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Journal Articles

Ezh1 Inhibits Commitment to Hemogenic Fate and HSPC Formation during Vertebrate Development

Rebecca Soto, BS, Edroaldo Lummertz da rocha, PhD, Linda T Vo, PhD, Mariam Hachimi, PhD, Jenna M Frame, PhD, Paul J. Wrighton, PhD, Wolfram Goessling, MD PhD, George Q. Daley, MD PhD, Trista E North, PhD

Blood (2019) 134 (Supplement_1): 3710.

https://doi.org/10.1182/blood-2019-131464

Published: 2019

Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2019) 134 (Supplement_1): 455.

https://doi.org/10.1182/blood-2019-129570

Published: 2019

Journal Articles

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Na Man, Gloria Mas Martin, PhD, Daniel Karl, PhD, Jun Sun, PhD, Fan Liu, PhD, Miguel Torres-Martin, PhD, Hidehiro Itonaga, MD PhD, Concepcion Martinez, B.S., Shi Chen, Stephanie Duffort, Pierre-Jacques Hamard, PhD, Ye Xu, PhD, Luisa Cimmino, PhDBSc, Feng-Chun Yang, MD PhD, Philip A. Cole, MD PhD, Mingjiang Xu, MD PhD, Maria E. Figueroa, MD, Stephen Nimer, MD

Blood (2019) 134 (Supplement_1): 561.

https://doi.org/10.1182/blood-2019-130507

Published: 2019

Journal Articles

Synergistic Pre-Clinical Activity of Targeted Inhibition of KDM1A and BET Proteins Against Human AML Blast Progenitor Cells

Warren Fiskus, BSc, PhD, Christopher Peter Mill, PhD BA, Raffaella Soldi, Roulan Han, Dyana T. Saenz, PhD, Agnieszka J Nowak, Baohua Sun, MD PhD, David N Saenz, Courtney D. DiNardo, MD MSc, Gautam Borthakur, MD, Tapan M. Kadia, MD, Wendy Jin, Thurika Ganesh, Vaishnavi Rao, Joseph David Khoury, MD, Sunil Sharma, MD, Kapil N. Bhalla, MD

Blood (2018) 132 (Supplement 1): 3930.

https://doi.org/10.1182/blood-2018-99-114198

Published: 2018

Journal Articles

Ing4 Regulates Hematopoiesis through Suppression of NF-Kb

Zanshe Thompson, Vera Binder, MD, Michelle Ammerman, Ellen Durand, Leonard I. Zon, MD, Katie Kathrein, PhD

Blood (2018) 132 (Supplement 1): 642.

https://doi.org/10.1182/blood-2018-99-120033

Published: 2018

Journal Articles

Loss-of-Function Mutation in tet2 in Zebrafish Leads to Early MDS like Phenotype

Vinothkumar Rajan, BS, Rachel Woodside, B.SC, Sergey V Prykhozhij, PhD, Jason Berman, MD

Blood (2018) 132 (Supplement 1): 2318.

https://doi.org/10.1182/blood-2018-99-118594

Published: 2018

Journal Articles

A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia

Anna Cordeiro-Santanach, PhD, Sergey V Prykhozhij, PhD, Adam P Deveau, MSc, Kate L Del Bel, MSc, Stuart E Turvey, MBBS DPhil FRCPC, Jason Berman, MD

Blood (2018) 132 (Supplement 1): 3060.

https://doi.org/10.1182/blood-2018-99-112124

Published: 2018

Journal Articles

Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

Mark C Wilkes, Jae Wook Lee, Sriya Kudaravalli, Anupama Narla, MD, Bertil Glader, MD, Kathleen M. Sakamoto, MD PhD

Blood (2017) 130 (Supplement 1): 78.

https://doi.org/10.1182/blood.V130.Suppl_1.78.78

Published: 2017

Journal Articles

Megakaryocytic Microparticles for Gene- and Cell- Therapies

Chen-Yuan Kao, Christian Escobar, Eleftherios Papoutsakis, PhD

Blood (2017) 130 (Supplement 1): 2065.

https://doi.org/10.1182/blood.V130.Suppl_1.2065.2065

Published: 2017

Journal Articles

Development of RUNX1-Independent Hematopoiesis in Three Zebrafish runx1 -KO Models

Erica Bresciani, PhD, Blake Carrington, Erika Mijin Kwon, PhD, Marypat Jones, Kevin Bishop, Elizabeth Broadbridge, Stefania Dell'Orso, Raman B. Sood, PhD, Paul P Liu, MD

Blood (2017) 130 (Supplement 1): 2422.

https://doi.org/10.1182/blood.V130.Suppl_1.2422.2422

Published: 2017

Journal Articles

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Min Wu, PhD, Li Li, MD PhD, Bao Nguyen, MS, Donald Small, MD PhD, Amy S. Duffield, MD PhD

Blood (2017) 130 (Supplement 1): 1216.

https://doi.org/10.1182/blood.V130.Suppl_1.1216.1216

Published: 2017

Journal Articles

Endothelial Cell-Selective Adhesion Molecule (ESAM) Plays Important Roles in the Adult-Type Hemoglobin Synthesis during Fetal Erythropoiesis

Tomoaki Ueda, Takafumi Yokota, MD PhD, Yasuhiro Shingai, Yukiko Doi, Tomohiko Ishibashi, Takao Sudo, Akira Tanimura, Michiko Ichii, MD PhD, Sachiko Ezoe, Hirohiko Shibayama, MD PhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2017) 130 (Supplement 1): 1157.

https://doi.org/10.1182/blood.V130.Suppl_1.1157.1157

Published: 2017

Journal Articles

TLR Activation By MSC Derived Extracellular Vesicles Drives Myeloid Commitment

Young Me Yoon, BS, Natalya A Goloviznina, B.S., John Butler, BS, Santhosh Chakkaramakkil Verghese, PhD, Peter Kurre, MD

Blood (2016) 128 (22): 1470.

https://doi.org/10.1182/blood.V128.22.1470.1470

Published: 2016

Journal Articles

GATA Factor Switching during Erythroid Differentiation Is Facilitated By FBW7 Mediated Clearance of GATA2

Alireza Ghamari, Gabriela Pregerning, Ernest Fraenkel, Alan B. Cantor

Blood (2016) 128 (22): 1479.

https://doi.org/10.1182/blood.V128.22.1479.1479

Published: 2016

Journal Articles

Interaction with the DNA Binding Domain of MLL and a Small Molecular Drug Induces Proteolysis of MLL-Fusion Proteins and Ablates Leukemic Stem Cell Activity

Jasper de Boer, PhD, Sandra Cantilena, MPhil

Blood (2016) 128 (22): 1549.

https://doi.org/10.1182/blood.V128.22.1549.1549

Published: 2016

Journal Articles

Protection from UV-Light Is an Evolutionarily Conserved Feature of the Hematopoietic Niche

Friedrich G Kapp, MD, Julie R Perlin, PhD, Eirini Trompouki, PhD, Charlotte M Niemeyer, MD, Wolfgang Driever, Prof, PhD, Leonard I. Zon, MD

Blood (2016) 128 (22): 2663.

https://doi.org/10.1182/blood.V128.22.2663.2663

Published: 2016

Journal Articles

Residual HSPC in the Leukemia Microenvironment Are Reprogrammed Via Extracellular Vesicle Trafficking

Sherif Abdelhamed, PhD, Noah I Hornick, PhD, Peter Kurre, MD

Blood (2016) 128 (22): 888.

https://doi.org/10.1182/blood.V128.22.888.888

Published: 2016

Journal Articles

Large-Sacle Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34 + Cells

Yu Zhang, PhD Candidate, Chen Wang, PhD, Lan Wang, M.S., Jing Tian, PhD Candidate, Bin Shen, PhD Candidate, Xin Guan, PhD Candidate, Zhihua Ren, MD PhD, Xinxin Ding, PhD, Yupo Ma, MD PhD, Wei Dai, PhD, Yongping Jiang, PhD

Blood (2016) 128 (22): 817.

https://doi.org/10.1182/blood.V128.22.817.817

Published: 2016

Journal Articles

Pilot-Scale Production of Megakaryocytes/Platelets from Cord Blood CD34 + Cells in a Bottle Turning Device Culture System

Xin Guan, PhD Candidate, Lan Wang, M.S., Yu Zhang, PhD Candidate, Bin Shen, PhD Candidate, Zhihua Ren, MD PhD, Yupo Ma, MD PhD, Wei Dai, PhD, Yongping Jiang, PhD

Blood (2016) 128 (22): 819.

https://doi.org/10.1182/blood.V128.22.819.819

Published: 2016

Journal Articles

Role of Mir-34 Upregulation in Disruption of c-Myc, c-Myb and NOTCH Signaling in Diamond-Blackfan Anemia

Mark Wilkes, PhD, Elena Bibikova, PhD, Minyoung Youn, PhD, Alex Gia Lee, PhD, Ascia Eskin, M.S., Stanley Nelson, MD, Bertil Glader, MD PhD, Anupama Narla, MD, Kathleen M. Sakamoto, MD PhD

Blood (2016) 128 (22): 3895.

https://doi.org/10.1182/blood.V128.22.3895.3895

Published: 2016

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Ezh1 Inhibits Commitment to Hemogenic Fate and HSPC Formation during Vertebrate Development

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Synergistic Pre-Clinical Activity of Targeted Inhibition of KDM1A and BET Proteins Against Human AML Blast Progenitor Cells

Ing4 Regulates Hematopoiesis through Suppression of NF-Kb

Loss-of-Function Mutation in tet2 in Zebrafish Leads to Early MDS like Phenotype

A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia

Nemo-like Kinase Hyper-Activated in Erythroid Progenitors in Models of Diamond Blackfan Anemia

Megakaryocytic Microparticles for Gene- and Cell- Therapies

Development of RUNX1-Independent Hematopoiesis in Three Zebrafish runx1 -KO Models

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Endothelial Cell-Selective Adhesion Molecule (ESAM) Plays Important Roles in the Adult-Type Hemoglobin Synthesis during Fetal Erythropoiesis

TLR Activation By MSC Derived Extracellular Vesicles Drives Myeloid Commitment

GATA Factor Switching during Erythroid Differentiation Is Facilitated By FBW7 Mediated Clearance of GATA2

Interaction with the DNA Binding Domain of MLL and a Small Molecular Drug Induces Proteolysis of MLL-Fusion Proteins and Ablates Leukemic Stem Cell Activity

Protection from UV-Light Is an Evolutionarily Conserved Feature of the Hematopoietic Niche

Residual HSPC in the Leukemia Microenvironment Are Reprogrammed Via Extracellular Vesicle Trafficking

Large-Sacle Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34 + Cells

Pilot-Scale Production of Megakaryocytes/Platelets from Cord Blood CD34 + Cells in a Bottle Turning Device Culture System

Role of Mir-34 Upregulation in Disruption of c-Myc, c-Myb and NOTCH Signaling in Diamond-Blackfan Anemia

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