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Journal Articles

ATRA Could Correct the Defective S1P-Mediated Cytoskeletal Reorganization in Proplatelet Formation of ITP

Qiu-Sha Huang, Jing Xue, Chen-Cong Wang, Ya-Zhen Qin, Lan-Ping Xu, Kaiyan Liu, Xiao-Jun Huang, MD, Xiao-Hui Zhang

Blood (2019) 134 (Supplement_1): 218.

https://doi.org/10.1182/blood-2019-126384

Published: 2019

Journal Articles

ROR1 Targeted Immunoliposomal Delivery of OSU-2S Show Selective Cytotoxicity in t(1;19) Translocated B-ALL

Swagata Goswami, MSc, Chi-Ling Chiang, PhD, Kevan Zapolnik, BS, Zhiliang Xie, James L. Lee, PhD, Sivasubramanian Baskar, Christoph Rader, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Bhavana Bhatnagar, DO, Natarajan Muthusamy, DVM,PhD

Blood (2019) 134 (Supplement_1): 3798.

https://doi.org/10.1182/blood-2019-128828

Published: 2019

Journal Articles

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Colin D. Crean, BS, Judith L Anderson, BS, G. David Roodman, MD PhD

Blood (2019) 134 (Supplement_1): 4387.

https://doi.org/10.1182/blood-2019-131106

Published: 2019

Journal Articles

The Gfi1-SphK1 Axis Regulates the Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Patrick Mulcrone, PhD, Colin D. Crean, BS, Judith L Anderson, BS, Quanhong Sun, PhD, Deborah Lynn Galson, PhD, G. David Roodman, MD PhD

Blood (2018) 132 (Supplement 1): 5615.

https://doi.org/10.1182/blood-2018-99-119507

Published: 2018

Journal Articles

Nocturnal Melatonin Renews Bone and Blood Forming Stem Cells Reservoir By Metabolic Reprograming

Karin Golan, PhD, Mayla Bertagna, MSc, Suditi Bhattacharya, MSc, Anoop Babu-Vasandan, PhD, Francesca Avemaria, PhD, Eman Khatib-Massalha, MSc, Zulma S. Ferreira, PhD, Orit Kollet, PhD, Abraham Avigdor, MD, Regina P. Markus, PhD, Tsvee Lapidot, PhD

Blood (2018) 132 (Supplement 1): 3326.

https://doi.org/10.1182/blood-2018-99-118354

Published: 2018

Journal Articles

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis

Karin von Wnuck Lipinski, Sarah Weske, Petra Keul, Susann Peters, Hideo A. Baba, Gerd Heusch, Markus H. Gräler, Bodo Levkau

Blood (2017) 130 (25): 2786–2798.

https://doi.org/10.1182/blood-2017-03-774356

Published: 2017

Includes: Supplemental data

Journal Articles

Dual Sphingosine Kinase and Bcl-2 Inhibition Exhibits Synergistic Cell Death in Acute Myeloid Leukemia

Alexander C. Lewis, BSc, Richard D'Andrea, BSc,PhD, Jason A Powell, BSc, PhD, Stuart M Pitson, PhD

Blood (2017) 130 (Supplement 1): 2660.

https://doi.org/10.1182/blood.V130.Suppl_1.2660.2660

Published: 2017

Journal Articles

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

Mateusz Adamiak, PhD, Lakshman Chelvarajan, Webster Santos, PhD, Kevin R Lynch, PhD, Ahmed Abdel-Latif, MD PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 4477.

https://doi.org/10.1182/blood.V130.Suppl_1.4477.4477

Published: 2017

Journal Articles

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM,PhD, Xiaokui Mo, PhD MAS, Pearlly S. Yan, PhD, Michael B Broe, PhD, Ralf Bundschuh, PhD, Larry State Beaver, Kevan Zapolnik, BS, Zhiliang Xie, Donna Bucci, David M. Lucas, PhD, Allison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B. Klisovic, MD, Ching-Shih Chen, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MDMBBS, Natarajan Muthusamy, DVM,PhD

Blood (2017) 130 (Supplement 1): 1247.

https://doi.org/10.1182/blood.V130.Suppl_1.1247.1247

Published: 2017

Journal Articles

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu, John Toubia, Melissa R. Pitman, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Diana Iarossi, Saumya E. Samaraweera, Nik Cummings, Hayley S. Ramshaw, Daniel Thomas, Andrew H. Wei, Angel F. Lopez, Richard J. D’Andrea, Ian D. Lewis, Stuart M. Pitson

Blood (2017) 129 (6): 771–782.

https://doi.org/10.1182/blood-2016-06-720433

Published: 2017

Includes: Supplemental data

Journal Articles

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

Jue Wang, PhD, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 16.

https://doi.org/10.1182/blood.V128.22.16.16

Published: 2016

Journal Articles

Metabolomic Profiling Defines Distinct Metabolic Signature Associated with FLT3/ITD AML

Bradley Stockard, Pharm.D, Timothy Garrett, Soheil Meshinchi, MD PhD, Jatinder K Lamba, PhD

Blood (2016) 128 (22): 1692.

https://doi.org/10.1182/blood.V128.22.1692.1692

Published: 2016

Journal Articles

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Mateusz Adamiak, MS, Ahmed Abdelbaset Ismail, PhD, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3342.

https://doi.org/10.1182/blood.V128.22.3342.3342

Published: 2016

Journal Articles

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Blood (2016) 128 (22): 2474.

https://doi.org/10.1182/blood.V128.22.2474.2474

Published: 2016

Journal Articles

Sphingosine-1-Phosphate (S1P) Signaling through S1P Receptor 1 (S1PR1) in Macrophage Contributes to Pain in Sickle Cell Disease

Morayo G. Adebiyi, BS, Yujin Zhang, MD, Kaiqi Sun, BS, Xia Hu, MD, Shusuan Zhao, MD, Hongyu Wu, PhD, Jacob Couturier, PhD, Dorothy L. Lewis, PhD, Edgar T. Walters, PhD, Yang Xia, MD PhD

Blood (2016) 128 (22): 2476.

https://doi.org/10.1182/blood.V128.22.2476.2476

Published: 2016

Journal Articles

S1P Receptor 1-Mediatd Elevated IL-6 Signaling Underlies Chronic Inflammation and Multiple Tissue Damage in Sickle Cell Disease

Yujin Zhang, PhD, Shushan Zhao, PhD, Jacob Couturier, PhD, Rodney E. Kellems, PhD, Dorothy L. Lewis, PhD, Yang Xia, MD PhD

Blood (2016) 128 (22): 4849.

https://doi.org/10.1182/blood.V128.22.4849.4849

Published: 2016

Journal Articles

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Karin Golan, PhD, Ashley Wellendorf, Yuji Takihara, MD PhD, Anju Kumari, PhD, Eman Khatib-Massalha, Msc, Orit Kollet, PhD, Hui Cheng, PhD, Tao Cheng, MD, Mark J. Althoff, Shiri Gur-Cohen, PhD, Tomer Itkin, PhD, Marie-Dominique Fillipi, PhD, Jose A Cancelas, MD PhD, Toshio Suda, MD PhD, Tsvee Lapidot, PhD

Blood (2016) 128 (22): 5.

https://doi.org/10.1182/blood.V128.22.5.5

Published: 2016

Journal Articles

Fingolimod Is Cytotoxic in Acute Myeloid Leukemia Independent of Additional Chemotherapeutic Agents

Carter Thomas Davis, MD, Arati V. Rao, MD, Eross Guadalupe, Dale J. Christensen, PhD, J. Brice Weinberg, MD

Blood (2016) 128 (22): 5126.

https://doi.org/10.1182/blood.V128.22.5126.5126

Published: 2016

Journal Articles

CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM PhD, Chi-Ling Chiang, MS, Frank W Frissora, M.S., Xiaokui Mo, PhD MAS, Zhiliang Xie, Donna Bucci, Amber Gordon, MLS, David M. Lucas, PhD, William Blum, MD, Alison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B Klisovic, MD, Ching-Shih Chen, PhD, Robert J Lee, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MBBS, Natarajan Muthusamy, DVM, PhD

Blood (2016) 128 (22): 2748.

https://doi.org/10.1182/blood.V128.22.2748.2748

Published: 2016

Journal Articles

Origin of (sporadic) Plasma Cell Myeloma: Lysolipids Are Not the Target of Clonal Immunoglobulins

Michael Pfreundschuh, MD, PhD, Natalie Fadle, Evi Regitz, Maria Kemele, Klaus-Dieter Preuss, PhD

Blood (2016) 128 (22): 2055.

https://doi.org/10.1182/blood.V128.22.2055.2055

Published: 2016

NARROW

ATRA Could Correct the Defective S1P-Mediated Cytoskeletal Reorganization in Proplatelet Formation of ITP

ROR1 Targeted Immunoliposomal Delivery of OSU-2S Show Selective Cytotoxicity in t(1;19) Translocated B-ALL

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

The Gfi1-SphK1 Axis Regulates the Growth and Survival of Myeloma Cells

Nocturnal Melatonin Renews Bone and Blood Forming Stem Cells Reservoir By Metabolic Reprograming

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis

Dual Sphingosine Kinase and Bcl-2 Inhibition Exhibits Synergistic Cell Death in Acute Myeloid Leukemia

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

Metabolomic Profiling Defines Distinct Metabolic Signature Associated with FLT3/ITD AML

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Sphingosine-1-Phosphate (S1P) Signaling through S1P Receptor 1 (S1PR1) in Macrophage Contributes to Pain in Sickle Cell Disease

S1P Receptor 1-Mediatd Elevated IL-6 Signaling Underlies Chronic Inflammation and Multiple Tissue Damage in Sickle Cell Disease

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Fingolimod Is Cytotoxic in Acute Myeloid Leukemia Independent of Additional Chemotherapeutic Agents

CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia

Origin of (sporadic) Plasma Cell Myeloma: Lysolipids Are Not the Target of Clonal Immunoglobulins

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American Society of Hematology

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ASH Publications

American Society of Hematology

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