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Journal Articles

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael Gonzalez, James Garifallou, Hakon Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy Speck, Deborah L. French, Paul Gadue, Mortimer Poncz

Blood (2021) 137 (19): 2662–2675.

DOI: https://doi.org/10.1182/blood.2020006389

Published: 2021

Includes: Supplemental data

Journal Articles

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Jane-Jane Chen, Shuping Zhang

Blood (2019) 134 (20): 1697–1707.

DOI: https://doi.org/10.1182/blood.2019001915

Published: 2019

Journal Articles

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Gang Lu, Christine Surka, Chin-Chun Lu, In Sock Jang, PhD, Kai Wang, PhD, Mark Rolfe, PhD

Blood (2019) 134 (Supplement_1): 405.

DOI: https://doi.org/10.1182/blood-2019-125492

Published: 2019

Journal Articles

Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies

Eric Lowe, BS, Andrea R Fan, PhD, Jing Jiang, Henry W. B. Johnson, PhD, Christopher J. Kirk, PhD, Dustin McMinn, PhD, Tony Muchamuel, MS, Yu Qian, PhD, Brian B. Tuch, PhD

Blood (2019) 134 (Supplement_1): 408.

DOI: https://doi.org/10.1182/blood-2019-123782

Published: 2019

Journal Articles

KLF4 Is Needed for Optimal Hydroxyurea Induction of Gamma-Globin in K562 Cells

Alireza Paikari, MD, Ankush Goyal, MA, Celeste K. Kanne, BA, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 971.

DOI: https://doi.org/10.1182/blood-2019-131214

Published: 2019

Journal Articles

Macrophage Hypercellularity Accompanies Erythroid Hyperplasia in Sickle Cell Mice and during Recovery from Blood Loss in Wild Type Mice

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Samit Ghosh, Frances Weidert, MS, Grant C. Bullock, MD PhD, Solomon Fiifi Ofori-Acquah, Gregory J Kato, MD

Blood (2019) 134 (Supplement_1): 3528.

DOI: https://doi.org/10.1182/blood-2019-127224

Published: 2019

Journal Articles

TR57, an Inhibitor of the Integrated Stress Response, Is Synergistic with Venetoclax Against CLL Cells, Independent of Their TP53 Status

Narjis Fatima, BSMedTech,MPhil, Yandong Shen, BMedSc (Hon) PhD, Kyle R Crassini, MBBS,BSc, Edwin Iwanowicz, PhD, Richard Christopherson, PhDEmeritus Professor, Giles Best, BSc, PhD, Stephen P. Mulligan, PhDFRACP,FRCPA,MBBS

Blood (2019) 134 (Supplement_1): 1735.

DOI: https://doi.org/10.1182/blood-2019-132160

Published: 2019

Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD

Blood (2019) 134 (Supplement_1): 2076.

DOI: https://doi.org/10.1182/blood-2019-125988

Published: 2019

Journal Articles

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Thomas P Loughran, Jr., MD, Brian Barth, PhD MS, BS

Blood (2019) 134 (Supplement_1): 1245.

DOI: https://doi.org/10.1182/blood-2019-130964

Published: 2019

Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD

Blood (2019) 134 (Supplement_1): 210.

DOI: https://doi.org/10.1182/blood-2019-129479

Published: 2019

Journal Articles

PML Plays a Key Role in Severe Congenital Neutropenia with Mutant ELANE Causing Neutrophil Elastase Protein Misfolding

Patricia Olofsen, MSc, Paulette van Strien, BSc, Onno Roovers, BSc, Hans De Looper, BSc, Remco Hoogenboezem, MSc, Dennis Bosch, BSc, Mehrnaz Ghazvini, PhD, Eric Bindels, PhD, Emma De Pater, PhD, Ivo Touw, PhD

Blood (2019) 134 (Supplement_1): 213.

DOI: https://doi.org/10.1182/blood-2019-122423

Published: 2019

Journal Articles

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

Brian Estevez, PhD, Sara Borst, BS, Danuta Jadwiga Jarocha, PhD, Varun Sudunagunta, Michael Gonzalez, PhD, Peng Gao, Kai Tan, Deborah L French, PhD, Paul Gadue, PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 220.

DOI: https://doi.org/10.1182/blood-2019-124851

Published: 2019

Journal Articles

Chaperone-Mediated Autophagy Ensures Hematopoietic Stem Cell Maintenance

Shuxian Dong, PhD, Britta Will, PhD, Ana Maria Cuervo, MD PhD

Blood (2019) 134 (Supplement_1): 272.

DOI: https://doi.org/10.1182/blood-2019-132230

Published: 2019

Journal Articles

Preclinical Validation of Ubiquitin Receptor PSMD4 As Therapeutic Target in Multiple Myeloma

Yan Song, PhD, Ting DU, PhD, Arghya Ray, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 4403.

DOI: https://doi.org/10.1182/blood-2019-122952

Published: 2019

Journal Articles

Proteomic Analysis Identifies Mechanism(s) of Overcoming Bortezomib-Resistance Via Targeting Ubiquitin Receptor Rpn13

Ting Du, PhD, Yan Song, PhD, Arghya Ray, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 3074.

DOI: https://doi.org/10.1182/blood-2019-130236

Published: 2019

Journal Articles

The Efficacy of a Novel Oral Proteasome Inhibitor NNU546 in Multiple Myeloma

Ye Yang, PhD, Yongqiang Zhu, Chunyan Gu

Blood (2019) 134 (Supplement_1): 5586.

DOI: https://doi.org/10.1182/blood-2019-127927

Published: 2019

Journal Articles

Expression of Human SBDS R126T in S bds Null Background Shows Eif6 Dysregulation: An Adult Zebrafish Model for Shwachman-Diamond Syndrome

Usua Oyarbide Cuervas-Mons, PhD MSc, BSc, Matthew Snyderman, MSc, Jacek Topczewski, PhD, Seth J. Corey, MD

Blood (2019) 134 (Supplement_1): 3737.

DOI: https://doi.org/10.1182/blood-2019-129014

Published: 2019

Journal Articles

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Blood (2019) 134 (Supplement_1): 3934.

DOI: https://doi.org/10.1182/blood-2019-124178

Published: 2019

Journal Articles

Inflammation Mediated Bone Marrow Remodeling

Marieke A. G. Essers, PhD

Blood (2019) 134 (Supplement_1): SCI-2.

DOI: https://doi.org/10.1182/blood-2019-121050

Published: 2019

Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 2490.

DOI: https://doi.org/10.1182/blood-2019-128241

Published: 2019

NARROW

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies

KLF4 Is Needed for Optimal Hydroxyurea Induction of Gamma-Globin in K562 Cells

Macrophage Hypercellularity Accompanies Erythroid Hyperplasia in Sickle Cell Mice and during Recovery from Blood Loss in Wild Type Mice

TR57, an Inhibitor of the Integrated Stress Response, Is Synergistic with Venetoclax Against CLL Cells, Independent of Their TP53 Status

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

PML Plays a Key Role in Severe Congenital Neutropenia with Mutant ELANE Causing Neutrophil Elastase Protein Misfolding

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

Chaperone-Mediated Autophagy Ensures Hematopoietic Stem Cell Maintenance

Preclinical Validation of Ubiquitin Receptor PSMD4 As Therapeutic Target in Multiple Myeloma

Proteomic Analysis Identifies Mechanism(s) of Overcoming Bortezomib-Resistance Via Targeting Ubiquitin Receptor Rpn13

The Efficacy of a Novel Oral Proteasome Inhibitor NNU546 in Multiple Myeloma

Expression of Human SBDS R126T in S bds Null Background Shows Eif6 Dysregulation: An Adult Zebrafish Model for Shwachman-Diamond Syndrome

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Inflammation Mediated Bone Marrow Remodeling

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

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American Society of Hematology

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American Society of Hematology

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