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Journal Articles

A Population-Based Analysis of Predictors of Survival and Trends in Outcomes of Elderly Patients with Multiple Myeloma (MM)

Vivek Kumar, MD, M.B.,B.S., Meghna Ailawadhi, MD, Mays F Abdulazeez, MBBS, Suman Biswas, MD, Sri Lekha Bodepudi, Leyla Bojanini, MD, Vivek Roy, MD, Taimur Sher, MD, Victoria R. Alegria, Rami Manochakian, MD, Aneel Paulus, MD, Asher A. Chanan-Khan, MD, Sikander Ailawadhi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4779.
https://doi.org/10.1182/blood-2019-125156
Published: 2019
Journal Articles

PD-1 Is Expressed at Low Levels on All Peripheral Blood Natural Killer Cells but Is a Significant Suppressor of NK Function Against PD-1 Ligand Expressing Tumor Targets

Zachary Davis, PhD BS, Martin Felices, PhD, Todd R Lenvik, Sujan Badal, Peter Hinderlie, Bruce R. Blazar, MD, Daniel A. Vallera, PhD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 621.
https://doi.org/10.1182/blood-2019-127261
Published: 2019
Journal Articles

Lisocabtagene Maraleucel (liso-cel) Manufacturing Process Control and Robustness across CD19+ Hematological Malignancies

Jeffrey Teoh, PhD, Timothy G. Johnstone, PhD, Brian Christin, BS, Rachel Yost, Neil A. Haig, Mary Mallaney, Aditya Radhakrishnan, Heidi H. Gillenwater, MD, Tina Albertson, MD, Paul Guptill, Lauren F. Brown, Christopher G. Ramsborg, Ronald J. Hause, PhD, Ryan P. Larson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 593.
https://doi.org/10.1182/blood-2019-127150
Published: 2019
Journal Articles

Efficacy and Safety of Fully Human Bcma Targeting CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma

Chunrui Li, MD PhD, Jue Wang, MD PhD, Di Wang, MD PhD, Guang Hu, Yongkun Yang, Xiaoxi Zhou, MD PhD, Li Meng, MD PhD, Zhenya Hong, MD PhD, Liting Chen, PhD, Xia Mao, MD PhD, Min Xiao, MD PhD, Jianfeng Zhou, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 929.
https://doi.org/10.1182/blood-2019-128468
Published: 2019
Journal Articles

A Phase 1 First-in-Human Study of the Anti-CD38 Dimeric Fusion Protein TAK-169 for the Treatment of Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM) Who Are Proteasome Inhibitor (PI)- and Immunomodulatory Drug (IMiD)-Refractory, Including Pts Relapsed/Refractory (R/R) or Naïve to Daratumumab (dara)

Shaji K. Kumar, MD, Robert F. Cornell, MD MS, Ola Landgren, MD PhD, Sikander Ailawadhi, MD, Jack P Higgins, PhD, Erin K Willert, Roger Waltzman, MD MBA, Jianchang Lin, PhD, Yuhong Zhang, Anya R Lublinsky, Ajeeta B Dash, PhD, Michael Hanley, Divya Manoharan, Morgan Leichter, Sean Ottinger, Richard J Labotka, John Newcomb, Alexander Vorog, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1867.
https://doi.org/10.1182/blood-2019-125629
Published: 2019
Journal Articles

Ex Vivo Activity of Immunotherapeutic Approaches Targeting CD38 Against Daratumumab-Resistant Multiple Myeloma Patient Samples

Maria Karvouni, MSc, PharmD, Heyue Zhou, Arnika Kathleen Wagner, PhD, Qiangzhong Ma, Alamdar H. Baloch, PhD, Tong Zhu, Hong Zhang, Mari Gilljam, Andreas Lundqvist, PhD, Gunnar F. Kaufmann, PhD, Evren Alici, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1848.
https://doi.org/10.1182/blood-2019-127893
Published: 2019
Journal Articles

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1941.
https://doi.org/10.1182/blood-2019-121973
Published: 2019
Journal Articles

Developing a Novel Anti-Bcma CAR-T for Relapsed or Refractory Multiple Myeloma

Xin Yao, PhD, Shigui Zhu, PhD, Jiaqi Huang, PhD, Xiaoyan Qu, MD PhD, Judy Zhu, MD, Yutian Wei, MS, Liping Lan, MS, Xiaoteng LV, MS, Junfeng Wu, PhD, Rirfei Wang, MS, Dingzhu Yang, Chengxiao Zheng, MD, DiJun Zhao, MS, Lei Fan, MD PhD, Fei Huang, Hua Lu, MD PhD, Chaocan Zhang, MS, Cheng Chen, PhD, Yanfeng Li, MS, Jiaqiang Ren, MD PhD, Li Zhang, MD, Michael Humphries, MD, Jianyong Li, MD, Yihong Yao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 50.
https://doi.org/10.1182/blood-2019-125372
Published: 2019
Journal Articles

Combined Infusion of Anti-CD19 and Anti-Bcma CART Cells after Early or Later Transplantation in the Front Line Was Superior to Salvage Therapy for High Risk MM

Xiaolan Shi, Lingzhi Yan, Jingjing Shang, Liqing Kang, Song Jin, Huizhu Kang, Ruju Wang, Zhu Mingqing, Jiazi Zhou, Feiran Gong, Guanghua Chen, Jin Zhou, Huirong Chang, Weiqin Yao, Ying Yao, Yong Liu, Zhi Yan, Juanjuan Su, Depei Wu, MD PhD, Lei Yu, Fu Cheng Cheng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1949.
https://doi.org/10.1182/blood-2019-131546
Published: 2019
Journal Articles

PD-L1 Checkpoint Blockade Augments Anti-Tumor Immune Response of GD2 or HER2-Bsab Ex Vivo Armed T-Cells (EVAT) Therapy in Osteosarcoma

Jeong A Park, MD PhD, Hong fen Guo, PhD, Hong Xu, PhD, Nai-Kong V. Cheung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1959.
https://doi.org/10.1182/blood-2019-131325
Published: 2019
Journal Articles

CD70-Specific CAR T Cells Have Potent Activity Against Acute Myeloid Leukemia (AML) without HSC Toxicity

Tim Sauer, MD, Kathan Parikh, Sandhya Sharma, Bilal Omer, MD, Stephen Gottschalk, MD, Cliona M. Rooney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1932.
https://doi.org/10.1182/blood-2019-125534
Published: 2019
Journal Articles

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Hyunsook Ahn, MSc, John Tkaczynski, BS, Khalil Bdeir, PhD, Victoria Stepanova, Douglas B. Cines, MD, Mortimer Poncz, MD, Sergei Zaitsev
Journal: Blood
Blood (2019) 134 (Supplement_1): 3627.
https://doi.org/10.1182/blood-2019-124501
Published: 2019
Journal Articles

A Phase 2a Open-Label Study to Investigate Safety and Tolerability (including the MTD), Efficacy, Pharmacokinetics, Pharmacodynamics and Immunogenicity of MT-3724 in Combination with Lenalidomide in Subjects with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Christine Burnett, Gary Gordon, MD PhD, Thomas Strack, MD, Tara Lehner, MS, PMP, Jack P Higgins, PhD, Jason Tache, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 1597.
https://doi.org/10.1182/blood-2019-128503
Published: 2019
Journal Articles

High Avidity IgM-Based CD20xCD3 Bispecific Antibody (IGM-2323) for Enhanced T-Cell Dependent Killing with Minimal Cytokine Release

Ramesh Baliga, PhD, Keyu Li, PhD, Marigold Manlusoc, Paul Hinton, Dean Ng, PhD, Madeline Tran, Bing Shan, PhD, Hai Lu, Avneesh Saini, PhD, Sachi Rahman, Yuan Cao, PhD, Chitra Saraiya, Marvin Peterson, PhD, Steve Carroll, PhD, Daniel Chen, MD PhD, Bruce Keyt, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1574.
https://doi.org/10.1182/blood-2019-131650
Published: 2019
Journal Articles

Response to Bcma CAR-T Cells Correlates with Pretreatment Target Antigen Density and Is Improved By Small Molecule Inhibition of Gamma Secretase

Damian J. Green, MD, Margot Pont, PhD, Andrew J. Cowan, MD, Gabriel O Cole, Blythe Duke Sather, PhD, Anne M Nagengast, RN, Xaoling Song, Sushma Thomas, Brent L Wood, MD PhD, Michelle L Blake, PhD, Melissa G Works, PhD, Ted A Gooley, PhD, David G. Maloney, MD PhD, Stanley R. Riddell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1856.
https://doi.org/10.1182/blood-2019-129582
Published: 2019
Journal Articles

A CD19/CD3 Bispecific Antibody Induces Superior T Cell Responses Against Chronic Lymphocytic Leukemia When Combined with Ibrutinib

Maissa Mhibik, PhD, Erika M Gaglione, Amy Blackburn, Keyvan Keyvanfar, Clare Sun, MD, Inhye E Ahn, MD, Maria Joao Baptista, Junpeng Qi, PhD, Christoph Rader, PhD, Adrian Wiestner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2861.
https://doi.org/10.1182/blood-2019-126186
Published: 2019
Journal Articles

First-in-Human CD4 CAR Clinical Trial on Peripheral T-Cell Lymphoma

Hongyu Zhang, MD PhD, Jia Feng, MD PhD, Wenli Zhang, MD, Qi Chen, PhD, Yuanzhen Cao, Kevin Pinz, Fang Liu, MD PhD, Yu Ma, Masayuki Wada, PhD, Yupo Ma, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2881.
https://doi.org/10.1182/blood-2019-122789
Published: 2019
Journal Articles

Foamy Virus Based Vectors for CAR-T Cell Development

Emmanouil Simantirakis, MSc, Vassilis Atsaves, PhD, Ioannis Tsironis, BSc MSc, Margarita Gkyzi, BSc, Kostas Konstantopoulos, MD PhD, George Vassilopoulos, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4646.
https://doi.org/10.1182/blood-2019-123022
Published: 2019
Journal Articles

Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)

Liora M Schultz, MD, Lori S Muffly, MD, Jay Y. Spiegel, MDFRCPC, Sneha Ramakrishna, MD, Nasheed Hossain, MD, Christina Baggott, RN, PhD, Bita Sahaf, PhD, Shabnum Patel, PhD, Juliana Craig, BA, Jenny Yoon, Meena Kadapakkam, MD, Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Courtney Erickson, Anne Cunniffe Marcy, MSBH, Michelle Fujimoto, Neehar Bhatia, Everett H Meyer, MD PhD, Katherine A. Kong, Emily Egeler, Sharon Mavroukakis, Haiying Qin, MS, Terry J. Fry, MD, Steven A Feldman, PhD, David B Miklos, MD PhD, Crystal L. Mackall, MD, Kara L. Davis, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 744.
https://doi.org/10.1182/blood-2019-129411
Published: 2019
Journal Articles

A Bispecific CAR-T Cell Therapy Targeting Bcma and CD38 for Relapsed/Refractory Multiple Myeloma: Updated Results from a Phase 1 Dose-Climbing Trial

Chenggong Li, Heng Mei, Yu Hu, MD PhD, Tao Guo, MD PhD, Lin Liu, MD PhD, Huiwen Jiang, Lu Tang, Yaohui Wu, MD PhD, Lisha Ai, MD PhD, Jun Deng, MD PhD, Dan Jin
Journal: Blood
Blood (2019) 134 (Supplement_1): 930.
https://doi.org/10.1182/blood-2019-130340
Published: 2019