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Journal Articles

Comprehensive Genomic Profiling of 104 Rare Histiocytic and Dendritic Cell Neoplasms Reveals Shared and Distinct Targetable Genomic Alterations

Lucas R. Massoth, MD, Yin P. Hung, MD, PhD, Judith A. Ferry, MD, Robert P. Hasserjian, MD, Abner Louissaint, Jr., MD PhD, Meagan Montesion, PhD, Ethan S. Sokol, PhD, Dean C. Pavlick, Nikunj Shah, Natalie Danziger, Jonathan Keith Killian, MD,PhD, Eric A. Severson, MD, PhD, MMSc, Daniel Duncan, MD, Julia A. Elvin, MD, PhD, Vincent A. Miller, MD, Jeffrey S. Ross, MD, Jo-Anne Vergilio, MD, Lawrence R. Zukerberg, MD, Erik A. Williams, MD

Blood (2019) 134 (Supplement_1): 2541.

https://doi.org/10.1182/blood-2019-123729

Published: 2019

Journal Articles

Discovery & Characterization of Therapeutically Targetable Ntrk Point Mutations in Leukemia

Sunil K Joshi, BA, William Bisson, PhD, Kristin Qian, Ariane Huang, Kevin Watanabe-Smith, PhD, Jeffrey W. Tyner, Monika Ashok Davare, PhD, Shannon K. McWeeney, PhD, Cristina E. Tognon, Brian J. Druker

Blood (2019) 134 (Supplement_1): 1256.

https://doi.org/10.1182/blood-2019-125908

Published: 2019

Journal Articles

Comprehensive Multi-Omics Analysis of Gene Fusions in a Large Multiple Myeloma Cohort

Steven M. Foltz, MS, Qingsong Gao, PhD, Christopher J. Yoon, MPhil, Amila Weerasinghe, PhD, Hua Sun, PhD, Lijun Yao, MS, Mark A. Fiala, BS, Daniel R. Kohnen, MBA, Justin King, BS, Yeong Seok Ju, MD PhD, John F. DiPersio, MD PhD, Ravi Vij, MBBS, Li Ding, PhD

Blood (2018) 132 (Supplement 1): 1898.

https://doi.org/10.1182/blood-2018-99-117245

Published: 2018

Journal Articles

Activating Mutations in CSF1R and Additional Receptor Tyrosine Kinases in Sporadic and Familial Histiocytic Neoplasms

Benjamin H Durham, MD BS, Estibaliz Lopez-Rodrigo, MD, David H Abramson, MD, Jennifer Picarsic, MD, Alessandro Pastore, Diana Mandelker, MD PhD, Michael Francis Walsh, MD, Maria E Arcila, MD, Marc Ladanyi, MD, David Solit, MD, Michael F. Berger, PhD, David M. Hyman, MD, Michelle Ki, BSc, Ira Dunkel, MD, Frederic Geissmann, MD PhD, Eli L Diamond, MD, Omar I Abdel-Wahab, MD

Blood (2018) 132 (Supplement 1): 49.

https://doi.org/10.1182/blood-2018-99-114248

Published: 2018

Journal Articles

Genomic Landscape of Multiple Myeloma with Elevated Lactate Dehydrogenase

Susan Bal, MBBS, Saulius K. Girnius, MD, Daniel T. Starczynowski, PhD, Heather J. Landau, MD, Kwangmin Choi, PhD

Blood (2018) 132 (Supplement 1): 470.

https://doi.org/10.1182/blood-2018-99-115523

Published: 2018

Journal Articles

Midostaurin Shows Efficacy in Refractory Multiple Myeloma with TP53 Mutation and Elevated Expression of NTRK1, NTRK3 and AURKA

Muntasir M Majumder, MSc, BPharm, David Tamborero, PhD, Pekka Anttila, Raija Helena Silvennoinen, MD, Samuli Eldfors, MSc, Juha Lievonen, Ashwini Kumar, MRes, Alun Parsons, Minna Suvela, MSC, Esa Jantunen, Kimmo Porkka, MD PhD, Caroline A Heckman, PhD

Blood (2017) 130 (Supplement 1): 4412.

https://doi.org/10.1182/blood.V130.Suppl_1.4412.4412

Published: 2017

Journal Articles

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Blood (2017) 130 (Supplement 1): 794.

https://doi.org/10.1182/blood.V130.Suppl_1.794.794

Published: 2017

Journal Articles

The Genomic Landscape of Childhood and Adult Acute Erythroid Leukemia

Blood (2016) 128 (22): 39.

https://doi.org/10.1182/blood.V128.22.39.39

Published: 2016

Journal Articles

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Benjamin Heath Durham, MD BS, Eli L. Diamond, MD, Julien Haroche, MD PhD, Zhan Yao, PhD, Jing Ma, PhD, Sameer A. Parikh, MD, John Choi, Eunhee Kim, PhD, Fleur Cohen-Aubart, Stanley Chun-Wei Lee, Yijun Gao, Jean-Baptiste Micol, MD, Patrick Campbell, MD PhD, Michael P. Walsh, Brooke Sylvester, Igor Dolgalev, Aminova Olga, Adriana Heguy, Paul Zappile, Joy Nakitandwe, BSc,MSc,PhD, James Dalton, BS, David W Ellison, MD, Juvianee Estrada-Veras, Mario Lacouture, William A. Gahl, MD PhD, Phil Stephens, PhD, Vincent A. Miller, MD, Jeffrey Ross, Siraj Ali, Sebastien Héritier, Jean Donadieu, MD PhD, David Solit, MD, David M. Hyman, Jose Baselga, MD PhD, Filip Janku, MDPhD, Barry S. Taylor, PhD, Christopher Y. Park, MD, PhD, Ahmet Dogan, MD PhD, Zahir Amoura, Jean-Francois Emile, Raajit K. Rampal, MD, PhD, Neal Rosen, MD PhD, Tanja A. Gruber, MD PhD, Omar Abdel-Wahab

Blood (2015) 126 (23): 481.

https://doi.org/10.1182/blood.V126.23.481.481

Published: 2015

Journal Articles

Novel Phenotypic and Genetic Analysis of T-Cell Prolymphocytic Leukemia (T-PLL)

Henan Zhang, Esteban Braggio, PhD, Jaime Davila, PhD, Andrew L. Feldman, MD, Timothy G. Call, MD, Thomas E. Witzig, MD, Yi Lin, MDPhD, Charla Secreto, Mrinal M. Patnaik, MBBS, James R Cerhan, MD PhD, Sameer A. Parikh, MD, Saurabh Baheti, Wei Ding, MD PhD

Blood (2014) 124 (21): 1682.

https://doi.org/10.1182/blood.V124.21.1682.1682

Published: 2014

Journal Articles

Screening JAK2 V617F-Negative and MPL W515K/L-Negative Essential Thrombocythemia Patients For Mutations In SESN2, DNAJC17, ST13, TOP1MT , and NTRK1

Carla AL Assaf, Els Lierman, PhD, Timothy Devos, MD, PhD, Johan Billiet, MD, Carlos Graux, MD, PhD, Petros Papadopoulos, PhD, Peter Vandenberghe, MD, PhD

Blood (2013) 122 (21): 5264.

https://doi.org/10.1182/blood.V122.21.5264.5264

Published: 2013

Journal Articles

Targeted Cancer Exome Sequencing Discovers Novel Recurrent Mutations In MPN

Elena Tenedini, PhD, Isabella Bernardis, MSc, Valentina Artusi, MSc, Lucia Artuso, PhD, Enrica Roncaglia, PhD, Paola Guglielmelli, PhD MD, Lisa Pieri, PhD MD, Costanza Bogani, PhD, Flavia Biamonte, BiSci, PhD, Elisa Bianchi, PhD, Alessandro Pancrazzi, BiSci, Carmela Mannarelli, BiSci, Tiziana Fanelli, BiSci, Giada Rotunno, BiSci, Guidantonio Malagoli Tagliazucchi, MSc, Sergio Ferrari, MD, Rossella Manfredini, PhD, Alessandro M Vannucchi, MD, Enrico Tagliafico, MD PhD

Blood (2013) 122 (21): 4099.

https://doi.org/10.1182/blood.V122.21.4099.4099

Published: 2013

Journal Articles

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Adrian Schwarzer, MD PhD, Helmut Holtmann, PhD, Celina Schauerte, M.Sc., Nomme Benn, Jan Völkel, Sabine Knöß, Johannes Zuber, MD, Zhixiong Li, MD, Axel Schambach, MD PhD, Christopher Baum, MD

Blood (2013) 122 (21): 3913.

https://doi.org/10.1182/blood.V122.21.3913.3913

Published: 2013

Journal Articles

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Adrian Schwarzer, MD, Johann Meyer, PhD, Martijn Brugman, PhD, Axel Schambach, MD PhD, Martin Stanulla, MD, MSc, Martin Schrappe, MD, Doris Steinemann, PhD, Brigitte Schlegelberger, M.D., Christopher Baum, MD, Zhixiong Li, MD

Blood (2011) 118 (21): 1381.

https://doi.org/10.1182/blood.V118.21.1381.1381

Published: 2011

Journal Articles

Mechanisms of Heme Oxygenase 1-Induced Resistance to Imatinib In CML Cells.

Daniele Tibullo, Ignazio Barbagallo, Antonio Branca, Cesarina Giallongo, Piera La Cava, PhD, Nunziatina Parrinello, Giovanni Li Volti, Angelo Vanella, Fabio Stagno, MD, Giuseppe A Palumbo, MD, Francesco Di Raimondo

Blood (2010) 116 (21): 3385.

https://doi.org/10.1182/blood.V116.21.3385.3385

Published: 2010

Journal Articles

Understanding the Role of TRKA Receptor in Acute Myeloid Leukemias: From Proliferation and Pro-Survival Signals to a Novel Therapeutic Approach

Maurizio L Ghisoli, MD, Wendy Fang, MD, Timothy C Graham, BS, Alejandro G Levy, MD, Lizhi Zeng, MD, Sankaranarayanan Kannan, PhD, Riitta M Nolo, PhD, Christine Pien, PhD, Jeffrey L Brown, PhD, Patrick A Zweidler-McKay, MD, PhD

Blood (2008) 112 (11): 3789.

https://doi.org/10.1182/blood.V112.11.3789.3789

Published: 2008

Journal Articles

Acquired 1p Uniparental Disomy Is Associated with Biallelic MPL W515L Mutation in RARS-T.

Hadrian Szpurka, MSc, PhD, Lukasz P Gondek, MD, Sanjay R Mohan, MD, Eric D Hsi, MD, Karl S Theil, MD, Mikkael A Sekeres, MD, MS, Jaroslaw P Maciejewski, MD, PhD

Blood (2008) 112 (11): 1643.

https://doi.org/10.1182/blood.V112.11.1643.1643

Published: 2008

Journal Articles

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

Blood (2008) 111 (9): 4797–4808.

https://doi.org/10.1182/blood-2007-09-113027

Published: 2008

Includes: Supplemental data

Journal Articles

Identification of Novel, Non-Synonymous Sequence Changes in the Tyrosine Kinase Genes of Patients with Acute Myeloid Leukemia.

Blood (2007) 110 (11): 823.

https://doi.org/10.1182/blood.V110.11.823.823

Published: 2007

Journal Articles

Fine Mapping and Expression Analysis of Chromosome 1 with the Aim of Defining Critically Deregulated Genes Important in the Pathogenesis of Myeloma.

Paola E. Leone, PhD, Matthew W. Jenner, MD, Brian A. Walker, PhD, David C. Johnson, BSc, David Gonzalez, PhD, Fiona M. Ross, PhD, Faith E. Davies, MD, Gareth J. Morgan, MD, PhD

Blood (2006) 108 (11): 112.

https://doi.org/10.1182/blood.V108.11.112.112

Published: 2006

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Comprehensive Genomic Profiling of 104 Rare Histiocytic and Dendritic Cell Neoplasms Reveals Shared and Distinct Targetable Genomic Alterations

Discovery & Characterization of Therapeutically Targetable Ntrk Point Mutations in Leukemia

Comprehensive Multi-Omics Analysis of Gene Fusions in a Large Multiple Myeloma Cohort

Activating Mutations in CSF1R and Additional Receptor Tyrosine Kinases in Sporadic and Familial Histiocytic Neoplasms

Genomic Landscape of Multiple Myeloma with Elevated Lactate Dehydrogenase

Midostaurin Shows Efficacy in Refractory Multiple Myeloma with TP53 Mutation and Elevated Expression of NTRK1, NTRK3 and AURKA

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

The Genomic Landscape of Childhood and Adult Acute Erythroid Leukemia

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Novel Phenotypic and Genetic Analysis of T-Cell Prolymphocytic Leukemia (T-PLL)

Screening JAK2 V617F-Negative and MPL W515K/L-Negative Essential Thrombocythemia Patients For Mutations In SESN2, DNAJC17, ST13, TOP1MT , and NTRK1

Targeted Cancer Exome Sequencing Discovers Novel Recurrent Mutations In MPN

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Mechanisms of Heme Oxygenase 1-Induced Resistance to Imatinib In CML Cells.

Understanding the Role of TRKA Receptor in Acute Myeloid Leukemias: From Proliferation and Pro-Survival Signals to a Novel Therapeutic Approach

Acquired 1p Uniparental Disomy Is Associated with Biallelic MPL W515L Mutation in RARS-T.

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

Identification of Novel, Non-Synonymous Sequence Changes in the Tyrosine Kinase Genes of Patients with Acute Myeloid Leukemia.

Fine Mapping and Expression Analysis of Chromosome 1 with the Aim of Defining Critically Deregulated Genes Important in the Pathogenesis of Myeloma.

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