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Journal Articles

Spontaneous Remission of Secondary Acute Lymphoblastic Leukemia Associated with Lenalidomide Therapy for Multiple Myeloma

Arjun Lakshman, MBBS, Cai Chen, Kayla Parr, Sarah McGregor, Sara Monaghan, MD, Steven H. Swerdlow, MD, Warren D Shlomchik, MD, Mounzer Agha, MD, Sawa Ito, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5200.
https://doi.org/10.1182/blood-2019-129257
Published: 2019
Journal Articles

AT1412, a Patient-Derived Antibody in Development for the Treatment of CD9 Positive Precursor B-Acute Lymphoblastic Leukemia

Greta De Jong, Sophie E Levie, Remko Schotte, PhD, Wouter Pos, PhD, Daniel Go, Etsuko Yasuda, Madalina Cercel, Susan E van Hal-van Veen, Esmay Frankin, Anikó Szabó, MD, Julien Villaudy, PhD, Pauline M van Helden, PhD, Hans van Eenennaam, PhD, Hergen Spits, PhD, Anita W Rijneveld, MD PhD, Mette D Hazenberg, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4461.
https://doi.org/10.1182/blood-2019-127894
Published: 2019
Journal Articles

Targeting Neurotrophic Receptor Tyrosine Kinase (NTRK) Fusion Structural Homologs in Refractory Pediatric Acute Lymphoblastic Leukemia (ALL)

Son Tran, Mehul Gupta, Sunand Kannappan, Chunfen Zhang, MD, Aru Narendran, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3882.
https://doi.org/10.1182/blood-2019-132223
Published: 2019
Journal Articles

Mutational Landscape and Temporal Evolution during Treatment of Relapsed Acute Lymphoblastic Leukemia

Benshang Li, Yongjin Li, PhD, Shuhong Shen, MD PhD, Yingchi Zhang, Samuel Brady, PhD, Xiaotu Ma, Yu Liu, PhD, Ningling Wang, Diane Flasch, Matthew Myers, Heather Mulder, BS, Yanling Liu, Liqing Tian, Kohei Hagiwara, MD, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Ting-Nien Lin, Lijuan Du, Fan Yang, Michael Rusch, BS, Michael Edmonson, John Easton, PhD, Xiaofan Zhu, PhD, Jingliao Zhang, MD, Cheng Cheng, PhD, Benjamin Raphael, Jing-Yan Tang, James R. Downing, MD, Bin-Bing Zhou, Ching-Hon Pui, MD, Jun J. Yang, PhD, Jinghui Zhang
Journal: Blood
Blood (2018) 132 (Supplement 1): 917.
https://doi.org/10.1182/blood-2018-99-119144
Published: 2018
Journal Articles

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Rumen Kostadinov, PhD, Byunggil Yoo, MS, Midhat S. Farooqi, MD PhD, Shannon Kelley, MS, Erin Guest, MD, Michael J. Burke, MD, Sarah Wheelan, MD PhD, Patrick Brown, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 918.
https://doi.org/10.1182/blood-2018-99-119206
Published: 2018
Journal Articles

Epigenetic Regulation and Therapeutic Targeting in Myeloma

Jonathan D. Licht, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): SCI-37.
https://doi.org/10.1182/blood-2018-99-109522
Published: 2018
Journal Articles

A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Gary Wright, Fernanda Castro, Bilyana Popova, Joan Casanovas Company, Catherine Irving, Winston Vetharoy, Rachel Richardson, Danielle Pinner, Jan Chu, Giovanna Lucchini, MD, Juliana Silva, MD, Oana Ciocarlie, Sarah Inglott, Kim Champion, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Anupama Gopala Rao, MB, MRCP, MRCPath, Philip Ancliffe, MD, Sujith Samarasinghe, Ajay Vora, MD, Paul Veys, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Robert Wynn, MD, Martin Pule, PhD, Persis J Amrolia
Journal: Blood
Blood (2017) 130 (Supplement 1): 806.
https://doi.org/10.1182/blood.V130.Suppl_1.806.806
Published: 2017
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation

Jessica I Hoell, MD, Sebastian Ginzel, MSc, Cornelia Eckert, PhD, Michael Gombert, PhD, Ute Fischer, PhD, Martin Stanulla, MD, Martin Schrappe, MD PhD, Udo zur Stadt, PhD, Peter Bader, MD, Brigitte Strahm, MD, Julia Alten, Anja Moericke, MD, Gabriele Escherich, MD, Arend Stackelberg, MD, Christina Peters, MD, Arndt Borkhardt, MD, Roland Meisel, MD
Journal: Blood
Blood (2016) 128 (22): 601.
https://doi.org/10.1182/blood.V128.22.601.601
Published: 2016
Journal Articles

Massive Parallel Sequencing and Mutations Analysis of Mismatch Repair Genes in Recurrent Childhood Acute Lymphoblastic Leukemia Cases-Identification of Possible Molecular Signature of Poor Clinical Outcome

Keisuke Kato, MD, Ai Yoshimi, MD, Satoru Matsushima, MD, Chie Kobayashi, MD, Kunio Fukuda, MD, Kazutoshi Koike, MD, Masahiro Tsuchida, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5266.
https://doi.org/10.1182/blood.V128.22.5266.5266
Published: 2016
Journal Articles

Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Yuka Yamashita, MS, Masashi Sanada, MD PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Hiroko Tanaka, BA, Yuichi Shiraishi, MD PhD, Kenichi Chiba, BA, Toshihiko Imamura, MD PhD, Satoru Miyano, MD PhD, Koji Kato, MD PhD, Seiji Kojima, MD PhD, Seishi Ogawa, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1425.
https://doi.org/10.1182/blood.V126.23.1425.1425
Published: 2015
Journal Articles

Post Induction Minimal Residual Disease Levels Identifies a Group of High Risk Relapsed Childhood Acute Lymphoblastic Leukemia (rALL) with a Favorable Outcome Independent of Induction Therapy

Catriona Anne Parker, PhD, Marie Reeves, MSc, Sharon Love, MSc, Jeremy Hancock, PhD, Peter M Hoogerbrugge, MD PhD, Rosemary Sutton, Tom Revesz, MD, Vaskar Saha, PhD FRCP, FRCPath
Journal: Blood
Blood (2015) 126 (23): 1294.
https://doi.org/10.1182/blood.V126.23.1294.1294
Published: 2015
Journal Articles

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Hui Li, PhD, Benshang Li, Fan Yang, Caiwen Duan, Yun Bai, Jun J Yang, PhD, Jing Chen, MD PhD, Arend von Stackelberg, MD, Hongzhuan Chen, PhD, JingYan Tang, MD, Adolfo A. Ferrando, MD PhD, Jinghui Zhang, PhD, Shengyue Wang, Renate Kirschner-Schwabe, PhD, Bin-Bing S. Zhou, PhD
Journal: Blood
Blood (2015) 126 (23): 2627.
https://doi.org/10.1182/blood.V126.23.2627.2627
Published: 2015
Journal Articles

Differential in Vitro Drug Resistance Profile Between First and Second Relapsed Acute Lymphoblastic Leukemia and Acute Myeloblastic Leukemia in Children

Jan Styczynski, Beata Kurylo-Rafinska, Malgorzata Kubicka, Beata Kolodziej, Monika Pogorzala, Krzysztof Czyzewski, Robert Debski, Magdalena Wisniewska, Mariusz Wysocki, Michal Matysiak, Prof., MDPhD, Iwona Malinowska, Walentyna Balwierz, Prof MDPhD, Edyta Juraszewska, Jacek Wachowiak, Benigna Konatkowska, Mariola Woszczyk, MDPhD, Igor Olejnik, MD, Maryna Krawczuk-Rybak, Prof MDPhD, Marta Kuzmicz, Jerzy Kowalczyk, Prof MDPhD, Maria Jolanta Stefaniak, MD PhD, Wanda Badowska, Tomasz Szczepanski, Prof MD PhD, Renata Tomaszewska, Elzbieta Adamkiewicz-Drozynska, Lucyna Maciejka-Kemblowska, Grazyna Sobol, Agnieszka Mizia-Malarz, Joanna Szczepanek
Journal: Blood
Blood (2015) 126 (23): 3696.
https://doi.org/10.1182/blood.V126.23.3696.3696
Published: 2015
Journal Articles

Phase Ib Trial of the mTOR Inhibitor Everolimus Given in Combination with Multiagent Chemotherapy in Relapsed Acute Lymphoblastic Leukemia

Andrew E. Place, MDPhD, Yana Pikman, MD, Kristen Stevenson, MS, Marian H. Harris, MD PhD, Todd M. Cooper, DO, Lia Gore, MD, Nobuko Hijiya, MD, Mignon L. Loh, MD, Melinda Pauly, MD, Maria Luisa Sulis, MD, Donna S Neuberg, ScD, Kimberly Stegmaier, MD, Stephen E. Sallan, MD, Lewis B. Silverman, MD
Journal: Blood
Blood (2015) 126 (23): 3765.
https://doi.org/10.1182/blood.V126.23.3765.3765
Published: 2015
Journal Articles

High Throughput Screening Identifies Potential Inhibitors of WHSC1/MMSET, a Histone Methyltransferase Oncoprotein in Multiple Myeloma and Acute Lymphocytic Leukemia

Christine M Will, MS, Michael Scholle, MS, Roodolph St. Pierre, BS, Gary Schiltz, PhD, James E. Bradner, MD, Milan Mrksich, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2015) 126 (23): 3251.
https://doi.org/10.1182/blood.V126.23.3251.3251
Published: 2015
Journal Articles

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Julia Etchin, PhD, Alla Berezovskaya, Amy Saur Conway, Weihsu Claire Chen, PhD, Erkan Baloglu, PhD, Yosef Landesman, PhD, William Senapedis, PhD, Joel Ellis, PhD, Dilara McCauley, PhD, Richard M. Stone, MD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Michael Kauffman, Sharon Shacham, Jean C.Y. Wang, MDPhD, A. Thomas Look, MD
Journal: Blood
Blood (2015) 126 (23): 326.
https://doi.org/10.1182/blood.V126.23.326.326
Published: 2015
Journal Articles

Irving J, Matheson E, Minto L, et al. Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood . 2014;124(23): 3420-3430 .

Journal: Blood
Blood (2015) 125 (5): 890.
https://doi.org/10.1182/blood-2014-12-617654
Published: 2015
Journal Articles

The UK ALLR3 Chemotherapy Regimen for Relapsed/Refractory Acute Lymphoblastic Leukemia of Childhood: A Multi-Institutional Retrospective Study of Treatment Related Adverse Events

Weili Sun, MDPhD, Alison Marie Smith, BS, Orgal Etan, MD, Richard Sposto, PhD, Jennifer J. Wilkes, MD, Rebecca A Gardner, MD, Hur Minjun, Vanessa Pineros, Emily Olson, MD, Yijuin Tan, Susan R. Rheingold, MD, Michael J. Burke, MD, Alan S. Wayne, MD
Journal: Blood
Blood (2014) 124 (21): 3647.
https://doi.org/10.1182/blood.V124.21.3647.3647
Published: 2014
Journal Articles

Deciphering the Epigenetic Landscape of Relapsed Pediatric Acute Lymphoblastic Leukemia

Teena Bhatla, MD, Roy Blum, PhD, Jinhua Wang, PhD, Courtney L Jones, PhD, Debra J. Morrison, PhD, Elizabeth A Raetz, MD, Michael J. Burke, MD, Patrick Brown, MD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Mignon Loh, MD, Stephen P. Hunger, MD, William L. Carroll, MD
Journal: Blood
Blood (2014) 124 (21): 612.
https://doi.org/10.1182/blood.V124.21.612.612
Published: 2014
Journal Articles

Clinical Significance of NT5C2 Mutations in Children with First Relapse of B-Cell Precursor Acute Lymphoblastic Leukemia

Jana Hof, MSc, Annabell Szymansky, MSc, Arend von Stackelberg, MD, Cornelia Eckert, PhD, Renate Kirschner-Schwabe, PhD
Journal: Blood
Blood (2014) 124 (21): 3789.
https://doi.org/10.1182/blood.V124.21.3789.3789
Published: 2014