bone Causing Osteopenia/Osteoporosis in Animal Models

Bin Yuan, Stanley Ly, Khoa Nguyen, Vivien Tran, Kiersten Maldonado, Charles Kinglsey, Jared K Burks, PhD, Xin Zhou, PhD, Benoit deCrombrugghe, Michael Andreeff, MD PhD, Venkata Lokesh Battula, PhD

Blood (2018) 132 (Supplement 1): 86.

DOI: https://doi.org/10.1182/blood-2018-99-117258

Published: 2018

Journal Articles

Exosomes Play a Key Role in Multiple Myeloma Bone Disease and Tumor Development

Sylvia Faict, MD, Josephine Muller, PhD, Kim De Veirman, PhD, Ken Maes, Elke De Bruyne, PhD, Rik Schots, Jo Caers, MD PhD, Karin Vanderkerken, PhD, Eline Menu, PhD

Blood (2018) 132 (Supplement 1): 4484.

DOI: https://doi.org/10.1182/blood-2018-99-112428

Published: 2018

Journal Articles

Preclinical Studies and a Phase I Trial of the TGF-β Receptor Inhibitor, Vactosertib (TEW-7197), in Combination with Pomalidomide in Patients with Multiple Myeloma Refractory to Bortezomib or Lenalidomide

Ehsan Malek, MD, Byung-Gyu Kim, PhD DVM, Jason Valent, MD, James Driscoll, MD PhD, Paolo Caimi, MD, Seong-Jin Kim, PhD, Marcos de Lima, MD, John Letterio, MD

Blood (2018) 132 (Supplement 1): 1962.

DOI: https://doi.org/10.1182/blood-2018-99-112449

Published: 2018

Journal Articles

Vactosertib, a TGF-ß Receptor I Kinase/ALK5 Inhibitor, Diminishes Tumor Progression and Bone Disease in a Mouse Model of Multiple Myeloma and Overcomes Resistance to Proteasome Inhibitors

Byung-Gyu Kim, PhD DVM, Sung Hee Choi, PhD, George Luo, Olga Sergeeva, PhD, Zhenghong Lee, PhD, James Driscoll, MD PhD, Marcos de Lima, MD, Rose Beck, MD PhD, Seong-Jin Kim, PhD, John Letterio, MD, Ehsan Malek, MD

Blood (2018) 132 (Supplement 1): 1918.

DOI: https://doi.org/10.1182/blood-2018-99-117852

Published: 2018

Journal Articles

Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

Janik Engelmann, Isabel Ben Batalla, PhD, Hanna Taipaleenmäki, PhD, Kristoffer Riecken, PhD, Victoria Gensch, Sarina Paesler, Nikolaus Berenbrok, Maria Elena Vargas, Jonas Waizenegger, MD, Boris Fehse, PhD, Klaus Pantel, MD, PhD, Ihab S Darwish, PhD, Somasekhar Bhamidipati, PhD, Esteban Masuda, PhD, Carsten Bokemeyer, MD, PhD, Eric Hesse, MD, PhD, Sonja Loges, MD, PhD

Blood (2018) 132 (Supplement 1): 1922.

DOI: https://doi.org/10.1182/blood-2018-99-118273

Published: 2018

Journal Articles

BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone

Toril Holien, PhD, Marita Westhrin, PhD, Siv Helen Moen, PhD, Muhammad Zahoor, PhD, Glenn Buene, Berit Størdal, Hanne Hella, Huipin Yuan, Joost D de Bruijn, PhD, Anton Martens, PhD, Richard WJ Groen, PhD, Fatima Bosch, PhD, Ulf Smith, MD PhD, Anders Sundan, PhD, Therese Standal, PhD

Blood (2018) 132 (Supplement 1): 1928.

DOI: https://doi.org/10.1182/blood-2018-99-112429

Published: 2018

Journal Articles

Neoplastic Monocyte-Derived Osteoclasts Are Highly Proliferative, but Sub-Functional in MPN-Associated Myelofibrosis

Ivo Veletic, MD, Taghi Manshouri, C. Cameron Yin, MD PhD, Kate J Newberry, PhD, Srdan Verstovsek, MD PhD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 1664.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1664.1664

Published: 2017

Journal Articles

Myeloma Lytic Bone Lesions Characterization with WB-LDCT and 18 f-FDG PET/MRI

Albana Lico, MD, Gregorio Barilà, MD, Filippo Crimì, MD, Lucia Checuz, MD, Tamara Berno, MD, Stefania Vio, MD, Antonio Branca, MD, Lucia Ammirati, MD, Matteo Leoncin, MD, Pietro Zucchetta, MD, Carmelo Lacognata, MD, Francesco Piazza, MD, Gianpietro Semenzato, MD, Renato Zambello, MD

Blood (2017) 130 (Supplement 1): 1788.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1788.1788

Published: 2017

Journal Articles

Low Intensity Vibration Treatment Reduces Myeloma Cell-Induced Osteoclast Formation By Inhibiting IL-6 and GFI-1 Production By MM Cells

Gabriel M. Pagnotti, PhD, Noriyoshi Kurihara, DDS, PhD, G David Roodman, MD PhD

Blood (2017) 130 (Supplement 1): 1775.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1775.1775

Published: 2017

Journal Articles

Depletion of Mature B Cells By Anti CD20-Directed Antibody Induces Trabecular Bone Loss in Young Mice: An Alert for Clinicians?

Albert Kolomansky, MD, Naamit Deshet-Unger, PhD, Alina Ostrovsky, Nathalie Ben-Califa, PhD, Sahar Hiram-Bab, PhD, Tamar Liron, PhD, Howard S. Oster, MD PhD, Moshe Mittelman, MD, Yankel Gabet, DMD, PhD, Drorit Neumann, PhD

Blood (2017) 130 (Supplement 1): 5642.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.5642.5642

Published: 2017

Journal Articles

Intraosseous Administration of Multipotent Mesenchymal Stromal Cells to Patients with Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation

Nataliya Petinati, PhD MD, Natalia Sats, PhD, Nina Drize, PhD, Natalia Risinskaya, Andrey Sudarikov, Maya Firsova, MD PhD, Natalia Popova, MD, Daria Dubnyak, MD, Olga Koroleva, MD, Larisa A. Kuzmina, MD PhD, Elena N. Parovichnikova, MD PhD, Valeriy G. Savchenko

Blood (2017) 130 (Supplement 1): 5475.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.5475.5475

Published: 2017

Journal Articles

Bone-Targeted Pharmacological Inhibition of Notch Signaling As a Novel Approach to Inhibit Myeloma Growth and Bone Destruction

Jesus Delgado-Calle, PhD, Gerald Wu, Jessica Nelson, Emily G Atkinson, Kevin McAndrews, Lifeng Xiao, Frank H Ebetino, Robert K Boeckman, Jr., David David Roodman, MD PhD, Teresita Bellido

Blood (2017) 130 (Supplement 1): 4419.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4419.4419

Published: 2017

Journal Articles

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Josephine Muller, Arnold Bolomsky, PhD, Kathrin Schonfelder, Frederic Baron, Yves Beguin, MD PhD, Heinz Ludwig, MD, Jo Caers, MD, Roy Heusschen, PhD

Blood (2017) 130 (Supplement 1): 4416.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4416.4416

Published: 2017

2 3 4 5

NARROW

The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis

L-Glutamine Increases IGF-1 Liver Expression to Prevent Bone Loss in Sickle Mice

Megakaryocyte-Driven Myelofibrosis Leads to Progressive Osteosclerosis in G6b-B Knockout Mice

Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-β Signaling Pathway

B Cell Specific Knockdown of the Erythropoietin (EPO) Receptor Attenuates EPO-Induced Bone Loss in Mice

Mature Osteoblasts Provide a Protective Niche Against Multiple Myeloma Growth and Survival within the Tumor Microenvironment

Erythropoietin (EPO) Regulates Bone Mass Via EPO Receptors on Myeloid and Lymphocytic Cells

Acute Myeloid Leukemia Expands Osteoprogenitor Rich Niche in the Bone Marrow but Resorbs Mature Bone Causing Osteopenia/Osteoporosis in Animal Models

Exosomes Play a Key Role in Multiple Myeloma Bone Disease and Tumor Development

Preclinical Studies and a Phase I Trial of the TGF-β Receptor Inhibitor, Vactosertib (TEW-7197), in Combination with Pomalidomide in Patients with Multiple Myeloma Refractory to Bortezomib or Lenalidomide

Vactosertib, a TGF-ß Receptor I Kinase/ALK5 Inhibitor, Diminishes Tumor Progression and Bone Disease in a Mouse Model of Multiple Myeloma and Overcomes Resistance to Proteasome Inhibitors

Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

BMP4 Gene Therapy Inhibits Myeloma Tumor Growth, but Has a Negative Impact on Bone

Neoplastic Monocyte-Derived Osteoclasts Are Highly Proliferative, but Sub-Functional in MPN-Associated Myelofibrosis

Myeloma Lytic Bone Lesions Characterization with WB-LDCT and 18 f-FDG PET/MRI

Low Intensity Vibration Treatment Reduces Myeloma Cell-Induced Osteoclast Formation By Inhibiting IL-6 and GFI-1 Production By MM Cells

Depletion of Mature B Cells By Anti CD20-Directed Antibody Induces Trabecular Bone Loss in Young Mice: An Alert for Clinicians?

Intraosseous Administration of Multipotent Mesenchymal Stromal Cells to Patients with Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation

Bone-Targeted Pharmacological Inhibition of Notch Signaling As a Novel Approach to Inhibit Myeloma Growth and Bone Destruction

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

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American Society of Hematology

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American Society of Hematology

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