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Journal Articles

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells

Brief Report
Pia Sommerkamp, Mari Carmen Romero-Mulero, Andreas Narr, Luisa Ladel, Lucie Hustin, Katharina Schönberger, Simon Renders, Sandro Altamura, Petra Zeisberger, Karin Jäcklein, Daniel Klimmeck, Alejo Rodriguez-Fraticelli, Fernando D. Camargo, Leïla Perié, Andreas Trumpp, Nina Cabezas-Wallscheid
Journal: Blood
Blood (2021) 137 (23): 3218–3224.
https://doi.org/10.1182/blood.2020007876
Published: 2021
Includes: Supplemental data
Journal Articles

CD86-based analysis enables observation of bona fide hematopoietic responses

Masashi Kanayama, Yuta Izumi, Yasuharu Yamauchi, Shoko Kuroda, Takaei Shin, Shun Ishikawa, Taku Sato, Mihoko Kajita, Toshiaki Ohteki
Journal: Blood
Blood (2020) 136 (10): 1144–1154.
https://doi.org/10.1182/blood.2020004923
Published: 2020
Includes: Supplemental data
Journal Articles

Leukemia-Associated HSC Vascular Niche Is Negatively Regulated By PERK of Unfolded Protein Response (UPR)

Lan Zhou, MD, Cui Liu, MBBS, PhD, Stanley A Adoro, PhD BSc, MSc, Lechuang Chen, PhD, Diana Ramirez, PhD, Ge Jin, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2486.
https://doi.org/10.1182/blood-2019-127607
Published: 2019
Journal Articles

Inhibiting Matrix Metalloproteinases Hinders Acute Myeloid Leukaemia and Prevents Healthy Stem Cell Loss

Chiara Pirillo, Myriam Haltalli, Sara Gonzalez-anton, George Adams, Delfim Duarte, Cristina Lo Celso
Journal: Blood
Blood (2019) 134 (Supplement_1): 2487.
https://doi.org/10.1182/blood-2019-129847
Published: 2019
Journal Articles

Establishment of a Spontaneous Stromal Microenvironment from Cord Blood Supports Human Dynamic Erythropoietic Temporal Maturation in Long-Term Serum- and Cytokine-Free 3D Cultures and Reveals a Distinct CD44 hi Population

Susana Brito Dos Santos, MSc PhD, Athanasios Mantalaris, PhD, Nicki Panoskaltsis, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2219.
https://doi.org/10.1182/blood-2019-131085
Published: 2019
Journal Articles

Mutant U2AF1 S34F and U2AF1 Q157P Induce Distinct RNA Splicing and Hematopoietic Phenotypes In Vivo

Michael O. Alberti, MD PhD, Meng'ou Zhu, BS, Sridhar Nonavinkere Srivatsan, MS, Tanzir Ahmed, PhD, Jin J. Shao, Brian Wadugu, BA, Cara Lunn Shirai, PhD, Matthew J. Walter, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 770.
https://doi.org/10.1182/blood-2019-123892
Published: 2019
Journal Articles

Non-Genotoxic Anti-CD117 Antibody Conditioning Results in Successful Hematopoietic Stem Cell Engraftment in Patients with Severe Combined Immunodeficiency

Rajni Agarwal, MD, Christopher C. Dvorak, MD, Hye-Sook Kwon, PhD, Janel R Long-Boyle, PharmD, PhD, Susan S Prohaska, PhD MS, Janice W Brown, MD, Anne Le, Alyssa Guttman-Klein, Irving L Weissman, MD, Morton J Cowan, MD, Aaron C. Logan, MD PhD, Kenneth I. Weinberg, MD, Robertson Parkman, MD, Maria-Grazia Roncarolo, MD, Judith A Shizuru, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 800.
https://doi.org/10.1182/blood-2019-126239
Published: 2019
Journal Articles

Functional Complementation between β-Catenin and Hoxa9 Sustains HSC Self-Renewal in a Prmt1-Dependent Manner

Jennifer Lynch, PhD, Clemence Virely, PhD, Priscilla Lau, PhD, Huacheng Luo, PhD, Suming Huang, PhD, Eric Chi Wai So, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 449.
https://doi.org/10.1182/blood-2019-131052
Published: 2019
Journal Articles

Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure

Yimeng Gao, PhD, Radovan Vasic, MD, Yuanbin Song, MD, Rhea Teng, B.Sc., Rana Gbyli, MS, Giulia Biancon, PhD, Raman Nelakanti, B.Sc., Eriko Kudo, B.Sc., Wei Liu, PhD, Anastasia Ardasheva, BS, Xiaoying Fu, MD, Xiaman Wang, MD PhD, Poorval Joshi, PhD, Burak Dura, PhD, Veronica Lee, Gabriella Viero, PhD, Akiko Iwasaki, PhD, Rong Fan, PhD, Andrew Xiao, PhD, Richard Flavell, PhD, Hua-Bing Li, PhD, Toma Tebaldi, PhD, Stephanie Halene, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 450.
https://doi.org/10.1182/blood-2019-130442
Published: 2019
Journal Articles

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

John F. Tisdale, MD, Robert E. Donahue, VMD, Naoya Uchida, MD, Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Allen Krouse, Nathaniel S. Linde, Aylin C. Bonifacino, Rajiv Panwar, PhD, Ganapathy N. Sarma, PhD, Lena Kien, BS, Kellie Latimer, Junia Dushime, BS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 610.
https://doi.org/10.1182/blood-2019-125968
Published: 2019
Journal Articles

Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors

Jizhou Zhang, Qingqing Wu, PhD, Courtney Johnson, BS, André Olsson, MS, PhD, Anastasiya Slaughter, BA, Margot Lindsay May, BS, Benjamin Weinhaus, BS, Emily Bowers, PhD, James Douglas Engel, PhD, Jean X. Jiang, PhD, Sherry L. Abboud-Werner, PhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD, Daniel Lucas-Alcaraz, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 528.
https://doi.org/10.1182/blood-2019-128809
Published: 2019
Journal Articles

VCAM1 Confers Innate Immune Tolerance on Hematopoietic and Leukemic Stem Cells

Sandra Pinho, PhD, Qiaozhi Wei, PhD, Maria Maryanovich, PhD, Halley Pierce, PhD, Fumio Nakahara, MD PhD, Jianing Xu, PhD, Daniel K. Borger, MS, Dachuan Zhang, PhD, Amit Verma, MBBS, Paul S. Frenette, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 524.
https://doi.org/10.1182/blood-2019-123431
Published: 2019
Journal Articles

Azacitidine for Pre-Emptive Treatment of Measurable-Residual Disease in MDS/AML Patients at High Risk of Hematological Relapse: Results of the Second Cohort of the RELAZA2 Trial

Uwe Platzbecker, MD, Jan Moritz Middeke, MD, Katja Sockel, MD, Regina Herbst, MD, Lars R. Fransecky, MD, Dominik Wolf, MD, Schumacher Martin, MD, Alwin Krämer, MD, Richard Noppeney, MD, Juergen Novotny, MD, Gesine Bug, Katharina Götze, Karsten Spiekermann, MD, Matthias Stelljes, MD, Christoph Groth, MD, Marion Subklewe, MD, Antje Schubert, Anke Mütherig, MD, Tilmann Bochtler, MD, Marika Mende, MD, Anne Sophie Kubasch, MD, Mathias Hänel, MD, Ulrich Dührsen, Prof, MD PhD, Johannes Schetelig, MD MSc, Christoph Röllig, MD MSC, Claudia D Baldus, Gerhard Ehninger, MD, Carsten Müller-Tidow, MD, Hubert Serve, MD, Michael Kramer, M.Sc., Martin Bornhäuser, MD, Christian Thiede, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 644.
https://doi.org/10.1182/blood-2019-129926
Published: 2019
Journal Articles

Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells

Zhaowei Tu, PhD, Chen Wang, MSc, Chuntao Zhao, PhD, Lei Huang, PhD, Nathan Salomonis, PhD, Richard Q Lu, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1191.
https://doi.org/10.1182/blood-2019-127313
Published: 2019
Journal Articles

Critical Requirement of U2AF1 in the Maintenance and Function of Hematopoietic Stem Cells

Avik Dutta, PhD, Yue Yang, PhD, Bao Le, Golam Mohi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1195.
https://doi.org/10.1182/blood-2019-132007
Published: 2019
Journal Articles

Defining Germline Predisposition to Dnmt3a -Mutant Clonal Hematopoiesis (CH)

Logan Sari Schwartz, BS, Kristina Mujica, Rebecca Bell, BA, Matthew Loberg, BA, Jennifer Trowbridge, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1198.
https://doi.org/10.1182/blood-2019-124530
Published: 2019
Journal Articles

IMPACT-TB*: A Phase II Trial Assessing the Capacity of Low Dose Imatinib to Induce Myelopoiesis and Enhance Host Anti-Microbial Immunity Against Tuberculosis. *Imatinib Mesylate per Oral As a Clinical Therapeutic for TB

Cynthia R. Giver, PhD, Pamela A Shaw, PhD, Helen Fletcher, PhD, Deepak Kaushal, PhD, Garcia Pamela, Deborah Omoyege, Gregory Bisson, MD, Tawanda Gumbo, MD, Robert Wallis, MD, Edmund K. Waller, PhDMD, Daniel Kalman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1050.
https://doi.org/10.1182/blood-2019-130275
Published: 2019
Journal Articles

KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia

Andrew Lewis, BS, Chun Shik Park, PhD, Monica Puppi, H. Daniel Lacorazza, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1231.
https://doi.org/10.1182/blood-2019-129164
Published: 2019
Journal Articles

Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes

Sina Staeble, MSc, Stephen Kraemer, MSc, Jens Langstein, MSc, Ruzhica Bogeska, PhD, Mark Hartmann, PhD, Maximilian Schoenung, MSc, Melinda Czeh, PhD, Julia Knoch, Natasha Anstee, PhD, Simon Haas, PhD, Abdelrahman Mahmoud, MSc, Julius Graesel, MSc, Daniel Huebschmann, MD PhD, Lars Feuerbach, PhD, Weichenhan Dieter, PhD, Benedikt Brors, PhD, Karsten Rippe, PhD, Jan-Philipp Mallm, PhD, Frank Rosenbauer, PhD, Christoph Plass, PhD, Matthias Schlesner, PhD, Michael D. Milsom, PhD, Daniel B. Lipka, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1179.
https://doi.org/10.1182/blood-2019-124429
Published: 2019
Journal Articles

Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

Yonghan He, MD, Jianhui Chang, Dongwen Lv, Ha-neui Kim, Maria Almeida, Xin Zhang, Xinjian Mao, PhD, Xinghui Zhao, PhD, Linheng Li, PhD, Judith Campisi, Ying Liang, MD PhD, Daohong Zhou
Journal: Blood
Blood (2019) 134 (Supplement_1): 1204.
https://doi.org/10.1182/blood-2019-123159
Published: 2019