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Journal Articles

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Matteo Marchesini, PhD, Andrea Gherli, Anna Montanaro, Samuel Kitara, Claudia Sorrentino, Luca Pagliaro, Anne-Marie Lund Winter, Chiara Rompietti, Donatella Stilli, Federica Rizzi, Kimberly Stegmaier, MD, Paolo Sportoletti, William Dalby-Brown, Giovanni Roti

Blood (2019) 134 (Supplement_1): 407.

https://doi.org/10.1182/blood-2019-125616

Published: 2019

Journal Articles

Dll1 and Dll4 Notch Ligands Prime T Cell Alloimmunity and Are Expressed in Non-Overlapping Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes at the Onset of Gvhd

Joshua D Brandstadter, MD PhD, Eric Perkey, Brian T. Gaudette, PhD, Léolène Carrington, PhD, Daniela Gomez-Atria, PhD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Anastasia Tikhonova, PhD, Iannis Aifantis, PhD, David Allman, PhD, Ivan Maillard, MD PhD

Blood (2019) 134 (Supplement_1): 588.

https://doi.org/10.1182/blood-2019-123533

Published: 2019

Journal Articles

From Graft-Versus-Host Disease to Lymphoma Pathogenesis: Emerging Roles for Stromal Notch Ligands in Hematology

Ivan Maillard, MD PhD

Blood (2019) 134 (Supplement_1): SCI-47.

https://doi.org/10.1182/blood-2019-121067

Published: 2019

Journal Articles

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Brandon Hadland, MD PhD, Barbara Varnum-Finney, PhD, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Cole Trapnell, PhD, Irwin D. Bernstein, MD

Blood (2019) 134 (Supplement_1): 3699.

https://doi.org/10.1182/blood-2019-126109

Published: 2019

Journal Articles

Prognostic Impact of Notch Signaling in Acute Myeloid Leukemia (AML)

Paul Takam Kamga, BSc, MSc, Federica Resci, MD, Giada Dal Collo, MSc, Annalisa Adamo, MSc, Riccardo Bazzoni, MSc, Angela Mercuri, MSc, Massimiliano Bonifacio, Mauro Krampera, MD PhD

Blood (2018) 132 (Supplement 1): 5242.

https://doi.org/10.1182/blood-2018-99-118701

Published: 2018

Journal Articles

Hypoxia and Notch Signaling Synergistically Expand Long-Term Repopulating Human Hematopoietic Stem/Progenitor Cells

Heather D. Huntsman, PhD, Daisuke Araki, MD, Richard H. Smith, PhD, Andre Larochelle, MD PhD

Blood (2018) 132 (Supplement 1): 2557.

https://doi.org/10.1182/blood-2018-99-119388

Published: 2018

Journal Articles

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis

Blood (2018) 131 (15): 1712–1719.

https://doi.org/10.1182/blood-2017-06-788505

Published: 2018

Includes: Supplemental data

Journal Articles

Canonical Notch Signaling Is Required for Kras G12D -Induced Myeloproliferative Neoplasm

Xiaona You, PhD, Guangyao Kong, Zhi Wen, Yuan-I Chang, Erik A. Ranheim, MD PhD, Eric Padron, MD, Jing Zhang, PhD

Blood (2017) 130 (Supplement 1): 1220.

https://doi.org/10.1182/blood.V130.Suppl_1.1220.1220

Published: 2017

Journal Articles

Notch Signaling Controls Drug Response in B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Paul Takam Kamga, BSc, MSc, Giada Dal Collo, MSc, Martina Midolo, PhD, Annalisa Adamo, MSc, Alessandro Gatti, MSc, Roberta Carusone, PhD, Elda Mimiola, MDPhD, Angela Mercuri, MSc, Massimiliano Bonifacio, MD, Mauro Krampera, MD PhD

Blood (2017) 130 (Supplement 1): 2535.

https://doi.org/10.1182/blood.V130.Suppl_1.2535.2535

Published: 2017

Journal Articles

Microenvironment-Specific Activation of Notch2 in Splenic Marginal Zone Lymphoma

Vignesh Shanmugam, MD, Scott B Lovitch, MD, PhD, Karim A. Benhadji, Gerald J. Oakley, MD, Jon C. Aster, MD PhD

Blood (2017) 130 (Supplement 1): 1485.

https://doi.org/10.1182/blood.V130.Suppl_1.1485.1485

Published: 2017

Journal Articles

EGFL7 Antagonizes NOTCH Signaling, Stimulates Blast Proliferation and Confers Poor Prognosis in Cytogenetically-Normal Acute Myeloid Leukemia (CN-AML)

Changxian Shen, Dimitrios Papaioannou, MD, Betina Mcneil, Deedra Nicolet, Malith Karunasiri, Matthew Burke, Zitzer Nina, Gregory K. Behbehani, MD PhD, Hatice G Ozer, PhD, Selen Yilmaz, Guido Marcucci, MD, Michael A. Caligiuri, MD, Clara D. Bloomfield, MD, Ramiro Garzon, MD, Adrienne Dorrance, PhD

Blood (2016) 128 (22): 2689.

https://doi.org/10.1182/blood.V128.22.2689.2689

Published: 2016

Journal Articles

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

Guangyao Kong, PhD, Yuan-I Chang, PhD, Jingfang Zhang, PhD, Erik A. Ranheim, MD, Xinmin Zhang, Yun Zhou, Yangang Liu, Lan Zhou, MD PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD

Blood (2016) 128 (22): 1565.

https://doi.org/10.1182/blood.V128.22.1565.1565

Published: 2016

Journal Articles

A Novel DLL1-Anti-CD19 Chimeric Protein Effectively Targets Notch Activation to B-Cell Acute Lymphoblastic Leukemia and Induces Cell Death

Rebecca E Wiersma, Sankaranarayanan Kannan, PhD, Srinivas S. Somanchi, PhD, Lizhi Zeng, Patrick A. Zweidler-McKay, MDPhD

Blood (2015) 126 (23): 4833.

https://doi.org/10.1182/blood.V126.23.4833.4833

Published: 2015

Journal Articles

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

Jonathan C. Poe, PhD, Wei Jia, MD, Zhiguo Li, PhD, Frances T. Hakim, PhD, Steven Z. Pavletic, MD, Jeremy J. Rose, BA, David A. Rizzieri, MD, Yiping Yang, MD PhD, Benny J. Chen, MD, Michael Green, MD, Sarah Anand, MD, Christian W. Siebel, PhD, Ivan Maillard, MD PhD, Nelson J. Chao, MD, Stefanie Sarantopoulos, MD PhD

Blood (2015) 126 (23): 145.

https://doi.org/10.1182/blood.V126.23.145.145

Published: 2015

Journal Articles

The Safety and Activity of BMS-906024, a Gamma Secretase Inhibitor (GSI) with Anti-Notch Activity, in Patients with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL): Initial Results of a Phase 1 Trial

Patrick A. Zweidler-McKay, MDPhD, Daniel J. DeAngelo, MDPhD, Dan Douer, MD, Hervé Dombret, MD, Oliver G. Ottmann, MD, Norbert Vey, MD, Deborah A. Thomas, MD, Lili Zhu, MSc, Fei Huang, PhD, Gaurav Bajaj, PhD, Bruce S. Fischer, MD

Blood (2014) 124 (21): 968.

https://doi.org/10.1182/blood.V124.21.968.968

Published: 2014

Journal Articles

Notch2 Is Critical for CLL Development in the IRF4 -/- Vh11 Mice

Vipul Shukla, Shibin Ma, Shantaram Joshi, PhD, Runqing Lu, PhD

Blood (2014) 124 (21): 891.

https://doi.org/10.1182/blood.V124.21.891.891

Published: 2014

Journal Articles

Loss of Notch Receptor-Ligand Engagement Leads to Increased Hematopoietic Stem and Progenitor Cell Egress and Mobilization

Lan Zhou, MD PhD, Weihuan Wang, MD PhD, Grant Zimmerman, Jay Myers, MS, Yuanshuai Huang, MD PhD, Vionnie W.C. Yu, PhD, Dan Huang, MD PhD, Shuiliang Yu, PhD, Yiwei Wang, MD PhD, Xiaoran Huang, MD, Jeongsup Shim, PhD, Minhong Yan, PhD, John Lowe, MD, Wei Xin, MD PhD, Pamela Stanley, PhD BSc, David T. Scadden, MD, Alex Y Huang, MD PhD, Christian W. Siebel, PhD

Blood (2014) 124 (21): 652.

https://doi.org/10.1182/blood.V124.21.652.652

Published: 2014

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

HoxA3 Controls Notch Pathway to Repress Blood Development

Valentina Sanghez, PhD, Dustin Kee, Steven Beuder, Danielle Rux, Mitsujiro Osawa, PhD, Joe Markson, PhD, Michael Elowitz, PhD, Michael Kyba, PhD, Michelina Iacovino, PhD

Blood (2014) 124 (21): 4338.

https://doi.org/10.1182/blood.V124.21.4338.4338

Published: 2014

Journal Articles

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

Guangyao Kong, PhD, Yuan-I Chang, PhD, Erik A. Ranheim, MD, Yun Zhou, Yangang Liu, Paul Lambert, PhD, Lan Zhou, MD PhD, Pamela Stanley, PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD

Blood (2014) 124 (21): 261.

https://doi.org/10.1182/blood.V124.21.261.261

Published: 2014

NARROW

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Dll1 and Dll4 Notch Ligands Prime T Cell Alloimmunity and Are Expressed in Non-Overlapping Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes at the Onset of Gvhd

From Graft-Versus-Host Disease to Lymphoma Pathogenesis: Emerging Roles for Stromal Notch Ligands in Hematology

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Prognostic Impact of Notch Signaling in Acute Myeloid Leukemia (AML)

Hypoxia and Notch Signaling Synergistically Expand Long-Term Repopulating Human Hematopoietic Stem/Progenitor Cells

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis

Canonical Notch Signaling Is Required for Kras G12D -Induced Myeloproliferative Neoplasm

Notch Signaling Controls Drug Response in B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Microenvironment-Specific Activation of Notch2 in Splenic Marginal Zone Lymphoma

EGFL7 Antagonizes NOTCH Signaling, Stimulates Blast Proliferation and Confers Poor Prognosis in Cytogenetically-Normal Acute Myeloid Leukemia (CN-AML)

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

A Novel DLL1-Anti-CD19 Chimeric Protein Effectively Targets Notch Activation to B-Cell Acute Lymphoblastic Leukemia and Induces Cell Death

Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

The Safety and Activity of BMS-906024, a Gamma Secretase Inhibitor (GSI) with Anti-Notch Activity, in Patients with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL): Initial Results of a Phase 1 Trial

Notch2 Is Critical for CLL Development in the IRF4 -/- Vh11 Mice

Loss of Notch Receptor-Ligand Engagement Leads to Increased Hematopoietic Stem and Progenitor Cell Egress and Mobilization

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

HoxA3 Controls Notch Pathway to Repress Blood Development

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

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American Society of Hematology

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American Society of Hematology

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