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Journal Articles

Introduction to a review series on small-molecule targeted therapies for lymphoid malignancies

Andrew W. Roberts, Freda K. Stevenson
Journal: Blood
Blood (2021) 138 (13): 1089.
DOI: https://doi.org/10.1182/blood.2021012674
Published: 2021
Journal Articles

Supercharging your CAR

Sneha Ramakrishna, Kara L. Davis
Journal: Blood
Blood (2020) 135 (9): 593–594.
DOI: https://doi.org/10.1182/blood.2019004469
Published: 2020
Journal Articles

Small Molecule Screening Identifies Rho-Associate Protein Kinase (ROCK) As a Regulator of NK Cell Cytotoxicity Against Cancer

Grace Lee, Sheela Karunanithi, Zachary Jackson, David Wald, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3607.
DOI: https://doi.org/10.1182/blood-2019-131947
Published: 2019
Journal Articles

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Brandon Hadland, MD PhD, Barbara Varnum-Finney, PhD, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Cole Trapnell, PhD, Irwin D. Bernstein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3699.
DOI: https://doi.org/10.1182/blood-2019-126109
Published: 2019
Journal Articles

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Nicolas Nassar, PhD, Shailaja N Hegde, PhD, Anjelika Gasilina, Mark Wunderlich, MS, Gurdat Premnauth, Edward Merino, PhD, Yuan Lin, PhD, Reza Ahmadian, PhD, Yi Zheng, PhD, Benjamin Mizukawa, Lisa Privette Vinnedge, PhD, Jose A Cancelas, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4647.
DOI: https://doi.org/10.1182/blood-2019-130250
Published: 2019
Journal Articles

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models

Heekyung Chung, PhD, Emily Creger, Lauren Sitts, Kevin Chiu, Chi-Ching Mak, PhD, Sunil KC, PhD, Betty Tam, PhD, Gail Bucci, Josh Stewart, Timothy Phalen, PhD, Steven Cha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1377.
DOI: https://doi.org/10.1182/blood-2019-130500
Published: 2019
Journal Articles

HM43239, a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations: Phase 1 /2 Study

Naval G. Daver, MD, Kyoo Hyung Lee, MD PhD, Sung-Soo Yoon, MD PhD, Chul Won Jung, MD PhD, Hyun Jeong Kang, Sooa Jung, Sujin Seo, Jiyeon Yoon, Hyunjin Kim, Young Su Noh, Yoonha Seo, Hyeyoung Kwon, Oakpil Han, Seungjae Baek, MD PhD, Kyounghee Seo, Kwee Hyun Suh, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1331.
DOI: https://doi.org/10.1182/blood-2019-129670
Published: 2019
Journal Articles

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Xiaoyang Su, PhD, Ying Chen, PhD, Maisarah Mokhtar, B.S, Gregory Dolnikowski, Frederick Lansigan, MD, William B Kinlaw, III, MD, Sandeep Dave, MD, Andrew M. Evens, DO, MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1573.
DOI: https://doi.org/10.1182/blood-2019-126382
Published: 2019
Journal Articles

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Håkan Mellstedt, MD PhD Prof., Amineh Ghaderi, MSc, Johanna Aschan, MSc, Fariba Mozaffari, MSc,PhD, Ali Moshfegh, MSc,PhD, Birgitta Sander, MD PhD Prof., Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Mohammad Hojjat-Farsangi, MSc,PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5312.
DOI: https://doi.org/10.1182/blood-2019-129773
Published: 2019
Journal Articles

Blocking Protein Secretion with Novel Small Molecule Inhibitors of Sec61 Represents a Potential Treatment Strategy Against Hematologic Malignancies

Eric Lowe, BS, Andrea R Fan, PhD, Jing Jiang, Henry W. B. Johnson, PhD, Christopher J. Kirk, PhD, Dustin McMinn, PhD, Tony Muchamuel, MS, Yu Qian, PhD, Brian B. Tuch, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 408.
DOI: https://doi.org/10.1182/blood-2019-123782
Published: 2019
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
DOI: https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 983.
DOI: https://doi.org/10.1182/blood-2019-127300
Published: 2019
Journal Articles

KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes

Adrian R. Wilkie, PhD, Leila J. Noetzli, PhD, Genevieve Couldwell, Anthony R. Sciaudone, Anjana Ray, PhD, Kellie R. Machlus, PhD, Joseph E. Italiano, Jr., BS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 721.
DOI: https://doi.org/10.1182/blood-2019-130803
Published: 2019
Journal Articles

VWF Exocytosis and Biogenesis of Weibel Palade Bodies in Endothelial Cells Are Differentially Controlled By Interactions between Bloc-2 and the Exocyst Complex

Anish V. Sharda, MBBS, MPH, Joshua Harrison, BS, Adrian R. Wilkie, PhD, Chao Fang, PhD, Lourdes M. Mendez, MD PhD, Joseph E. Italiano, Jr., BS, PhD, Robert C. Flaumenhaft, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 8.
DOI: https://doi.org/10.1182/blood-2019-127712
Published: 2019
Journal Articles

Response to Bcma CAR-T Cells Correlates with Pretreatment Target Antigen Density and Is Improved By Small Molecule Inhibition of Gamma Secretase

Damian J. Green, MD, Margot Pont, PhD, Andrew J. Cowan, MD, Gabriel O Cole, Blythe Duke Sather, PhD, Anne M Nagengast, RN, Xaoling Song, Sushma Thomas, Brent L Wood, MD PhD, Michelle L Blake, PhD, Melissa G Works, PhD, Ted A Gooley, PhD, David G. Maloney, MD PhD, Stanley R. Riddell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1856.
DOI: https://doi.org/10.1182/blood-2019-129582
Published: 2019
Journal Articles

Identification of Small Molecule Kinase Inhibitors That Potently and Reversibly Block Chimeric Antigen Receptor T Cell Proliferation and Cytotoxicity

Parmeshwar Amatya, PhD, Matthew L. Cooper, PhD, Alun J Carter, PhD BSc, John F. DiPersio, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2068.
DOI: https://doi.org/10.1182/blood-2019-126165
Published: 2019
Journal Articles

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Martine Humbert, PhD, Armelle Goubard, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 2075.
DOI: https://doi.org/10.1182/blood-2019-122540
Published: 2019
Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2076.
DOI: https://doi.org/10.1182/blood-2019-125988
Published: 2019
Journal Articles

Targeting Homologous Recombination in Lymphoid Malignancies: Evaluation of Four Small Molecule Inhibitors of RAD51

Melinda Day, PhD, Tyler Maclay, Amber Cyr, Muneer G Hasham, PhD, Kin-hoe Chow, ED Keniston, Kevin Mills, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2080.
DOI: https://doi.org/10.1182/blood-2019-131747
Published: 2019
Journal Articles

Automation Platform for CAR-T Manufacturing: The Benefits and the Clinical Outcomes

Min Wang, PhD, Fengtao You, PhD, Xingbing Wang, MD, Bingzong Li, MD PhD, Hanying Xu, MS, Yu Wang, MS, Guifang Pan, MS, Song Sun, MS, Huimin Meng, MD PhD, Yanmei Zhao, MS, Yu-Sheng Chen, PhD, Bozhen Zhang, MBA, Lin Yang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1960.
DOI: https://doi.org/10.1182/blood-2019-123656
Published: 2019