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Journal Articles

Therapeutic Stratification of PTEN-MYC Axis Appears to be Promising for Molecular Targeted Therapies in Refractory and Relapsed T-Cell Acute Lymphoblastic Leukemia

Heinz Ahlert, MSc, BSc, Sanil Bhatia, PhD, Marc Remke, MD, Melf Sönnichsen, M.Sc., Niklas Dienstbier, M.Sc., Ute Fischer, PhD, Julia Hauer, MD, Arndt Borkhardt, MD

Blood (2019) 134 (Supplement_1): 3883.

https://doi.org/10.1182/blood-2019-128136

Published: 2019

Journal Articles

Idh2R140Q Cooperates with NHD13 to Induce Immature T Cell Leukemia By Targeting Early T Cell Progenitors or DN2 Thymocytes

Vijay Negi, PhD, Liat Goldberg, PhD, Yang Jo Chung, PhD, Masahiro Onozawa, MD, Peter D. Aplan, MD

Blood (2019) 134 (Supplement_1): 1346.

https://doi.org/10.1182/blood-2019-128675

Published: 2019

Journal Articles

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Sridhar reddy Srivatsan, MS, Sarath Chandra Janga, PhD, Axel Roers, PhD, Alexander Gerbaulet, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 3055.

https://doi.org/10.1182/blood-2018-99-118721

Published: 2018

Journal Articles

Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH)

Wenyi Shen, MD, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Hideki Makishima, MD PhD, Louis Williams, MD MBA, Sudipto Mukherjee, MD PhD MPH, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 2583.

https://doi.org/10.1182/blood-2018-99-115228

Published: 2018

Journal Articles

IGFBP7 As a Potential Therapeutic Target for AML

Yina Niu, PhD, Shuiyan Wu, MD, Shaoyan Hu, MD PhD

Blood (2018) 132 (Supplement 1): 5134.

https://doi.org/10.1182/blood-2018-99-119528

Published: 2018

Journal Articles

CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Olga Dashevsky, PhD, Brian Glassner, PhD, Olivia Bare, John G Doench, PhD, Constantine S. Mitsiades, MD PhD

Blood (2018) 132 (Supplement 1): 1915.

https://doi.org/10.1182/blood-2018-99-114986

Published: 2018

Journal Articles

The Gef Domain of the BCR-FGFR1 Chimeric Kinase Attenuates SCLL Progression through the RhoA/Rock/Pten Signaling Axis

Tianxiang Hu, PhD, Yating Chong, MSc, Sumin Lu, PhD, John Kenneth Cowell, PhD DSc, FRCPath

Blood (2018) 132 (Supplement 1): 4325.

https://doi.org/10.1182/blood-2018-99-119204

Published: 2018

Journal Articles

Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes

Mianmian Yin, PhD, Timour Baslan, PhD, Amy Freeland, PhD, Toshihiro Matsukawa, PhD, Steven C. Pruitt, PhD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1332.

https://doi.org/10.1182/blood-2018-99-115176

Published: 2018

Journal Articles

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Laurens Van Der Meer, PhD, Rene Marke, MSc, Miriam Butler, MSc, Dorette van Ingen Schenau, MSc, Blanca Scheijen, PhD, Frank van Leeuwen, PhD

Blood (2018) 132 (Supplement 1): 4088.

https://doi.org/10.1182/blood-2018-99-112888

Published: 2018

Journal Articles

Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia

Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi

Blood (2018) 131 (3): 289–300.

https://doi.org/10.1182/blood-2017-04-778829

Published: 2018

Includes: Supplemental data

Journal Articles

Reduced PTEN Involved in Primary Immune Thrombocytopenia Via Contributing to B Cell Hyper-Responsiveness

Shixuan Wang, Jr., MD, Yue Guan, Yunlong Wang, Huiyuan Li, Jr., Donglei Zhang, Renchi Yang, Sr., MD

Blood (2017) 130 (Supplement 1): 234.

https://doi.org/10.1182/blood.V130.Suppl_1.234.234

Published: 2017

Journal Articles

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

Lakshmi Reddy Palam, PhD, Raghuveer Mali, PhD, Baskar Ramdas, PhD, Bart Vanhaesebroeck, PhD, Reuben Kapur, PhD

Blood (2017) 130 (Supplement 1): 3754.

https://doi.org/10.1182/blood.V130.Suppl_1.3754.3754

Published: 2017

Journal Articles

Multi-Omics of Adult T Cell Acute Lymphoblastic Leukemia

Martin Neumann, Michael P Schroeder, PhD, Lorenz Bastian, Jutta Ortiz Tanchez, Cornelia Schlee, Konstandina Isaakidis, Alva Rani James, Lars R. Fransecky, Sebastian Vosberg, Stefan Krebs, PhD, Helmut Blum, PhD, Stefan Schwartz, MD, Thomas Burmeister, Dieter Hoelzer, MD PhD, Philipp A. Greif, MD, Monika Brüggemann, Nicola Goekbuget, MD, Claudia D. Baldus, MD

Blood (2017) 130 (Supplement 1): 2725.

https://doi.org/10.1182/blood.V130.Suppl_1.2725.2725

Published: 2017

Journal Articles

NEDD4-1 Modulates the Resistance of Multiple Myeloma to Bortezomib Via PTEN/PI3K/Akt Signaling Pathway

Xi Huang, Zhang En Fan, Qingxiao Chen, MS, Haimeng Yan, Xu Ruyi, Xinling Liu, Huiyao Gu, Jingsong He, MD, He Huang, MD PhD, Qing Yi, MD PhD, Zhen Cai, MD PhD

Blood (2017) 130 (Supplement 1): 1787.

https://doi.org/10.1182/blood.V130.Suppl_1.1787.1787

Published: 2017

Journal Articles

PTEN Alterations Are Related to Unfavorable Prognosis in Children with T-Cell Acute Lymphoblastic Leukemia Treated According to ALL IC-BFM Protocols

Bronisława Szarzyńska-Zawadzka, Joachim B. Kunz, MD, Maria Kosmalska, Katarzyna Zdon, Przemysław Biecek, PhD, Obul Reddy Bandapalli, PhD, Sędek Łukasz, PhD, Jerzy R. Kowalczyk, Prof, MD PhD, Tomasz Szczepański, MD PhD, Andreas E. Kulozik, MD PhD, Michał Witt, MD PhD, Malgorzata Dawidowska, PhD

Blood (2017) 130 (Supplement 1): 1446.

https://doi.org/10.1182/blood.V130.Suppl_1.1446.1446

Published: 2017

Journal Articles

MAP3K7 Is Recurrently Deleted in Pediatric T-Lymphoblastic Leukemia and Affects Cell Proliferation Independently of NF-κB

David M. Cordas dos Santos, Juliane Eilers, Alfonso Vizcaino, Elena Orlova, Martin Zimmermann, PhD, Martin Stanulla, MD PhD, Martin Schrappe, MD PhD, Kathleen Börner, PhD, Dirk Grimm, PhD, Martina Muckenthaler, Andreas E. Kulozik, MD PhD, Joachim B. Kunz, MD

Blood (2017) 130 (Supplement 1): 1447.

https://doi.org/10.1182/blood.V130.Suppl_1.1447.1447

Published: 2017

Journal Articles

Personalized Therapy Design for Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Using Computational Biology Modeling with in Vitro Validation

Madeleine Turcotte, MS, Raphael Charles Bosse, BS, MD PhD, Kimberly E. Hawkins, PhD BS, Amy Meacham, MS, Vindhya Vijay, MS, Girish Chinnaswamy, MD MRCP, Manju Sengar, MD DM, Ansu Kumar, MS, Shwetha K, BE, Anisha Kamath, BT, Anjana T. Nair, MS, Karthik S. Raju, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD

Blood (2017) 130 (Supplement 1): 1448.

https://doi.org/10.1182/blood.V130.Suppl_1.1448.1448

Published: 2017

Journal Articles

The Role of PLEKHA8 Gene in T Cell Lymphoblastic Leukemia

Tian Yuan, MD PhD, Yaling Yang, PhD, Wuping Li, MD PhD, Bing Xia, MD, Wen Xu, MD, Yizhuo Zhang, MD PhD, M. James You, MD PhD

Blood (2017) 130 (Supplement 1): 5122.

https://doi.org/10.1182/blood.V130.Suppl_1.5122.5122

Published: 2017

Journal Articles

Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish

Roman A. Li, David Traver, Thomas Matthes, Julien Y. Bertrand

Blood (2016) 128 (26): 3052–3060.

https://doi.org/10.1182/blood-2016-09-742502

Published: 2016

Includes: Supplemental data

Journal Articles

Phosphoproteomic Landscaping Unveils Constitutive cKIT Activation in Human Erythroblasts from Polycythemia Vera (PV) Patients

Lilian Varricchio, PhD, Giulia Federici, PhD, Francesca Masiello, MS, Fabrizio Martelli, PhD, Mario Falchi, PhD, Orietta Picconi, Gabriella Girelli, MD, Agostino Tafuri, MD, Emanuel Petricoin III, PhD, Ann Zeuner, PhD, Anna Rita Migliaccio, PhD

Blood (2016) 128 (22): 399.

https://doi.org/10.1182/blood.V128.22.399.399

Published: 2016

NARROW

Therapeutic Stratification of PTEN-MYC Axis Appears to be Promising for Molecular Targeted Therapies in Refractory and Relapsed T-Cell Acute Lymphoblastic Leukemia

Idh2R140Q Cooperates with NHD13 to Induce Immature T Cell Leukemia By Targeting Early T Cell Progenitors or DN2 Thymocytes

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH)

IGFBP7 As a Potential Therapeutic Target for AML

CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior

The Gef Domain of the BCR-FGFR1 Chimeric Kinase Attenuates SCLL Progression through the RhoA/Rock/Pten Signaling Axis

Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia

Reduced PTEN Involved in Primary Immune Thrombocytopenia Via Contributing to B Cell Hyper-Responsiveness

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

Multi-Omics of Adult T Cell Acute Lymphoblastic Leukemia

NEDD4-1 Modulates the Resistance of Multiple Myeloma to Bortezomib Via PTEN/PI3K/Akt Signaling Pathway

PTEN Alterations Are Related to Unfavorable Prognosis in Children with T-Cell Acute Lymphoblastic Leukemia Treated According to ALL IC-BFM Protocols

MAP3K7 Is Recurrently Deleted in Pediatric T-Lymphoblastic Leukemia and Affects Cell Proliferation Independently of NF-κB

Personalized Therapy Design for Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Using Computational Biology Modeling with in Vitro Validation

The Role of PLEKHA8 Gene in T Cell Lymphoblastic Leukemia

Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish

Phosphoproteomic Landscaping Unveils Constitutive cKIT Activation in Human Erythroblasts from Polycythemia Vera (PV) Patients

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American Society of Hematology

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American Society of Hematology

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