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Journal Articles

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Blood (2020) 135 (1): 41–55.

https://doi.org/10.1182/blood.2019002220

Published: 2020

Includes: Supplemental data

Journal Articles

Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALL

Chelsea L. Dieck, Adolfo Ferrando

Blood (2019) 133 (21): 2263–2268.

https://doi.org/10.1182/blood-2019-01-852392

Published: 2019

Journal Articles

Inflammatory Bowel Disease and Hodgkin's Lymphoma: Two New Observations

Zoubida Tazi Mezalek, MD, Myriam Bourkia, Sofia Habib Allah, Noha Al Waragli, Majdouline Bouaouad, Amina Lhoussni, MD, Hajar Khibri, Wafaa Ammouri, Mouna Maamar, Hicham Harmouche, Mohammed Adnaoui

Blood (2018) 132 (Supplement 1): 5353.

https://doi.org/10.1182/blood-2018-99-110615

Published: 2018

Journal Articles

Genetic Heterogeneity and Evolution in Lymphoid Malignancies

Charles G. Mullighan, MBBS, MD

Blood (2018) 132 (Supplement 1): SCI-34.

https://doi.org/10.1182/blood-2018-99-109499

Published: 2018

Journal Articles

Preclinical evaluation of NUDT15 -guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

Blood (2018) 131 (22): 2466–2474.

https://doi.org/10.1182/blood-2017-11-815506

Published: 2018

Includes: Supplemental data

Journal Articles

Adjusting Dosage of Mercaptopurine By NUDT15 Polymorphisms in Childhood Acute Lymphoblastic Leukemia

Der-Shiun Wang, MD, Chih-Hsiang Yu, Ph. D student, Wen-Chien Chou, MD, PhD, Ya-Hsuan Chang, Chien-Yu Lin, Kai-Hsin Lin, Shiann-Tarng Jou, MD PhD, Meng Yao Lu, MD, Hsiu-Hao Chang, MD PhD, Shu-Wha Lin, PhD, Dong-Tsamn Lin, Professor, Hsuan-Yu Chen, Ph. D, Yung-Li Yang, MD PhD

Blood (2017) 130 (Supplement 1): 2566.

https://doi.org/10.1182/blood.V130.Suppl_1.2566.2566

Published: 2017

Journal Articles

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

Takaya Moriyama, MDPhD, Rina Nishii, Laura Janke, DVM, PhD, Lie Li, Chen Ru, Scott A Brown, PhD, Ting-Nien Lin, Chase Suiter, Kentaro Kihira, MD, Hidemi Toyoda, MD PhD, Motohiro Kato, MD PhD, Atushi Manabe, MD PhD, Katsuyoshi Koh, MD, Masatoshi Takagi, MD PhD, Hiroki Hori, MD PhD, Jun J. Yang, PhD

Blood (2017) 130 (Supplement 1): 3879.

https://doi.org/10.1182/blood.V130.Suppl_1.3879.3879

Published: 2017

Journal Articles

PACSIN2 rs2413739 Polymorphism and Thiopurine Pharmacokinetics: Validation Studies in Pediatric Patients

Gabriele Stocco, PhD, Raffaella Franca, Diego Favretto, Nagua Giurici, Alessandro Ventura, Giuliana Decorti, Luciana Vinti, MD, Antonella Colombini, Erica Brivio, Laura Rachele Bettini, Ilaria Bini, Francesca Sismondi, Alessandra Mandese, Noelia Malusà, Stefano Martelossi, Marco Rabusin

Blood (2017) 130 (Supplement 1): 4999.

https://doi.org/10.1182/blood.V130.Suppl_1.4999.4999

Published: 2017

Journal Articles

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Farhad Forouhar, Zachary Carpenter, PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Liang Tong, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 715.

https://doi.org/10.1182/blood.V130.Suppl_1.715.715

Published: 2017

Journal Articles

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

Takaya Moriyama, Yung-Li Yang, Rina Nishii, Hany Ariffin, Chengcheng Liu, Ting-Nien Lin, Wenjian Yang, Dong-Tsamn Lin, Chih-Hsiang Yu, Shirley Kham, Ching-Hon Pui, William E. Evans, Sima Jeha, Mary V. Relling, Allen Eng-Juh Yeoh, Jun J. Yang

Blood (2017) 130 (10): 1209–1212.

https://doi.org/10.1182/blood-2017-05-782383

Published: 2017

Includes: Supplemental data

Journal Articles

Thiopurine Methyl Transferase (TPMT) Activity and Erythrocyte Thioguanine Nucleotide Levels Are Reliable Markers of Tolerability to 6-Mercaptopurine in Adult Acute Lymphoblastic Leukemia

Manju Sengar, MD DM, Murari Gurjar, Anand Patil, Vikram Gota, Hasmukh Jain, MDDM, Hari Menon, MD DM, Uma Dangi

Blood (2015) 126 (23): 3761.

https://doi.org/10.1182/blood.V126.23.3761.3761

Published: 2015

Journal Articles

NT5C2 As a Major Contributor to Thiopurine Resistance at ALL Relapse Via Multiple Mechanisms

Takaya Moriyama, MD, Julia Meyer, PhD, Shuguang Liu, PhD, Xujie Zhao, Zhaohong Ying, MD, William L. Carroll, MD, Jun J Yang, PhD

Blood (2015) 126 (23): 446.

https://doi.org/10.1182/blood.V126.23.446.446

Published: 2015

Journal Articles

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Hui Li, PhD, Benshang Li, Fan Yang, Caiwen Duan, Yun Bai, Jun J Yang, PhD, Jing Chen, MD PhD, Arend von Stackelberg, MD, Hongzhuan Chen, PhD, JingYan Tang, MD, Adolfo A. Ferrando, MD PhD, Jinghui Zhang, PhD, Shengyue Wang, Renate Kirschner-Schwabe, PhD, Bin-Bing S. Zhou, PhD

Blood (2015) 126 (23): 2627.

https://doi.org/10.1182/blood.V126.23.2627.2627

Published: 2015

Journal Articles

Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia

Blood (2015) 126 (23): 692.

https://doi.org/10.1182/blood.V126.23.692.692

Published: 2015

Journal Articles

Lymphoproliferative Disease Risk in Patients with Autoimmune Disease: Clustering of Primary CNS Lymphoma with Drug Regimen and Disease Process

Genevieve Marie Crane, MD PhD, Helen Powell, PhD, Rumen Kostadinov, PhD, Peter C. Burger, MD, Richard F. Ambinder, MD PhD, Lode J. Swinnen, MBChB, Michael J. Borowitz, MD PhD, Amy S. Duffield, MD PhD

Blood (2015) 126 (23): 1490.

https://doi.org/10.1182/blood.V126.23.1490.1490

Published: 2015

Journal Articles

Pharmacokinetics of Fludarabine in Patients with Aplastic Anemia Undergoing Hematopoietic Stem Cell Transplantation

Ezhil Pavai Mohanan, MSc, John C Panetta, PhD, Kavitha M Lakshmi, MSc, Fouzia NA, MD, Abhijeet Ganapule, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Vikram Mathews, MD, Biju George, MD, Poonkuzhali Balasubramanian, PhD

Blood (2014) 124 (21): 3884.

https://doi.org/10.1182/blood.V124.21.3884.3884

Published: 2014

Journal Articles

An Association Between Hodgkin’s Lymphoma and Crohn’s Disease: A Case Series

Chaitra S. Ujjani, MD, Philip Cohen, MD

Blood (2014) 124 (21): 1611.

https://doi.org/10.1182/blood.V124.21.1611.1611

Published: 2014

Journal Articles

Meta-Analysis Of Overall Risk Of Lymphoma In Patients With Inflammatory Bowel Disease On Thiopurine Therapy With Inclusion Of New Nationwide Population Based Studies: Differences Between Referral Center Studies and Population Based Studies

David S Kotlyar, MD, James D Lewis, MD, Laurent Beaugerie, MD, Ann Tierney, MS, Colleen Brensinger, MS, Edward Loftus, MD, Javier Gisbert, MD, Wojciech C Blonski, MD, PhD, Manuel Van Domselaar, MD, Maria Chaparro, MD, Sandipani Sandilya, MD, Gary R Lichtenstein, MD

Blood (2013) 122 (21): 4276.

https://doi.org/10.1182/blood.V122.21.4276.4276

Published: 2013

Journal Articles

Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness

Laura B. Ramsey, PhD, Laura Janke, DVM, PhD, Mathew Edick, PhD, Cheng Cheng, PhD, Richard T Williams, MBBS, PhD, Charles J. Sherr, MD, PhD, William E. Evans, PharmD, Mary V. Relling, PharmD

Blood (2012) 120 (21): 3560.

https://doi.org/10.1182/blood.V120.21.3560.3560

Published: 2012

Journal Articles

Average Absolute Neutrophil Count During Maintenance Chemotherapy In Latino Versus Non-Latino Caucasian Patients with Childhood Acute Lymphoblastic Leukemia

Amy C. Fowler, MD, David Leonard, PhD, Tamra Slone, MD, Naomi Winick, MD

Blood (2010) 116 (21): 3237.

https://doi.org/10.1182/blood.V116.21.3237.3237

Published: 2010

NARROW

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALL

Inflammatory Bowel Disease and Hodgkin's Lymphoma: Two New Observations

Genetic Heterogeneity and Evolution in Lymphoid Malignancies

Preclinical evaluation of NUDT15 -guided thiopurine therapy and its effects on toxicity and antileukemic efficacy

Adjusting Dosage of Mercaptopurine By NUDT15 Polymorphisms in Childhood Acute Lymphoblastic Leukemia

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

PACSIN2 rs2413739 Polymorphism and Thiopurine Pharmacokinetics: Validation Studies in Pediatric Patients

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

Thiopurine Methyl Transferase (TPMT) Activity and Erythrocyte Thioguanine Nucleotide Levels Are Reliable Markers of Tolerability to 6-Mercaptopurine in Adult Acute Lymphoblastic Leukemia

NT5C2 As a Major Contributor to Thiopurine Resistance at ALL Relapse Via Multiple Mechanisms

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia

Lymphoproliferative Disease Risk in Patients with Autoimmune Disease: Clustering of Primary CNS Lymphoma with Drug Regimen and Disease Process

Pharmacokinetics of Fludarabine in Patients with Aplastic Anemia Undergoing Hematopoietic Stem Cell Transplantation

An Association Between Hodgkin’s Lymphoma and Crohn’s Disease: A Case Series

Meta-Analysis Of Overall Risk Of Lymphoma In Patients With Inflammatory Bowel Disease On Thiopurine Therapy With Inclusion Of New Nationwide Population Based Studies: Differences Between Referral Center Studies and Population Based Studies

Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness

Average Absolute Neutrophil Count During Maintenance Chemotherapy In Latino Versus Non-Latino Caucasian Patients with Childhood Acute Lymphoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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