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Journal Articles

Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinases Exerts Synergistic Effect Against Chronic Myeloid Leukemia Cells

Sylwia Flis, Ewelina Bratek, Tomasz Chojnacki, Marlena Piskorek, Tomasz Skorski, MD PhD

Blood (2019) 134 (Supplement_1): 4143.

https://doi.org/10.1182/blood-2019-129093

Published: 2019

Journal Articles

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

Sun-Mi Park, PhD, Hyunwoo Cho, PhD, Angela Thornton, PhD, Trevor Stephen Barlowe, BA, Timothy Chou, BS, Sagar Chhangawala, PhD, Lauren Fairchild, PhD, Arthur Chow, BA, James Taggart, BA, Alexander Schurer, BA, Antoine Gruet, Matthew Witkin, Jun Hyun Kim, Ethan Shevach, Andrei Krivstov, Scott A. Armstrong, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 3881.

https://doi.org/10.1182/blood-2018-99-115034

Published: 2018

Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 883.

https://doi.org/10.1182/blood-2018-99-112543

Published: 2018

Journal Articles

Lethal and Sub-Lethal Irradiation of Sprague-Dawley Rats Causes Development of Dense Red Blood Cells

Janice Zawaski, PhD, Alireza Paikari, MD, Celeste K Kanne, BA, Omaima Sabek, PhD, M Waleed Gaber, PhD, Vivien Sheehan, MD PhD

Blood (2017) 130 (Supplement 1): 4738.

https://doi.org/10.1182/blood.V130.Suppl_1.4738.4738

Published: 2017

Journal Articles

Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia

Fabio H Silva, PhD, Eduardo C Alexandre, PhD, Fabiano B Calmasini, PhD, Carla Fernanda Franco-Penteado, BSc, PhD, Edson Antunes, PhD, Kleber Yotsumoto Fertrin, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2017) 130 (Supplement 1): 3470.

https://doi.org/10.1182/blood.V130.Suppl_1.3470.3470

Published: 2017

Journal Articles

Defective Function of KCa3.1 Channels in Lysosomal Storage Disorders

Pilar Giraldo, PhD, Jorge J Cebolla, fellow, Pilar Irun, PhD, Laura Lopez de Frutos, MSc, Marcio Andrade-Campos, PhD, Ralf Köhler, PhD

Blood (2017) 130 (Supplement 1): 3562.

https://doi.org/10.1182/blood.V130.Suppl_1.3562.3562

Published: 2017

Journal Articles

Hydroxyurea Induces Growth Inhibition in BCR-ABL1 T315I+ Clones and Synergizes with Ponatinib in Killing TKI-Resistant CML Cells

Mathias A Schneeweiss, MD, Konstantin Byrgazov, PhD, Chantal B Lucini, PhD, Susanne Herndlhofer, Wolfgang R. Sperr, MD, Thomas Lion, PhD, Gregor Hoermann, Michael W. Deininger, MD PhD, Peter Valent, MD, Karoline V Gleixner, MD

Blood (2016) 128 (22): 5425.

https://doi.org/10.1182/blood.V128.22.5425.5425

Published: 2016

Journal Articles

Anti-Leukemic Effects of Venetoclax on Philadelphia Chromosome Positive Leukemia Cells

Seiichi Okabe, MD PhD, Tetsuzo Tauchi, MD PhD, Yuko Tanaka, MD PhD, Kazuma Ohyashiki, MD PhD

Blood (2016) 128 (22): 5428.

https://doi.org/10.1182/blood.V128.22.5428.5428

Published: 2016

Journal Articles

MPL mRNA Expression in Venous Blood Leukocytes Is Reduced in Patients with Hematologic Malignancies Excluding MPN

Aleksey Gorbenko, Marina Stolyar, Igor Olkhovskiy, PhD, Evgeniy Vasiliev, Mikhail Mikhalev, Maria Smelyanskaiya

Blood (2016) 128 (22): 5102.

https://doi.org/10.1182/blood.V128.22.5102.5102

Published: 2016

Journal Articles

Parthenolide and DMAPT Induce Cell Death in Chronic Myeloid Leukemia Cells Via Generation of Reactive Oxygen Species

Gabriela Flores-López, PhD Candidate, Hector Mayani, PhD, María Antonieta Chávez-Gonzalez, PhD

Blood (2016) 128 (22): 4242.

https://doi.org/10.1182/blood.V128.22.4242.4242

Published: 2016

Journal Articles

Superior Identification of Prognostic Relevant Copy Number Abnormalities By SNP-Based Genomic Arrays As Compared to Interphase FISH in Multiple Myeloma

Marian Stevens-Kroef, PhD, Daniel Olde Weghuis, Simone Wezenberg, Sandra Croockewit, Hans Wessels, Marjolein van der Mespel, Sonja Zweegman, MD PhD, Pino J. Poddighe, PhD

Blood (2016) 128 (22): 4426.

https://doi.org/10.1182/blood.V128.22.4426.4426

Published: 2016

Journal Articles

BGB324 Inhibits BCR-ABL TKI-Resistant Chronic Myeloid Leukemia

Blood (2015) 126 (23): 1569.

https://doi.org/10.1182/blood.V126.23.1569.1569

Published: 2015

Journal Articles

ABL001, a Potent, Allosteric Inhibitor of BCR-ABL, Exhibits Safety and Promising Single- Agent Activity in a Phase I Study of Patients with CML with Failure of Prior TKI Therapy

Oliver G. Ottmann, MD, Giuliana Alimena, Daniel J. DeAngelo, MD PhD, Yeow-Tee Goh, MBBS, MMed, Michael C. Heinrich, MD, Andreas Hochhaus, MD, Timothy P. Hughes, MD MBBS, FRACP, FRCPA, Francois-Xavier Mahon, MD PhD Professor, Michael J. Mauro, MD, Hironobu Minami, MD D.MDSci., Marie Huong Nguyen, MD, Delphine Rea, Juan Luis Steegmann, MD, Arkendu Chatterjee, Varsha Iyer, Noelia Martinez, Gary J. Vanasse, MD, Kim Dong-Wook, MD PhD

Blood (2015) 126 (23): 138.

https://doi.org/10.1182/blood.V126.23.138.138

Published: 2015

Journal Articles

MS4A3 Improves Imatinib Response and Survival in BCR-ABL1 Primary TKI Resistance and in Blastic Transformation of Chronic Myeloid Leukemia

Anna M. Eiring, PhD, Jamshid S. Khorashad, MD PhD, Anupriya Agarwal, PhD, Clinton C. Mason, PhD, Fan Yu, MD, Hannah M. Redwine, Amber D. Bowler, Kevin C. Gantz, Kimberly R. Reynolds, MS, Phillip M. Clair, MS, David J. Anderson, MBA, Srinivas K Tantravahi, Shannon K. McWeeney, PhD, Brian J. Druker, MD, Derek L. Stirewalt, MD, Vivian G. Oehler, MD, Thomas O'Hare, PhD, Michael W. Deininger

Blood (2015) 126 (23): 14.

https://doi.org/10.1182/blood.V126.23.14.14

Published: 2015

Journal Articles

Oxidative Stress Contributes to Overactive Bladder in the Transgenic Sickle Cell Mouse

Fabio Henrique Silva, M.Sc, PhD, Celso Saragosa Ramos Filho, PhD, Fabiano Beraldi Calmasini, M.Sc, Eduardo Costa Alexandre, M.Sc, Roger Barbosa Ferreira, Mariana Goncalves de Oliveira, M.Sc, Mário Angelo Claudino, BSc, PhD, Carla Fernanda Franco-Penteado, BSc, PhD, Edson Antunes, PhD, Fernando F Costa, MD, PhD

Blood (2015) 126 (23): 4582.

https://doi.org/10.1182/blood.V126.23.4582.4582

Published: 2015

Journal Articles

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

Blood (2014) 124 (21): 4512.

https://doi.org/10.1182/blood.V124.21.4512.4512

Published: 2014

Journal Articles

ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia

Blood (2014) 124 (21): 398.

https://doi.org/10.1182/blood.V124.21.398.398

Published: 2014

Journal Articles

Metabolic Shift In Hypoxia-Adapted CML Cells and Mechanisms Of Acquired Dasatinib Resistance Uncovered By Proteomic iTRAQ Profiling

Yoko Tabe, MD, PhD, Linhua Jin, PhD, Hiroko Iwanami, Hiromichi Matsushita, MD, PhD, Saiko Kazuno, Tsutomu Fujimura, Takashi Ueno, Takashi Miida, MD, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD, Shinya Kimura, MD, PhD

Blood (2013) 122 (21): 3991.

https://doi.org/10.1182/blood.V122.21.3991.3991

Published: 2013

Journal Articles

Philadelphia Chromosome (Ph)-Positive Leukemia Patients Who Fail ABL1 Tyrosine Kinase Inhibitors Without BCR-ABL1 Kinase Domain Point Mutations Demonstrate Sensitivity To PI3-K/AKT Inhibitors

Christopher A. Eide, Samantha L. Savage, Jade Bryant, Anupriya Agarwal, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Thomas O'Hare, Michael W. Deininger, Marc M. Loriaux, Cristina E. Tognon, Jeffrey W. Tyner, Brian J. Druker

Blood (2013) 122 (21): 3994.

https://doi.org/10.1182/blood.V122.21.3994.3994

Published: 2013

Journal Articles

Dual Specific Inhibitors Of The BCR-ABL and MNK Kinases As Potential Therapeutics For Blast Crisis Chronic Myeloid Leukemia

Blood (2013) 122 (21): 2702.

https://doi.org/10.1182/blood.V122.21.2702.2702

Published: 2013

NARROW

Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinases Exerts Synergistic Effect Against Chronic Myeloid Leukemia Cells

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Lethal and Sub-Lethal Irradiation of Sprague-Dawley Rats Causes Development of Dense Red Blood Cells

Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia

Defective Function of KCa3.1 Channels in Lysosomal Storage Disorders

Hydroxyurea Induces Growth Inhibition in BCR-ABL1 T315I+ Clones and Synergizes with Ponatinib in Killing TKI-Resistant CML Cells

Anti-Leukemic Effects of Venetoclax on Philadelphia Chromosome Positive Leukemia Cells

MPL mRNA Expression in Venous Blood Leukocytes Is Reduced in Patients with Hematologic Malignancies Excluding MPN

Parthenolide and DMAPT Induce Cell Death in Chronic Myeloid Leukemia Cells Via Generation of Reactive Oxygen Species

Superior Identification of Prognostic Relevant Copy Number Abnormalities By SNP-Based Genomic Arrays As Compared to Interphase FISH in Multiple Myeloma

BGB324 Inhibits BCR-ABL TKI-Resistant Chronic Myeloid Leukemia

ABL001, a Potent, Allosteric Inhibitor of BCR-ABL, Exhibits Safety and Promising Single- Agent Activity in a Phase I Study of Patients with CML with Failure of Prior TKI Therapy

MS4A3 Improves Imatinib Response and Survival in BCR-ABL1 Primary TKI Resistance and in Blastic Transformation of Chronic Myeloid Leukemia

Oxidative Stress Contributes to Overactive Bladder in the Transgenic Sickle Cell Mouse

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia

Metabolic Shift In Hypoxia-Adapted CML Cells and Mechanisms Of Acquired Dasatinib Resistance Uncovered By Proteomic iTRAQ Profiling

Philadelphia Chromosome (Ph)-Positive Leukemia Patients Who Fail ABL1 Tyrosine Kinase Inhibitors Without BCR-ABL1 Kinase Domain Point Mutations Demonstrate Sensitivity To PI3-K/AKT Inhibitors

Dual Specific Inhibitors Of The BCR-ABL and MNK Kinases As Potential Therapeutics For Blast Crisis Chronic Myeloid Leukemia

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American Society of Hematology

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American Society of Hematology

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